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Entry version 138 (07 Oct 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Pre-B-cell leukemia transcription factor-interacting protein 1

Gene

PBXIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96AQ6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pre-B-cell leukemia transcription factor-interacting protein 1
Alternative name(s):
Hematopoietic PBX-interacting protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PBXIP1
Synonyms:HPIP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000163346.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21199, PBXIP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618819, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96AQ6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi615 – 619LASLL → AASAA: Reduces interaction with ESR1. 1 Publication5

Organism-specific databases

DisGeNET

More...
DisGeNETi
57326

Open Targets

More...
OpenTargetsi
ENSG00000163346

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134956095

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96AQ6, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PBXIP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751749

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003061151 – 731Pre-B-cell leukemia transcription factor-interacting protein 1Add BLAST731

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei43PhosphoserineCombined sources1
Modified residuei129PhosphoserineCombined sources1
Modified residuei146PhosphoserineCombined sources1
Modified residuei147PhosphoserineCombined sources1
Modified residuei148PhosphoserineCombined sources1
Modified residuei152PhosphothreonineCombined sources1
Modified residuei567PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96AQ6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96AQ6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96AQ6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96AQ6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96AQ6

PeptideAtlas

More...
PeptideAtlasi
Q96AQ6

PRoteomics IDEntifications database

More...
PRIDEi
Q96AQ6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75987 [Q96AQ6-1]
75988 [Q96AQ6-2]
75989 [Q96AQ6-3]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1622, 3 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q96AQ6, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96AQ6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96AQ6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q96AQ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in early hematopoietic precursors.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163346, Expressed in lower esophagus muscularis layer and 247 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96AQ6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96AQ6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000163346, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TEX11 (By similarity).

Interacts with ESR1, PBX1, PBX2 and PBX3.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96AQ6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili270 – 348Sequence analysisAdd BLAST79
Coiled coili377 – 417Sequence analysisAdd BLAST41

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi485 – 505Nuclear localization signalSequence analysisAdd BLAST21
Motifi695 – 720Nuclear localization signalSequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi160 – 165Poly-Arg6
Compositional biasi721 – 729His-rich9

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal domain (AA 443-731) contains a nuclear export signal.
Association to the cytoskeleton through a N-terminal leucine rich-domain (AA 190-218).

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QRIW, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162147

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_024505_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96AQ6

Identification of Orthologs from Complete Genome Data

More...
OMAi
LMQQPKG

Database of Orthologous Groups

More...
OrthoDBi
640123at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96AQ6

TreeFam database of animal gene trees

More...
TreeFami
TF333202

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033589, PBXIP1

The PANTHER Classification System

More...
PANTHERi
PTHR28638:SF1, PTHR28638:SF1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96AQ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASCPDSDNS WVLAGSESLP VETLGPASRM DPESERALQA PHSPSKTDGK
60 70 80 90 100
ELAGTMDGEG TLFQTESPQS GSILTEETEV KGTLEGDVCG VEPPGPGDTV
110 120 130 140 150
VQGDLQETTV VTGLGPDTQD LEGQSPPQSL PSTPKAAWIR EEGRCSSSDD
160 170 180 190 200
DTDVDMEGLR RRRGREAGPP QPMVPLAVEN QAGGEGAGGE LGISLNMCLL
210 220 230 240 250
GALVLLGLGV LLFSGGLSES ETGPMEEVER QVLPDPEVLE AVGDRQDGLR
260 270 280 290 300
EQLQAPVPPD SVPSLQNMGL LLDKLAKENQ DIRLLQAQLQ AQKEELQSLM
310 320 330 340 350
HQPKGLEEEN AQLRGALQQG EAFQRALESE LQQLRARLQG LEADCVRGPD
360 370 380 390 400
GVCLSGGRGP QGDKAIREQG PREQEPELSF LKQKEQLEAE AQALRQELER
410 420 430 440 450
QRRLLGSVQQ DLERSLQDAS RGDPAHAGLA ELGHRLAQKL QGLENWGQDP
460 470 480 490 500
GVSANASKAW HQKSHFQNSR EWSGKEKWWD GQRDRKAEHW KHKKEESGRE
510 520 530 540 550
RKKNWGGQED REPAGRWKEG RPRVEESGSK KEGKRQGPKE PPRKSGSFHS
560 570 580 590 600
SGEKQKQPRW REGTKDSHDP LPSWAELLRP KYRAPQGCSG VDECARQEGL
610 620 630 640 650
TFFGTELAPV RQQELASLLR TYLARLPWAG QLTKELPLSP AFFGEDGIFR
660 670 680 690 700
HDRLRFRDFV DALEDSLEEV AVQQTGDDDE VDDFEDFIFS HFFGDKALKK
710 720 730
RSGKKDKHSQ SPRAAGPREG HSHSHHHHHR G
Length:731
Mass (Da):80,643
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD9AB1F22A12E178D
GO
Isoform 2 (identifier: Q96AQ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Show »
Length:702
Mass (Da):77,684
Checksum:iD90E6A7742683C0F
GO
Isoform 3 (identifier: Q96AQ6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     566-634: Missing.

