Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 111 (26 Feb 2020)
Sequence version 2 (20 Mar 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Protein FAM131C

Gene

FAM131C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM131C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM131C
Synonyms:C1orf117
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26717 FAM131C

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96AQ9

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000185519

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162386082

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96AQ9 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM131C

Domain mapping of disease mutations (DMDM)

More...
DMDMi
134035394

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002804011 – 280Protein FAM131CAdd BLAST280

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96AQ9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96AQ9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96AQ9

PeptideAtlas

More...
PeptideAtlasi
Q96AQ9

PRoteomics IDEntifications database

More...
PRIDEi
Q96AQ9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75995

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96AQ9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96AQ9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185519 Expressed in C1 segment of cervical spinal cord and 76 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96AQ9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031046

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
131523, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q96AQ9, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000364814

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96AQ9 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96AQ9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi214 – 264Pro-richAdd BLAST51

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM131 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKD9 Eukaryota
ENOG41120RD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183106

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_092457_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96AQ9

Identification of Orthologs from Complete Genome Data

More...
OMAi
EWKGWRA

Database of Orthologous Groups

More...
OrthoDBi
1247596at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96AQ9

TreeFam database of animal gene trees

More...
TreeFami
TF331537

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026782 FAM131

The PANTHER Classification System

More...
PANTHERi
PTHR15736 PTHR15736, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15010 FAM131, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96AQ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSCVSRDLF TSAHKNCPMP QGADPLNPDL PSGRTPTVAP DCVIGKDKQM
60 70 80 90 100
DFCWDPWQRC FQTTNGYLSD SRSRPGNYNV AALATSSLVG VVQSIKDHIT
110 120 130 140 150
KPTAMARGRV AHLIEWKGWS AQPAGWELSP AEDEHYCCLP DELREARFAA
160 170 180 190 200
GVAEQFAITE ATLSAWSSLD EEELHPENSP QGIVQLQDLE SIYLQDSLPS
210 220 230 240 250
GPSQDDSLQA FSSPSPSPDS CPSPEEPPST AGIPQPPSPE LQHRRRLPGA
260 270 280
QGPEGGTHPP GSLPSMDSGS LWEEDEVFYN
Length:280
Mass (Da):30,351
Last modified:March 20, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i674631222FA8095C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti19M → I in BAC04282 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03113048K → E2 PublicationsCorresponds to variant dbSNP:rs2863458Ensembl.1
Natural variantiVAR_031131107R → Q1 PublicationCorresponds to variant dbSNP:rs71510977Ensembl.1
Natural variantiVAR_031132123P → R2 PublicationsCorresponds to variant dbSNP:rs11576236Ensembl.1
Natural variantiVAR_031133215S → I. Corresponds to variant dbSNP:rs1832151Ensembl.1
Natural variantiVAR_031134226E → D1 PublicationCorresponds to variant dbSNP:rs17853749Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK094085 mRNA Translation: BAC04282.1
AL355994 Genomic DNA No translation available.
BC016848 mRNA Translation: AAH16848.1
BC037394 mRNA Translation: AAH37394.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41270.1

NCBI Reference Sequences

More...
RefSeqi
NP_872429.2, NM_182623.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000375662; ENSP00000364814; ENSG00000185519

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
348487

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:348487

UCSC genome browser

More...
UCSCi
uc001axz.5 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094085 mRNA Translation: BAC04282.1
AL355994 Genomic DNA No translation available.
BC016848 mRNA Translation: AAH16848.1
BC037394 mRNA Translation: AAH37394.1
CCDSiCCDS41270.1
RefSeqiNP_872429.2, NM_182623.2

3D structure databases

SMRiQ96AQ9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi131523, 11 interactors
IntActiQ96AQ9, 8 interactors
STRINGi9606.ENSP00000364814

PTM databases

iPTMnetiQ96AQ9
PhosphoSitePlusiQ96AQ9

Polymorphism and mutation databases

BioMutaiFAM131C
DMDMi134035394

Proteomic databases

jPOSTiQ96AQ9
MassIVEiQ96AQ9
PaxDbiQ96AQ9
PeptideAtlasiQ96AQ9
PRIDEiQ96AQ9
ProteomicsDBi75995

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
348487

Genome annotation databases

EnsembliENST00000375662; ENSP00000364814; ENSG00000185519
GeneIDi348487
KEGGihsa:348487
UCSCiuc001axz.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
348487

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM131C
HGNCiHGNC:26717 FAM131C
HPAiHPA031046
neXtProtiNX_Q96AQ9
OpenTargetsiENSG00000185519
PharmGKBiPA162386082

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IKD9 Eukaryota
ENOG41120RD LUCA
GeneTreeiENSGT00950000183106
HOGENOMiCLU_092457_0_0_1
InParanoidiQ96AQ9
OMAiEWKGWRA
OrthoDBi1247596at2759
PhylomeDBiQ96AQ9
TreeFamiTF331537

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAM131C human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
348487
PharosiQ96AQ9 Tdark

Protein Ontology

More...
PROi
PR:Q96AQ9
RNActiQ96AQ9 protein

Gene expression databases

BgeeiENSG00000185519 Expressed in C1 segment of cervical spinal cord and 76 other tissues
GenevisibleiQ96AQ9 HS

Family and domain databases

InterProiView protein in InterPro
IPR026782 FAM131
PANTHERiPTHR15736 PTHR15736, 1 hit
PfamiView protein in Pfam
PF15010 FAM131, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF131C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96AQ9
Secondary accession number(s): Q5T5Q5, Q8N3X3, Q8N9P9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: February 26, 2020
This is version 111 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again