Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Coiled-coil domain-containing protein 74A

Gene

CCDC74A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 74A
Gene namesi
Name:CCDC74A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000163040.14
HGNCiHGNC:25197 CCDC74A
neXtProtiNX_Q96AQ1

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163040
PharmGKBiPA143485425

Polymorphism and mutation databases

BioMutaiCCDC74A
DMDMi74731140

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002743741 – 378Coiled-coil domain-containing protein 74AAdd BLAST378

Proteomic databases

PaxDbiQ96AQ1
PeptideAtlasiQ96AQ1
PRIDEiQ96AQ1
ProteomicsDBi75984
75985 [Q96AQ1-2]

PTM databases

iPTMnetiQ96AQ1
PhosphoSitePlusiQ96AQ1

Expressioni

Gene expression databases

BgeeiENSG00000163040 Expressed in 86 organ(s), highest expression level in right uterine tube
CleanExiHS_CCDC74A
ExpressionAtlasiQ96AQ1 baseline and differential
GenevisibleiQ96AQ1 HS

Organism-specific databases

HPAiHPA060727

Interactioni

Protein-protein interaction databases

BioGridi124734, 22 interactors
IntActiQ96AQ1, 4 interactors
MINTiQ96AQ1
STRINGi9606.ENSP00000295171

Structurei

3D structure databases

ProteinModelPortaliQ96AQ1
SMRiQ96AQ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili47 – 90Sequence analysisAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi21 – 26Poly-Arg6

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J255 Eukaryota
ENOG4112DFU LUCA
GeneTreeiENSGT00390000007249
HOGENOMiHOG000111398
HOVERGENiHBG081034
InParanoidiQ96AQ1
OMAiGRQMMGV
OrthoDBiEOG091G0GX9
PhylomeDBiQ96AQ1
TreeFamiTF329669

Family and domain databases

InterProiView protein in InterPro
IPR033226 CCDC74
IPR029422 CCDC74_C
IPR039496 CCDC92/74_CC_dom
PANTHERiPTHR14882:SF5 PTHR14882:SF5, 1 hit
PfamiView protein in Pfam
PF14917 CCDC74_C, 1 hit
PF14916 CCDC92, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96AQ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGAGVAAGT RPPSSPTPGS RRRRQRPSVG VQSLRPQSPQ LRQSDPQKRN
60 70 80 90 100
LDLEKSLQFL QQQHSEMLAK LHEEIEHLKR ENKDLHYKLI MNQTSQKKDG
110 120 130 140 150
PSGNHLSRAS APLGARWVCI NGVWVEPGGP SPARLKEGSS RTHRPGGKRG
160 170 180 190 200
RLAGGSADTV RSPADSLSMS SFQSVKSISN SGKARPQPGS FNKQDSKADV
210 220 230 240 250
SQKADLEEEP LLHNSKLDKV PGVQGQARKE KAEASNAGAA CMGNSQHQGR
260 270 280 290 300
QMGAGAHPPM ILPLPLRKPT TLRQCEVLIR ELWNTNLLQT QELRHLKSLL
310 320 330 340 350
EGSQRPQAAP EEASFPRDQE ATHFPKVSTK SLSKKCLSPP VAERAILPAL
360 370
KQTPKNNFAE RQKRLQAMQK RRLHRSVL
Length:378
Mass (Da):41,605
Last modified:December 1, 2001 - v1
Checksum:i61D9EAAA5EDC34F9
GO
Isoform 2 (identifier: Q96AQ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     100-165: Missing.

