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Protein

Protein mago nashi homolog 2

Gene

MAGOHB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in mRNA splicing and in the nonsense-mediated decay (NMD) pathway.By similarity

GO - Molecular functioni

GO - Biological processi

  • mRNA 3'-end processing Source: Reactome
  • mRNA export from nucleus Source: Reactome
  • mRNA splicing, via spliceosome Source: Reactome
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: HGNC
  • RNA export from nucleus Source: Reactome
  • RNA splicing Source: GO_Central

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing, mRNA transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
Protein mago nashi homolog 2
Gene namesi
Name:MAGOHB
Synonyms:MAGOH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111196.9
HGNCiHGNC:25504 MAGOHB
neXtProtiNX_Q96A72

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55110
OpenTargetsiENSG00000111196
PharmGKBiPA162394899

Polymorphism and mutation databases

BioMutaiMAGOHB
DMDMi74731095

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001741462 – 148Protein mago nashi homolog 2Add BLAST147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ96A72
MaxQBiQ96A72
PaxDbiQ96A72
PeptideAtlasiQ96A72
PRIDEiQ96A72
ProteomicsDBi75929
TopDownProteomicsiQ96A72

PTM databases

iPTMnetiQ96A72
PhosphoSitePlusiQ96A72

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000111196 Expressed in 171 organ(s), highest expression level in kidney
CleanExiHS_MAGOHB
ExpressionAtlasiQ96A72 baseline and differential
GenevisibleiQ96A72 HS

Organism-specific databases

HPAiHPA043036
HPA047754

Interactioni

Subunit structurei

Interacts with RBM8A and is part of the exon junction complex (EJC).By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi120420, 35 interactors
ComplexPortaliCPX-680 Exon junction subcomplex MAGOHB-Y14
CPX-682 Exon junction core complex, MAGOHB variant
IntActiQ96A72, 80 interactors
MINTiQ96A72
STRINGi9606.ENSP00000319240

Structurei

3D structure databases

ProteinModelPortaliQ96A72
SMRiQ96A72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mago nashi family.Curated

Phylogenomic databases

eggNOGiKOG3392 Eukaryota
ENOG4111FJ7 LUCA
GeneTreeiENSGT00390000003156
HOGENOMiHOG000207428
HOVERGENiHBG004353
InParanoidiQ96A72
KOiK12877
OMAiDRVGRQX
OrthoDBiEOG091G0UKA
PhylomeDBiQ96A72
TreeFamiTF300128

Family and domain databases

CDDicd11295 Mago_nashi, 1 hit
Gene3Di3.30.1560.10, 1 hit
InterProiView protein in InterPro
IPR004023 Mago_nashi
IPR036605 Mago_nashi_sf
PANTHERiPTHR12638 PTHR12638, 1 hit
PfamiView protein in Pfam
PF02792 Mago_nashi, 1 hit
SUPFAMiSSF89817 SSF89817, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q96A72-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVASDFYLR YYVGHKGKFG HEFLEFEFRP DGKLRYANNS NYKNDVMIRK
60 70 80 90 100
EAYVHKSVME ELKRIIDDSE ITKEDDALWP PPDRVGRQEL EIVIGDEHIS
110 120 130 140
FTTSKIGSLI DVNQSKDPEG LRVFYYLVQD LKCLVFSLIG LHFKIKPI
Length:148
Mass (Da):17,276
Last modified:December 1, 2001 - v1
Checksum:i0C7D8F79ACC09E39
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H6P7F5H6P7_HUMAN
Protein mago nashi homolog 2
MAGOHB
102Annotation score:
F5H6N1F5H6N1_HUMAN
Protein mago nashi homolog 2
MAGOHB
90Annotation score:
F5H3U9F5H3U9_HUMAN
Protein mago nashi homolog 2
MAGOHB
44Annotation score:
F5H124F5H124_HUMAN
Protein mago nashi homolog 2
MAGOHB
81Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036431119E → K in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF165518 mRNA Translation: AAF86648.1
AK001154 mRNA Translation: BAA91522.1
AK022720 mRNA Translation: BAB14202.1
BC010905 mRNA Translation: AAH10905.1
CCDSiCCDS8628.1
RefSeqiNP_001306914.1, NM_001319985.1
NP_060518.1, NM_018048.4
UniGeneiHs.104650

Genome annotation databases

EnsembliENST00000320756; ENSP00000319240; ENSG00000111196
GeneIDi55110
KEGGihsa:55110
UCSCiuc001qyq.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF165518 mRNA Translation: AAF86648.1
AK001154 mRNA Translation: BAA91522.1
AK022720 mRNA Translation: BAB14202.1
BC010905 mRNA Translation: AAH10905.1
CCDSiCCDS8628.1
RefSeqiNP_001306914.1, NM_001319985.1
NP_060518.1, NM_018048.4
UniGeneiHs.104650

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XJCelectron microscopy3.60v1-148[»]
5YZGelectron microscopy4.10v1-148[»]
ProteinModelPortaliQ96A72
SMRiQ96A72
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120420, 35 interactors
ComplexPortaliCPX-680 Exon junction subcomplex MAGOHB-Y14
CPX-682 Exon junction core complex, MAGOHB variant
IntActiQ96A72, 80 interactors
MINTiQ96A72
STRINGi9606.ENSP00000319240

PTM databases

iPTMnetiQ96A72
PhosphoSitePlusiQ96A72

Polymorphism and mutation databases

BioMutaiMAGOHB
DMDMi74731095

Proteomic databases

EPDiQ96A72
MaxQBiQ96A72
PaxDbiQ96A72
PeptideAtlasiQ96A72
PRIDEiQ96A72
ProteomicsDBi75929
TopDownProteomicsiQ96A72

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320756; ENSP00000319240; ENSG00000111196
GeneIDi55110
KEGGihsa:55110
UCSCiuc001qyq.3 human

Organism-specific databases

CTDi55110
DisGeNETi55110
EuPathDBiHostDB:ENSG00000111196.9
GeneCardsiMAGOHB
HGNCiHGNC:25504 MAGOHB
HPAiHPA043036
HPA047754
neXtProtiNX_Q96A72
OpenTargetsiENSG00000111196
PharmGKBiPA162394899
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3392 Eukaryota
ENOG4111FJ7 LUCA
GeneTreeiENSGT00390000003156
HOGENOMiHOG000207428
HOVERGENiHBG004353
InParanoidiQ96A72
KOiK12877
OMAiDRVGRQX
OrthoDBiEOG091G0UKA
PhylomeDBiQ96A72
TreeFamiTF300128

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRSiMAGOHB human
GenomeRNAii55110
PROiPR:Q96A72

Gene expression databases

BgeeiENSG00000111196 Expressed in 171 organ(s), highest expression level in kidney
CleanExiHS_MAGOHB
ExpressionAtlasiQ96A72 baseline and differential
GenevisibleiQ96A72 HS

Family and domain databases

CDDicd11295 Mago_nashi, 1 hit
Gene3Di3.30.1560.10, 1 hit
InterProiView protein in InterPro
IPR004023 Mago_nashi
IPR036605 Mago_nashi_sf
PANTHERiPTHR12638 PTHR12638, 1 hit
PfamiView protein in Pfam
PF02792 Mago_nashi, 1 hit
SUPFAMiSSF89817 SSF89817, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMGN2_HUMAN
AccessioniPrimary (citable) accession number: Q96A72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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