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Protein

Vesicle transport through interaction with t-SNAREs homolog 1A

Gene

VTI1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence.2 Publications

GO - Molecular functioni

  • SNAP receptor activity Source: HGNC
  • SNARE binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6811438 Intra-Golgi traffic
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
SIGNORiQ96AJ9

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle transport through interaction with t-SNAREs homolog 1A
Alternative name(s):
Vesicle transport v-SNARE protein Vti1-like 2
Vti1-rp2
Gene namesi
Name:VTI1A
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000151532.13
HGNCiHGNC:17792 VTI1A
MIMi614316 gene
neXtProtiNX_Q96AJ9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 192CytoplasmicSequence analysisAdd BLAST192
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 217ExtracellularSequence analysis4

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi143187
OpenTargetsiENSG00000151532
PharmGKBiPA134928049

Polymorphism and mutation databases

BioMutaiVTI1A
DMDMi374095459

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002182251 – 217Vesicle transport through interaction with t-SNAREs homolog 1AAdd BLAST217

Proteomic databases

EPDiQ96AJ9
PaxDbiQ96AJ9
PeptideAtlasiQ96AJ9
PRIDEiQ96AJ9
ProteomicsDBi75969
75970 [Q96AJ9-1]

PTM databases

iPTMnetiQ96AJ9
PhosphoSitePlusiQ96AJ9

Expressioni

Gene expression databases

BgeeiENSG00000151532 Expressed in 191 organ(s), highest expression level in corpus callosum
CleanExiHS_VTI1A
GenevisibleiQ96AJ9 HS

Organism-specific databases

HPAiHPA054108

Interactioni

Subunit structurei

Interacts with distinct SNARE complexes that contain either STX5 or STX6. Interacts with NAPA and, to a lesser extent, with NAPG. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126789, 15 interactors
CORUMiQ96AJ9
DIPiDIP-44223N
IntActiQ96AJ9, 7 interactors
MINTiQ96AJ9
STRINGi9606.ENSP00000376792

Structurei

3D structure databases

ProteinModelPortaliQ96AJ9
SMRiQ96AJ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili31 – 92Sequence analysisAdd BLAST62
Coiled coili112 – 178Sequence analysisAdd BLAST67

Sequence similaritiesi

Belongs to the VTI1 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1666 Eukaryota
ENOG4111J90 LUCA
GeneTreeiENSGT00530000063466
HOGENOMiHOG000116573
HOVERGENiHBG104027
InParanoidiQ96AJ9
KOiK08493
OMAiVESHRAE
OrthoDBiEOG091G0L3Z
PhylomeDBiQ96AJ9
TreeFamiTF312874

Family and domain databases

Gene3Di1.20.58.400, 1 hit
InterProiView protein in InterPro
IPR027027 GOSR2/Membrin/Bos1
IPR010989 SNARE
IPR000727 T_SNARE_dom
IPR038407 v-SNARE_N_sf
IPR007705 Vesicle_trsprt_v-SNARE_N
PfamiView protein in Pfam
PF05008 V-SNARE, 1 hit
PIRSFiPIRSF028865 Membrin-2, 1 hit
SMARTiView protein in SMART
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 2 (identifier: Q96AJ9-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSDFEGYEQ DFAVLTAEIT SKIARVPRLP PDEKKQMVAN VEKQLEEAKE
60 70 80 90 100
LLEQMDLEVR EIPPQSRGMY SNRMRSYKQE MGKLETDFKR SRIAYSDEVR
110 120 130 140 150
NELLGDDGNS SENQRAHLLD NTERLERSSR RLEAGYQIAV ETEQIGQEML
160 170 180 190 200
ENLSHDREKI QRARERLRET DANLGKSSRI LTGMLRRIIQ NRILLVILGI
210
IVVITILMAI TFSVRRH
Length:217
Mass (Da):25,218
Last modified:January 25, 2012 - v2
Checksum:i3FE5FE787B5958F0
GO
Isoform 1 (identifier: Q96AJ9-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     188-217: IIQNRILLVILGIIVVITILMAITFSVRRH → GCSVKKQCNLSLAPKA

