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UniProtKB - Q96AM1 (MRGRF_HUMAN)
Protein
Mas-related G-protein coupled receptor member F
Gene
MRGPRF
Organism
Homo sapiens (Human)
Status
Functioni
Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).
By similarityGO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q96AM1 |
SignaLinki | Q96AM1 |
Protein family/group databases
TCDBi | 9.A.14.13.7, the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Mas-related G-protein coupled receptor member FShort name: Mas-related gene F protein Alternative name(s): G-protein coupled receptor 140 G-protein coupled receptor 168 |
Gene namesi | Name:MRGPRF Synonyms:GPR140, GPR168, MRGF ORF Names:PSEC0142 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24828, MRGPRF |
MIMi | 607233, gene |
neXtProti | NX_Q96AM1 |
VEuPathDBi | HostDB:ENSG00000172935 |
Subcellular locationi
Plasma membrane
Nucleus
- nuclear membrane Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 44 | ExtracellularSequence analysisAdd BLAST | 44 | |
Transmembranei | 45 – 66 | Helical; Name=1Sequence analysisAdd BLAST | 22 | |
Topological domaini | 67 – 82 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 83 – 104 | Helical; Name=2Sequence analysisAdd BLAST | 22 | |
Topological domaini | 105 – 123 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 124 – 144 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 145 – 160 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 161 – 181 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 182 – 198 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 199 – 220 | Helical; Name=5Sequence analysisAdd BLAST | 22 | |
Topological domaini | 221 – 241 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 242 – 263 | Helical; Name=6Sequence analysisAdd BLAST | 22 | |
Topological domaini | 264 – 273 | ExtracellularSequence analysis | 10 | |
Transmembranei | 274 – 294 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 295 – 343 | CytoplasmicSequence analysisAdd BLAST | 49 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 116535 |
OpenTargetsi | ENSG00000172935 |
PharmGKBi | PA134896544 |
Miscellaneous databases
Pharosi | Q96AM1, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4523903 |
Genetic variation databases
BioMutai | MRGPRF |
DMDMi | 24638055 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069764 | 1 – 343 | Mas-related G-protein coupled receptor member FAdd BLAST | 343 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 4 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q96AM1 |
MassIVEi | Q96AM1 |
PaxDbi | Q96AM1 |
PeptideAtlasi | Q96AM1 |
PRIDEi | Q96AM1 |
ProteomicsDBi | 75974 |
PTM databases
GlyGeni | Q96AM1, 1 site |
iPTMneti | Q96AM1 |
PhosphoSitePlusi | Q96AM1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000172935, Expressed in uterus and 192 other tissues |
ExpressionAtlasi | Q96AM1, baseline and differential |
Genevisiblei | Q96AM1, HS |
Organism-specific databases
HPAi | ENSG00000172935, Tissue enhanced (endometrium) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 125520, 2 interactors |
IntActi | Q96AM1, 4 interactors |
MINTi | Q96AM1 |
STRINGi | 9606.ENSP00000309782 |
Miscellaneous databases
RNActi | Q96AM1, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 320 – 343 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 325 – 343 | Polar residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SIXZ, Eukaryota |
GeneTreei | ENSGT01030000234639 |
HOGENOMi | CLU_009579_4_1_1 |
InParanoidi | Q96AM1 |
OMAi | VGNCSWE |
OrthoDBi | 835806at2759 |
PhylomeDBi | Q96AM1 |
TreeFami | TF336336 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR026228, MRGPCRF IPR026234, MRGPCRFAMILY |
PANTHERi | PTHR11334, PTHR11334, 1 hit PTHR11334:SF3, PTHR11334:SF3, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR02112, MRGPCRF PR02108, MRGPCRFAMILY |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q96AM1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGNCSWEAH PGNRNKMCPG LSEAPELYSR GFLTIEQIAM LPPPAVMNYI
60 70 80 90 100
FLLLCLCGLV GNGLVLWFFG FSIKRNPFSI YFLHLASADV GYLFSKAVFS
110 120 130 140 150
