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Entry version 113 (11 Dec 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Transmembrane protein 143

Gene

TMEM143

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 143
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM143
ORF Names:UNQ5922/PRO19813
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000161558.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25603 TMEM143

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96AN5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei280 – 300HelicalSequence analysisAdd BLAST21
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000161558

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA144596251

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96AN5 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM143

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74731136

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002859581 – 459Transmembrane protein 143Add BLAST459

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei332PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96AN5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96AN5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96AN5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96AN5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96AN5

PeptideAtlas

More...
PeptideAtlasi
Q96AN5

PRoteomics IDEntifications database

More...
PRIDEi
Q96AN5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75976 [Q96AN5-1]
75977 [Q96AN5-2]
75978 [Q96AN5-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96AN5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96AN5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000161558 Expressed in 172 organ(s), highest expression level in muscle of leg

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96AN5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96AN5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA014476
HPA058645

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120551, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q96AN5, 14 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000293261

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96AN5 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJB5 Eukaryota
ENOG41105JD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154315

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000013108

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96AN5

Identification of Orthologs from Complete Genome Data

More...
OMAi
ERFIPFR

Database of Orthologous Groups

More...
OrthoDBi
1506124at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96AN5

TreeFam database of animal gene trees

More...
TreeFami
TF329116

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022227 DUF3754

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12576 DUF3754, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96AN5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTVELWLRLR GKGLAMLHVT RGVWGSRVRV WPLLPALLGP PRALSSLAAK
60 70 80 90 100
MGEYRKMWNP REPRDWAQQY RERFIPFSKE QLLRLLIQEF HSSPAEKAAL
110 120 130 140 150
EAFSAHVDFC TLFHYHQILA RLQALYDPIN PDRETLDQPS LTDPQRLSNE
160 170 180 190 200
QEVLRALEPL LAQANFSPLS EDTLAYALVV HHPQDEVQVT VNLDQYVYIH
210 220 230 240 250
FWALGQRVGQ MPLKSSVGSR RGFFTKLPPA ERRYFKRVVL AARTKRGHLV
260 270 280 290 300
LKSFKDTPLE GLEQLLPELK VRTPTLQRAL LNLMLVVSGV AIFVNVGMVV
310 320 330 340 350
LTDLKVATSL LLLLFAIFMG LRASKMFGQR RSAQALELAH MLYYRSTSNN
360 370 380 390 400
SELLSALALR AQDEHTKEAL LAHSFLARRP GGTQGSPEET SRWLRSEVEN
410 420 430 440 450
WLLAKSGCEV TFNGTRALAH LQALTPSMGL YPPPGFPKLD PVAPITSEPP

QATPSSNIS
Length:459
Mass (Da):51,715
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2BF3166AF38BF80
GO
Isoform 2 (identifier: Q96AN5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-187: Missing.

Show »
Length:359
Mass (Da):40,412
Checksum:iBE77855DDC34FAC6
GO
Isoform 3 (identifier: Q96AN5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-128: EFHSSPAEKA...LARLQALYDP → VTGIPLESGR...PNPGPAAGLI
     129-459: Missing.

Show »
Length:128
Mass (Da):14,304
Checksum:i0C0B0AEF4D7FA72D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DMT0B4DMT0_HUMAN
Transmembrane protein 143
TMEM143
424Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZ02M0QZ02_HUMAN
Transmembrane protein 143
TMEM143
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R153M0R153_HUMAN
Transmembrane protein 143
TMEM143
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1H7M0R1H7_HUMAN
Transmembrane protein 143
TMEM143
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R325M0R325_HUMAN
Transmembrane protein 143
TMEM143
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032058143D → N. Corresponds to variant dbSNP:rs34488893Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02493088 – 187Missing in isoform 2. 2 PublicationsAdd BLAST100
Alternative sequenceiVSP_02493189 – 128EFHSS…ALYDP → VTGIPLESGREGGFGGVLSP RGLLHPVPLPPNPGPAAGLI in isoform 3. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_024932129 – 459Missing in isoform 3. 1 PublicationAdd BLAST331

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY358161 mRNA Translation: AAQ88528.1
AK001784 mRNA No translation available.
AK291521 mRNA Translation: BAF84210.1
CH471177 Genomic DNA Translation: EAW52337.1
BC016919 mRNA Translation: AAH16919.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12716.1 [Q96AN5-1]
CCDS77325.1 [Q96AN5-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001290469.1, NM_001303540.1 [Q96AN5-2]
NP_060743.2, NM_018273.3 [Q96AN5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000293261; ENSP00000293261; ENSG00000161558 [Q96AN5-1]
ENST00000377431; ENSP00000366649; ENSG00000161558 [Q96AN5-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55260

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55260

UCSC genome browser

More...
UCSCi
uc002pix.2 human [Q96AN5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358161 mRNA Translation: AAQ88528.1
AK001784 mRNA No translation available.
AK291521 mRNA Translation: BAF84210.1
CH471177 Genomic DNA Translation: EAW52337.1
BC016919 mRNA Translation: AAH16919.1
CCDSiCCDS12716.1 [Q96AN5-1]
CCDS77325.1 [Q96AN5-2]
RefSeqiNP_001290469.1, NM_001303540.1 [Q96AN5-2]
NP_060743.2, NM_018273.3 [Q96AN5-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi120551, 7 interactors
IntActiQ96AN5, 14 interactors
STRINGi9606.ENSP00000293261

PTM databases

iPTMnetiQ96AN5
PhosphoSitePlusiQ96AN5

Polymorphism and mutation databases

BioMutaiTMEM143
DMDMi74731136

Proteomic databases

EPDiQ96AN5
jPOSTiQ96AN5
MassIVEiQ96AN5
MaxQBiQ96AN5
PaxDbiQ96AN5
PeptideAtlasiQ96AN5
PRIDEiQ96AN5
ProteomicsDBi75976 [Q96AN5-1]
75977 [Q96AN5-2]
75978 [Q96AN5-3]

Genome annotation databases

EnsembliENST00000293261; ENSP00000293261; ENSG00000161558 [Q96AN5-1]
ENST00000377431; ENSP00000366649; ENSG00000161558 [Q96AN5-2]
GeneIDi55260
KEGGihsa:55260
UCSCiuc002pix.2 human [Q96AN5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55260
EuPathDBiHostDB:ENSG00000161558.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM143
HGNCiHGNC:25603 TMEM143
HPAiHPA014476
HPA058645
neXtProtiNX_Q96AN5
OpenTargetsiENSG00000161558
PharmGKBiPA144596251

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJB5 Eukaryota
ENOG41105JD LUCA
GeneTreeiENSGT00940000154315
HOGENOMiHOG000013108
InParanoidiQ96AN5
OMAiERFIPFR
OrthoDBi1506124at2759
PhylomeDBiQ96AN5
TreeFamiTF329116

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55260
PharosiQ96AN5 Tdark

Protein Ontology

More...
PROi
PR:Q96AN5
RNActiQ96AN5 protein

Gene expression databases

BgeeiENSG00000161558 Expressed in 172 organ(s), highest expression level in muscle of leg
ExpressionAtlasiQ96AN5 baseline and differential
GenevisibleiQ96AN5 HS

Family and domain databases

InterProiView protein in InterPro
IPR022227 DUF3754
PfamiView protein in Pfam
PF12576 DUF3754, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM143_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96AN5
Secondary accession number(s): A8K656, Q6UXY4, Q9NV49
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: December 1, 2001
Last modified: December 11, 2019
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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