Show »
Length:312
Mass (Da):34,910
Checksum:i58D38A8072D6D5F4
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GZA4F5GZA4_HUMAN
Coiled-coil domain-containing prote...
CCDC74A
272Annotation score:
F8WEI8F8WEI8_HUMAN
Coiled-coil domain-containing prote...
CCDC74A
135Annotation score:
C9IYK9C9IYK9_HUMAN
Coiled-coil domain-containing prote...
CCDC74A
206Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030268302G → R. Corresponds to variant dbSNP:rs13660Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022729100 – 165Missing in isoform 2. 1 PublicationAdd BLAST66

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093838 Genomic DNA Translation: AAY14809.1
BC016861 mRNA Translation: AAH16861.1
BC063387 mRNA Translation: AAH63387.1
CCDSiCCDS2167.1 [Q96AQ1-1]
CCDS58732.1 [Q96AQ1-2]
RefSeqiNP_001245235.1, NM_001258306.1 [Q96AQ1-2]
NP_620125.1, NM_138770.2 [Q96AQ1-1]
UniGeneiHs.351461

Genome annotation databases

EnsembliENST00000295171; ENSP00000295171; ENSG00000163040 [Q96AQ1-1]
ENST00000409856; ENSP00000387009; ENSG00000163040 [Q96AQ1-2]
GeneIDi90557
KEGGihsa:90557
UCSCiuc002tta.5 human [Q96AQ1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093838 Genomic DNA Translation: AAY14809.1
BC016861 mRNA Translation: AAH16861.1
BC063387 mRNA Translation: AAH63387.1
CCDSiCCDS2167.1 [Q96AQ1-1]
CCDS58732.1 [Q96AQ1-2]
RefSeqiNP_001245235.1, NM_001258306.1 [Q96AQ1-2]
NP_620125.1, NM_138770.2 [Q96AQ1-1]
UniGeneiHs.351461

3D structure databases

ProteinModelPortaliQ96AQ1
SMRiQ96AQ1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124734, 22 interactors
IntActiQ96AQ1, 4 interactors
MINTiQ96AQ1
STRINGi9606.ENSP00000295171

PTM databases

iPTMnetiQ96AQ1
PhosphoSitePlusiQ96AQ1

Polymorphism and mutation databases

BioMutaiCCDC74A
DMDMi74731140

Proteomic databases

PaxDbiQ96AQ1
PeptideAtlasiQ96AQ1
PRIDEiQ96AQ1
ProteomicsDBi75984
75985 [Q96AQ1-2]

Protocols and materials databases

DNASUi90557
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295171; ENSP00000295171; ENSG00000163040 [Q96AQ1-1]
ENST00000409856; ENSP00000387009; ENSG00000163040 [Q96AQ1-2]
GeneIDi90557
KEGGihsa:90557
UCSCiuc002tta.5 human [Q96AQ1-1]

Organism-specific databases

CTDi90557
EuPathDBiHostDB:ENSG00000163040.14
GeneCardsiCCDC74A
HGNCiHGNC:25197 CCDC74A
HPAiHPA060727
neXtProtiNX_Q96AQ1
OpenTargetsiENSG00000163040
PharmGKBiPA143485425
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J255 Eukaryota
ENOG4112DFU LUCA
GeneTreeiENSGT00390000007249
HOGENOMiHOG000111398
HOVERGENiHBG081034
InParanoidiQ96AQ1
OMAiGRQMMGV
OrthoDBiEOG091G0GX9
PhylomeDBiQ96AQ1
TreeFamiTF329669

Miscellaneous databases

GenomeRNAii90557
PROiPR:Q96AQ1

Gene expression databases

BgeeiENSG00000163040 Expressed in 86 organ(s), highest expression level in right uterine tube
CleanExiHS_CCDC74A
ExpressionAtlasiQ96AQ1 baseline and differential
GenevisibleiQ96AQ1 HS

Family and domain databases

InterProiView protein in InterPro
IPR033226 CCDC74
IPR029422 CCDC74_C
IPR039496 CCDC92/74_CC_dom
PANTHERiPTHR14882:SF5 PTHR14882:SF5, 1 hit
PfamiView protein in Pfam
PF14917 CCDC74_C, 1 hit
PF14916 CCDC92, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCC74A_HUMAN
AccessioniPrimary (citable) accession number: Q96AQ1
Secondary accession number(s): Q6P4I5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again