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Protein

Ribulose-phosphate 3-epimerase

Gene

RPE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe2+1 Publication, Mn2+1 Publication, Zn2+1 Publication, Co2+1 PublicationNote: Binds 1 divalent metal cation per subunit. Active with Fe2+, and probably also with Mn2+, Zn2+ and Co2+.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei10Substrate1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi35Divalent metal cation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei37Proton acceptorCurated1
Metal bindingi37Divalent metal cation1
Metal bindingi70Divalent metal cation1
Binding sitei70Substrate1
Active sitei175Proton donorCurated1
Metal bindingi175Divalent metal cation1
Binding sitei177Substrate; via amide nitrogen1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: IntAct
  • metal ion binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • ribulose-phosphate 3-epimerase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism
LigandCobalt, Iron, Manganese, Metal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
5.1.3.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-71336 Pentose phosphate pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribulose-phosphate 3-epimerase (EC:5.1.3.1)
Alternative name(s):
Ribulose-5-phosphate-3-epimerase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPE
ORF Names:HUSSY-17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000197713.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10293 RPE

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
180480 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96AT9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi10S → A: Nearly abolishes enzyme activity. 1 Publication1
Mutagenesisi12L → A: Reduces enzyme activity by half. 1 Publication1
Mutagenesisi35H → A: Alters protein structure. Nearly abolishes enzyme activity. 1 Publication1
Mutagenesisi37D → A: Alters protein structure. Nearly abolishes enzyme activity. 1 Publication1
Mutagenesisi39M → A: Lowers enzyme activity by 10%. 1 Publication1
Mutagenesisi70H → A: Alters protein structure. 1 Publication1
Mutagenesisi72M → A: Reduces enzyme activity by half. 1 Publication1
Mutagenesisi141M → A: No effect on enzyme activity. 1 Publication1
Mutagenesisi175D → A: Alters protein structure. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
6120

Open Targets

More...
OpenTargetsi
ENSG00000197713

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34654

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34924986

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001715872 – 228Ribulose-phosphate 3-epimeraseAdd BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96AT9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96AT9

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96AT9

PeptideAtlas

More...
PeptideAtlasi
Q96AT9

PRoteomics IDEntifications database

More...
PRIDEi
Q96AT9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75997
75998 [Q96AT9-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q96AT9-1 [Q96AT9-1]
Q96AT9-2 [Q96AT9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96AT9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96AT9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197713 Expressed in 215 organ(s), highest expression level in adrenal tissue

CleanEx database of gene expression profiles

More...
CleanExi
HS_RPE

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96AT9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96AT9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036498
HPA036499

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself5EBI-372480,EBI-372480

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112040, 51 interactors

Protein interaction database and analysis system

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IntActi
Q96AT9, 4 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000352401

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1228
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q96AT9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96AT9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q96AT9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni146 – 149Substrate binding4
Regioni197 – 198Substrate binding2

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3111 Eukaryota
COG0036 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001447

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000259349

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG044821

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96AT9

KEGG Orthology (KO)

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KOi
K01783

Identification of Orthologs from Complete Genome Data

More...
OMAi
CHLMIED

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0JMQ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96AT9

TreeFam database of animal gene trees

More...
TreeFami
TF300157

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00429 RPE, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013785 Aldolase_TIM
IPR026019 Ribul_P_3_epim
IPR000056 Ribul_P_3_epim-like
IPR011060 RibuloseP-bd_barrel

The PANTHER Classification System

More...
PANTHERi
PTHR11749 PTHR11749, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00834 Ribul_P_3_epim, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001461 RPE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51366 SSF51366, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01163 rpe, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01085 RIBUL_P_3_EPIMER_1, 1 hit
PS01086 RIBUL_P_3_EPIMER_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96AT9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASGCKIGPS ILNSDLANLG AECLRMLDSG ADYLHLDVMD GHFVPNITFG
60 70 80 90 100
HPVVESLRKQ LGQDPFFDMH MMVSKPEQWV KPMAVAGANQ YTFHLEATEN
110 120 130 140 150
PGALIKDIRE NGMKVGLAIK PGTSVEYLAP WANQIDMALV MTVEPGFGGQ
160 170 180 190 200
KFMEDMMPKV HWLRTQFPSL DIEVDGGVGP DTVHKCAEAG ANMIVSGSAI
210 220
MRSEDPRSVI NLLRNVCSEA AQKRSLDR
Length:228
Mass (Da):24,928
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i447130018AC52331
GO
Isoform 2 (identifier: Q96AT9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-68: Missing.
     114-114: K → KSCSVTQAEVQWHSQGPLQ

Note: No experimental confirmation available.
Show »
Length:220
Mass (Da):23,924
Checksum:i626FAFD9426AE406
GO
Isoform 3 (identifier: Q96AT9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.
     114-114: K → KSCSVTQAEVQWHSQGPLQ

Note: Gene prediction based on EST data.
Show »
Length:178
Mass (Da):19,537
Checksum:iC2D4353C7FFAEC41
GO
Isoform 4 (identifier: Q96AT9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     160-188: Missing.

