UniProtKB - Q96AX2 (RAB37_HUMAN)
Protein
Ras-related protein Rab-37
Gene
RAB37
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 36 – 43 | GTPBy similarity | 8 | |
Nucleotide bindingi | 85 – 89 | GTPBy similarity | 5 | |
Nucleotide bindingi | 143 – 146 | GTPBy similarity | 4 |
GO - Molecular functioni
- GTPase activity Source: InterPro
- GTP binding Source: UniProtKB-KW
GO - Biological processi
- neutrophil degranulation Source: Reactome
- protein transport Source: UniProtKB-KW
Keywordsi
Biological process | Protein transport, Transport |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q96AX2 |
Reactomei | R-HSA-6798695, Neutrophil degranulation R-HSA-8873719, RAB geranylgeranylation |
Names & Taxonomyi
Protein namesi | Recommended name: Ras-related protein Rab-37 |
Gene namesi | Name:RAB37 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30268, RAB37 |
MIMi | 609956, gene |
neXtProti | NX_Q96AX2 |
VEuPathDBi | HostDB:ENSG00000172794.19 |
Subcellular locationi
Other locations
Note: Secretory granules.By similarity
Endosome
- endosome Source: GO_Central
Golgi apparatus
- Golgi apparatus Source: GO_Central
Lysosome
- azurophil granule membrane Source: Reactome
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB
- specific granule membrane Source: Reactome
Keywords - Cellular componenti
Cytoplasmic vesiclePathology & Biotechi
Organism-specific databases
DisGeNETi | 326624 |
OpenTargetsi | ENSG00000172794 |
PharmGKBi | PA134901093 |
Miscellaneous databases
Pharosi | Q96AX2, Tbio |
Genetic variation databases
BioMutai | RAB37 |
DMDMi | 20139581 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000121249 | 2 – 220 | Ras-related protein Rab-37Add BLAST | 219 | |
PropeptideiPRO_0000370828 | 221 – 223 | Removed in mature formSequence analysis | 3 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylthreonine1 Publication | 1 | |
Lipidationi | 219 | S-geranylgeranyl cysteineBy similarity | 1 | |
Modified residuei | 220 | Cysteine methyl esterSequence analysis | 1 | |
Lipidationi | 220 | S-geranylgeranyl cysteineBy similarity | 1 |
Keywords - PTMi
Acetylation, Lipoprotein, Methylation, PrenylationProteomic databases
jPOSTi | Q96AX2 |
MassIVEi | Q96AX2 |
MaxQBi | Q96AX2 |
PaxDbi | Q96AX2 |
PeptideAtlasi | Q96AX2 |
PRIDEi | Q96AX2 |
ProteomicsDBi | 76005 [Q96AX2-1] 76006 [Q96AX2-2] 76007 [Q96AX2-3] 76008 [Q96AX2-4] |
PTM databases
iPTMneti | Q96AX2 |
PhosphoSitePlusi | Q96AX2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000172794, Expressed in right hemisphere of cerebellum and 148 other tissues |
ExpressionAtlasi | Q96AX2, baseline and differential |
Genevisiblei | Q96AX2, HS |
Organism-specific databases
HPAi | ENSG00000172794, Tissue enhanced (blood, brain) |
Interactioni
Subunit structurei
Interacts with RIMS1.
By similarityBinary interactionsi
Q96AX2
With | #Exp. | IntAct |
---|---|---|
MAL2 [Q969L2] | 3 | EBI-748121,EBI-944295 |
Protein-protein interaction databases
BioGRIDi | 130604, 6 interactors |
IntActi | Q96AX2, 5 interactors |
STRINGi | 9606.ENSP00000376390 |
Miscellaneous databases
RNActi | Q96AX2, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 59 – 67 | Effector regionBy similarity | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0083, Eukaryota |
GeneTreei | ENSGT00940000158883 |
InParanoidi | Q96AX2 |
OMAi | AYYTTAY |
OrthoDBi | 1018397at2759 |
PhylomeDBi | Q96AX2 |
TreeFami | TF323428 |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96AX2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTGTPGAVAT RDGEAPERSP PCSPSYDLTG KVMLLGDTGV GKTCFLIQFK
60 70 80 90 100
DGAFLSGTFI ATVGIDFRNK VVTVDGVRVK LQIWDTAGQE RFRSVTHAYY
110 120 130 140 150
RDAQALLLLY DITNKSSFDN IRAWLTEIHE YAQRDVVIML LGNKADMSSE
160 170 180 190 200
RVIRSEDGET LAREYGVPFL ETSAKTGMNV ELAFLAIAKE LKYRAGHQAD
210 220
EPSFQIRDYV ESQKKRSSCC SFM
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA8MTC6 | A8MTC6_HUMAN | RAB37, member RAS oncogene family, ... | RAB37 hCG_1986458 | 189 | Annotation score: | ||
B7Z3L0 | B7Z3L0_HUMAN | Ras-related protein Rab-37 | RAB37 | 196 | Annotation score: | ||
A8MSP2 | A8MSP2_HUMAN | RAB37, member RAS oncogene family, ... | RAB37 hCG_1986458 | 182 | Annotation score: | ||
A8MZI4 | A8MZI4_HUMAN | Ras-related protein Rab-37 | RAB37 | 191 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034434 | 188 | A → P. Corresponds to variant dbSNP:rs34215331Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041268 | 1 – 68 | MTGTP…GIDFR → MDLQRPDSYQGGAGPDFNDH VLHKTILVGDSGVGKTSLLV QFDQGKFIPGSFSATVGIGF T in isoform 2. 2 PublicationsAdd BLAST | 68 | |
Alternative sequenceiVSP_043155 | 1 – 30 | MTGTP…YDLTG → MWLMSEAHGAEPVLLREAAR PFTQTLRLCVPSGNS in isoform 3. 1 PublicationAdd BLAST | 30 | |
Alternative sequenceiVSP_043156 | 32 – 68 | Missing in isoform 4. 1 PublicationAdd BLAST | 37 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK098068 mRNA Translation: BAC05227.1 AK290202 mRNA Translation: BAF82891.1 AK296172 mRNA Translation: BAH12272.1 AK303442 mRNA Translation: BAH13962.1 AC016888 Genomic DNA No translation available. AC064805 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89180.1 BC016615 mRNA Translation: AAH16615.1 BC040547 mRNA Translation: AAH40547.1 |
CCDSi | CCDS11703.1 [Q96AX2-2] CCDS32722.1 [Q96AX2-1] CCDS54161.1 [Q96AX2-3] CCDS54162.1 [Q96AX2-4] |
RefSeqi | NP_001006639.1, NM_001006638.2 [Q96AX2-1] NP_001157461.1, NM_001163989.1 [Q96AX2-3] NP_001157462.1, NM_001163990.1 [Q96AX2-4] NP_001317400.1, NM_001330471.1 NP_783865.1, NM_175738.4 [Q96AX2-2] |
Genome annotation databases
Ensembli | ENST00000392612; ENSP00000376388; ENSG00000172794 [Q96AX2-4] ENST00000392613; ENSP00000376389; ENSG00000172794 [Q96AX2-1] ENST00000392614; ENSP00000376390; ENSG00000172794 [Q96AX2-3] ENST00000402449; ENSP00000383934; ENSG00000172794 [Q96AX2-2] ENST00000481224; ENSP00000436563; ENSG00000172794 [Q96AX2-1] ENST00000613645; ENSP00000483155; ENSG00000172794 [Q96AX2-1] |
GeneIDi | 326624 |
KEGGi | hsa:326624 |
UCSCi | uc002jlk.4, human [Q96AX2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK098068 mRNA Translation: BAC05227.1 AK290202 mRNA Translation: BAF82891.1 AK296172 mRNA Translation: BAH12272.1 AK303442 mRNA Translation: BAH13962.1 AC016888 Genomic DNA No translation available. AC064805 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89180.1 BC016615 mRNA Translation: AAH16615.1 BC040547 mRNA Translation: AAH40547.1 |
CCDSi | CCDS11703.1 [Q96AX2-2] CCDS32722.1 [Q96AX2-1] CCDS54161.1 [Q96AX2-3] CCDS54162.1 [Q96AX2-4] |
RefSeqi | NP_001006639.1, NM_001006638.2 [Q96AX2-1] NP_001157461.1, NM_001163989.1 [Q96AX2-3] NP_001157462.1, NM_001163990.1 [Q96AX2-4] NP_001317400.1, NM_001330471.1 NP_783865.1, NM_175738.4 [Q96AX2-2] |
3D structure databases
SMRi | Q96AX2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 130604, 6 interactors |
IntActi | Q96AX2, 5 interactors |
STRINGi | 9606.ENSP00000376390 |
PTM databases
iPTMneti | Q96AX2 |
PhosphoSitePlusi | Q96AX2 |
Genetic variation databases
BioMutai | RAB37 |
DMDMi | 20139581 |
Proteomic databases
jPOSTi | Q96AX2 |
MassIVEi | Q96AX2 |
MaxQBi | Q96AX2 |
PaxDbi | Q96AX2 |
PeptideAtlasi | Q96AX2 |
PRIDEi | Q96AX2 |
ProteomicsDBi | 76005 [Q96AX2-1] 76006 [Q96AX2-2] 76007 [Q96AX2-3] 76008 [Q96AX2-4] |
Protocols and materials databases
Antibodypediai | 31994, 350 antibodies |
Genome annotation databases
Ensembli | ENST00000392612; ENSP00000376388; ENSG00000172794 [Q96AX2-4] ENST00000392613; ENSP00000376389; ENSG00000172794 [Q96AX2-1] ENST00000392614; ENSP00000376390; ENSG00000172794 [Q96AX2-3] ENST00000402449; ENSP00000383934; ENSG00000172794 [Q96AX2-2] ENST00000481224; ENSP00000436563; ENSG00000172794 [Q96AX2-1] ENST00000613645; ENSP00000483155; ENSG00000172794 [Q96AX2-1] |
GeneIDi | 326624 |
KEGGi | hsa:326624 |
UCSCi | uc002jlk.4, human [Q96AX2-1] |
Organism-specific databases
CTDi | 326624 |
DisGeNETi | 326624 |
GeneCardsi | RAB37 |
HGNCi | HGNC:30268, RAB37 |
HPAi | ENSG00000172794, Tissue enhanced (blood, brain) |
MIMi | 609956, gene |
neXtProti | NX_Q96AX2 |
OpenTargetsi | ENSG00000172794 |
PharmGKBi | PA134901093 |
VEuPathDBi | HostDB:ENSG00000172794.19 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0083, Eukaryota |
GeneTreei | ENSGT00940000158883 |
InParanoidi | Q96AX2 |
OMAi | AYYTTAY |
OrthoDBi | 1018397at2759 |
PhylomeDBi | Q96AX2 |
TreeFami | TF323428 |
Enzyme and pathway databases
PathwayCommonsi | Q96AX2 |
Reactomei | R-HSA-6798695, Neutrophil degranulation R-HSA-8873719, RAB geranylgeranylation |
Miscellaneous databases
BioGRID-ORCSi | 326624, 3 hits in 985 CRISPR screens |
ChiTaRSi | RAB37, human |
GeneWikii | RAB37 |
GenomeRNAii | 326624 |
Pharosi | Q96AX2, Tbio |
PROi | PR:Q96AX2 |
RNActi | Q96AX2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000172794, Expressed in right hemisphere of cerebellum and 148 other tissues |
ExpressionAtlasi | Q96AX2, baseline and differential |
Genevisiblei | Q96AX2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RAB37_HUMAN | |
Accessioni | Q96AX2Primary (citable) accession number: Q96AX2 Secondary accession number(s): A8MXF5, A8MYT0, Q8IWA7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 31, 2002 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 176 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families