PTH2

Functionⁱ

Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits.4 Publications

GO - Biological processⁱ

G protein-coupled receptor signaling pathway Source: Reactome
neuropeptide signaling pathway Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Neuropeptide

Molecular function

Neuropeptide

Enzyme and pathway databases

Reactomeⁱ	R-HSA-373080 Class B/2 (Secretin family receptors) R-HSA-418555 G alpha (s) signalling events
SIGNORⁱ	Q96A98

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tuberoinfundibular peptide of 39 residues Short name: TIP39 Alternative name(s): Parathyroid hormone 2
Gene namesⁱ	Name:PTH2 Synonyms:TIP39, TIPF39
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000142538.1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30828 PTH2
MIMⁱ	608386 gene
neXtProtⁱ	NX_Q96A98

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	113091
Open Targets More...OpenTargetsⁱ	ENSG00000142538
PharmGKBⁱ	PA162400324

Polymorphism and mutation databases

BioMutaⁱ	PTH2

BioMutaⁱ

PTH2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 30	Sequence analysisAdd BLAST	30
PropeptideⁱPRO_0000045942	31 – 59	Add BLAST	29
PeptideⁱPRO_0000045943	62 – 100	Tuberoinfundibular peptide of 39 residuesAdd BLAST	39

Keywords - PTMⁱ

Cleavage on pair of basic residues

Proteomic databases

PaxDbⁱ	Q96A98
PeptideAtlas More...PeptideAtlasⁱ	Q96A98
PRIDEⁱ	Q96A98
ProteomicsDBⁱ	75938

PTM databases

iPTMnetⁱ	Q96A98
PhosphoSitePlusⁱ	Q96A98

Expressionⁱ

Tissue specificityⁱ

Highly expressed in fetal and adult brain, cerebellum and trachea. Weakly expressed in spinal cord, fetal liver, kidney and heart.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000142538 Expressed in 48 organ(s), highest expression level in cerebellar hemisphere
CleanExⁱ	HS_PTH2
Genevisibleⁱ	Q96A98 HS

Interactionⁱ

Subunit structureⁱ

Ligand of high affinity for the PTH2 receptor (PTH2R).

Protein-protein interaction databases

BioGridⁱ	125223, 1 interactor
STRINGⁱ	9606.ENSP00000270631

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96A98
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the parathyroid hormone family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J15Z Eukaryota ENOG410Y2YH LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00410000026259
HOGENOMⁱ	HOG000154591
HOVERGENⁱ	HBG094047
InParanoidⁱ	Q96A98
OMAⁱ	YMHKLLV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G16L2
PhylomeDBⁱ	Q96A98
TreeFamⁱ	TF353520

Family and domain databases

InterProⁱ	View protein in InterPro IPR029396 TIP39
PANTHERⁱ	PTHR28585 PTHR28585, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14980 TIP39, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q96A98-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
METRQVSRSP RVRLLLLLLL LLVVPWGVRT ASGVALPPVG VLSLRPPGRA 
        60         70         80         90        100
WADPATPRPR RSLALADDAA FRERARLLAA LERRHWLNSY MHKLLVLDAP

Length:100

Mass (Da):11,202

Last modified:December 1, 2001 - v1

Checksum:ⁱ7F0F1A273829E8F6

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY037555 mRNA Translation: AAK68689.1 BC093995 mRNA Translation: AAH93995.1 BC093997 mRNA Translation: AAH93997.1 AY048588 mRNA Translation: AAL06597.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12763.1
NCBI Reference Sequences More...RefSeqⁱ	NP_848544.1, NM_178449.3
UniGeneⁱ	Hs.339845

Genome annotation databases

Ensemblⁱ	ENST00000270631; ENSP00000270631; ENSG00000142538
GeneIDⁱ	113091
KEGGⁱ	hsa:113091
UCSC genome browser More...UCSCⁱ	uc002pnn.1 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96A98	Tuberoinfundibular peptide of 39 residues		BOVIN		100	UniRef100_Q96A98