Note: No experimental confirmation available.
Show »
Length:199
Mass (Da):21,739
Checksum:i88D6C3598F28A1E1
GO
Isoform 5 (identifier: Q96AT9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.

Note: Gene prediction based on EST data.
Show »
Length:160
Mass (Da):17,570
Checksum:i9B6890E5E78B7D35
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9IZU8C9IZU8_HUMAN
Ribulose-phosphate 3-epimerase
RPE
225Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J9T0C9J9T0_HUMAN
Ribulose-5-phosphate-3-epimerase, i...
RPE hCG_2012337
191Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IYE8C9IYE8_HUMAN
Ribulose-phosphate 3-epimerase
RPE
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J6A7C9J6A7_HUMAN
Ribulose-phosphate 3-epimerase
RPE
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JCL8C9JCL8_HUMAN
Ribulose-phosphate 3-epimerase
RPE
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J8S0C9J8S0_HUMAN
Ribulose-phosphate 3-epimerase
RPE
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ESZ6E7ESZ6_HUMAN
Ribulose-phosphate 3-epimerase
RPE
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PBG9E9PBG9_HUMAN
Ribulose-phosphate 3-epimerase
RPE
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBT4F8WBT4_HUMAN
Ribulose-phosphate 3-epimerase
RPE
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB71076 differs from that shown. Reason: Frameshift at position 69.Curated
The sequence BAC04212 differs from that shown. Reason: Frameshift at position 42.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti180P → L in BAC04212 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0471171 – 68Missing in isoform 3 and isoform 5. CuratedAdd BLAST68
Alternative sequenceiVSP_00831743 – 68Missing in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_008318114K → KSCSVTQAEVQWHSQGPLQ in isoform 2 and isoform 3. 1 Publication1
Alternative sequenceiVSP_055265160 – 188Missing in isoform 4. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK056028 mRNA Translation: BAB71076.1 Frameshift.
AK093658 mRNA Translation: BAC04212.1 Frameshift.
AK291035 mRNA Translation: BAF83724.1
AK303184 mRNA Translation: BAG64278.1
AC007038 Genomic DNA Translation: AAX93087.1
CH471063 Genomic DNA Translation: EAW70473.1
CH471063 Genomic DNA Translation: EAW70474.1
BC005148 mRNA Translation: AAH05148.2
BC016764 mRNA Translation: AAH16764.1
BC072401 mRNA Translation: AAH72401.1
AJ224326 mRNA Translation: CAA11895.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS2388.1 [Q96AT9-1]
CCDS42810.1 [Q96AT9-3]
CCDS63107.1 [Q96AT9-4]
CCDS63108.1 [Q96AT9-5]

NCBI Reference Sequences

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RefSeqi
NP_001265211.1, NM_001278282.1 [Q96AT9-3]
NP_001265212.1, NM_001278283.1 [Q96AT9-3]
NP_001265214.1, NM_001278285.1 [Q96AT9-4]
NP_001265215.1, NM_001278286.1 [Q96AT9-5]
NP_001265217.1, NM_001278288.1 [Q96AT9-5]
NP_001265218.1, NM_001278289.1
NP_001305855.1, NM_001318926.1
NP_001305856.1, NM_001318927.1
NP_001305857.1, NM_001318928.1
NP_001305858.1, NM_001318929.1
NP_001305859.1, NM_001318930.1 [Q96AT9-5]
NP_001305860.1, NM_001318931.1 [Q96AT9-5]
NP_008847.1, NM_006916.2 [Q96AT9-3]
NP_954699.1, NM_199229.2 [Q96AT9-1]
XP_006712740.1, XM_006712677.3 [Q96AT9-5]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.282260
Hs.591638
Hs.734255

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000354506; ENSP00000346501; ENSG00000197713 [Q96AT9-4]
ENST00000359429; ENSP00000352401; ENSG00000197713 [Q96AT9-1]
ENST00000411934; ENSP00000389411; ENSG00000197713 [Q96AT9-5]
ENST00000429921; ENSP00000401838; ENSG00000197713 [Q96AT9-3]
ENST00000436630; ENSP00000403808; ENSG00000197713 [Q96AT9-3]
ENST00000438204; ENSP00000402061; ENSG00000197713 [Q96AT9-5]
ENST00000454822; ENSP00000394455; ENSG00000197713 [Q96AT9-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6120

