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Entry version 121 (02 Dec 2020)
Sequence version 2 (29 Mar 2005)
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Protein
Submitted name:

PBX3 protein

Gene

PBX3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi147 – 230HomeoboxPROSITE-ProRule annotationAdd BLAST84

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
PBX3 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PBX3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32972

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q96AL5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96AL5, HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q96AL5
With#Exp.IntAct
AGTRAP [Q6RW13]3EBI-741171,EBI-741181
AGTRAP - isoform 2 [Q6RW13-2]3EBI-741171,EBI-11522760
ARFIP2 [P53365]3EBI-741171,EBI-638194
BIK [Q13323]3EBI-741171,EBI-700794
BSND [Q8WZ55]3EBI-741171,EBI-7996695
CAV3 [P56539]3EBI-741171,EBI-3905936
CIDEB [Q9UHD4]3EBI-741171,EBI-7062247
CMTM4 - isoform 2 [Q8IZR5-2]3EBI-741171,EBI-17278014
CMTM5 - isoform 2 [Q96DZ9-2]3EBI-741171,EBI-11522780
COQ8A [Q8NI60]3EBI-741171,EBI-745535
CPLX2 [Q6PUV4]3EBI-741171,EBI-2689453
DESI2 [Q9BSY9]3EBI-741171,EBI-12878374
DGAT2L6 [Q6ZPD8]3EBI-741171,EBI-12831978
FADS6 [Q8N9I5]3EBI-741171,EBI-3943864
FAM177A1 - isoform 2 [Q8N128-2]3EBI-741171,EBI-12201693
FKBP7 [Q9Y680]3EBI-741171,EBI-3918971
FSD2 [A1L4K1]3EBI-741171,EBI-5661036
GAD2 [Q05329]3EBI-741171,EBI-9304251
GBP7 [Q8N8V2]3EBI-741171,EBI-21835810
HIGD1C [A8MV81]3EBI-741171,EBI-12809676
HSD17B13 [Q7Z5P4]3EBI-741171,EBI-18053395
INPP5K [Q9BT40]3EBI-741171,EBI-749162
INSYN1 [Q2T9L4]3EBI-741171,EBI-4311436
ITGB3BP [Q13352]3EBI-741171,EBI-712105
KRT27 [Q7Z3Y8]3EBI-741171,EBI-3044087
KRT31 [Q15323]3EBI-741171,EBI-948001
LIME1 [Q9H400]3EBI-741171,EBI-2830566
MAL2 [Q969L2]3EBI-741171,EBI-944295
MBLAC2 [Q68D91]3EBI-741171,EBI-21018038
MDK [P21741]3EBI-741171,EBI-722444
MICOS13 [Q5XKP0]3EBI-741171,EBI-1053887
MTERF3 [Q96E29]3EBI-741171,EBI-7825321
NUDT9 [Q9BW91]3EBI-741171,EBI-2682941
PLIN3 [O60664]3EBI-741171,EBI-725795
PRB3 [Q04118]3EBI-741171,EBI-13360404
PTPN9 [P43378]3EBI-741171,EBI-742898
RABAC1 [Q9UI14]5EBI-741171,EBI-712367
REEP5 [Q00765]3EBI-741171,EBI-1549827
RHBDD2 - isoform 3 [Q6NTF9-3]3EBI-741171,EBI-17589229
RHEX [Q6ZWK4]3EBI-741171,EBI-18304046
RNF186 [Q9NXI6]3EBI-741171,EBI-2129361
RPRM [Q9NS64]3EBI-741171,EBI-1052363
SCAMP1 [O15126]3EBI-741171,EBI-954338
SFT2D2 [O95562]3EBI-741171,EBI-4402330
SIN3A [H3BQL7]5EBI-741171,EBI-13384308
SMPD2 [O60906]3EBI-741171,EBI-12828299
SYP [P08247]5EBI-741171,EBI-9071725
SYPL1 [Q16563]3EBI-741171,EBI-2800683
TFIP11 [Q9UBB9]3EBI-741171,EBI-1105213
TMCO2 [Q7Z6W1]3EBI-741171,EBI-12807858
TMEM196 - isoform 3 [Q5HYL7-3]3EBI-741171,EBI-12822537
TPD52L1 - isoform 2 [Q16890-2]3EBI-741171,EBI-18777952
TRAF1 [Q13077]3EBI-741171,EBI-359224
TVP23B [Q9NYZ1]3EBI-741171,EBI-11343401
ZNF655 [Q8N720]3EBI-741171,EBI-625509

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q96AL5, 54 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini145 – 229HomeoboxInterPro annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni259 – 280DisorderedSequence analysisAdd BLAST22
Regioni336 – 367DisorderedSequence analysisAdd BLAST32

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili79 – 99Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TALE/PBX homeobox family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, HomeoboxPROSITE-ProRule annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
804740at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086, homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057, Homeobox-like_sf
IPR001356, Homeobox_dom
IPR008422, Homeobox_KN_domain
IPR005542, PBX

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05920, Homeobox_KN, 1 hit
PF03792, PBC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389, HOX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50071, HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q96AL5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
EKTGLSIRGA QEEDPPDPQL MRLDNMLLAE GVSGPEKGGG SAAAAAAAAA
60 70 80 90 100
SGGSSDNSIE HSDYRAKLTQ IRQIYHTELE KYEQACNEFT THVMNLLREQ
110 120 130 140 150
SRTRPISPKE IERMVGIIHR KFSSIQMQLK QSTCEAVMIL RSRFLDARRK
160 170 180 190 200
RRNFSKQATE ILNEYFYSHL SNPYPSEEAK EELAKKCSIT VSQSLVKDPK
210 220 230 240 250
ERGSKGSDIQ PTSVVSNWFG NKRIRYKKNI GKFQEEANLY AAKTAVTAAH
260 270 280 290 300
AVAAAVQNNQ TNSPTTPNSG SSGSFNLPNS GDMFMNMQSL NGDSYQGSQV
310 320 330 340 350
GANVQSQVDT LRHVINQTGG YSDGLGGNSL YSPHNLNANG GWQDATTPSS
360
VTSPTEGPGS VHSDTSN
Length:367
Mass (Da):39,924
Last modified:March 29, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0FE7B826B9983265
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC016977 mRNA Translation: AAH16977.2

NCBI Reference Sequences

More...
RefSeqi
NP_006186.1, NM_006195.5

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5090

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5090

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC016977 mRNA Translation: AAH16977.2
RefSeqiNP_006186.1, NM_006195.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ96AL5, 54 interactors

Proteomic databases

PeptideAtlasiQ96AL5

Genome annotation databases

GeneIDi5090
KEGGihsa:5090

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5090
PharmGKBiPA32972

Phylogenomic databases

OrthoDBi804740at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
5090, 2 hits in 863 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PBX3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5090

Gene expression databases

GenevisibleiQ96AL5, HS

Family and domain databases

CDDicd00086, homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR001356, Homeobox_dom
IPR008422, Homeobox_KN_domain
IPR005542, PBX
PfamiView protein in Pfam
PF05920, Homeobox_KN, 1 hit
PF03792, PBC, 1 hit
SMARTiView protein in SMART
SM00389, HOX, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071, HOMEOBOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ96AL5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96AL5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: March 29, 2005
Last modified: December 2, 2020
This is version 121 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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