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Protein

Transmembrane protein 125

Gene

TMEM125

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 125
Gene namesi
Name:TMEM125
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000179178.10
HGNCiHGNC:28275 TMEM125
neXtProtiNX_Q96AQ2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179178
PharmGKBiPA143485644

Polymorphism and mutation databases

BioMutaiTMEM125
DMDMi74731141

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002517161 – 219Transmembrane protein 125Add BLAST219

Proteomic databases

PaxDbiQ96AQ2
PeptideAtlasiQ96AQ2
PRIDEiQ96AQ2
ProteomicsDBi75986

PTM databases

iPTMnetiQ96AQ2
PhosphoSitePlusiQ96AQ2

Expressioni

Gene expression databases

BgeeiENSG00000179178 Expressed in 154 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_TMEM125
ExpressionAtlasiQ96AQ2 baseline and differential
GenevisibleiQ96AQ2 HS

Organism-specific databases

HPAiHPA015796

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000429275

Structurei

3D structure databases

ProteinModelPortaliQ96AQ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZE5 Eukaryota
ENOG4111SNN LUCA
GeneTreeiENSGT00390000003015
HOGENOMiHOG000154606
HOVERGENiHBG080613
InParanoidiQ96AQ2
OMAiNDMYISG
OrthoDBiEOG091G0SBI
PhylomeDBiQ96AQ2
TreeFamiTF332758

Family and domain databases

InterProiView protein in InterPro
IPR028165 TMEM125
PANTHERiPTHR31416 PTHR31416, 1 hit
PfamiView protein in Pfam
PF15109 TMEM125, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q96AQ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEQEAQAPG GRGLPPDMLA EQVELWWSQQ PRRSALCFVV AVGLVAGCGA
60 70 80 90 100
GGVALLSTTS SRSGEWRLAT GTVLCLLALL VLVKQLMSSA VQDMNCIRQA
110 120 130 140 150
HHVALLRSGG GADALVVLLS GLVLLVTGLT LAGLAAAPAP ARPLAAMLSV
160 170 180 190 200
GIALAALGSL LLLGLLLYQV GVSGHCPSIC MATPSTHSGH GGHGSIFSIS
210
GQLSAGRRHE TTSSIASLI
Length:219
Mass (Da):22,172
Last modified:December 1, 2001 - v1
Checksum:i868D23D63AD804A0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RHB0E5RHB0_HUMAN
Transmembrane protein 125
TMEM125
15Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035669107R → L in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_051428112A → D. Corresponds to variant dbSNP:rs35880191Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471059 Genomic DNA Translation: EAX07110.1
CH471059 Genomic DNA Translation: EAX07111.1
BC016858 mRNA Translation: AAH16858.1
CCDSiCCDS480.1
RefSeqiNP_001307173.1, NM_001320244.1
NP_653227.1, NM_144626.2
XP_005270524.1, XM_005270467.3
XP_011539007.1, XM_011540705.2
UniGeneiHs.104476

Genome annotation databases

EnsembliENST00000432792; ENSP00000429275; ENSG00000179178
ENST00000439858; ENSP00000429775; ENSG00000179178
GeneIDi128218
KEGGihsa:128218
UCSCiuc001cir.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471059 Genomic DNA Translation: EAX07110.1
CH471059 Genomic DNA Translation: EAX07111.1
BC016858 mRNA Translation: AAH16858.1
CCDSiCCDS480.1
RefSeqiNP_001307173.1, NM_001320244.1
NP_653227.1, NM_144626.2
XP_005270524.1, XM_005270467.3
XP_011539007.1, XM_011540705.2
UniGeneiHs.104476

3D structure databases

ProteinModelPortaliQ96AQ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000429275

PTM databases

iPTMnetiQ96AQ2
PhosphoSitePlusiQ96AQ2

Polymorphism and mutation databases

BioMutaiTMEM125
DMDMi74731141

Proteomic databases

PaxDbiQ96AQ2
PeptideAtlasiQ96AQ2
PRIDEiQ96AQ2
ProteomicsDBi75986

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000432792; ENSP00000429275; ENSG00000179178
ENST00000439858; ENSP00000429775; ENSG00000179178
GeneIDi128218
KEGGihsa:128218
UCSCiuc001cir.4 human

Organism-specific databases

CTDi128218
EuPathDBiHostDB:ENSG00000179178.10
GeneCardsiTMEM125
HGNCiHGNC:28275 TMEM125
HPAiHPA015796
neXtProtiNX_Q96AQ2
OpenTargetsiENSG00000179178
PharmGKBiPA143485644
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZE5 Eukaryota
ENOG4111SNN LUCA
GeneTreeiENSGT00390000003015
HOGENOMiHOG000154606
HOVERGENiHBG080613
InParanoidiQ96AQ2
OMAiNDMYISG
OrthoDBiEOG091G0SBI
PhylomeDBiQ96AQ2
TreeFamiTF332758

Miscellaneous databases

ChiTaRSiTMEM125 human
GenomeRNAii128218
PROiPR:Q96AQ2

Gene expression databases

BgeeiENSG00000179178 Expressed in 154 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_TMEM125
ExpressionAtlasiQ96AQ2 baseline and differential
GenevisibleiQ96AQ2 HS

Family and domain databases

InterProiView protein in InterPro
IPR028165 TMEM125
PANTHERiPTHR31416 PTHR31416, 1 hit
PfamiView protein in Pfam
PF15109 TMEM125, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM125_HUMAN
AccessioniPrimary (citable) accession number: Q96AQ2
Secondary accession number(s): D3DPX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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