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Entry version 138 (17 Jun 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Cell death activator CIDE-3

Gene

CIDEC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment. As mature adipocytes, that express high CIDEC levels, are quite resistant to apoptotic stimuli, the physiological significance of its role in apoptosis is unclear. May play a role in the modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its target genes expression.5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processApoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8963889 Assembly of active LPL and LIPC lipase complexes [Q96AQ7-1]
R-HSA-8964572 Lipid particle organization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell death activator CIDE-3
Alternative name(s):
Cell death-inducing DFFA-like effector protein C
Fat-specific protein FSP27 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CIDEC
Synonyms:FSP27
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000187288.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24229 CIDEC

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612120 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96AQ7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Lipid droplet, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

In omental adipose tissue of obese patients matched for BMI, expression levels tend to correlate with insulin sensitivity. Expression is increased 2-3 fold in the group of patients with high insulin sensitivity, compared to the insulin-resistant group. This observation is consistent with the idea that triglyceride storage in adipocytes plays an important role in sequestering triglycerides and fatty acids away from the circulation and peripheral tissues, thus enhancing insulin sensitivity in liver and muscle. This effect is not significant in subcutaneous adipose tissue (PubMed:18509062). In subcutaneous adipose tissue of diabetic patients, tends to negatively correlate with body mass index and total fat mass, independently of insulin sensitivity (PubMed:18334488).2 Publications
Lipodystrophy, familial partial, 5 (FPLD5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of lipodystrophy characterized by loss of subcutaneous adipose tissue affecting limb, femorogluteal and subcutaneous abdominal fat, preservation of visceral, neck and axilliary fat, hepatomegaly, hepatic steatosis and insulin-resistant diabetes.
Related information in OMIM

Organism-specific databases

DisGeNET

More...
DisGeNETi
63924

MalaCards human disease database

More...
MalaCardsi
CIDEC
MIMi615238 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000187288

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
435651 CIDEC-related familial partial lipodystrophy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134923736

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96AQ7 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CIDEC

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20138281

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001447221 – 238Cell death activator CIDE-3Add BLAST238

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated and targeted to proteasomal degradation, resulting in a short half-life. Protein stability depends on triaclyglycerol synthesis, fatty acid availability and lipid droplet formation (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96AQ7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96AQ7

PeptideAtlas

More...
PeptideAtlasi
Q96AQ7

PRoteomics IDEntifications database

More...
PRIDEi
Q96AQ7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
10869
75990 [Q96AQ7-1]
75991 [Q96AQ7-2]
75992 [Q96AQ7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96AQ7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96AQ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed mainly in adipose tissue, small intestine, heart, colon and stomach and, at lower levels, in brain, kidney and liver.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000187288 Expressed in adipose tissue and 137 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96AQ7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96AQ7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000187288 Group enriched (adipose tissue, breast, intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity).

Interacts with CEBPB.

Interacts with NFAT5; this interaction is direct and retains NFAT5 in the cytoplasm (By similarity).

Interacts with CIDEA.

Interacts with PLIN1.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
121993, 7 interactors

Protein interaction database and analysis system

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IntActi
Q96AQ7, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000373328

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96AQ7 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 118CIDE-NPROSITE-ProRule annotationAdd BLAST78

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CIDE-N domain is involved in homodimerization which is crucial for its function in promoting lipid exchange and transfer.By similarity

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IWQS Eukaryota
ENOG4111HCT LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018596

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_090011_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96AQ7

Database of Orthologous Groups

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OrthoDBi
1421916at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96AQ7

TreeFam database of animal gene trees

More...
TreeFami
TF334321

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003508 CIDE-N_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02017 CIDE-N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00266 CAD, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51135 CIDE_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96AQ7-1) [UniParc]FASTAAdd to basket
Also known as: CIDE-3

