Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Clusterin-associated protein 1

Gene

CLUAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling.By similarity

Miscellaneous

Associated with a number of cancers such as colon (PubMed:15480429) and bone cancer (PubMed:17203229). Possibly involved in polycystic kidney diseases (PubMed:15530380).3 Publications

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-HSA-5620924 Intraflagellar transport

Names & Taxonomyi

Protein namesi
Recommended name:
Clusterin-associated protein 1
Alternative name(s):
Qilin1 Publication
Gene namesi
Name:CLUAP1
Synonyms:KIAA0643
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000103351.12
HGNCiHGNC:19009 CLUAP1
neXtProtiNX_Q96AJ1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23059
OpenTargetsiENSG00000103351
PharmGKBiPA128394600

Polymorphism and mutation databases

BioMutaiCLUAP1
DMDMi108935970

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002394511 – 413Clusterin-associated protein 1Add BLAST413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei314PhosphoserineBy similarity1
Modified residuei324PhosphoserineBy similarity1
Modified residuei326PhosphoserineBy similarity1
Modified residuei409PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96AJ1
MaxQBiQ96AJ1
PaxDbiQ96AJ1
PeptideAtlasiQ96AJ1
PRIDEiQ96AJ1
ProteomicsDBi75967
75968 [Q96AJ1-2]

PTM databases

iPTMnetiQ96AJ1
PhosphoSitePlusiQ96AJ1

Expressioni

Tissue specificityi

Expressed in testis, thyroid and trachea and to a lower extent in spinal cord and adrenal gland. Highly expressed in colon cancer and osteosarcoma cell lines.2 Publications

Gene expression databases

BgeeiENSG00000103351
CleanExiHS_CLUAP1
ExpressionAtlasiQ96AJ1 baseline and differential
GenevisibleiQ96AJ1 HS

Organism-specific databases

HPAiHPA036976
HPA044191

Interactioni

Subunit structurei

Interacts with CLU/clusterin (PubMed:15480429). Interacts with UBXN10; the interaction is direct (PubMed:26389662).2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116694, 33 interactors
IntActiQ96AJ1, 21 interactors
STRINGi9606.ENSP00000460850

Structurei

3D structure databases

ProteinModelPortaliQ96AJ1
SMRiQ96AJ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili198 – 291Sequence analysisAdd BLAST94

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi360 – 386Asp-richAdd BLAST27

Sequence similaritiesi

Belongs to the CLUAP1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3647 Eukaryota
ENOG410XRVS LUCA
GeneTreeiENSGT00390000008957
HOGENOMiHOG000257815
HOVERGENiHBG081253
InParanoidiQ96AJ1
KOiK19684
PhylomeDBiQ96AJ1
TreeFamiTF314639

Family and domain databases

InterProiView protein in InterPro
IPR019366 Clusterin-associated_protein-1
PANTHERiPTHR21547 PTHR21547, 1 hit
PfamiView protein in Pfam
PF10234 Cluap1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96AJ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFRDLRNFT EMMRALGYPR HISMENFRTP NFGLVSEVLL WLVKRYEPQT
60 70 80 90 100
DIPPDVDTEQ DRVFFIKAIA QFMATKAHIK LNTKKLYQAD GYAVKELLKI
110 120 130 140 150
TSVLYNAMKT KGMEGSEIVE EDVNKFKFDL GSKIADLKAA RQLASEITSK
160 170 180 190 200
GASLYDLLGM EVELREMRTE AIARPLEINE TEKVMRIAIK EILTQVQKTK
210 220 230 240 250
DLLNNVASDE ANLEAKIEKR KLELERNRKR LETLQSVRPC FMDEYEKTEE
260 270 280 290 300
ELQKQYDTYL EKFQNLTYLE QQLEDHHRME QERFEEAKNT LCLIQNKLKE
310 320 330 340 350
EEKRLLKSGS NDDSDIDIQE DDESDSELEE RRLPKPQTAM EMLMQGRPGK
360 370 380 390 400
RIVGTMQGGD SDDNEDSEES EIDMEDDDDE DDDLEDESIS LSPTKPNRRV
410
RKSEPLDESD NDF
Length:413
Mass (Da):48,125
Last modified:June 13, 2006 - v4
Checksum:i7A23D4FA2EBE5A9F
GO
Isoform 2 (identifier: Q96AJ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-166: Missing.

Note: No experimental confirmation available.
Show »
Length:247
Mass (Da):29,093
Checksum:i04DEC4E12F4D36F3
GO

Sequence cautioni

The sequence BAA31618 differs from that shown. Intron retention.Curated
The sequence BAB14523 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05086968A → S. Corresponds to variant dbSNP:rs34115694Ensembl.1
Natural variantiVAR_050870401R → W1 PublicationCorresponds to variant dbSNP:rs9790Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0192291 – 166Missing in isoform 2. 1 PublicationAdd BLAST166

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB089691 mRNA Translation: BAD44779.1
AB014543 mRNA Translation: BAA31618.1 Sequence problems.
AK023319 mRNA Translation: BAB14523.1 Different initiation.
AK023359 mRNA Translation: BAB14542.1
BC017070 mRNA Translation: AAH17070.3
CCDSiCCDS32381.1 [Q96AJ1-1]
CCDS45398.1 [Q96AJ1-2]
RefSeqiNP_055856.1, NM_015041.2 [Q96AJ1-1]
NP_079069.1, NM_024793.2 [Q96AJ1-2]
UniGeneiHs.155995

Genome annotation databases

EnsembliENST00000572600; ENSP00000460889; ENSG00000103351 [Q96AJ1-2]
ENST00000576634; ENSP00000460850; ENSG00000103351 [Q96AJ1-1]
GeneIDi23059
KEGGihsa:23059
UCSCiuc002cvk.3 human [Q96AJ1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCLUA1_HUMAN
AccessioniPrimary (citable) accession number: Q96AJ1
Secondary accession number(s): O75138
, Q65ZA3, Q9H8R4, Q9H8T1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: July 18, 2018
This is version 127 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health