UniProtKB - Q96AE7 (TTC17_HUMAN)
Protein
Tetratricopeptide repeat protein 17
Gene
TTC17
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in primary ciliogenesis by modulating actin polymerization.1 Publication
GO - Biological processi
- actin filament polymerization Source: UniProtKB
- cilium organization Source: UniProtKB
Keywordsi
Biological process | Cilium biogenesis/degradation |
Enzyme and pathway databases
PathwayCommonsi | Q96AE7 |
Names & Taxonomyi
Protein namesi | Recommended name: Tetratricopeptide repeat protein 17Short name: TPR repeat protein 17 |
Gene namesi | Name:TTC17 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000052841.14 |
HGNCi | HGNC:25596, TTC17 |
neXtProti | NX_Q96AE7 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 1 Publication
Plasma membrane
- Cell membrane 1 Publication
Other locations
- Cytoplasm 1 Publication
Note: Colocalized with CATIP at F-actin rich zones and at dynamic plasma membrane protrusions.
Cytoskeleton
- actin cytoskeleton Source: UniProtKB
Cytosol
- cytosol Source: HPA
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Cytoskeleton, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 55761 |
OpenTargetsi | ENSG00000052841 |
PharmGKBi | PA134912435 |
Miscellaneous databases
Pharosi | Q96AE7, Tdark |
Polymorphism and mutation databases
BioMutai | TTC17 |
DMDMi | 52783467 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000106406 | 1 – 1141 | Tetratricopeptide repeat protein 17Add BLAST | 1141 |
Proteomic databases
EPDi | Q96AE7 |
jPOSTi | Q96AE7 |
MassIVEi | Q96AE7 |
MaxQBi | Q96AE7 |
PaxDbi | Q96AE7 |
PeptideAtlasi | Q96AE7 |
PRIDEi | Q96AE7 |
ProteomicsDBi | 33701 75960 [Q96AE7-1] |
PTM databases
GlyConnecti | 1799, 3 N-Linked glycans (1 site) |
GlyGeni | Q96AE7, 1 site |
iPTMneti | Q96AE7 |
PhosphoSitePlusi | Q96AE7 |
Expressioni
Tissue specificityi
Expressed in germ cells as well as in somatic cells of the testis (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000052841, Expressed in lung and 233 other tissues |
ExpressionAtlasi | Q96AE7, baseline and differential |
Genevisiblei | Q96AE7, HS |
Organism-specific databases
HPAi | ENSG00000052841, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with CATIP.
1 PublicationProtein-protein interaction databases
BioGRIDi | 120879, 40 interactors |
IntActi | Q96AE7, 28 interactors |
STRINGi | 9606.ENSP00000039989 |
Miscellaneous databases
RNActi | Q96AE7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 295 – 328 | TPR 1Add BLAST | 34 | |
Repeati | 619 – 652 | TPR 2Add BLAST | 34 | |
Repeati | 689 – 722 | TPR 3Add BLAST | 34 | |
Repeati | 1014 – 1048 | TPR 4Add BLAST | 35 | |
Repeati | 1051 – 1084 | TPR 5Add BLAST | 34 | |
Repeati | 1085 – 1118 | TPR 6Add BLAST | 34 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 340 – 382 | Sequence analysisAdd BLAST | 43 |
Sequence similaritiesi
Belongs to the TTC17 family.Curated
Keywords - Domaini
Coiled coil, Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG4507, Eukaryota |
GeneTreei | ENSGT00390000006196 |
HOGENOMi | CLU_008510_0_0_1 |
InParanoidi | Q96AE7 |
OMAi | DDHARQI |
OrthoDBi | 310025at2759 |
PhylomeDBi | Q96AE7 |
TreeFami | TF315005 |
Family and domain databases
Gene3Di | 1.25.40.10, 3 hits |