Show »
Length:662
Mass (Da):72,920
Checksum:iE41A0F9A58F7E9E9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T173Q5T173_HUMAN
Pre-B-cell leukemia transcription f...
PBXIP1
315Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2Z8F2Z2Z8_HUMAN
Pre-B-cell leukemia transcription f...
PBXIP1
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti139I → F in BAB14059 (PubMed:14702039).Curated1
Sequence conflicti268M → I in AAG02026 (PubMed:10825160).Curated1
Sequence conflicti268M → I in BAB14471 (PubMed:14702039).Curated1
Sequence conflicti381L → P in BAB14059 (PubMed:14702039).Curated1
Sequence conflicti595A → P in AAG02026 (PubMed:10825160).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051263356G → D. Corresponds to variant dbSNP:rs2061690Ensembl.1
Natural variantiVAR_035265357G → D2 PublicationsCorresponds to variant dbSNP:rs2061690Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0284181 – 29Missing in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_028419566 – 634Missing in isoform 3. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF221521 mRNA Translation: AAG02026.1
AK022497 mRNA Translation: BAB14059.1
AK023219 mRNA Translation: BAB14471.1
AL451085 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53175.1
CH471121 Genomic DNA Translation: EAW53176.1
BC016852 mRNA Translation: AAH16852.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1074.1 [Q96AQ6-1]
CCDS81382.1 [Q96AQ6-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001304663.1, NM_001317734.1 [Q96AQ6-2]
NP_001304664.1, NM_001317735.1
NP_065385.2, NM_020524.3 [Q96AQ6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000368463; ENSP00000357448; ENSG00000163346 [Q96AQ6-1]
ENST00000368465; ENSP00000357450; ENSG00000163346 [Q96AQ6-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57326

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57326

UCSC genome browser

More...
UCSCi
uc001ffr.4, human [Q96AQ6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF221521 mRNA Translation: AAG02026.1
AK022497 mRNA Translation: BAB14059.1
AK023219 mRNA Translation: BAB14471.1
AL451085 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53175.1
CH471121 Genomic DNA Translation: EAW53176.1
BC016852 mRNA Translation: AAH16852.1
CCDSiCCDS1074.1 [Q96AQ6-1]
CCDS81382.1 [Q96AQ6-2]
RefSeqiNP_001304663.1, NM_001317734.1 [Q96AQ6-2]
NP_001304664.1, NM_001317735.1
NP_065385.2, NM_020524.3 [Q96AQ6-1]

3D structure databases

SMRiQ96AQ6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121486, 123 interactors
DIPiDIP-46922N
IntActiQ96AQ6, 57 interactors
MINTiQ96AQ6
STRINGi9606.ENSP00000357448

PTM databases

GlyConnecti1622, 3 N-Linked glycans (1 site)
GlyGeniQ96AQ6, 1 site
iPTMnetiQ96AQ6
PhosphoSitePlusiQ96AQ6
SwissPalmiQ96AQ6

Polymorphism and mutation databases

BioMutaiPBXIP1
DMDMi74751749

Proteomic databases

EPDiQ96AQ6
jPOSTiQ96AQ6
MassIVEiQ96AQ6
MaxQBiQ96AQ6
PaxDbiQ96AQ6
PeptideAtlasiQ96AQ6
PRIDEiQ96AQ6
ProteomicsDBi75987 [Q96AQ6-1]
75988 [Q96AQ6-2]
75989 [Q96AQ6-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
1813, 155 antibodies

The DNASU plasmid repository

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DNASUi
57326

Genome annotation databases

EnsembliENST00000368463; ENSP00000357448; ENSG00000163346 [Q96AQ6-1]
ENST00000368465; ENSP00000357450; ENSG00000163346 [Q96AQ6-2]
GeneIDi57326
KEGGihsa:57326
UCSCiuc001ffr.4, human [Q96AQ6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57326
DisGeNETi57326
EuPathDBiHostDB:ENSG00000163346.16

GeneCards: human genes, protein and diseases

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GeneCardsi
PBXIP1
HGNCiHGNC:21199, PBXIP1
HPAiENSG00000163346, Low tissue specificity
MIMi618819, gene
neXtProtiNX_Q96AQ6
OpenTargetsiENSG00000163346
PharmGKBiPA134956095

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502QRIW, Eukaryota
GeneTreeiENSGT00940000162147
HOGENOMiCLU_024505_0_0_1
InParanoidiQ96AQ6
OMAiLMQQPKG
OrthoDBi640123at2759
PhylomeDBiQ96AQ6
TreeFamiTF333202

Enzyme and pathway databases

PathwayCommonsiQ96AQ6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
57326, 13 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PBXIP1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57326
PharosiQ96AQ6, Tbio

Protein Ontology

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PROi
PR:Q96AQ6
RNActiQ96AQ6, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000163346, Expressed in lower esophagus muscularis layer and 247 other tissues
ExpressionAtlasiQ96AQ6, baseline and differential
GenevisibleiQ96AQ6, HS

Family and domain databases

InterProiView protein in InterPro
IPR033589, PBXIP1
PANTHERiPTHR28638:SF1, PTHR28638:SF1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPBIP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96AQ6
Secondary accession number(s): Q5T174
, Q5T176, Q9H8X6, Q9HA02, Q9HD85
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 1, 2001
Last modified: October 7, 2020
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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