UniProtKB - Q96AX9 (MIB2_HUMAN)
E3 ubiquitin-protein ligase MIB2
MIB2
Functioni
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 143 – 190 | ZZ-typePROSITE-ProRule annotationAdd BLAST | 48 | |
Zinc fingeri | 890 – 925 | RING-type 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Zinc fingeri | 969 – 1002 | RING-type 2PROSITE-ProRule annotationAdd BLAST | 34 |
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- ubiquitin protein ligase activity Source: Ensembl
- ubiquitin-protein transferase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- Notch signaling pathway Source: UniProtKB-KW
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- protein polyubiquitination Source: Reactome
- protein ubiquitination Source: GO_Central
Keywordsi
Molecular function | Actin-binding, Transferase |
Biological process | Notch signaling pathway, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q96AX9 |
Reactomei | R-HSA-2122948, Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2691232, Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2979096, NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-9013507, NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | Q96AX9 |
SIGNORi | Q96AX9 |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: E3 ubiquitin-protein ligase MIB2 (EC:2.3.2.27)Alternative name(s): Mind bomb homolog 2 Novel zinc finger protein Short name: Novelzin Putative NF-kappa-B-activating protein 002N RING-type E3 ubiquitin transferase MIB2Curated Skeletrophin Zinc finger ZZ type with ankyrin repeat domain protein 1 |
Gene namesi | Name:MIB2 Synonyms:SKD, ZZANK1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30577, MIB2 |
MIMi | 611141, gene |
neXtProti | NX_Q96AX9 |
VEuPathDBi | HostDB:ENSG00000197530.12 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Endosome
- early endosome Source: Ensembl
Other locations
- cytoplasm Source: GO_Central
- ubiquitin ligase complex Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, EndosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 142678 |
MalaCardsi | MIB2 |
OpenTargetsi | ENSG00000197530 |
Orphaneti | 54260, Left ventricular noncompaction |
PharmGKBi | PA134924284 |
Miscellaneous databases
Pharosi | Q96AX9, Tbio |
Genetic variation databases
BioMutai | MIB2 |
DMDMi | 209572707 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000055947 | 1 – 1013 | E3 ubiquitin-protein ligase MIB2Add BLAST | 1013 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 309 | PhosphoserineCombined sources | 1 | ||
Isoform 8 (identifier: Q96AX9-8) | |||||
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | ||
Isoform 10 (identifier: Q96AX9-10) | |||||
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q96AX9 |
MassIVEi | Q96AX9 |
MaxQBi | Q96AX9 |
PaxDbi | Q96AX9 |
PeptideAtlasi | Q96AX9 |
PRIDEi | Q96AX9 |
ProteomicsDBi | 20393 20580 30446 3825 76009 [Q96AX9-1] 76010 [Q96AX9-2] 76011 [Q96AX9-3] 76012 [Q96AX9-4] 76013 [Q96AX9-5] 76014 [Q96AX9-6] 76015 [Q96AX9-7] 76016 [Q96AX9-8] 76017 [Q96AX9-9] |
PTM databases
iPTMneti | Q96AX9 |
PhosphoSitePlusi | Q96AX9 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000197530, Expressed in pituitary gland and 182 other tissues |
ExpressionAtlasi | Q96AX9, baseline and differential |
Genevisiblei | Q96AX9, HS |
Organism-specific databases
HPAi | ENSG00000197530, Tissue enriched (skeletal) |
Interactioni
Subunit structurei
Interacts with actin monomer.
