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Entry version 126 (16 Oct 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Mitochondrial calcium uniporter regulator 1

Gene

MCUR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion (PubMed:23178883, PubMed:26445506, PubMed:27184846, PubMed:26976564). Plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU (PubMed:23178883). Probably involved in the assembly of the membrane components of the uniporter complex (uniplex) (PubMed:27184846).4 Publications

Caution

A paper reported that MCUR1 has an indirect role as a regulator of mitochondrial calcium uniporter (MCU) and is involved in cytochrome c oxidase (COX) assembly instead (PubMed:25565209). Subsequent publications however confirmed the function of MCUR1 as a regulator of MCU (PubMed:26445506, PubMed:27184846).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCalcium transport, Ion transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitochondrial calcium uniporter regulator 11 Publication
Short name:
MCU regulator 11 Publication
Alternative name(s):
Coiled-coil domain-containing protein 90A, mitochondrialCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MCUR11 Publication
Synonyms:C6orf79Imported, CCDC90AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21097 MCUR1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616952 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96AQ8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 68Mitochondrial intermembrane1 PublicationAdd BLAST68
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei69 – 85HelicalSequence analysisAdd BLAST17
Topological domaini86 – 338Mitochondrial matrix1 PublicationAdd BLAST253
Transmembranei339 – 358HelicalSequence analysisAdd BLAST20
Topological domaini359Mitochondrial intermembrane1 Publication1

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000050393

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162381944

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96AQ8

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MCUR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751750

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002956921 – 359Mitochondrial calcium uniporter regulator 1Add BLAST359

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96AQ8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96AQ8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96AQ8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96AQ8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96AQ8

PeptideAtlas

More...
PeptideAtlasi
Q96AQ8

PRoteomics IDEntifications database

More...
PRIDEi
Q96AQ8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75993 [Q96AQ8-1]
75994 [Q96AQ8-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q96AQ8-1 [Q96AQ8-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96AQ8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96AQ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000050393 Expressed in 231 organ(s), highest expression level in duodenum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96AQ8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96AQ8 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via coiled coil regions) with MCU; the interaction is direct (PubMed:23178883, PubMed:26341627, PubMed:27184846, PubMed:26976564).

Interacts with SMDT1/EMRE; the interaction is direct (PubMed:27184846).

Interacts with PPIF (PubMed:26976564).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q8NE86-14EBI-14404755,EBI-15932889

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122001, 4 interactors

Database of interacting proteins

More...
DIPi
DIP-61861N

Protein interaction database and analysis system

More...
IntActi
Q96AQ8, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000368468

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96AQ8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili235 – 310Sequence analysisAdd BLAST76

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CCDC90 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3156 Eukaryota
ENOG4111F9W LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158957

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294135

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96AQ8

KEGG Orthology (KO)

More...
KOi
K22137

Identification of Orthologs from Complete Genome Data

More...
OMAi
CEGRKLF

Database of Orthologous Groups

More...
OrthoDBi
1252164at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96AQ8

TreeFam database of animal gene trees

More...
TreeFami
TF331442

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024461 DUF1640
IPR012439 MCUR1

The PANTHER Classification System

More...
PANTHERi
PTHR14360 PTHR14360, 1 hit
PTHR14360:SF11 PTHR14360:SF11, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07798 DUF1640, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96AQ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDCGSVGGQR TQRLPGRQRL LFLPVGLSGR PGGSETSARR CLSALSDGLG
60 70 80 90 100
ALRPRAPAAR GGVSRASPLL LLLLVPSPRL AAAAPRRQLG DWERSRLGYA
110 120 130 140 150
APPAGRSSAW RCSPGVAAAA GALPQYHGPA PALVSCRREL SLSAGSLQLE
160 170 180 190 200
RKRRDFTSSG SRKLYFDTHA LVCLLEDNGF ATQQAEIIVS ALVKILEANM
210 220 230 240 250
DIVYKDMVTK MQQEITFQQV MSQIANVKKD MIILEKSEFS ALRAENEKIK
260 270 280 290 300
LELHQLKQQV MDEVIKVRTD TKLDFNLEKS RVKELYSLNE KKLLELRTEI
310 320 330 340 350
VALHAQQDRA LTQTDRKIET EVAGLKTMLE SHKLDNIKYL AGSIFTCLTV

ALGFYRLWI
Length:359
Mass (Da):39,694
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i488A2ABECFA2780B
GO
Isoform 2 (identifier: Q96AQ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-257: GFATQQAEII...KIKLELHQLK → ESHSFIQAGV...TSSDPPTLAS
     258-359: Missing.

