UniProtKB - Q96A98 (TIP39_HUMAN)
Protein
Tuberoinfundibular peptide of 39 residues
Gene
PTH2
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits.4 Publications
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: Reactome
- negative regulation of inflammatory response to antigenic stimulus Source: Reactome
- neuropeptide signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Neuropeptide |
Enzyme and pathway databases
PathwayCommonsi | Q96A98 |
Reactomei | R-HSA-373080, Class B/2 (Secretin family receptors) R-HSA-418555, G alpha (s) signalling events R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
SIGNORi | Q96A98 |
Names & Taxonomyi
Protein namesi | Recommended name: Tuberoinfundibular peptide of 39 residuesShort name: TIP39 Alternative name(s): Parathyroid hormone 2 |
Gene namesi | Name:PTH2 Synonyms:TIP39, TIPF39 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30828, PTH2 |
MIMi | 608386, gene |
neXtProti | NX_Q96A98 |
VEuPathDBi | HostDB:ENSG00000142538.1 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 113091 |
OpenTargetsi | ENSG00000142538 |
PharmGKBi | PA162400324 |
Miscellaneous databases
Pharosi | Q96A98, Tdark |
Genetic variation databases
BioMutai | PTH2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 30 | Sequence analysisAdd BLAST | 30 | |
PropeptideiPRO_0000045942 | 31 – 59 | Add BLAST | 29 | |
PeptideiPRO_0000045943 | 62 – 100 | Tuberoinfundibular peptide of 39 residuesAdd BLAST | 39 |
Keywords - PTMi
Cleavage on pair of basic residuesProteomic databases
PaxDbi | Q96A98 |
PeptideAtlasi | Q96A98 |
PRIDEi | Q96A98 |
ProteomicsDBi | 75938 |
PTM databases
iPTMneti | Q96A98 |
PhosphoSitePlusi | Q96A98 |
Expressioni
Tissue specificityi
Highly expressed in fetal and adult brain, cerebellum and trachea. Weakly expressed in spinal cord, fetal liver, kidney and heart.1 Publication
Gene expression databases
Bgeei | ENSG00000142538, Expressed in cerebellar hemisphere and 60 other tissues |
Genevisiblei | Q96A98, HS |
Organism-specific databases
HPAi | ENSG00000142538, Group enriched (blood, brain, testis) |
Interactioni
Subunit structurei
Ligand of high affinity for the PTH2 receptor (PTH2R).
Protein-protein interaction databases
BioGRIDi | 125223, 1 interactor |
IntActi | Q96A98, 1 interactor |
STRINGi | 9606.ENSP00000270631 |
Miscellaneous databases
RNActi | Q96A98, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the parathyroid hormone family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S3PJ, Eukaryota |
GeneTreei | ENSGT00410000026259 |
HOGENOMi | CLU_2319483_0_0_1 |
InParanoidi | Q96A98 |
OMAi | LVSWGHR |
OrthoDBi | 1601028at2759 |
PhylomeDBi | Q96A98 |
TreeFami | TF353520 |
Family and domain databases
InterProi | View protein in InterPro IPR029396, TIP39 |
PANTHERi | PTHR28585, PTHR28585, 1 hit |
Pfami | View protein in Pfam PF14980, TIP39, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q96A98-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
METRQVSRSP RVRLLLLLLL LLVVPWGVRT ASGVALPPVG VLSLRPPGRA
60 70 80 90 100
WADPATPRPR RSLALADDAA FRERARLLAA LERRHWLNSY MHKLLVLDAP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY037555 mRNA Translation: AAK68689.1 BC093995 mRNA Translation: AAH93995.1 BC093997 mRNA Translation: AAH93997.1 AY048588 mRNA Translation: AAL06597.1 |
CCDSi | CCDS12763.1 |
RefSeqi | NP_848544.1, NM_178449.3 |
Genome annotation databases
Ensembli | ENST00000270631; ENSP00000270631; ENSG00000142538 |
GeneIDi | 113091 |
KEGGi | hsa:113091 |
UCSCi | uc002pnn.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY037555 mRNA Translation: AAK68689.1 BC093995 mRNA Translation: AAH93995.1 BC093997 mRNA Translation: AAH93997.1 AY048588 mRNA Translation: AAL06597.1 |
CCDSi | CCDS12763.1 |
RefSeqi | NP_848544.1, NM_178449.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 125223, 1 interactor |
IntActi | Q96A98, 1 interactor |
STRINGi | 9606.ENSP00000270631 |
PTM databases
iPTMneti | Q96A98 |
PhosphoSitePlusi | Q96A98 |
Genetic variation databases
BioMutai | PTH2 |
Proteomic databases
PaxDbi | Q96A98 |
PeptideAtlasi | Q96A98 |
PRIDEi | Q96A98 |
ProteomicsDBi | 75938 |
Protocols and materials databases
Antibodypediai | 31997, 48 antibodies |
Genome annotation databases
Ensembli | ENST00000270631; ENSP00000270631; ENSG00000142538 |
GeneIDi | 113091 |
KEGGi | hsa:113091 |
UCSCi | uc002pnn.1, human |
Organism-specific databases
CTDi | 113091 |
DisGeNETi | 113091 |
GeneCardsi | PTH2 |
HGNCi | HGNC:30828, PTH2 |
HPAi | ENSG00000142538, Group enriched (blood, brain, testis) |
MIMi | 608386, gene |
neXtProti | NX_Q96A98 |
OpenTargetsi | ENSG00000142538 |
PharmGKBi | PA162400324 |
VEuPathDBi | HostDB:ENSG00000142538.1 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S3PJ, Eukaryota |
GeneTreei | ENSGT00410000026259 |
HOGENOMi | CLU_2319483_0_0_1 |
InParanoidi | Q96A98 |
OMAi | LVSWGHR |
OrthoDBi | 1601028at2759 |
PhylomeDBi | Q96A98 |
TreeFami | TF353520 |
Enzyme and pathway databases
PathwayCommonsi | Q96A98 |
Reactomei | R-HSA-373080, Class B/2 (Secretin family receptors) R-HSA-418555, G alpha (s) signalling events R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
SIGNORi | Q96A98 |
Miscellaneous databases
BioGRID-ORCSi | 113091, 11 hits in 972 CRISPR screens |
GeneWikii | TIP39 |
GenomeRNAii | 113091 |
Pharosi | Q96A98, Tdark |
PROi | PR:Q96A98 |
RNActi | Q96A98, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000142538, Expressed in cerebellar hemisphere and 60 other tissues |
Genevisiblei | Q96A98, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029396, TIP39 |
PANTHERi | PTHR28585, PTHR28585, 1 hit |
Pfami | View protein in Pfam PF14980, TIP39, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TIP39_HUMAN | |
Accessioni | Q96A98Primary (citable) accession number: Q96A98 Secondary accession number(s): Q96DJ4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 7, 2006 |
Last sequence update: | December 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families