ILNTGGFLGT FADYIRSVCR VLGLCMFLTG VSLLPAVSAE RCASVIFPAW
160 170 180 190 200
YWRRRPKRLS AVVCALLWVL SLLVTCLHNY FCVFLGRGAP GAACRHMDIF
210 220 230 240 250
LGILLFLLCC PLMVLPCLAL ILHVECRARR RQRSAKLNHV ILAMVSVFLV
260 270 280 290 300
SSIYLGIDWF LFWVFQIPAP FPEYVTDLCI CINSSAKPIV YFLAGRDKSQ
310 320 330 340
RLWEPLRVVF QRALRDGAEL GEAGGSTPNT VTMEMQCPPG NAS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF5H5R4 | F5H5R4_HUMAN | Mas-related G-protein-coupled recep... | MRGPRF | 104 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061220 | 16 | K → R1 PublicationCorresponds to variant dbSNP:rs11544721Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK075450 mRNA Translation: BAC11628.1 AK122669 mRNA Translation: BAG53655.1 CH471076 Genomic DNA Translation: EAW74730.1 BC016964 mRNA Translation: AAH16964.1 |
CCDSi | CCDS8188.1 |
RefSeqi | NP_001091985.1, NM_001098515.1 NP_659452.3, NM_145015.4 XP_016872659.1, XM_017017170.1 |
Genome annotation databases
Ensembli | ENST00000309099; ENSP00000309782; ENSG00000172935 ENST00000441623; ENSP00000403660; ENSG00000172935 |
GeneIDi | 116535 |
KEGGi | hsa:116535 |
MANE-Selecti | ENST00000309099.7; ENSP00000309782.6; NM_145015.5; NP_659452.3 |
UCSCi | uc001ooo.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK075450 mRNA Translation: BAC11628.1 AK122669 mRNA Translation: BAG53655.1 CH471076 Genomic DNA Translation: EAW74730.1 BC016964 mRNA Translation: AAH16964.1 |
CCDSi | CCDS8188.1 |
RefSeqi | NP_001091985.1, NM_001098515.1 NP_659452.3, NM_145015.4 XP_016872659.1, XM_017017170.1 |
3D structure databases
SMRi | Q96AM1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125520, 2 interactors |
IntActi | Q96AM1, 4 interactors |
MINTi | Q96AM1 |
STRINGi | 9606.ENSP00000309782 |
Chemistry databases
ChEMBLi | CHEMBL4523903 |
Protein family/group databases
TCDBi | 9.A.14.13.7, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyGeni | Q96AM1, 1 site |
iPTMneti | Q96AM1 |
PhosphoSitePlusi | Q96AM1 |
Genetic variation databases
BioMutai | MRGPRF |
DMDMi | 24638055 |
Proteomic databases
jPOSTi | Q96AM1 |
MassIVEi | Q96AM1 |
PaxDbi | Q96AM1 |
PeptideAtlasi | Q96AM1 |
PRIDEi | Q96AM1 |
ProteomicsDBi | 75974 |
Protocols and materials databases
Antibodypediai | 16748, 281 antibodies from 30 providers |
DNASUi | 116535 |
Genome annotation databases
Ensembli | ENST00000309099; ENSP00000309782; ENSG00000172935 ENST00000441623; ENSP00000403660; ENSG00000172935 |
GeneIDi | 116535 |
KEGGi | hsa:116535 |
MANE-Selecti | ENST00000309099.7; ENSP00000309782.6; NM_145015.5; NP_659452.3 |
UCSCi | uc001ooo.5, human |
Organism-specific databases
CTDi | 116535 |
DisGeNETi | 116535 |
GeneCardsi | MRGPRF |
HGNCi | HGNC:24828, MRGPRF |
HPAi | ENSG00000172935, Tissue enhanced (endometrium) |
MIMi | 607233, gene |
neXtProti | NX_Q96AM1 |
OpenTargetsi | ENSG00000172935 |
PharmGKBi | PA134896544 |
VEuPathDBi | HostDB:ENSG00000172935 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SIXZ, Eukaryota |
GeneTreei | ENSGT01030000234639 |
HOGENOMi | CLU_009579_4_1_1 |
InParanoidi | Q96AM1 |
OMAi | VGNCSWE |
OrthoDBi | 835806at2759 |
PhylomeDBi | Q96AM1 |
TreeFami | TF336336 |
Enzyme and pathway databases
PathwayCommonsi | Q96AM1 |
SignaLinki | Q96AM1 |
Miscellaneous databases
BioGRID-ORCSi | 116535, 12 hits in 1034 CRISPR screens |
ChiTaRSi | MRGPRF, human |
GeneWikii | MRGPRF |
GenomeRNAii | 116535 |
Pharosi | Q96AM1, Tbio |
PROi | PR:Q96AM1 |
RNActi | Q96AM1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000172935, Expressed in uterus and 192 other tissues |
ExpressionAtlasi | Q96AM1, baseline and differential |
Genevisiblei | Q96AM1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR026228, MRGPCRF IPR026234, MRGPCRFAMILY |
PANTHERi | PTHR11334, PTHR11334, 1 hit PTHR11334:SF3, PTHR11334:SF3, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR02112, MRGPCRF PR02108, MRGPCRFAMILY |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MRGRF_HUMAN | |
Accessioni | Q96AM1Primary (citable) accession number: Q96AM1 Secondary accession number(s): B3KV43, Q8NBK8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 2002 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families