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEYAMKSLSL LYPKSLSRHV SVRTSVVTQQ LLSEPSPKAP RARPCRVSTA
60 70 80 90 100
DRSVRKGIMA YSLEDLLLKV RDTLMLADKP FFLVLEEDGT TVETEEYFQA
110 120 130 140 150
LAGDTVFMVL QKGQKWQPPS EQGTRHPLSL SHKPAKKIDV ARVTFDLYKL
160 170 180 190 200
NPQDFIGCLN VKATFYDTYS LSYDLHCCGA KRIMKEAFRW ALFSMQATGH
210 220 230
VLLGTSCYLQ QLLDATEEGQ PPKGKASSLI PTCLKILQ
Length:238
Mass (Da):26,754
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5CF774929E821DA5
GO
Isoform 2 (identifier: Q96AQ7-2) [UniParc]FASTAAdd to basket
Also known as: CIDE-3alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: Missing.

Show »
Length:164
Mass (Da):18,439
Checksum:i1D1F849599635189
GO
Isoform 3 (identifier: Q96AQ7-3) [UniParc]FASTAAdd to basket
Also known as: CIDE-3beta

The sequence of this isoform differs from the canonical sequence as follows:
     70-129: VRDTLMLADK...SEQGTRHPLS → GSFPLGPLQH...DTAVKAQVLG
     130-238: Missing.

Show »
Length:129
Mass (Da):14,013
Checksum:i13CC037E2590D992
GO
Isoform 4 (identifier: Q96AQ7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-69: K → KTRNPEARSQE

Show »
Length:248
Mass (Da):27,923
Checksum:iF6955819613B0A64
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MRY9A0A0A0MRY9_HUMAN
Cell death activator CIDE-3
CIDEC
251Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DG75A0A0C4DG75_HUMAN
Cell death activator CIDE-3
CIDEC
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti149K → N in CD518729 (PubMed:16641997).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0127381 – 74Missing in isoform 2. 2 PublicationsAdd BLAST74
Alternative sequenceiVSP_04505169K → KTRNPEARSQE in isoform 4. 1 Publication1
Alternative sequenceiVSP_01273970 – 129VRDTL…RHPLS → GSFPLGPLQHAGHRPRTAWH LLLPAAAPRCYGGRAAPQGQ GLIPYPDLSEDTAVKAQVLG in isoform 3. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_012740130 – 238Missing in isoform 3. 1 PublicationAdd BLAST109

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF303893 mRNA Translation: AAN32612.1
AY364640 mRNA Translation: AAQ65242.1
AY364638 mRNA Translation: AAR23106.1
AK024524 mRNA Translation: BAB14920.1
AK024530 mRNA Translation: BAB14922.1
AC018809 Genomic DNA No translation available.
BC016851 mRNA Translation: AAH16851.1
CD518729 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2587.1 [Q96AQ7-1]
CCDS56239.1 [Q96AQ7-4]
CCDS82731.1 [Q96AQ7-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001186480.1, NM_001199551.1 [Q96AQ7-4]
NP_001186481.1, NM_001199552.1 [Q96AQ7-1]
NP_001186552.1, NM_001199623.1
NP_001308071.1, NM_001321142.1 [Q96AQ7-1]
NP_001308072.1, NM_001321143.1 [Q96AQ7-2]
NP_001308073.1, NM_001321144.1 [Q96AQ7-2]
NP_071377.2, NM_022094.3 [Q96AQ7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000336832; ENSP00000338642; ENSG00000187288 [Q96AQ7-1]
ENST00000423850; ENSP00000400649; ENSG00000187288 [Q96AQ7-2]
ENST00000430427; ENSP00000408631; ENSG00000187288 [Q96AQ7-4]
ENST00000455015; ENSP00000392975; ENSG00000187288 [Q96AQ7-2]
ENST00000618572; ENSP00000483641; ENSG00000187288 [Q96AQ7-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
63924