1 PublicationBinary interactionsi
Q96AX9
With | #Exp. | IntAct |
---|---|---|
TBK1 [Q9UHD2] | 2 | EBI-2130249,EBI-356402 |
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 126769, 37 interactors |
IntActi | Q96AX9, 17 interactors |
STRINGi | 9606.ENSP00000426103 |
Miscellaneous databases
RNActi | Q96AX9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 59 – 138 | MIB/HERC2 1PROSITE-ProRule annotationAdd BLAST | 80 | |
Domaini | 207 – 285 | MIB/HERC2 2PROSITE-ProRule annotationAdd BLAST | 79 | |
Repeati | 522 – 551 | ANK 1Add BLAST | 30 | |
Repeati | 555 – 584 | ANK 2Add BLAST | 30 | |
Repeati | 588 – 617 | ANK 3Add BLAST | 30 | |
Repeati | 621 – 653 | ANK 4Add BLAST | 33 | |
Repeati | 657 – 686 | ANK 5Add BLAST | 30 | |
Repeati | 691 – 721 | ANK 6Add BLAST | 31 | |
Repeati | 725 – 754 | ANK 7Add BLAST | 30 | |
Repeati | 758 – 786 | ANK 8Add BLAST | 29 | |
Repeati | 827 – 856 | ANK 9Add BLAST | 30 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 143 – 190 | ZZ-typePROSITE-ProRule annotationAdd BLAST | 48 | |
Zinc fingeri | 890 – 925 | RING-type 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Zinc fingeri | 969 – 1002 | RING-type 2PROSITE-ProRule annotationAdd BLAST | 34 |
Keywords - Domaini
ANK repeat, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0504, Eukaryota KOG4582, Eukaryota |
GeneTreei | ENSGT00940000158097 |
InParanoidi | Q96AX9 |
OMAi | HDAIGKD |
OrthoDBi | 220300at2759 |
PhylomeDBi | Q96AX9 |
TreeFami | TF324147 |
Family and domain databases
CDDi | cd02339, ZZ_Mind_bomb, 1 hit |
Gene3Di | 1.25.40.20, 1 hit 2.30.30.920, 2 hits 3.30.40.10, 2 hits 3.30.60.90, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR042056, MIB1/2_ZZ IPR010606, Mib_Herc2 IPR037252, Mib_Herc2_sf IPR040847, SH3_15 IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR000433, Znf_ZZ IPR043145, Znf_ZZ_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF06701, MIB_HERC2, 2 hits PF18346, SH3_15, 2 hits PF00569, ZZ, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 9 hits SM00184, RING, 2 hits SM00291, ZnF_ZZ, 1 hit |
SUPFAMi | SSF159034, SSF159034, 2 hits SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 5 hits PS51416, MIB_HERC2, 2 hits PS50089, ZF_RING_2, 2 hits PS01357, ZF_ZZ_1, 1 hit PS50135, ZF_ZZ_2, 1 hit |
s (14+)i Sequence
Sequence statusi: Complete.
This entry describes 14 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 14 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGWKPSEARG QSQSFQASGL QPRSLKAARR ATGRPDRSRA ARPTMDPSAH
60 70 80 90 100
RSRAAPPNMD PDPQAGVQVG MRVVRGVDWK WGQQDGGEGG VGTVVELGRH
110 120 130 140 150
GSPSTPDRTV VVQWDQGTRT NYRAGYQGAH DLLLYDNAQI GVRHPNIICD
160 170 180 190 200
CCKKHGLRGM RWKCRVCLDY DLCTQCYMHN KHELAHAFDR YETAHSRPVT
210 220 230 240 250
LSPRQGLPRI PLRGIFQGAK VVRGPDWEWG SQDGGEGKPG RVVDIRGWDV
260 270 280 290 300
ETGRSVASVT WADGTTNVYR VGHKGKVDLK CVGEAAGGFY YKDHLPRLGK
310 320 330 340 350
PAELQRRVSA DSQPFQHGDK VKCLLDTDVL REMQEGHGGW NPRMAEFIGQ
360 370 380 390 400
TGTVHRITDR GDVRVQFNHE TRWTFHPGAL TKHHSFWVGD VVRVIGDLDT
410 420 430 440 450
VKRLQAGHGE WTDDMAPALG RVGKVVKVFG DGNLRVAVAG QRWTFSPSCL
460 470 480 490 500
VAYRPEEDAN LDVAERAREN KSSLSVALDK LRAQKSDPEH PGRLVVEVAL
510 520 530 540 550
GNAARALDLL RRRPEQVDTK NQGRTALQVA AYLGQVELIR LLLQARAGVD
560 570 580 590 600
LPDDEGNTAL HYAALGNQPE ATRVLLSAGC RADAINSTQS TALHVAVQRG
610 620 630 640 650
FLEVVRALCE RGCDVNLPDA HSDTPLHSAI SAGTGASGIV EVLTEVPNID
660 670 680 690 700
VTATNSQGFT LLHHASLKGH ALAVRKILAR ARQLVDAKKE DGFTALHLAA
710 720 730 740 750
LNNHREVAQI LIREGRCDVN VRNRKLQSPL HLAVQQAHVG LVPLLVDAGC
760 770 780 790 800
SVNAEDEEGD TALHVALQRH QLLPLVADGA GGDPGPLQLL SRLQASGLPG
810 820 830 840 850
SAELTVGAAV ACFLALEGAD VSYTNHRGRS PLDLAAEGRV LKALQGCAQR
860 870 880 890 900
FRERQAGGGA APGPRQTLGT PNTVTNLHVG AAPGPEAAEC LVCSELALLV
910 920 930 940 950
LFSPCQHRTV CEECARRMKK CIRCQVVVSK KLRPDGSEVA SAAPAPGPPR
960 970 980 990 1000
QLVEELQSRY RQMEERITCP ICIDSHIRLV FQCGHGACAP CGSALSACPI
1010
CRQPIRDRIQ IFV
The sequence of this isoform differs from the canonical sequence as follows:
1-58: Missing.
