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Protein

Ras-related protein Rab-7b

Gene

RAB7B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22GTPBy similarity8
Nucleotide bindingi34 – 40GTPBy similarity7
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi124 – 127GTPBy similarity4
Nucleotide bindingi154 – 155GTPBy similarity2

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-8854214 TBC/RABGAPs
R-HSA-8873719 RAB geranylgeranylation
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-7b
Gene namesi
Name:RAB7B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000276600.4
HGNCiHGNC:30513 RAB7B
neXtProtiNX_Q96AH8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi338382
OpenTargetsiENSG00000276600
PharmGKBiPA134940117

Polymorphism and mutation databases

DMDMi50401122

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211251 – 199Ras-related protein Rab-7bAdd BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei186PhosphoserineBy similarity1
Lipidationi198S-geranylgeranyl cysteineBy similarity1
Lipidationi199S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ96AH8
PeptideAtlasiQ96AH8
PRIDEiQ96AH8
ProteomicsDBi75966
TopDownProteomicsiQ96AH8

PTM databases

PhosphoSitePlusiQ96AH8

Expressioni

Tissue specificityi

Expressed in heart, placenta, lung, skeletal muscle and peripheral blood leukocyte.1 Publication

Gene expression databases

BgeeiENSG00000276600 Expressed in 130 organ(s), highest expression level in skin of abdomen
CleanExiHS_RAB7B
ExpressionAtlasiQ96AH8 baseline and differential
GenevisibleiQ96AH8 HS

Interactioni

Protein-protein interaction databases

BioGridi130725, 9 interactors
IntActiQ96AH8, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ96AH8
SMRiQ96AH8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi37 – 45Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

GeneTreeiENSGT00760000119125
HOVERGENiHBG009351
InParanoidiQ96AH8
KOiK07898
OMAiDYRTTLG
OrthoDBiEOG091G0MVE
PhylomeDBiQ96AH8

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q96AH8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPRKKVDLK LIIVGAIGVG KTSLLHQYVH KTFYEEYQTT LGASILSKII
60 70 80 90 100
ILGDTTLKLQ IWDTGGQERF RSMVSTFYKG SDGCILAFDV TDLESFEALD
110 120 130 140 150
IWRGDVLAKI VPMEQSYPMV LLGNKIDLAD RKVPQEVAQG WCREKDIPYF
160 170 180 190
EVSAKNDINV VQAFEMLASR ALSRYQSILE NHLTESIKLS PDQSRSRCC
Length:199
Mass (Da):22,511
Last modified:December 1, 2001 - v1
Checksum:i161C41ABC0EBA529
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A096LP44A0A096LP44_HUMAN
Ras-related protein Rab-7b
RAB7B
157Annotation score:
A0A096LPF0A0A096LPF0_HUMAN
Ras-related protein Rab-7b
RAB7B
91Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY094596 mRNA Translation: AAM22519.1
BC017092 mRNA Translation: AAH17092.1
CCDSiCCDS73011.1
RefSeqiNP_001157994.1, NM_001164522.2
NP_796377.3, NM_177403.5
UniGeneiHs.534612

Genome annotation databases

EnsembliENST00000617070; ENSP00000482499; ENSG00000276600
ENST00000617991; ENSP00000479762; ENSG00000276600
ENST00000623597; ENSP00000485468; ENSG00000276600
GeneIDi338382
KEGGihsa:338382
UCSCiuc031vlc.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY094596 mRNA Translation: AAM22519.1
BC017092 mRNA Translation: AAH17092.1
CCDSiCCDS73011.1
RefSeqiNP_001157994.1, NM_001164522.2
NP_796377.3, NM_177403.5
UniGeneiHs.534612

3D structure databases

ProteinModelPortaliQ96AH8
SMRiQ96AH8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130725, 9 interactors
IntActiQ96AH8, 2 interactors

PTM databases

PhosphoSitePlusiQ96AH8

Polymorphism and mutation databases

DMDMi50401122

Proteomic databases

EPDiQ96AH8
PeptideAtlasiQ96AH8
PRIDEiQ96AH8
ProteomicsDBi75966
TopDownProteomicsiQ96AH8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000617070; ENSP00000482499; ENSG00000276600
ENST00000617991; ENSP00000479762; ENSG00000276600
ENST00000623597; ENSP00000485468; ENSG00000276600
GeneIDi338382
KEGGihsa:338382
UCSCiuc031vlc.2 human

Organism-specific databases

CTDi338382
DisGeNETi338382
EuPathDBiHostDB:ENSG00000276600.4
GeneCardsiRAB7B
HGNCiHGNC:30513 RAB7B
neXtProtiNX_Q96AH8
OpenTargetsiENSG00000276600
PharmGKBiPA134940117
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119125
HOVERGENiHBG009351
InParanoidiQ96AH8
KOiK07898
OMAiDYRTTLG
OrthoDBiEOG091G0MVE
PhylomeDBiQ96AH8

Enzyme and pathway databases

ReactomeiR-HSA-8854214 TBC/RABGAPs
R-HSA-8873719 RAB geranylgeranylation
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSiRAB7B human
GeneWikiiRAB7B
GenomeRNAii338382
PROiPR:Q96AH8

Gene expression databases

BgeeiENSG00000276600 Expressed in 130 organ(s), highest expression level in skin of abdomen
CleanExiHS_RAB7B
ExpressionAtlasiQ96AH8 baseline and differential
GenevisibleiQ96AH8 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB7B_HUMAN
AccessioniPrimary (citable) accession number: Q96AH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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