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Entry version 130 (18 Sep 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Vesicular, overexpressed in cancer, prosurvival protein 1

Gene

VOPP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed.1 Publication

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vesicular, overexpressed in cancer, prosurvival protein 1
Alternative name(s):
EGFR-coamplified and overexpressed protein
Short name:
ECop
Glioblastoma-amplified secreted protein
Putative NF-kappa-B-activating protein 055N
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VOPP1
Synonyms:ECOP, GASP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:34518 VOPP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611915 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96AW1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 60ExtracellularSequence analysisAdd BLAST38
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Topological domaini82 – 172CytoplasmicSequence analysisAdd BLAST91

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
81552

Open Targets

More...
OpenTargetsi
ENSG00000154978

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165618503

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
VOPP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74760714

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032591723 – 172Vesicular, overexpressed in cancer, prosurvival protein 1Add BLAST150

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96AW1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96AW1

PeptideAtlas

More...
PeptideAtlasi
Q96AW1

PRoteomics IDEntifications database

More...
PRIDEi
Q96AW1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
12027
76001 [Q96AW1-1]
76002 [Q96AW1-2]
76003 [Q96AW1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96AW1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96AW1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with highest levels in thymus and ovary.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000154978 Expressed in 243 organ(s), highest expression level in forebrain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96AW1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96AW1 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123516, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q96AW1, 16 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000285279

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi87 – 164Pro-richAdd BLAST78

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VOPP1/ECOP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IVPU Eukaryota
ENOG4111SC5 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015821

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000065719

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96AW1

Identification of Orthologs from Complete Genome Data

More...
OMAi
FHVQPNS

Database of Orthologous Groups

More...
OrthoDBi
1458369at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96AW1

TreeFam database of animal gene trees

More...
TreeFami
TF332098

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026229 VOPP1

The PANTHER Classification System

More...
PANTHERi
PTHR14971 PTHR14971, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02068 VOPPROTEIN1

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96AW1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRRQPAKVAA LLLGLLLECT EAKKHCWYFE GLYPTYYICR SYEDCCGSRC
60 70 80 90 100
CVRALSIQRL WYFWFLLMMG VLFCCGAGFF IRRRMYPPPL IEEPAFNVSY
110 120 130 140 150
TRQPPNPGPG AQQPGPPYYT DPGGPGMNPV GNSMAMAFQV PPNSPQGSVA
160 170
CPPPPAYCNT PPPPYEQVVK AK
Length:172
Mass (Da):19,224
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7F7F75231C2A4276
GO
Isoform 2 (identifier: Q96AW1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     4-18: QPAKVAALLLGLLLE → TGSHAQ

Note: No experimental confirmation available.
Show »
Length:163
Mass (Da):18,275
Checksum:i3D8E449D6A98A9C8
GO
Isoform 3 (identifier: Q96AW1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-18: RRQPAKVAALLLGLLLE → LSETLGYLSSVLLQ

Note: No experimental confirmation available.
Show »
Length:169
Mass (Da):18,886
Checksum:i472021D3ECE5C0E5
GO
Isoform 4 (identifier: Q96AW1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MRRQPAKVAALLLGLLLE → M

Note: Gene prediction based on EST data.
Show »
Length:155
Mass (Da):17,381
Checksum:iD522150B1C5E469B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JVH1C9JVH1_HUMAN
Vesicular, overexpressed in cancer,...
VOPP1
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J827C9J827_HUMAN
Vesicular, overexpressed in cancer,...
VOPP1
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JF99C9JF99_HUMAN
Vesicular, overexpressed in cancer,...
VOPP1
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JTY8C9JTY8_HUMAN
Vesicular, overexpressed in cancer,...
VOPP1
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JIM1C9JIM1_HUMAN
Vesicular, overexpressed in cancer,...
VOPP1
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J548C9J548_HUMAN
Vesicular, overexpressed in cancer,...
VOPP1
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQ18C9JQ18_HUMAN
Vesicular, overexpressed in cancer,...
VOPP1
21Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK82888 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti92E → K in CAG38514 (Ref. 4) Curated1
Sequence conflicti111A → T in BAC11590 (PubMed:14702039).Curated1
Sequence conflicti134M → T in CAB66545 (PubMed:12761501).Curated1
Sequence conflicti134M → T in CAG38514 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0557231 – 18MRRQP…GLLLE → M in isoform 4. CuratedAdd BLAST18
Alternative sequenceiVSP_0438672 – 18RRQPA…GLLLE → LSETLGYLSSVLLQ in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_0438684 – 18QPAKV…GLLLE → TGSHAQ in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL136610 mRNA Translation: CAB66545.1
AB097004 mRNA Translation: BAC77357.1
AK075391 mRNA Translation: BAC11590.1
AK092992 mRNA Translation: BAG52634.1
AK314338 mRNA Translation: BAG36981.1
AK315882 mRNA Translation: BAF98773.1
CR533483 mRNA Translation: CAG38514.1
AC073237 Genomic DNA No translation available.
AC073347 Genomic DNA No translation available.
AC099681 Genomic DNA No translation available.
CH236957 Genomic DNA Translation: EAL23811.1
CH471201 Genomic DNA Translation: EAW50969.1
BC016650 mRNA Translation: AAH16650.1
AF395824 mRNA Translation: AAK82888.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47588.1 [Q96AW1-1]
CCDS64654.1 [Q96AW1-2]
CCDS64655.1 [Q96AW1-3]
CCDS64656.1 [Q96AW1-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001271211.1, NM_001284282.1 [Q96AW1-4]
NP_001271212.1, NM_001284283.1 [Q96AW1-3]
NP_001271213.1, NM_001284284.1 [Q96AW1-2]
NP_001308178.1, NM_001321249.1
NP_001308179.1, NM_001321250.1
NP_001308180.1, NM_001321251.1
NP_110423.3, NM_030796.4 [Q96AW1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000285279; ENSP00000285279; ENSG00000154978 [Q96AW1-1]
ENST00000418904; ENSP00000393210; ENSG00000154978 [Q96AW1-4]
ENST00000433959; ENSP00000415230; ENSG00000154978 [Q96AW1-2]
ENST00000625836; ENSP00000486983; ENSG00000154978 [Q96AW1-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
81552