234-298: Missing.
853-1013: ERQAGGGAAP...PIRDRIQIFV → VRAQDEEVHQVPGGRQQETAPRRL
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MAGALRRGRALGSRPSGPTVSSRRSPQCPVAQEGLGARSRPRVAPRSLARCGPSSRLM
42-55: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MAGALRRGRALGSRPSGPTVSSRRSPQCPVAQEGLGARSRPRVAPRSLARCGPSSRLM
234-298: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MAGALRRGRALGSRPSGPTVSSRRSPQCPVAQEGLGARSRPRVAPRSLARCGPSSRLM
347-350: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MAGALRRGRALGSRPSGPTVSSRRSPQCPVAQEGLGARSRPRVAPRSLARCGPSSRLM
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PD12 | E9PD12_HUMAN | RING-type E3 ubiquitin transferase | MIB2 | 969 | Annotation score: | ||
H0YAM8 | H0YAM8_HUMAN | RING-type E3 ubiquitin transferase | MIB2 | 829 | Annotation score: | ||
D6RAZ0 | D6RAZ0_HUMAN | RING-type E3 ubiquitin transferase | MIB2 | 816 | Annotation score: | ||
F2Z2L2 | F2Z2L2_HUMAN | RING-type E3 ubiquitin transferase | MIB2 | 919 | Annotation score: | ||
D6RED3 | D6RED3_HUMAN | E3 ubiquitin-protein ligase MIB2 | MIB2 | 395 | Annotation score: | ||
J3QR95 | J3QR95_HUMAN | E3 ubiquitin-protein ligase MIB2 | MIB2 | 332 | Annotation score: | ||
D6RFJ2 | D6RFJ2_HUMAN | E3 ubiquitin-protein ligase MIB2 | MIB2 | 148 | Annotation score: | ||
D6RE96 | D6RE96_HUMAN | E3 ubiquitin-protein ligase MIB2 | MIB2 | 175 | Annotation score: | ||
J3QLE0 | J3QLE0_HUMAN | E3 ubiquitin-protein ligase MIB2 | MIB2 | 57 | Annotation score: | ||
D6RDI1 | D6RDI1_HUMAN | E3 ubiquitin-protein ligase MIB2 | MIB2 | 114 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 80 | K → N in AAH16490 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 176 – 177 | CY → SN in BAB82979 (Ref. 2) Curated | 2 | |
Sequence conflicti | 221 | V → A in BAB82979 (Ref. 2) Curated | 1 | |
Sequence conflicti | 226 | D → F in BAC77353 (PubMed:12761501).Curated | 1 | |
Sequence conflicti | 235 | G → R in BAG63969 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 273 | H → Y in AAH37542 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 375 | F → L in BAC04646 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 508 | D → G in AAH37542 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 637 | S → G in AAH37542 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 689 | K → E in BAC04752 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 692 | G → D in BAG53705 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 937 | S → F in BAC04646 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 975 | S → R in BAC77353 (PubMed:12761501).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_046668 | 15 | F → L2 PublicationsCorresponds to variant dbSNP:rs7418389Ensembl. | 1 | |
Natural variantiVAR_046669 | 45 | M → T3 PublicationsCorresponds to variant dbSNP:rs12755088Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035508 | 1 – 159 | Missing in isoform 7. 1 PublicationAdd BLAST | 159 | |
Alternative sequenceiVSP_035509 | 1 – 58 | Missing in isoform 8 and isoform 10. 1 PublicationAdd BLAST | 58 | |
Alternative sequenceiVSP_046405 | 1 | M → MAGALRRGRALGSRPSGPTV SSRRSPQCPVAQEGLGARSR PRVAPRSLARCGPSSRLM in isoform 11, isoform 12, isoform 13 and isoform 14. 1 Publication | 1 | |
Alternative sequenceiVSP_014392 | 37 – 50 | Missing in isoform 2. 3 PublicationsAdd BLAST | 14 | |
Alternative sequenceiVSP_046406 | 42 – 55 | Missing in isoform 11. 1 PublicationAdd BLAST | 14 | |
Alternative sequenceiVSP_014393 | 234 – 298 | Missing in isoform 4, isoform 10 and isoform 12. 2 PublicationsAdd BLAST | 65 | |
