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Protein

Vesicular, overexpressed in cancer, prosurvival protein 1

Gene

VOPP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed.1 Publication

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicular, overexpressed in cancer, prosurvival protein 1
Alternative name(s):
EGFR-coamplified and overexpressed protein
Short name:
ECop
Glioblastoma-amplified secreted protein
Putative NF-kappa-B-activating protein 055N
Gene namesi
Name:VOPP1
Synonyms:ECOP, GASP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000154978.12
HGNCiHGNC:34518 VOPP1
MIMi611915 gene
neXtProtiNX_Q96AW1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 60ExtracellularSequence analysisAdd BLAST38
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Topological domaini82 – 172CytoplasmicSequence analysisAdd BLAST91

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi81552
OpenTargetsiENSG00000154978
PharmGKBiPA165618503

Polymorphism and mutation databases

BioMutaiVOPP1
DMDMi74760714

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000032591723 – 172Vesicular, overexpressed in cancer, prosurvival protein 1Add BLAST150

Proteomic databases

PaxDbiQ96AW1
PeptideAtlasiQ96AW1
PRIDEiQ96AW1
ProteomicsDBi76001
76002 [Q96AW1-2]
76003 [Q96AW1-3]

PTM databases

iPTMnetiQ96AW1
PhosphoSitePlusiQ96AW1

Expressioni

Tissue specificityi

Widely expressed with highest levels in thymus and ovary.1 Publication

Gene expression databases

BgeeiENSG00000154978 Expressed in 243 organ(s), highest expression level in forebrain
ExpressionAtlasiQ96AW1 baseline and differential
GenevisibleiQ96AW1 HS

Interactioni

Protein-protein interaction databases

IntActiQ96AW1, 16 interactors
STRINGi9606.ENSP00000285279

Structurei

3D structure databases

ProteinModelPortaliQ96AW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi87 – 164Pro-richAdd BLAST78

Sequence similaritiesi

Belongs to the VOPP1/ECOP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVPU Eukaryota
ENOG4111SC5 LUCA
GeneTreeiENSGT00390000015821
HOGENOMiHOG000065719
InParanoidiQ96AW1
OMAiFHVQPNS
OrthoDBiEOG091G0WGQ
PhylomeDBiQ96AW1
TreeFamiTF332098

Family and domain databases

InterProiView protein in InterPro
IPR026229 VOPP1
PRINTSiPR02068 VOPPROTEIN1

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q96AW1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRRQPAKVAA LLLGLLLECT EAKKHCWYFE GLYPTYYICR SYEDCCGSRC
60 70 80 90 100
CVRALSIQRL WYFWFLLMMG VLFCCGAGFF IRRRMYPPPL IEEPAFNVSY
110 120 130 140 150
TRQPPNPGPG AQQPGPPYYT DPGGPGMNPV GNSMAMAFQV PPNSPQGSVA
160 170
CPPPPAYCNT PPPPYEQVVK AK
Length:172
Mass (Da):19,224
Last modified:December 1, 2001 - v1
Checksum:i7F7F75231C2A4276
GO
Isoform 2 (identifier: Q96AW1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     4-18: QPAKVAALLLGLLLE → TGSHAQ

Note: No experimental confirmation available.
Show »
Length:163
Mass (Da):18,275
Checksum:i3D8E449D6A98A9C8
GO
Isoform 3 (identifier: Q96AW1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-18: RRQPAKVAALLLGLLLE → LSETLGYLSSVLLQ

Note: No experimental confirmation available.
Show »
Length:169
Mass (Da):18,886
Checksum:i472021D3ECE5C0E5
GO
Isoform 4 (identifier: Q96AW1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MRRQPAKVAALLLGLLLE → M

Note: Gene prediction based on EST data.
Show »
Length:155
Mass (Da):17,381
Checksum:iD522150B1C5E469B
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JVH1C9JVH1_HUMAN
Vesicular, overexpressed in cancer,...
VOPP1
170Annotation score:
C9J827C9J827_HUMAN
Vesicular, overexpressed in cancer,...
VOPP1
109Annotation score:
C9JF99C9JF99_HUMAN
Vesicular, overexpressed in cancer,...
VOPP1
85Annotation score:
C9JTY8C9JTY8_HUMAN
Vesicular, overexpressed in cancer,...
VOPP1
96Annotation score:
C9J548C9J548_HUMAN
Vesicular, overexpressed in cancer,...
VOPP1
52Annotation score:
C9JIM1C9JIM1_HUMAN
Vesicular, overexpressed in cancer,...
VOPP1
105Annotation score:
C9JQ18C9JQ18_HUMAN
Vesicular, overexpressed in cancer,...
VOPP1
21Annotation score:

Sequence cautioni

The sequence AAK82888 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92E → K in CAG38514 (Ref. 4) Curated1
Sequence conflicti111A → T in BAC11590 (PubMed:14702039).Curated1
Sequence conflicti134M → T in CAB66545 (PubMed:12761501).Curated1
Sequence conflicti134M → T in CAG38514 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0557231 – 18MRRQP…GLLLE → M in isoform 4. CuratedAdd BLAST18
Alternative sequenceiVSP_0438672 – 18RRQPA…GLLLE → LSETLGYLSSVLLQ in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_0438684 – 18QPAKV…GLLLE → TGSHAQ in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136610 mRNA Translation: CAB66545.1
AB097004 mRNA Translation: BAC77357.1
AK075391 mRNA Translation: BAC11590.1
AK092992 mRNA Translation: BAG52634.1
AK314338 mRNA Translation: BAG36981.1
AK315882 mRNA Translation: BAF98773.1
CR533483 mRNA Translation: CAG38514.1
AC073237 Genomic DNA No translation available.
AC073347 Genomic DNA No translation available.
AC099681 Genomic DNA No translation available.
CH236957 Genomic DNA Translation: EAL23811.1
CH471201 Genomic DNA Translation: EAW50969.1
BC016650 mRNA Translation: AAH16650.1
AF395824 mRNA Translation: AAK82888.1 Sequence problems.
CCDSiCCDS47588.1 [Q96AW1-1]
CCDS64654.1 [Q96AW1-2]
CCDS64655.1 [Q96AW1-3]
CCDS64656.1 [Q96AW1-4]
RefSeqiNP_001271211.1, NM_001284282.1 [Q96AW1-4]
NP_001271212.1, NM_001284283.1 [Q96AW1-3]
NP_001271213.1, NM_001284284.1 [Q96AW1-2]
NP_001308178.1, NM_001321249.1
NP_001308179.1, NM_001321250.1
NP_001308180.1, NM_001321251.1
NP_110423.3, NM_030796.4 [Q96AW1-1]
UniGeneiHs.488307
Hs.680358

Genome annotation databases

EnsembliENST00000285279; ENSP00000285279; ENSG00000154978 [Q96AW1-1]
ENST00000418904; ENSP00000393210; ENSG00000154978 [Q96AW1-4]
ENST00000433959; ENSP00000415230; ENSG00000154978 [Q96AW1-2]
ENST00000625836; ENSP00000486983; ENSG00000154978 [Q96AW1-3]
GeneIDi81552
KEGGihsa:81552
UCSCiuc003tqq.5 human [Q96AW1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiVOPP1_HUMAN
AccessioniPrimary (citable) accession number: Q96AW1
Secondary accession number(s): B0AZU1
, B2RAT4, B3KS72, C9JWR3, Q6FIE3, Q8NBN8, Q96RE5, Q9H0W4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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