Note: No experimental confirmation available.
Show »
Length:257
Mass (Da):27,468
Checksum:i64BF5C21B0B3E49A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KQP8U3KQP8_HUMAN
Mitochondrial calcium uniporter reg...
MCUR1
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti42L → P in BAB14934 (PubMed:14702039).Curated1
Sequence conflicti309R → W in AAH08234 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033320108S → G1 PublicationCorresponds to variant dbSNP:rs1204145Ensembl.1
Natural variantiVAR_033321216T → A. Corresponds to variant dbSNP:rs3180196Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_026998179 – 257GFATQ…LHQLK → ESHSFIQAGVQWHSLGLLQP PPPGFKRSSHLILLSSWDYR HAPPHLDNFSVFLLETGFHH VGQAGLKLLTSSDPPTLAS in isoform 2. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_026999258 – 359Missing in isoform 2. 1 PublicationAdd BLAST102

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK024611 mRNA Translation: BAB14934.1
AL023583 Genomic DNA No translation available.
BC008234 mRNA Translation: AAH08234.1
BC016850 mRNA Translation: AAH16850.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35495.1 [Q96AQ8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001026883.1, NM_001031713.3 [Q96AQ8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000379170; ENSP00000368468; ENSG00000050393 [Q96AQ8-1]
ENST00000488770; ENSP00000476162; ENSG00000050393 [Q96AQ8-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
63933

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:63933

UCSC genome browser

More...
UCSCi
uc003nbc.3 human [Q96AQ8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024611 mRNA Translation: BAB14934.1
AL023583 Genomic DNA No translation available.
BC008234 mRNA Translation: AAH08234.1
BC016850 mRNA Translation: AAH16850.1
CCDSiCCDS35495.1 [Q96AQ8-1]
RefSeqiNP_001026883.1, NM_001031713.3 [Q96AQ8-1]

3D structure databases

SMRiQ96AQ8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122001, 4 interactors
DIPiDIP-61861N
IntActiQ96AQ8, 5 interactors
STRINGi9606.ENSP00000368468

PTM databases

iPTMnetiQ96AQ8
PhosphoSitePlusiQ96AQ8

Polymorphism and mutation databases

BioMutaiMCUR1
DMDMi74751750

Proteomic databases

EPDiQ96AQ8
jPOSTiQ96AQ8
MassIVEiQ96AQ8
MaxQBiQ96AQ8
PaxDbiQ96AQ8
PeptideAtlasiQ96AQ8
PRIDEiQ96AQ8
ProteomicsDBi75993 [Q96AQ8-1]
75994 [Q96AQ8-2]
TopDownProteomicsiQ96AQ8-1 [Q96AQ8-1]

Genome annotation databases

EnsembliENST00000379170; ENSP00000368468; ENSG00000050393 [Q96AQ8-1]
ENST00000488770; ENSP00000476162; ENSG00000050393 [Q96AQ8-2]
GeneIDi63933
KEGGihsa:63933
UCSCiuc003nbc.3 human [Q96AQ8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
63933

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MCUR1
HGNCiHGNC:21097 MCUR1
MIMi616952 gene
neXtProtiNX_Q96AQ8
OpenTargetsiENSG00000050393
PharmGKBiPA162381944

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3156 Eukaryota
ENOG4111F9W LUCA
GeneTreeiENSGT00940000158957
HOGENOMiHOG000294135
InParanoidiQ96AQ8
KOiK22137
OMAiCEGRKLF
OrthoDBi1252164at2759
PhylomeDBiQ96AQ8
TreeFamiTF331442

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MCUR1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
63933
PharosiQ96AQ8

Protein Ontology

More...
PROi
PR:Q96AQ8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000050393 Expressed in 231 organ(s), highest expression level in duodenum
ExpressionAtlasiQ96AQ8 baseline and differential
GenevisibleiQ96AQ8 HS

Family and domain databases

InterProiView protein in InterPro
IPR024461 DUF1640
IPR012439 MCUR1
PANTHERiPTHR14360 PTHR14360, 1 hit
PTHR14360:SF11 PTHR14360:SF11, 1 hit
PfamiView protein in Pfam
PF07798 DUF1640, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMCUR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96AQ8
Secondary accession number(s): Q96JS7, Q9H7F8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 1, 2001
Last modified: October 16, 2019
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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