Alternative sequenceiVSP_014394 | 347 – 382 | Missing in isoform 6. CuratedAdd BLAST | 36 | |
Alternative sequenceiVSP_014395 | 347 – 350 | Missing in isoform 3 and isoform 13. 1 Publication | 4 | |
Alternative sequenceiVSP_014396 | 383 – 417 | Missing in isoform 5. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_035510 | 673 – 1013 | Missing in isoform 9. 1 PublicationAdd BLAST | 341 | |
Alternative sequenceiVSP_045186 | 853 – 1013 | ERQAG…IQIFV → VRAQDEEVHQVPGGRQQETA PRRL in isoform 10. 1 PublicationAdd BLAST | 161 | |
Alternative sequenceiVSP_035511 | 858 – 860 | GGA → RGR in isoform 8. 1 Publication | 3 | |
Alternative sequenceiVSP_035512 | 861 – 1013 | Missing in isoform 8. 1 PublicationAdd BLAST | 153 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB074480 mRNA Translation: BAB92950.1 AB064367 mRNA Translation: BAB82979.1 Frameshift. AB076691 mRNA Translation: BAC00992.1 AB076692 mRNA Translation: BAC00993.1 AB076693 mRNA Translation: BAC00994.1 AB097000 mRNA Translation: BAC77353.1 AK091610 mRNA Translation: BAC03707.1 Different initiation. AK095914 mRNA Translation: BAC04646.1 Different initiation. AK096295 mRNA Translation: BAC04752.1 Different initiation. AK097106 mRNA Translation: BAC04952.1 Different initiation. AK098785 mRNA Translation: BAC05413.1 AK122751 mRNA Translation: BAG53705.1 AK122863 mRNA Translation: BAG53766.1 AK128167 mRNA Translation: BAG54643.1 AK302757 mRNA Translation: BAG63969.1 AL691432 Genomic DNA No translation available. BC016490 mRNA Translation: AAH16490.1 Different initiation. BC037542 mRNA Translation: AAH37542.1 AL834527 mRNA Translation: CAD39183.1 |
CCDSi | CCDS53264.1 [Q96AX9-10] |
RefSeqi | NP_001164157.1, NM_001170686.1 [Q96AX9-3] NP_001164158.1, NM_001170687.1 [Q96AX9-2] NP_001164159.1, NM_001170688.1 [Q96AX9-12] NP_001164160.1, NM_001170689.1 [Q96AX9-10] NP_543151.2, NM_080875.2 [Q96AX9-1] |
Genome annotation databases
Ensembli | ENST00000355826; ENSP00000348081; ENSG00000197530 [Q96AX9-11] ENST00000378712; ENSP00000367984; ENSG00000197530 [Q96AX9-10] ENST00000505820; ENSP00000426103; ENSG00000197530 [Q96AX9-14] ENST00000518681; ENSP00000428264; ENSG00000197530 [Q96AX9-12] ENST00000520777; ENSP00000428660; ENSG00000197530 [Q96AX9-13] |
GeneIDi | 142678 |
KEGGi | hsa:142678 |
UCSCi | uc001agg.4, human [Q96AX9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB074480 mRNA Translation: BAB92950.1 AB064367 mRNA Translation: BAB82979.1 Frameshift. AB076691 mRNA Translation: BAC00992.1 AB076692 mRNA Translation: BAC00993.1 AB076693 mRNA Translation: BAC00994.1 AB097000 mRNA Translation: BAC77353.1 AK091610 mRNA Translation: BAC03707.1 Different initiation. AK095914 mRNA Translation: BAC04646.1 Different initiation. AK096295 mRNA Translation: BAC04752.1 Different initiation. AK097106 mRNA Translation: BAC04952.1 Different initiation. AK098785 mRNA Translation: BAC05413.1 AK122751 mRNA Translation: BAG53705.1 AK122863 mRNA Translation: BAG53766.1 AK128167 mRNA Translation: BAG54643.1 AK302757 mRNA Translation: BAG63969.1 AL691432 Genomic DNA No translation available. BC016490 mRNA Translation: AAH16490.1 Different initiation. BC037542 mRNA Translation: AAH37542.1 AL834527 mRNA Translation: CAD39183.1 |
CCDSi | CCDS53264.1 [Q96AX9-10] |
RefSeqi | NP_001164157.1, NM_001170686.1 [Q96AX9-3] NP_001164158.1, NM_001170687.1 [Q96AX9-2] NP_001164159.1, NM_001170688.1 [Q96AX9-12] NP_001164160.1, NM_001170689.1 [Q96AX9-10] NP_543151.2, NM_080875.2 [Q96AX9-1] |
3D structure databases
SMRi | Q96AX9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126769, 37 interactors |
IntActi | Q96AX9, 17 interactors |