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:81552

UCSC genome browser

More...
UCSCi
uc003tqq.5 human [Q96AW1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136610 mRNA Translation: CAB66545.1
AB097004 mRNA Translation: BAC77357.1
AK075391 mRNA Translation: BAC11590.1
AK092992 mRNA Translation: BAG52634.1
AK314338 mRNA Translation: BAG36981.1
AK315882 mRNA Translation: BAF98773.1
CR533483 mRNA Translation: CAG38514.1
AC073237 Genomic DNA No translation available.
AC073347 Genomic DNA No translation available.
AC099681 Genomic DNA No translation available.
CH236957 Genomic DNA Translation: EAL23811.1
CH471201 Genomic DNA Translation: EAW50969.1
BC016650 mRNA Translation: AAH16650.1
AF395824 mRNA Translation: AAK82888.1 Sequence problems.
CCDSiCCDS47588.1 [Q96AW1-1]
CCDS64654.1 [Q96AW1-2]
CCDS64655.1 [Q96AW1-3]
CCDS64656.1 [Q96AW1-4]
RefSeqiNP_001271211.1, NM_001284282.1 [Q96AW1-4]
NP_001271212.1, NM_001284283.1 [Q96AW1-3]
NP_001271213.1, NM_001284284.1 [Q96AW1-2]
NP_001308178.1, NM_001321249.1
NP_001308179.1, NM_001321250.1
NP_001308180.1, NM_001321251.1
NP_110423.3, NM_030796.4 [Q96AW1-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi123516, 1 interactor
IntActiQ96AW1, 16 interactors
STRINGi9606.ENSP00000285279

PTM databases

iPTMnetiQ96AW1
PhosphoSitePlusiQ96AW1

Polymorphism and mutation databases

BioMutaiVOPP1
DMDMi74760714

Proteomic databases

MassIVEiQ96AW1
PaxDbiQ96AW1
PeptideAtlasiQ96AW1
PRIDEiQ96AW1
ProteomicsDBi12027
76001 [Q96AW1-1]
76002 [Q96AW1-2]
76003 [Q96AW1-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
81552
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285279; ENSP00000285279; ENSG00000154978 [Q96AW1-1]
ENST00000418904; ENSP00000393210; ENSG00000154978 [Q96AW1-4]
ENST00000433959; ENSP00000415230; ENSG00000154978 [Q96AW1-2]
ENST00000625836; ENSP00000486983; ENSG00000154978 [Q96AW1-3]
GeneIDi81552
KEGGihsa:81552
UCSCiuc003tqq.5 human [Q96AW1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
81552
DisGeNETi81552

GeneCards: human genes, protein and diseases

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GeneCardsi
VOPP1
HGNCiHGNC:34518 VOPP1
MIMi611915 gene
neXtProtiNX_Q96AW1
OpenTargetsiENSG00000154978
PharmGKBiPA165618503

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IVPU Eukaryota
ENOG4111SC5 LUCA
GeneTreeiENSGT00390000015821
HOGENOMiHOG000065719
InParanoidiQ96AW1
OMAiFHVQPNS
OrthoDBi1458369at2759
PhylomeDBiQ96AW1
TreeFamiTF332098

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
VOPP1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ECOP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
81552

Pharos

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Pharosi
Q96AW1

Protein Ontology

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PROi
PR:Q96AW1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000154978 Expressed in 243 organ(s), highest expression level in forebrain
ExpressionAtlasiQ96AW1 baseline and differential
GenevisibleiQ96AW1 HS

Family and domain databases

InterProiView protein in InterPro
IPR026229 VOPP1
PANTHERiPTHR14971 PTHR14971, 1 hit
PRINTSiPR02068 VOPPROTEIN1

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVOPP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96AW1
Secondary accession number(s): B0AZU1
, B2RAT4, B3KS72, C9JWR3, Q6FIE3, Q8NBN8, Q96RE5, Q9H0W4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 1, 2001
Last modified: September 18, 2019
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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