InterProi | View protein in InterPro IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF13181, TPR_8, 2 hits |
SMARTi | View protein in SMART SM00028, TPR, 7 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50005, TPR, 4 hits PS50293, TPR_REGION, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96AE7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAAVGVRGR YELPPCSGPG WLLSLSALLS VAARGAFATT HWVVTEDGKI
60 70 80 90 100
QQQVDSPMNL KHPHDLVILM RQEATVNYLK ELEKQLVAQK IHIEENEDRD
110 120 130 140 150
TGLEQRHNKE DPDCIKAKVP LGDLDLYDGT YITLESKDIS PEDYIDTESP
160 170 180 190 200
VPPDPEQPDC TKILELPYSI HAFQHLRGVQ ERVNLSAPLL PKEDPIFTYL
210 220 230 240 250
SKRLGRSIDD IGHLIHEGLQ KNTSSWVLYN MASFYWRIKN EPYQVVECAM
260 270 280 290 300
RALHFSSRHN KDIALVNLAN VLHRAHFSAD AAVVVHAALD DSDFFTSYYT
310 320 330 340 350
LGNIYAMLGE YNHSVLCYDH ALQARPGFEQ AIKRKHAVLC QQKLEQKLEA
360 370 380 390 400
QHRSLQRTLN ELKEYQKQHD HYLRQQEILE KHKLIQEEQI LRNIIHETQM
410 420 430 440 450
AKEAQLGNHQ ICRLVNQQHS LHCQWDQPVR YHRGDIFENV DYVQFGEDSS
460 470 480 490 500
TSSMMSVNFD VQSNQSDIND SVKSSPVAHS ILWIWGRDSD AYRDKQHILW
510 520 530 540 550
PKRADCTESY PRVPVGGELP TYFLPPENKG LRIHELSSDD YSTEEEAQTP
560 570 580 590 600
DCSITDFRKS HTLSYLVKEL EVRMDLKAKM PDDHARKILL SRINNYTIPE
610 620 630 640 650
EEIGSFLFHA INKPNAPIWL ILNEAGLYWR AVGNSTFAIA CLQRALNLAP
660 670 680 690 700
LQYQDVPLVN LANLLIHYGL HLDATKLLLQ ALAINSSEPL TFLSLGNAYL
710 720 730 740 750
ALKNISGALE AFRQALKLTT KCPECENSLK LIRCMQFYPF LYNITSSVCS
760 770 780 790 800
GTVVEESNGS DEMENSDETK MSEEILALVD EFQQAWPLEG FGGALEMKGR
810 820 830 840 850
RLDLQGIRVL KKGPQDGVAR SSCYGDCRSE DDEATEWITF QVKRVKKPKG
860 870 880 890 900
DHKKTPGKKV ETGQIENGHR YQANLEITGP KVASPGPQGK KRDYQRLGWP
910 920 930 940 950
SPDECLKLRW VELTAIVSTW LAVSSKNIDI TEHIDFATPI QQPAMEPLCN
960 970 980 990 1000
GNLPTSMHTL DHLHGVSNRA SLHYTGESQL TEVLQNLGKD QYPQQSLEQI
1010 1020 1030 1040 1050
GTRIAKVLEK NQTSWVLSSM AALYWRVKGQ GKKAIDCLRQ ALHYAPHQMK
1060 1070 1080 1090 1100
DVPLISLANI LHNAKLWNDA VIVATMAVEI APHFAVNHFT LGNVYVAMEE
1110 1120 1130 1140
FEKALVWYES TLKLQPEFVP AKNRIQTIQC HLMLKKGRRS P
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y6S0 | H0Y6S0_HUMAN | Tetratricopeptide repeat protein 17 | TTC17 | 172 | Annotation score: | ||
A0A075B7B2 | A0A075B7B2_HUMAN | Tetratricopeptide repeat protein 17 | TTC17 | 140 | Annotation score: | ||
E9PN79 | E9PN79_HUMAN | Tetratricopeptide repeat protein 17 | TTC17 | 54 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 2 (identifier: Q96AE7-2) | |||||
Sequence conflicti | 787 | E → G in AAH33000 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034135 | 145 | I → L. Corresponds to variant dbSNP:rs12099204Ensembl. | 1 | |
Natural variantiVAR_052627 | 270 | N → H. Corresponds to variant dbSNP:rs16937479Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056857 | 751 | G → GNCHEKTLDNSHDKQKYFDN SQSLDAAEEEPSERGTEEDP VFSVENSGRDSDALRLES in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_056858 | 890 – 898 | KKRDYQRLG → LLDWKTRKV in isoform 2. 1 Publication | 9 | |
Alternative sequenceiVSP_056859 | 899 – 1140 | Missing in isoform 2. 1 PublicationAdd BLAST | 242 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC023085 Genomic DNA No translation available. AC087276 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68094.1 BC017238 mRNA Translation: AAH17238.1 BC033000 mRNA Translation: AAH33000.1 |
