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Protein

Collagen alpha-1(XXVI) chain

Gene

COL26A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • positive regulation of cell-substrate adhesion Source: GO_Central

Enzyme and pathway databases

ReactomeiR-HSA-1442490 Collagen degradation
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-8948216 Collagen chain trimerization

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XXVI) chain
Alternative name(s):
Alpha-1 type XXVI collagen
EMI domain-containing protein 2
Emilin and multimerin domain-containing protein 2
Short name:
Emu2
Gene namesi
Name:COL26A1
Synonyms:EMID2, EMU2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000160963.13
HGNCiHGNC:18038 COL26A1
MIMi608927 gene
neXtProtiNX_Q96A83

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi136227
OpenTargetsiENSG00000160963
PharmGKBiPA134887081

Polymorphism and mutation databases

DMDMi37537825

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000000782521 – 441Collagen alpha-1(XXVI) chainAdd BLAST421

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 118PROSITE-ProRule annotation
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi83 ↔ 89PROSITE-ProRule annotation
Disulfide bondi117 ↔ 126PROSITE-ProRule annotation
Glycosylationi132N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Hydroxylated on proline residues.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PeptideAtlasiQ96A83
PRIDEiQ96A83
ProteomicsDBi75933
75934 [Q96A83-2]

PTM databases

iPTMnetiQ96A83
PhosphoSitePlusiQ96A83

Expressioni

Gene expression databases

BgeeiENSG00000160963 Expressed in 162 organ(s), highest expression level in islet of Langerhans
CleanExiHS_EMID2
GenevisibleiQ96A83 HS

Organism-specific databases

HPAiHPA027059

Interactioni

Subunit structurei

Homotrimer or heterotrimer.By similarity

Protein-protein interaction databases

BioGridi126448, 4 interactors
ComplexPortaliCPX-1767 Collagen type XXVI trimer
IntActiQ96A83, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ96A83
SMRiQ96A83
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 128EMIPROSITE-ProRule annotationAdd BLAST77
Domaini199 – 267Collagen-like 1Add BLAST69
Domaini302 – 355Collagen-like 2Add BLAST54

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

GeneTreeiENSGT00660000095314
HOGENOMiHOG000038011
HOVERGENiHBG096014
InParanoidiQ96A83
OMAiPPPWNED
OrthoDBiEOG091G0C3E
PhylomeDBiQ96A83

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR011489 EMI_domain
PfamiView protein in Pfam
PF01391 Collagen, 2 hits
PF07546 EMI, 1 hit
PROSITEiView protein in PROSITE
PS51041 EMI, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96A83-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLALLLPWA CCCLCGSALA TGFLYPFSAA ALQQHGYPEP GAGSPGSGYA
60 70 80 90 100
SRRHWCHHTV TRTVSCQVQN GSETVVQRVY QSCRWPGPCA NLVSYRTLIR
110 120 130 140 150
PTYRVSYRTV TVLEWRCCPG FTGSNCDEEC MNCTRLSDMS ERLTTLEAKV
160 170 180 190 200
LLLEAAERPS SPDNDLPAPE STPPTWNEDF LPDAIPLAHP VPRQRRPTGP
210 220 230 240 250
AGPPGQTGPP GPAGPPGSKG DRGQTGEKGP AGPPGLLGPP GPRGLPGEMG
260 270 280 290 300
RPGPPGPPGP AGNPGPSPNS PQGALYSLQP PTDKDNGDSR LASAIVDTVL
310 320 330 340 350
AGVPGPRGPP GPPGPPGPRG PPGPPGTPGS QGLAGERGTV GPSGEPGVKG
360 370 380 390 400
EEGEKAATAE GEGVQQLREA LKILAERVLI LEHMIGIHDP LASPEGGSGQ
410 420 430 440
DAALRANLKM KRGGAQPDGV LAALLGPDPG QKSVDQASSR K
Length:441
Mass (Da):45,381
Last modified:December 1, 2001 - v1
Checksum:i896CA2AC52B20E92
GO
Isoform 2 (identifier: Q96A83-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-95: Missing.

Note: May be due to a competing acceptor splice site.
Show »
Length:439
Mass (Da):45,131
Checksum:i9F13E4A77BA723D9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057530427P → L. Corresponds to variant dbSNP:rs17471501Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00844794 – 95Missing in isoform 2. 2 Publications2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ416091 mRNA Translation: CAC94778.1
AC004953 Genomic DNA No translation available.
AC004965 Genomic DNA No translation available.
AC006329 Genomic DNA No translation available.
BC109254 mRNA Translation: AAI09255.1
BC110393 mRNA Translation: AAI10394.1
CCDSiCCDS64739.1 [Q96A83-1]
RefSeqiNP_001265492.1, NM_001278563.2 [Q96A83-1]
NP_597714.2, NM_133457.4 [Q96A83-2]
UniGeneiHs.654854

Genome annotation databases

EnsembliENST00000313669; ENSP00000318234; ENSG00000160963 [Q96A83-1]
ENST00000613501; ENSP00000482102; ENSG00000160963 [Q96A83-2]
GeneIDi136227
KEGGihsa:136227
UCSCiuc033aas.1 human [Q96A83-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ416091 mRNA Translation: CAC94778.1
AC004953 Genomic DNA No translation available.
AC004965 Genomic DNA No translation available.
AC006329 Genomic DNA No translation available.
BC109254 mRNA Translation: AAI09255.1
BC110393 mRNA Translation: AAI10394.1
CCDSiCCDS64739.1 [Q96A83-1]
RefSeqiNP_001265492.1, NM_001278563.2 [Q96A83-1]
NP_597714.2, NM_133457.4 [Q96A83-2]
UniGeneiHs.654854

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AU2X-ray2.30E/F/G/H/I/J312-325[»]
4AU3X-ray2.78E/F/G/H/I/J309-326[»]
4BJ3X-ray3.04C/D/E308-326[»]
ProteinModelPortaliQ96A83
SMRiQ96A83
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126448, 4 interactors
ComplexPortaliCPX-1767 Collagen type XXVI trimer
IntActiQ96A83, 2 interactors

PTM databases

iPTMnetiQ96A83
PhosphoSitePlusiQ96A83

Polymorphism and mutation databases

DMDMi37537825

Proteomic databases

PeptideAtlasiQ96A83
PRIDEiQ96A83
ProteomicsDBi75933
75934 [Q96A83-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313669; ENSP00000318234; ENSG00000160963 [Q96A83-1]
ENST00000613501; ENSP00000482102; ENSG00000160963 [Q96A83-2]
GeneIDi136227
KEGGihsa:136227
UCSCiuc033aas.1 human [Q96A83-1]

Organism-specific databases

CTDi136227
DisGeNETi136227
EuPathDBiHostDB:ENSG00000160963.13
GeneCardsiCOL26A1
H-InvDBiHIX0033568
HGNCiHGNC:18038 COL26A1
HPAiHPA027059
MIMi608927 gene
neXtProtiNX_Q96A83
OpenTargetsiENSG00000160963
PharmGKBiPA134887081
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00660000095314
HOGENOMiHOG000038011
HOVERGENiHBG096014
InParanoidiQ96A83
OMAiPPPWNED
OrthoDBiEOG091G0C3E
PhylomeDBiQ96A83

Enzyme and pathway databases

ReactomeiR-HSA-1442490 Collagen degradation
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-8948216 Collagen chain trimerization

Miscellaneous databases

ChiTaRSiCOL26A1 human
GeneWikiiEMID2
GenomeRNAii136227
PROiPR:Q96A83
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160963 Expressed in 162 organ(s), highest expression level in islet of Langerhans
CleanExiHS_EMID2
GenevisibleiQ96A83 HS

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR011489 EMI_domain
PfamiView protein in Pfam
PF01391 Collagen, 2 hits
PF07546 EMI, 1 hit
PROSITEiView protein in PROSITE
PS51041 EMI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOQA1_HUMAN
AccessioniPrimary (citable) accession number: Q96A83
Secondary accession number(s): Q32M90
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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