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Protein

Kinesin-like protein KIFC2

Gene

KIFC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for the transport of multivesicular body (MVB)-like organelles in dendrites (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi484 – 491ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • microtubule binding Source: GO_Central
  • microtubule motor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIFC2
Gene namesi
Name:KIFC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000167702.11
HGNCiHGNC:29530 KIFC2
MIMi615216 gene
neXtProtiNX_Q96AC6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167702
PharmGKBiPA134874212

Polymorphism and mutation databases

BioMutaiKIFC2
DMDMi34098674

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254291 – 838Kinesin-like protein KIFC2Add BLAST838

Proteomic databases

EPDiQ96AC6
PaxDbiQ96AC6
PeptideAtlasiQ96AC6
PRIDEiQ96AC6
ProteomicsDBi75953

PTM databases

iPTMnetiQ96AC6
PhosphoSitePlusiQ96AC6

Expressioni

Gene expression databases

BgeeiENSG00000167702 Expressed in 188 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_KIFC2
GenevisibleiQ96AC6 HS

Organism-specific databases

HPAiHPA029264

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124785, 3 interactors
IntActiQ96AC6, 7 interactors
MINTiQ96AC6
STRINGi9606.ENSP00000301332

Structurei

3D structure databases

ProteinModelPortaliQ96AC6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini409 – 740Kinesin motorPROSITE-ProRule annotationAdd BLAST332

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili186 – 351Sequence analysisAdd BLAST166

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi181 – 332Gln-richAdd BLAST152
Compositional biasi720 – 831Pro-richAdd BLAST112

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0239 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00920000149025
HOGENOMiHOG000113226
HOVERGENiHBG052258
InParanoidiQ96AC6
KOiK10406
OMAiMGTGGQH
OrthoDBiEOG091G03NM
PhylomeDBiQ96AC6
TreeFamiTF105238

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96AC6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYAFYSLLIY IFYSLFRRDG GAAAAAEPGD PAQRARKPRG RRRPDLPAPE
60 70 80 90 100
LWTELTGLAA SSEPEDGSEG AAEGRAAAVS LEEALLRLAE FLSVQLGAEE
110 120 130 140 150
SCGGPADLGQ SGEVPSLLTV TSQLLALLAW LRSPRGRQAL LQGTQPAPRV
160 170 180 190 200
RPPSPDGSTS QEESPSHFTA VPGEPLGDET QGQQPLQLEE DQRAWQRLEQ
210 220 230 240 250
LILGQLEELK QQLEQQEEEL GRLRLGVGAT DSEKRVQHLT LENEALKQSL
260 270 280 290 300
SLMRDLLLHW GPGPPIRAPQ EEAEALLELQ GRLQEAQDTT EALRAQLGVQ
310 320 330 340 350
EVQLQGLQGA LQQLQQETEQ NCRRELQQMH GQLAGLRARM ASLRQGCGDL
360 370 380 390 400
RGLVSTFTQS CQGSLSEARG QVSWALGALS SGGPGTQLPE GQQGPPAGCP
410 420 430 440 450
GRLPELKGNI RVLCRLRPGT SSSLVSVEPG PGGTVTTCYR GRHRRFRLDW
460 470 480 490 500
VFPPDASQEE VFRELEPAVL SCLRGYSVCI FTYGQTGTGK TYSMEGPPED
510 520 530 540 550
PGIVPRALQS LFREMGAGRQ HRVTLSMVEI YNEAVRDLLA PGPPERLAVR
560 570 580 590 600
QGPEGQGGIQ VAGLTHWDVP NLETLHQMLK LGRSNRATAA TAMNQRSSRS
610 620 630 640 650
HALVTLTLRA ASPPRAPGTA GTLHLVDLAG SERARKAGAA GPPRGDPDGA
660 670 680 690 700
RRLREAQTIN RSLLALGGVM AALRAHRPHV PFRDSQLTRL LQPALGPGTT
710 720 730 740 750
AVLLLQVGAG AGQVCACRSP PTRARPPAPL ARRSPRGRRI SGRQSAPSSS
760 770 780 790 800
PTEWVKWSWG QPGAAGSRAP PGRLLPSAPT LRSPGPPAPL RRPLAVLHAP
810 820 830
VPTTARARLS RPQRACPSSP GSRPCPWGLR PGLCWQRR
Length:838
Mass (Da):90,147
Last modified:December 1, 2001 - v1
Checksum:i5C692E0B67A0BE77
GO
Isoform 2 (identifier: Q96AC6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-252: Missing.
     523-551: VTLSMVEIYNEAVRDLLAPGPPERLAVRQ → RYHGRCLSPAESPEHPRPGLPPCRARSPL
     552-838: Missing.

Note: No experimental confirmation available.
Show »
Length:299
Mass (Da):32,600
Checksum:i4893497BE5D7E08C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8YEU8A0A2R8YEU8_HUMAN
Kinesin-like protein
KIFC2 hCG_24018
791Annotation score:
A0A2R8Y870A0A2R8Y870_HUMAN
Kinesin-like protein
KIFC2
744Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04968467G → E. Corresponds to variant dbSNP:rs35817880Ensembl.1
Natural variantiVAR_049685166S → F. Corresponds to variant dbSNP:rs12675537Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0561021 – 252Missing in isoform 2. 1 PublicationAdd BLAST252
Alternative sequenceiVSP_056103523 – 551VTLSM…LAVRQ → RYHGRCLSPAESPEHPRPGL PPCRARSPL in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_056104552 – 838Missing in isoform 2. 1 PublicationAdd BLAST287

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055045 mRNA Translation: BAB70844.1
AC084125 Genomic DNA No translation available.
CH471162 Genomic DNA Translation: EAW82085.1
BC017311 mRNA Translation: AAH17311.1
CCDSiCCDS6427.1 [Q96AC6-1]
RefSeqiNP_665697.1, NM_145754.3 [Q96AC6-1]
UniGeneiHs.528713

Genome annotation databases

EnsembliENST00000301332; ENSP00000301332; ENSG00000167702 [Q96AC6-1]
GeneIDi90990
KEGGihsa:90990
UCSCiuc003zcz.4 human [Q96AC6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055045 mRNA Translation: BAB70844.1
AC084125 Genomic DNA No translation available.
CH471162 Genomic DNA Translation: EAW82085.1
BC017311 mRNA Translation: AAH17311.1
CCDSiCCDS6427.1 [Q96AC6-1]
RefSeqiNP_665697.1, NM_145754.3 [Q96AC6-1]
UniGeneiHs.528713

3D structure databases

ProteinModelPortaliQ96AC6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124785, 3 interactors
IntActiQ96AC6, 7 interactors
MINTiQ96AC6
STRINGi9606.ENSP00000301332

PTM databases

iPTMnetiQ96AC6
PhosphoSitePlusiQ96AC6

Polymorphism and mutation databases

BioMutaiKIFC2
DMDMi34098674

Proteomic databases

EPDiQ96AC6
PaxDbiQ96AC6
PeptideAtlasiQ96AC6
PRIDEiQ96AC6
ProteomicsDBi75953

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301332; ENSP00000301332; ENSG00000167702 [Q96AC6-1]
GeneIDi90990
KEGGihsa:90990
UCSCiuc003zcz.4 human [Q96AC6-1]

Organism-specific databases

CTDi90990
EuPathDBiHostDB:ENSG00000167702.11
GeneCardsiKIFC2
HGNCiHGNC:29530 KIFC2
HPAiHPA029264
MIMi615216 gene
neXtProtiNX_Q96AC6
OpenTargetsiENSG00000167702
PharmGKBiPA134874212
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0239 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00920000149025
HOGENOMiHOG000113226
HOVERGENiHBG052258
InParanoidiQ96AC6
KOiK10406
OMAiMGTGGQH
OrthoDBiEOG091G03NM
PhylomeDBiQ96AC6
TreeFamiTF105238

Enzyme and pathway databases

ReactomeiR-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins

Miscellaneous databases

ChiTaRSiKIFC2 human
GenomeRNAii90990
PROiPR:Q96AC6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167702 Expressed in 188 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_KIFC2
GenevisibleiQ96AC6 HS

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKIFC2_HUMAN
AccessioniPrimary (citable) accession number: Q96AC6
Secondary accession number(s): E9PHB2, Q96NN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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