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:63924

UCSC genome browser

More...
UCSCi
uc003btq.4 human [Q96AQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303893 mRNA Translation: AAN32612.1
AY364640 mRNA Translation: AAQ65242.1
AY364638 mRNA Translation: AAR23106.1
AK024524 mRNA Translation: BAB14920.1
AK024530 mRNA Translation: BAB14922.1
AC018809 Genomic DNA No translation available.
BC016851 mRNA Translation: AAH16851.1
CD518729 mRNA No translation available.
CCDSiCCDS2587.1 [Q96AQ7-1]
CCDS56239.1 [Q96AQ7-4]
CCDS82731.1 [Q96AQ7-2]
RefSeqiNP_001186480.1, NM_001199551.1 [Q96AQ7-4]
NP_001186481.1, NM_001199552.1 [Q96AQ7-1]
NP_001186552.1, NM_001199623.1
NP_001308071.1, NM_001321142.1 [Q96AQ7-1]
NP_001308072.1, NM_001321143.1 [Q96AQ7-2]
NP_001308073.1, NM_001321144.1 [Q96AQ7-2]
NP_071377.2, NM_022094.3 [Q96AQ7-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi121993, 7 interactors
IntActiQ96AQ7, 8 interactors
STRINGi9606.ENSP00000373328

PTM databases

iPTMnetiQ96AQ7
PhosphoSitePlusiQ96AQ7

Polymorphism and mutation databases

BioMutaiCIDEC
DMDMi20138281

Proteomic databases

MassIVEiQ96AQ7
PaxDbiQ96AQ7
PeptideAtlasiQ96AQ7
PRIDEiQ96AQ7
ProteomicsDBi10869
75990 [Q96AQ7-1]
75991 [Q96AQ7-2]
75992 [Q96AQ7-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
10363 291 antibodies

The DNASU plasmid repository

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DNASUi
63924

Genome annotation databases

EnsembliENST00000336832; ENSP00000338642; ENSG00000187288 [Q96AQ7-1]
ENST00000423850; ENSP00000400649; ENSG00000187288 [Q96AQ7-2]
ENST00000430427; ENSP00000408631; ENSG00000187288 [Q96AQ7-4]
ENST00000455015; ENSP00000392975; ENSG00000187288 [Q96AQ7-2]
ENST00000618572; ENSP00000483641; ENSG00000187288 [Q96AQ7-4]
GeneIDi63924
KEGGihsa:63924
UCSCiuc003btq.4 human [Q96AQ7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
63924
DisGeNETi63924
EuPathDBiHostDB:ENSG00000187288.10

GeneCards: human genes, protein and diseases

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GeneCardsi
CIDEC
HGNCiHGNC:24229 CIDEC
HPAiENSG00000187288 Group enriched (adipose tissue, breast, intestine)
MalaCardsiCIDEC
MIMi612120 gene
615238 phenotype
neXtProtiNX_Q96AQ7
OpenTargetsiENSG00000187288
Orphaneti435651 CIDEC-related familial partial lipodystrophy
PharmGKBiPA134923736

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IWQS Eukaryota
ENOG4111HCT LUCA
GeneTreeiENSGT00390000018596
HOGENOMiCLU_090011_1_0_1
InParanoidiQ96AQ7
OrthoDBi1421916at2759
PhylomeDBiQ96AQ7
TreeFamiTF334321

Enzyme and pathway databases

ReactomeiR-HSA-8963889 Assembly of active LPL and LIPC lipase complexes [Q96AQ7-1]
R-HSA-8964572 Lipid particle organization

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
63924 2 hits in 789 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CIDEC human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
63924
PharosiQ96AQ7 Tbio

Protein Ontology

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PROi
PR:Q96AQ7
RNActiQ96AQ7 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000187288 Expressed in adipose tissue and 137 other tissues
ExpressionAtlasiQ96AQ7 baseline and differential
GenevisibleiQ96AQ7 HS

Family and domain databases

InterProiView protein in InterPro
IPR003508 CIDE-N_dom
PfamiView protein in Pfam
PF02017 CIDE-N, 1 hit
SMARTiView protein in SMART
SM00266 CAD, 1 hit
PROSITEiView protein in PROSITE
PS51135 CIDE_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCIDEC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96AQ7
Secondary accession number(s): C9JMN7, Q67DW9, Q9GZY9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: June 17, 2020
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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