CCDSi | CCDS31466.1 [Q96AE7-1] CCDS76396.1 [Q96AE7-2] |
RefSeqi | NP_001294872.1, NM_001307943.1 [Q96AE7-2] NP_060729.2, NM_018259.5 [Q96AE7-1] |
Genome annotation databases
Ensembli | ENST00000039989; ENSP00000039989; ENSG00000052841 [Q96AE7-1] ENST00000299240; ENSP00000299240; ENSG00000052841 [Q96AE7-2] |
GeneIDi | 55761 |
KEGGi | hsa:55761 |
UCSCi | uc001mxh.4, human [Q96AE7-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC023085 Genomic DNA No translation available. AC087276 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68094.1 BC017238 mRNA Translation: AAH17238.1 BC033000 mRNA Translation: AAH33000.1 |
CCDSi | CCDS31466.1 [Q96AE7-1] CCDS76396.1 [Q96AE7-2] |
RefSeqi | NP_001294872.1, NM_001307943.1 [Q96AE7-2] NP_060729.2, NM_018259.5 [Q96AE7-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 120879, 40 interactors |
IntActi | Q96AE7, 28 interactors |
STRINGi | 9606.ENSP00000039989 |
PTM databases
GlyConnecti | 1799, 3 N-Linked glycans (1 site) |
GlyGeni | Q96AE7, 1 site |
iPTMneti | Q96AE7 |
PhosphoSitePlusi | Q96AE7 |
Polymorphism and mutation databases
BioMutai | TTC17 |
DMDMi | 52783467 |
Proteomic databases
EPDi | Q96AE7 |
jPOSTi | Q96AE7 |
MassIVEi | Q96AE7 |
MaxQBi | Q96AE7 |
PaxDbi | Q96AE7 |
PeptideAtlasi | Q96AE7 |
PRIDEi | Q96AE7 |
ProteomicsDBi | 33701 75960 [Q96AE7-1] |
Protocols and materials databases
Antibodypediai | 26045, 38 antibodies |
Genome annotation databases
Ensembli | ENST00000039989; ENSP00000039989; ENSG00000052841 [Q96AE7-1] ENST00000299240; ENSP00000299240; ENSG00000052841 [Q96AE7-2] |
GeneIDi | 55761 |
KEGGi | hsa:55761 |
UCSCi | uc001mxh.4, human [Q96AE7-1] |
Organism-specific databases
CTDi | 55761 |
DisGeNETi | 55761 |
EuPathDBi | HostDB:ENSG00000052841.14 |
GeneCardsi | TTC17 |
HGNCi | HGNC:25596, TTC17 |
HPAi | ENSG00000052841, Low tissue specificity |
neXtProti | NX_Q96AE7 |
OpenTargetsi | ENSG00000052841 |
PharmGKBi | PA134912435 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4507, Eukaryota |
GeneTreei | ENSGT00390000006196 |
HOGENOMi | CLU_008510_0_0_1 |
InParanoidi | Q96AE7 |
OMAi | DDHARQI |
OrthoDBi | 310025at2759 |
PhylomeDBi | Q96AE7 |
TreeFami | TF315005 |
Enzyme and pathway databases
PathwayCommonsi | Q96AE7 |
Miscellaneous databases
BioGRID-ORCSi | 55761, 4 hits in 843 CRISPR screens |
ChiTaRSi | TTC17, human |
GenomeRNAii | 55761 |
Pharosi | Q96AE7, Tdark |
PROi | PR:Q96AE7 |
RNActi | Q96AE7, protein |
Gene expression databases
Bgeei | ENSG00000052841, Expressed in lung and 233 other tissues |
ExpressionAtlasi | Q96AE7, baseline and differential |
Genevisiblei | Q96AE7, HS |
Family and domain databases
Gene3Di | 1.25.40.10, 3 hits |
InterProi | View protein in InterPro IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF13181, TPR_8, 2 hits |
SMARTi | View protein in SMART SM00028, TPR, 7 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50005, TPR, 4 hits PS50293, TPR_REGION, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TTC17_HUMAN | |
Accessioni | Q96AE7Primary (citable) accession number: Q96AE7 Secondary accession number(s): G3XAB3, Q8NEC0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2004 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations