Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

EMI domain-containing protein 1

Gene

EMID1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
EMI domain-containing protein 1
Alternative name(s):
Emilin and multimerin domain-containing protein 1
Short name:
Emu1
Gene namesi
Name:EMID1
Synonyms:EMU1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000186998.15
HGNCiHGNC:18036 EMID1
MIMi608926 gene
neXtProtiNX_Q96A84

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186998
PharmGKBiPA134921314

Polymorphism and mutation databases

BioMutaiEMID1
DMDMi37537826

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000782323 – 441EMI domain-containing protein 1Add BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 96PROSITE-ProRule annotation
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi62 ↔ 68PROSITE-ProRule annotation
Disulfide bondi95 ↔ 104PROSITE-ProRule annotation
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96A84
PeptideAtlasiQ96A84
PRIDEiQ96A84
ProteomicsDBi75935
75936 [Q96A84-2]
75937 [Q96A84-3]

PTM databases

iPTMnetiQ96A84

Expressioni

Gene expression databases

BgeeiENSG00000186998
CleanExiHS_EMID1
ExpressionAtlasiQ96A84 baseline and differential
GenevisibleiQ96A84 HS

Organism-specific databases

HPAiHPA000592

Interactioni

Subunit structurei

Homo- or heteromers.

Protein-protein interaction databases

BioGridi126183, 9 interactors
IntActiQ96A84, 2 interactors
STRINGi9606.ENSP00000335481

Structurei

3D structure databases

ProteinModelPortaliQ96A84
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 106EMIPROSITE-ProRule annotationAdd BLAST74
Domaini179 – 368Collagen-likeAdd BLAST190

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiENOG410IXT5 Eukaryota
ENOG4111G7V LUCA
GeneTreeiENSGT00660000095314
HOGENOMiHOG000038011
HOVERGENiHBG051472
InParanoidiQ96A84
PhylomeDBiQ96A84
TreeFamiTF336589

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR011489 EMI_domain
PfamiView protein in Pfam
PF01391 Collagen, 3 hits
PF07546 EMI, 1 hit
PROSITEiView protein in PROSITE
PS51041 EMI, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96A84-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGPRAWALL CLGLLLPGGG AAWSIGAAPF SGRRNWCSYV VTRTISCHVQ
60 70 80 90 100
NGTYLQRVLQ NCPWPMSCPG SSYRTVVRPT YKVMYKIVTA REWRCCPGHS
110 120 130 140 150
GVSCEEASSA SLEPMWSGST MRRMALRPTA FSGCLNCSKV SELTERLKVL
160 170 180 190 200
EAKMTMLTVI EQPVPPTPAT PEDPAPLWGP PPAQGSPGDG GLQDQVGAWG
210 220 230 240 250
LPGPTGPKGD AGSRGPMGMR GPPGPQGPPG SPGRAGAVGT PGERGPPGPP
260 270 280 290 300
GPPGPPGPPA PVGPPHARIS QHGDPLLSNT FTETNNHWPQ GPTGPPGPPG
310 320 330 340 350
PMGPPGPPGP TGVPGSPGHI GPPGPTGPKG ISGHPGEKGE RGLRGEPGPQ
360 370 380 390 400
GSAGQRGEPG PKGDPGEKSH WGEGLHQLRE ALKILAERVL ILETMIGLYE
410 420 430 440
PELGSGAGPA GTGTPSLLRG KRGGHATNYR IVAPRSRDER G
Length:441
Mass (Da):45,292
Last modified:December 1, 2001 - v1
Checksum:i676D491C4083E18E
GO
Isoform 2 (identifier: Q96A84-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-73: Missing.

Note: May be due to a competing acceptor splice site.
Show »
Length:439
Mass (Da):45,042
Checksum:i7031515BF121D13C
GO
Isoform 3 (identifier: Q96A84-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-106: E → EVA

Note: May be due to a competing acceptor splice site.
Show »
Length:443
Mass (Da):45,463
Checksum:iF3588C50456978A2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019803107A → G1 PublicationCorresponds to variant dbSNP:rs743920Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00844572 – 73Missing in isoform 2. 1 Publication2
Alternative sequenceiVSP_011824106E → EVA in isoform 3. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ416090 mRNA Translation: CAC94777.1
CH471095 Genomic DNA Translation: EAW59776.1
AL031186 Genomic DNA No translation available.
Z95116 Genomic DNA No translation available.
BC046358 mRNA Translation: AAH46358.1
CR456407 mRNA Translation: CAG30293.1
CCDSiCCDS33630.1 [Q96A84-3]
RefSeqiNP_001254824.1, NM_001267895.1 [Q96A84-1]
NP_597712.2, NM_133455.3 [Q96A84-3]
UniGeneiHs.289106

Genome annotation databases

EnsembliENST00000334018; ENSP00000335481; ENSG00000186998 [Q96A84-3]
GeneIDi129080
KEGGihsa:129080
UCSCiuc003aem.5 human [Q96A84-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiEMID1_HUMAN
AccessioniPrimary (citable) accession number: Q96A84
Secondary accession number(s): B0QYK6, Q6ICG1, Q86SS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health