Note: No experimental confirmation available.
Show »
Length:203
Mass (Da):23,435
Checksum:i751DB052B552BC09
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83K → E in BAG64649 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039848188 – 217IIQNR…SVRRH → GCSVKKQCNLSLAPKA in isoform 1. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303646 mRNA Translation: BAG64649.1
AC022018 Genomic DNA No translation available.
AL139120 Genomic DNA No translation available.
AL158212 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49524.1
CH471066 Genomic DNA Translation: EAW49525.1
BC017052 mRNA Translation: AAH17052.1
CCDSiCCDS7575.2 [Q96AJ9-2]
RefSeqiNP_001305132.1, NM_001318203.1
NP_001305134.1, NM_001318205.1
NP_660207.2, NM_145206.3 [Q96AJ9-2]
XP_005269601.1, XM_005269544.4 [Q96AJ9-1]
UniGeneiHs.194554

Genome annotation databases

EnsembliENST00000393077; ENSP00000376792; ENSG00000151532 [Q96AJ9-2]
ENST00000432306; ENSP00000395017; ENSG00000151532 [Q96AJ9-1]
GeneIDi143187
KEGGihsa:143187
UCSCiuc001kzz.5 human [Q96AJ9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303646 mRNA Translation: BAG64649.1
AC022018 Genomic DNA No translation available.
AL139120 Genomic DNA No translation available.
AL158212 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49524.1
CH471066 Genomic DNA Translation: EAW49525.1
BC017052 mRNA Translation: AAH17052.1
CCDSiCCDS7575.2 [Q96AJ9-2]
RefSeqiNP_001305132.1, NM_001318203.1
NP_001305134.1, NM_001318205.1
NP_660207.2, NM_145206.3 [Q96AJ9-2]
XP_005269601.1, XM_005269544.4 [Q96AJ9-1]
UniGeneiHs.194554

3D structure databases

ProteinModelPortaliQ96AJ9
SMRiQ96AJ9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126789, 15 interactors
CORUMiQ96AJ9
DIPiDIP-44223N
IntActiQ96AJ9, 7 interactors
MINTiQ96AJ9
STRINGi9606.ENSP00000376792

PTM databases

iPTMnetiQ96AJ9
PhosphoSitePlusiQ96AJ9

Polymorphism and mutation databases

BioMutaiVTI1A
DMDMi374095459

Proteomic databases

EPDiQ96AJ9
PaxDbiQ96AJ9
PeptideAtlasiQ96AJ9
PRIDEiQ96AJ9
ProteomicsDBi75969
75970 [Q96AJ9-1]

Protocols and materials databases

DNASUi143187
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393077; ENSP00000376792; ENSG00000151532 [Q96AJ9-2]
ENST00000432306; ENSP00000395017; ENSG00000151532 [Q96AJ9-1]
GeneIDi143187
KEGGihsa:143187
UCSCiuc001kzz.5 human [Q96AJ9-2]

Organism-specific databases

CTDi143187
DisGeNETi143187
EuPathDBiHostDB:ENSG00000151532.13
GeneCardsiVTI1A
H-InvDBiHIX0023094
HGNCiHGNC:17792 VTI1A
HPAiHPA054108
MIMi614316 gene
neXtProtiNX_Q96AJ9
OpenTargetsiENSG00000151532
PharmGKBiPA134928049
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1666 Eukaryota
ENOG4111J90 LUCA
GeneTreeiENSGT00530000063466
HOGENOMiHOG000116573
HOVERGENiHBG104027
InParanoidiQ96AJ9
KOiK08493
OMAiVESHRAE
OrthoDBiEOG091G0L3Z
PhylomeDBiQ96AJ9
TreeFamiTF312874

Enzyme and pathway databases

ReactomeiR-HSA-6811438 Intra-Golgi traffic
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
SIGNORiQ96AJ9

Miscellaneous databases

ChiTaRSiVTI1A human
GeneWikiiVTI1A
GenomeRNAii143187
PROiPR:Q96AJ9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151532 Expressed in 191 organ(s), highest expression level in corpus callosum
CleanExiHS_VTI1A
GenevisibleiQ96AJ9 HS

Family and domain databases

Gene3Di1.20.58.400, 1 hit
InterProiView protein in InterPro
IPR027027 GOSR2/Membrin/Bos1
IPR010989 SNARE
IPR000727 T_SNARE_dom
IPR038407 v-SNARE_N_sf
IPR007705 Vesicle_trsprt_v-SNARE_N
PfamiView protein in Pfam
PF05008 V-SNARE, 1 hit
PIRSFiPIRSF028865 Membrin-2, 1 hit
SMARTiView protein in SMART
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVTI1A_HUMAN
AccessioniPrimary (citable) accession number: Q96AJ9
Secondary accession number(s): A2A307, B4E137, Q5W0D7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: January 25, 2012
Last modified: November 7, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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