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6120

UCSC genome browser

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UCSCi
uc002vdn.5 human [Q96AT9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056028 mRNA Translation: BAB71076.1 Frameshift.
AK093658 mRNA Translation: BAC04212.1 Frameshift.
AK291035 mRNA Translation: BAF83724.1
AK303184 mRNA Translation: BAG64278.1
AC007038 Genomic DNA Translation: AAX93087.1
CH471063 Genomic DNA Translation: EAW70473.1
CH471063 Genomic DNA Translation: EAW70474.1
BC005148 mRNA Translation: AAH05148.2
BC016764 mRNA Translation: AAH16764.1
BC072401 mRNA Translation: AAH72401.1
AJ224326 mRNA Translation: CAA11895.1
CCDSiCCDS2388.1 [Q96AT9-1]
CCDS42810.1 [Q96AT9-3]
CCDS63107.1 [Q96AT9-4]
CCDS63108.1 [Q96AT9-5]
RefSeqiNP_001265211.1, NM_001278282.1 [Q96AT9-3]
NP_001265212.1, NM_001278283.1 [Q96AT9-3]
NP_001265214.1, NM_001278285.1 [Q96AT9-4]
NP_001265215.1, NM_001278286.1 [Q96AT9-5]
NP_001265217.1, NM_001278288.1 [Q96AT9-5]
NP_001265218.1, NM_001278289.1
NP_001305855.1, NM_001318926.1
NP_001305856.1, NM_001318927.1
NP_001305857.1, NM_001318928.1
NP_001305858.1, NM_001318929.1
NP_001305859.1, NM_001318930.1 [Q96AT9-5]
NP_001305860.1, NM_001318931.1 [Q96AT9-5]
NP_008847.1, NM_006916.2 [Q96AT9-3]
NP_954699.1, NM_199229.2 [Q96AT9-1]
XP_006712740.1, XM_006712677.3 [Q96AT9-5]
UniGeneiHs.282260
Hs.591638
Hs.734255

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3OVPX-ray1.70A/B1-228[»]
3OVQX-ray2.00A/B1-228[»]
3OVRX-ray1.95A/B1-228[»]
3QC3X-ray2.20A/B1-224[»]
ProteinModelPortaliQ96AT9
SMRiQ96AT9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112040, 51 interactors
IntActiQ96AT9, 4 interactors
STRINGi9606.ENSP00000352401

PTM databases

iPTMnetiQ96AT9
PhosphoSitePlusiQ96AT9

Polymorphism and mutation databases

DMDMi34924986

Proteomic databases

EPDiQ96AT9
MaxQBiQ96AT9
PaxDbiQ96AT9
PeptideAtlasiQ96AT9
PRIDEiQ96AT9
ProteomicsDBi75997
75998 [Q96AT9-2]
TopDownProteomicsiQ96AT9-1 [Q96AT9-1]
Q96AT9-2 [Q96AT9-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6120
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354506; ENSP00000346501; ENSG00000197713 [Q96AT9-4]
ENST00000359429; ENSP00000352401; ENSG00000197713 [Q96AT9-1]
ENST00000411934; ENSP00000389411; ENSG00000197713 [Q96AT9-5]
ENST00000429921; ENSP00000401838; ENSG00000197713 [Q96AT9-3]
ENST00000436630; ENSP00000403808; ENSG00000197713 [Q96AT9-3]
ENST00000438204; ENSP00000402061; ENSG00000197713 [Q96AT9-5]
ENST00000454822; ENSP00000394455; ENSG00000197713 [Q96AT9-3]
GeneIDi6120
KEGGihsa:6120
UCSCiuc002vdn.5 human [Q96AT9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6120
DisGeNETi6120
EuPathDBiHostDB:ENSG00000197713.14

GeneCards: human genes, protein and diseases

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GeneCardsi
RPE

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0190555
HGNCiHGNC:10293 RPE
HPAiHPA036498
HPA036499
MIMi180480 gene
neXtProtiNX_Q96AT9
OpenTargetsiENSG00000197713
PharmGKBiPA34654

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3111 Eukaryota
COG0036 LUCA
GeneTreeiENSGT00390000001447
HOGENOMiHOG000259349
HOVERGENiHBG044821
InParanoidiQ96AT9
KOiK01783
OMAiCHLMIED
OrthoDBiEOG091G0JMQ
PhylomeDBiQ96AT9
TreeFamiTF300157

Enzyme and pathway databases

BRENDAi5.1.3.1 2681
ReactomeiR-HSA-71336 Pentose phosphate pathway

Miscellaneous databases

EvolutionaryTraceiQ96AT9

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RPE_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6120

Protein Ontology

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PROi
PR:Q96AT9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000197713 Expressed in 215 organ(s), highest expression level in adrenal tissue
CleanExiHS_RPE
ExpressionAtlasiQ96AT9 baseline and differential
GenevisibleiQ96AT9 HS

Family and domain databases

CDDicd00429 RPE, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR026019 Ribul_P_3_epim
IPR000056 Ribul_P_3_epim-like
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR11749 PTHR11749, 1 hit
PfamiView protein in Pfam
PF00834 Ribul_P_3_epim, 1 hit
PIRSFiPIRSF001461 RPE, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR01163 rpe, 1 hit
PROSITEiView protein in PROSITE
PS01085 RIBUL_P_3_EPIMER_1, 1 hit
PS01086 RIBUL_P_3_EPIMER_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPE_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96AT9
Secondary accession number(s): A8K4S0
, B4E016, C9JPQ7, O43767, Q53TV9, Q8N215, Q96N34, Q9BSB5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: December 1, 2001
Last modified: December 5, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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