STRINGi | 9606.ENSP00000426103 |
PTM databases
iPTMneti | Q96AX9 |
PhosphoSitePlusi | Q96AX9 |
Genetic variation databases
BioMutai | MIB2 |
DMDMi | 209572707 |
Proteomic databases
jPOSTi | Q96AX9 |
MassIVEi | Q96AX9 |
MaxQBi | Q96AX9 |
PaxDbi | Q96AX9 |
PeptideAtlasi | Q96AX9 |
PRIDEi | Q96AX9 |
ProteomicsDBi | 20393 20580 30446 3825 76009 [Q96AX9-1] 76010 [Q96AX9-2] 76011 [Q96AX9-3] 76012 [Q96AX9-4] 76013 [Q96AX9-5] 76014 [Q96AX9-6] 76015 [Q96AX9-7] 76016 [Q96AX9-8] 76017 [Q96AX9-9] |
Protocols and materials databases
Antibodypediai | 26451, 100 antibodies |
DNASUi | 142678 |
Genome annotation databases
Ensembli | ENST00000355826; ENSP00000348081; ENSG00000197530 [Q96AX9-11] ENST00000378712; ENSP00000367984; ENSG00000197530 [Q96AX9-10] ENST00000505820; ENSP00000426103; ENSG00000197530 [Q96AX9-14] ENST00000518681; ENSP00000428264; ENSG00000197530 [Q96AX9-12] ENST00000520777; ENSP00000428660; ENSG00000197530 [Q96AX9-13] |
GeneIDi | 142678 |
KEGGi | hsa:142678 |
UCSCi | uc001agg.4, human [Q96AX9-1] |
Organism-specific databases
CTDi | 142678 |
DisGeNETi | 142678 |
GeneCardsi | MIB2 |
HGNCi | HGNC:30577, MIB2 |
HPAi | ENSG00000197530, Tissue enriched (skeletal) |
MalaCardsi | MIB2 |
MIMi | 611141, gene |
neXtProti | NX_Q96AX9 |
OpenTargetsi | ENSG00000197530 |
Orphaneti | 54260, Left ventricular noncompaction |
PharmGKBi | PA134924284 |
VEuPathDBi | HostDB:ENSG00000197530.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0504, Eukaryota KOG4582, Eukaryota |
GeneTreei | ENSGT00940000158097 |
InParanoidi | Q96AX9 |
OMAi | HDAIGKD |
OrthoDBi | 220300at2759 |
PhylomeDBi | Q96AX9 |
TreeFami | TF324147 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | Q96AX9 |
Reactomei | R-HSA-2122948, Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2691232, Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2979096, NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-9013507, NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | Q96AX9 |
SIGNORi | Q96AX9 |
Miscellaneous databases
BioGRID-ORCSi | 142678, 23 hits in 995 CRISPR screens |
ChiTaRSi | MIB2, human |
GeneWikii | MIB2_(gene) |
GenomeRNAii | 142678 |
Pharosi | Q96AX9, Tbio |
PROi | PR:Q96AX9 |
RNActi | Q96AX9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000197530, Expressed in pituitary gland and 182 other tissues |
ExpressionAtlasi | Q96AX9, baseline and differential |
Genevisiblei | Q96AX9, HS |
Family and domain databases
CDDi | cd02339, ZZ_Mind_bomb, 1 hit |
Gene3Di | 1.25.40.20, 1 hit 2.30.30.920, 2 hits 3.30.40.10, 2 hits 3.30.60.90, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR042056, MIB1/2_ZZ IPR010606, Mib_Herc2 IPR037252, Mib_Herc2_sf IPR040847, SH3_15 IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR000433, Znf_ZZ IPR043145, Znf_ZZ_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF06701, MIB_HERC2, 2 hits PF18346, SH3_15, 2 hits PF00569, ZZ, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 9 hits SM00184, RING, 2 hits SM00291, ZnF_ZZ, 1 hit |
SUPFAMi | SSF159034, SSF159034, 2 hits SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 5 hits PS51416, MIB_HERC2, 2 hits PS50089, ZF_RING_2, 2 hits PS01357, ZF_ZZ_1, 1 hit PS50135, ZF_ZZ_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MIB2_HUMAN | |
Accessioni | Q96AX9Primary (citable) accession number: Q96AX9 Secondary accession number(s): A2AGM5 Q8WYN1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2005 |
Last sequence update: | October 14, 2008 | |
Last modified: | April 7, 2021 | |
This is version 181 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways