RAB37

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	36 – 43	GTPBy similarity	8
Nucleotide bindingⁱ	85 – 89	GTPBy similarity	5
Nucleotide bindingⁱ	143 – 146	GTPBy similarity	4

GO - Molecular functionⁱ

GTPase activity Source: InterPro
GTP binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

neutrophil degranulation Source: Reactome
protein localization to plasma membrane Source: GO_Central
protein secretion Source: GO_Central
regulation of exocytosis Source: GO_Central
vesicle docking involved in exocytosis Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport
Ligand	GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation R-HSA-8873719 RAB geranylgeranylation

Reactomeⁱ

R-HSA-6798695 Neutrophil degranulation
R-HSA-8873719 RAB geranylgeranylation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-related protein Rab-37
Gene namesⁱ	Name:RAB37
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000172794.19
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30268 RAB37
MIMⁱ	609956 gene
neXtProtⁱ	NX_Q96AX2

Keywords - Cellular componentⁱ

Cytoplasmic vesicle

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	326624
Open Targets More...OpenTargetsⁱ	ENSG00000172794
PharmGKBⁱ	PA134901093

Polymorphism and mutation databases

BioMutaⁱ	RAB37
DMDMⁱ	20139581

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000121249	2 – 220	Ras-related protein Rab-37Add BLAST	219
PropeptideⁱPRO_0000370828	221 – 223	Removed in mature formSequence analysis	3

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylthreonine1 Publication	1
Lipidationⁱ	219	S-geranylgeranyl cysteineBy similarity	1
Modified residueⁱ	220	Cysteine methyl esterSequence analysis	1
Lipidationⁱ	220	S-geranylgeranyl cysteineBy similarity	1

Keywords - PTMⁱ

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDⁱ	Q96AX2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96AX2
PaxDbⁱ	Q96AX2
PeptideAtlas More...PeptideAtlasⁱ	Q96AX2
PRIDEⁱ	Q96AX2
ProteomicsDBⁱ	76005 76006 [Q96AX2-2] 76007 [Q96AX2-3] 76008 [Q96AX2-4]

PTM databases

iPTMnetⁱ	Q96AX2
PhosphoSitePlusⁱ	Q96AX2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000172794 Expressed in 135 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_RAB37
ExpressionAtlasⁱ	Q96AX2 baseline and differential
Genevisibleⁱ	Q96AX2 HS

Interactionⁱ

Subunit structureⁱ

Interacts with RIMS1.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
MAL2	Q969L2	3	EBI-748121,EBI-944295

With

Entry

#Exp.

IntAct

Notes

MAL2

Q969L2

3

EBI-748121,EBI-944295

Protein-protein interaction databases

BioGridⁱ	130604, 5 interactors
IntActⁱ	Q96AX2, 5 interactors
STRINGⁱ	9606.ENSP00000376390

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96AX2
SMRⁱ	Q96AX2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	59 – 67	Effector regionBy similarity		9

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0083 Eukaryota ENOG410Z9H6 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140786
HOGENOMⁱ	HOG000233968
HOVERGENⁱ	HBG009351
InParanoidⁱ	Q96AX2
KEGG Orthology (KO) More...KOⁱ	K07914
OMAⁱ	SGCCSYF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JXU
PhylomeDBⁱ	Q96AX2
TreeFamⁱ	TF323428

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q96AX2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTGTPGAVAT RDGEAPERSP PCSPSYDLTG KVMLLGDTGV GKTCFLIQFK 
        60         70         80         90        100
DGAFLSGTFI ATVGIDFRNK VVTVDGVRVK LQIWDTAGQE RFRSVTHAYY 
       110        120        130        140        150
RDAQALLLLY DITNKSSFDN IRAWLTEIHE YAQRDVVIML LGNKADMSSE 
       160        170        180        190        200
RVIRSEDGET LAREYGVPFL ETSAKTGMNV ELAFLAIAKE LKYRAGHQAD 
       210        220 
EPSFQIRDYV ESQKKRSSCC SFM

Length:223

Mass (Da):24,815

Last modified:January 23, 2007 - v3

Checksum:ⁱ5A7A4887BCBB84A8

GO

Isoform 2 (identifier: Q96AX2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-68: MTGTPGAVAT...FIATVGIDFR → MDLQRPDSYQ...FSATVGIGFT

« Hide

        10         20         30         40         50
MDLQRPDSYQ GGAGPDFNDH VLHKTILVGD SGVGKTSLLV QFDQGKFIPG 
        60         70         80         90        100
SFSATVGIGF TNKVVTVDGV RVKLQIWDTA GQERFRSVTH AYYRDAQALL 
       110        120        130        140        150
LLYDITNKSS FDNIRAWLTE IHEYAQRDVV IMLLGNKADM SSERVIRSED 
       160        170        180        190        200
GETLAREYGV PFLETSAKTG MNVELAFLAI AKELKYRAGH QADEPSFQIR 
       210 
DYVESQKKRS SCCSFM

Show »

Length:216

Mass (Da):24,169

Checksum:ⁱ5EBF94A735395D58

GO

Isoform 3 (identifier: Q96AX2-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-30: MTGTPGAVATRDGEAPERSPPCSPSYDLTG → MWLMSEAHGAEPVLLREAARPFTQTLRLCVPSGNS

« Hide

        10         20         30         40         50
MWLMSEAHGA EPVLLREAAR PFTQTLRLCV PSGNSKVMLL GDTGVGKTCF 
        60         70         80         90        100
LIQFKDGAFL SGTFIATVGI DFRNKVVTVD GVRVKLQIWD TAGQERFRSV 
       110        120        130        140        150
THAYYRDAQA LLLLYDITNK SSFDNIRAWL TEIHEYAQRD VVIMLLGNKA 
       160        170        180        190        200
DMSSERVIRS EDGETLAREY GVPFLETSAK TGMNVELAFL AIAKELKYRA 
       210        220 
GHQADEPSFQ IRDYVESQKK RSSCCSFM

Note: No experimental confirmation available.

Show »

Length:228

Mass (Da):25,663

Checksum:ⁱ151A1E30411A53B6

GO

Isoform 4 (identifier: Q96AX2-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
32-68: Missing.

« Hide

        10         20         30         40         50
MTGTPGAVAT RDGEAPERSP PCSPSYDLTG KNKVVTVDGV RVKLQIWDTA 
        60         70         80         90        100
GQERFRSVTH AYYRDAQALL LLYDITNKSS FDNIRAWLTE IHEYAQRDVV 
       110        120        130        140        150
IMLLGNKADM SSERVIRSED GETLAREYGV PFLETSAKTG MNVELAFLAI 
       160        170        180 
AKELKYRAGH QADEPSFQIR DYVESQKKRS SCCSFM

Note: No experimental confirmation available.

Show »

Length:186

Mass (Da):20,894

Checksum:ⁱ728BB40C23162B5F

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B7Z3L0	B7Z3L0_HUMAN	cDNA FLJ61124, highly similar to Ra... cDNA FLJ61124, highly similar to Ras-related protein Rab-37	RAB37	196	Annotation score:
A8MTC6	A8MTC6_HUMAN	RAB37, member RAS oncogene family, ... RAB37, member RAS oncogene family, isoform CRA_a (Ras-related protein Rab-37)	RAB37 hCG_1986458	189	Annotation score:
A8MSP2	A8MSP2_HUMAN	RAB37, member RAS oncogene family, ... RAB37, member RAS oncogene family, isoform CRA_e (Ras-related protein Rab-37) (cDNA FLJ45130 fis, clone BRAWH3037428, highly similar to Homo sapiens RAB37, member RAS oncogene family (RAB37), transcript variant 3, mRNA)	RAB37 hCG_1986458	182	Annotation score:
A8MZI4	A8MZI4_HUMAN	Ras-related protein Rab-37 Ras-related protein Rab-37	RAB37	191	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_034434	188	A → P. Corresponds to variant dbSNP:rs34215331Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_041268	1 – 68	MTGTP…GIDFR → MDLQRPDSYQGGAGPDFNDH VLHKTILVGDSGVGKTSLLV QFDQGKFIPGSFSATVGIGF T in isoform 2. 2 PublicationsAdd BLAST	68
Alternative sequenceⁱVSP_043155	1 – 30	MTGTP…YDLTG → MWLMSEAHGAEPVLLREAAR PFTQTLRLCVPSGNS in isoform 3. 1 PublicationAdd BLAST	30
Alternative sequenceⁱVSP_043156	32 – 68	Missing in isoform 4. 1 PublicationAdd BLAST	37

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK098068 mRNA Translation: BAC05227.1 AK290202 mRNA Translation: BAF82891.1 AK296172 mRNA Translation: BAH12272.1 AK303442 mRNA Translation: BAH13962.1 AC016888 Genomic DNA No translation available. AC064805 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89180.1 BC016615 mRNA Translation: AAH16615.1 BC040547 mRNA Translation: AAH40547.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11703.1 [Q96AX2-2] CCDS32722.1 [Q96AX2-1] CCDS54161.1 [Q96AX2-3] CCDS54162.1 [Q96AX2-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001006639.1, NM_001006638.2 NP_001157461.1, NM_001163989.1 [Q96AX2-3] NP_001157462.1, NM_001163990.1 [Q96AX2-4] NP_001317400.1, NM_001330471.1 NP_783865.1, NM_175738.4 [Q96AX2-2]
UniGeneⁱ	Hs.351413

Genome annotation databases

Ensemblⁱ	ENST00000392612; ENSP00000376388; ENSG00000172794 [Q96AX2-4] ENST00000392613; ENSP00000376389; ENSG00000172794 [Q96AX2-1] ENST00000392614; ENSP00000376390; ENSG00000172794 [Q96AX2-3] ENST00000402449; ENSP00000383934; ENSG00000172794 [Q96AX2-2] ENST00000481224; ENSP00000436563; ENSG00000172794 [Q96AX2-1] ENST00000613645; ENSP00000483155; ENSG00000172794 [Q96AX2-1]
GeneIDⁱ	326624
KEGGⁱ	hsa:326624
UCSC genome browser More...UCSCⁱ	uc002jlk.4 human [Q96AX2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96AX2	RAB37, member RAS oncogene family, isoform CRA_c		HUMAN		223	UniRef100_Q96AX2
RAB37, member RAS oncogene family, isoform CRA_a		HUMAN		189
Q96AX2-2	RAB37, member RAS oncogene family, isoform CRA_e		HUMAN		182	UniRef100_A8MSP2
Q96AX2-3	RAB37, member RAS oncogene family		GORGO		221	UniRef100_A0A2I2YYW4

Protein	Similar proteins		Species	Score	Length	Source
Q96AX2	Ras-related protein Rab-37		MOUSE		223	UniRef90_Q96AX2
RAB37, member RAS oncogene family, isoform CRA_c		HUMAN		223
Uncharacterized protein		CAVPO		224
RAB37, member RAS oncogene family		MACMU		223
Uncharacterized protein		MACFA		223
+105
Q96AX2-2	RAB37, member RAS oncogene family		BOVIN		216	UniRef90_E1BLD5
RAB37 isoform 12		PANTR		216
RAB37, member RAS oncogene family		CALJA		216
Uncharacterized protein		PROCO		216
RAB37, member RAS oncogene family		SAIBB		216
+65
Q96AX2-3	RAB37 isoform 1		PANTR		228	UniRef90_A0A2I3RY02
Uncharacterized protein		PANPA		228
RAB37, member RAS oncogene family		SAIBB		227
Uncharacterized protein		Cebus capucinus imitator		222
Uncharacterized protein		AOTNA		222
+9
Q96AX2-4	Uncharacterized protein		AOTNA		199	UniRef90_Q96AX2-4
RAB37 isoform 3		PANTR		186
Uncharacterized protein		PROCO		186
RAB37, member RAS oncogene family		SAIBB		186
Uncharacterized protein		CALJA		186
+32

Protein	Similar proteins		Species	Score	Length	Source
Q96AX2	Ras-related protein Rab-37		MOUSE		223	UniRef50_Q96AX2
RAB37, member RAS oncogene family, isoform CRA_c		HUMAN		223
Uncharacterized protein		CAVPO		224
Ras-related protein Rab-37		MYODS		223
RAB37 isoform 13		PONAB		223
+216
Q96AX2-2	RAB26, member RAS oncogene family		HORSE		192	UniRef50_F6TI68
ras-related protein Rab-26 isoform X1		ERIEU		228
Uncharacterized protein		MYOLU		192
Ras-related protein Rab-26		MYODS		190
ras-related protein Rab-26 isoform X1		DIPOR		190
+340
Q96AX2-3	RAB37 isoform 1		PANTR		228	UniRef50_A0A2I3RY02
Uncharacterized protein		PANPA		228
RAB37, member RAS oncogene family		SAIBB		227
Uncharacterized protein		AOTNA		222
Uncharacterized protein		Cebus capucinus imitator		222
+47
Q96AX2-4	Uncharacterized protein		AOTNA		199	UniRef50_Q96AX2-4
Uncharacterized protein		CALJA		186
Uncharacterized protein		COLAP		186
ras-related protein Rab-37 isoform X4		ERIEU		186
RAB37 isoform 3		PANTR		186
+116

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK098068 mRNA Translation: BAC05227.1 AK290202 mRNA Translation: BAF82891.1 AK296172 mRNA Translation: BAH12272.1 AK303442 mRNA Translation: BAH13962.1 AC016888 Genomic DNA No translation available. AC064805 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89180.1 BC016615 mRNA Translation: AAH16615.1 BC040547 mRNA Translation: AAH40547.1
CCDSⁱ	CCDS11703.1 [Q96AX2-2] CCDS32722.1 [Q96AX2-1] CCDS54161.1 [Q96AX2-3] CCDS54162.1 [Q96AX2-4]
RefSeqⁱ	NP_001006639.1, NM_001006638.2 NP_001157461.1, NM_001163989.1 [Q96AX2-3] NP_001157462.1, NM_001163990.1 [Q96AX2-4] NP_001317400.1, NM_001330471.1 NP_783865.1, NM_175738.4 [Q96AX2-2]
UniGeneⁱ	Hs.351413

3D structure databases

ProteinModelPortalⁱ	Q96AX2
SMRⁱ	Q96AX2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	130604, 5 interactors
IntActⁱ	Q96AX2, 5 interactors
STRINGⁱ	9606.ENSP00000376390

PTM databases

iPTMnetⁱ	Q96AX2
PhosphoSitePlusⁱ	Q96AX2

Polymorphism and mutation databases

BioMutaⁱ	RAB37
DMDMⁱ	20139581

Proteomic databases

EPDⁱ	Q96AX2
MaxQBⁱ	Q96AX2
PaxDbⁱ	Q96AX2
PeptideAtlasⁱ	Q96AX2
PRIDEⁱ	Q96AX2
ProteomicsDBⁱ	76005 76006 [Q96AX2-2] 76007 [Q96AX2-3] 76008 [Q96AX2-4]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000392612; ENSP00000376388; ENSG00000172794 [Q96AX2-4] ENST00000392613; ENSP00000376389; ENSG00000172794 [Q96AX2-1] ENST00000392614; ENSP00000376390; ENSG00000172794 [Q96AX2-3] ENST00000402449; ENSP00000383934; ENSG00000172794 [Q96AX2-2] ENST00000481224; ENSP00000436563; ENSG00000172794 [Q96AX2-1] ENST00000613645; ENSP00000483155; ENSG00000172794 [Q96AX2-1]
GeneIDⁱ	326624
KEGGⁱ	hsa:326624
UCSCⁱ	uc002jlk.4 human [Q96AX2-1]

Organism-specific databases

CTDⁱ	326624
DisGeNETⁱ	326624
EuPathDBⁱ	HostDB:ENSG00000172794.19
GeneCardsⁱ	RAB37
HGNCⁱ	HGNC:30268 RAB37
MIMⁱ	609956 gene
neXtProtⁱ	NX_Q96AX2
OpenTargetsⁱ	ENSG00000172794
PharmGKBⁱ	PA134901093
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0083 Eukaryota ENOG410Z9H6 LUCA
GeneTreeⁱ	ENSGT00900000140786
HOGENOMⁱ	HOG000233968
HOVERGENⁱ	HBG009351
InParanoidⁱ	Q96AX2
KOⁱ	K07914
OMAⁱ	SGCCSYF
OrthoDBⁱ	EOG091G0JXU
PhylomeDBⁱ	Q96AX2
TreeFamⁱ	TF323428

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation R-HSA-8873719 RAB geranylgeranylation

Reactomeⁱ

R-HSA-6798695 Neutrophil degranulation
R-HSA-8873719 RAB geranylgeranylation

Miscellaneous databases

ChiTaRSⁱ	RAB37 human
GeneWikiⁱ	RAB37
GenomeRNAiⁱ	326624
Protein Ontology More...PROⁱ	PR:Q96AX2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000172794 Expressed in 135 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_RAB37
ExpressionAtlasⁱ	Q96AX2 baseline and differential
Genevisibleⁱ	Q96AX2 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RAB37_HUMAN
Accessionⁱ	Q96AX2Primary (citable) accession number: Q96AX2 Secondary accession number(s): A8MXF5, A8MYT0, Q8IWA7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 158 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

UniProtKB

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UniProtKB - Q96AX2 (RAB37_HUMAN)

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Ras-related protein Rab-37

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Endosome

Lysosome

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