Protein	Similar proteins		Species	Score	Length	Source
Q96A98	Tuberoinfundibular peptide of 39 residues		BOVIN		100	UniRef90_Q96A98
PTH2 isoform 1		PANTR		99
Parathyroid hormone 2		CALJA		99
PTH2 isoform 1		PONAB		99
Uncharacterized protein		RHIBE		99
+7

Protein	Similar proteins		Species	Score	Length	Source
Q96A98	Tuberoinfundibular peptide of 39 residues		MOUSE		100	UniRef50_Q91W27
Tuberoinfundibular peptide of 39 residues		RAT		100
Tuberoinfundibular peptide of 39 residues		BOVIN		100
tuberoinfundibular peptide of 39 residues		MESAU		100
tuberoinfundibular peptide of 39 residues		BALAS		97
+33

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY037555 mRNA Translation: AAK68689.1 BC093995 mRNA Translation: AAH93995.1 BC093997 mRNA Translation: AAH93997.1 AY048588 mRNA Translation: AAL06597.1
CCDSⁱ	CCDS12763.1
RefSeqⁱ	NP_848544.1, NM_178449.3
UniGeneⁱ	Hs.339845

3D structure databases

ProteinModelPortalⁱ	Q96A98
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	125223, 1 interactor
STRINGⁱ	9606.ENSP00000270631

PTM databases

iPTMnetⁱ	Q96A98
PhosphoSitePlusⁱ	Q96A98

Polymorphism and mutation databases

BioMutaⁱ	PTH2

BioMutaⁱ

PTH2

Proteomic databases

PaxDbⁱ	Q96A98
PeptideAtlasⁱ	Q96A98
PRIDEⁱ	Q96A98
ProteomicsDBⁱ	75938

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000270631; ENSP00000270631; ENSG00000142538
GeneIDⁱ	113091
KEGGⁱ	hsa:113091
UCSCⁱ	uc002pnn.1 human

Organism-specific databases

CTDⁱ	113091
DisGeNETⁱ	113091
EuPathDBⁱ	HostDB:ENSG00000142538.1
GeneCardsⁱ	PTH2
HGNCⁱ	HGNC:30828 PTH2
MIMⁱ	608386 gene
neXtProtⁱ	NX_Q96A98
OpenTargetsⁱ	ENSG00000142538
PharmGKBⁱ	PA162400324
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J15Z Eukaryota ENOG410Y2YH LUCA
GeneTreeⁱ	ENSGT00410000026259
HOGENOMⁱ	HOG000154591
HOVERGENⁱ	HBG094047
InParanoidⁱ	Q96A98
OMAⁱ	YMHKLLV
OrthoDBⁱ	EOG091G16L2
PhylomeDBⁱ	Q96A98
TreeFamⁱ	TF353520

Enzyme and pathway databases

Reactomeⁱ	R-HSA-373080 Class B/2 (Secretin family receptors) R-HSA-418555 G alpha (s) signalling events
SIGNORⁱ	Q96A98

Miscellaneous databases

GeneWikiⁱ	TIP39
GenomeRNAiⁱ	113091
Protein Ontology More...PROⁱ	PR:Q96A98
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000142538 Expressed in 48 organ(s), highest expression level in cerebellar hemisphere
CleanExⁱ	HS_PTH2
Genevisibleⁱ	Q96A98 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR029396 TIP39
PANTHERⁱ	PTHR28585 PTHR28585, 1 hit
Pfamⁱ	View protein in Pfam PF14980 TIP39, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TIP39_HUMAN
Accessionⁱ	Q96A98Primary (citable) accession number: Q96A98 Secondary accession number(s): Q96DJ4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 7, 2006
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - Q96A98 (TIP39_HUMAN)

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Tuberoinfundibular peptide of 39 residues

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