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UniProtKB - Q96A72 (MGN2_HUMAN)

Entry version 149 (07 Oct 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Protein mago nashi homolog 2

Gene

MAGOHB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961, PubMed:30705154). Plays a redundant role with MAGOH in the exon junction complex and in the nonsense-mediated decay (NMD) pathway (PubMed:23917022).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing, mRNA transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96A72

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72163, mRNA Splicing - Major Pathway
R-HSA-72187, mRNA 3'-end processing
R-HSA-73856, RNA Polymerase II Transcription Termination
R-HSA-9010553, Regulation of expression of SLITs and ROBOs
R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein mago nashi homolog 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAGOHB
Synonyms:MAGOH2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000111196.9

Human Gene Nomenclature Database

More...HGNCi		HGNC:25504, MAGOHB

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96A72

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55110

Open Targets

More...OpenTargetsi		ENSG00000111196

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162394899

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96A72, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MAGOHB

Domain mapping of disease mutations (DMDM)

More...DMDMi		74731095

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001741462 – 148Protein mago nashi homolog 2Add BLAST147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96A72

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96A72

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96A72

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96A72

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96A72

PeptideAtlas

More...PeptideAtlasi		Q96A72

PRoteomics IDEntifications database

More...PRIDEi		Q96A72

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75929

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q96A72

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96A72

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96A72

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q96A72

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000111196, Expressed in calcaneal tendon and 185 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96A72, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96A72, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000111196, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the pre-catalytic, catalytic and post-catalytic spliceosome complexes (PubMed:28502770, PubMed:29301961, PubMed:30705154). Heterodimer with RBM8A. Core component of the mRNA splicing-dependent exon junction complex (EJC); the core complex contains CASC3, EIF4A3, MAGOH or MAGOHB, and RBM8A (PubMed:23917022).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q96A72
With#Exp.IntAct
ADAMTSL4 - isoform 3 [Q6UY14-3]3EBI-746778,EBI-10173507
AMOTL2 [Q9Y2J4]4EBI-746778,EBI-746752
BEND7 - isoform 2 [Q8N7W2-2]3EBI-746778,EBI-10181188
CALCOCO2 [Q13137]6EBI-746778,EBI-739580
CARD10 [Q9BWT7]3EBI-746778,EBI-3866279
CCDC102B [Q68D86]6EBI-746778,EBI-10171570
CCDC106 [Q9BWC9]3EBI-746778,EBI-711501
DVL3 [Q92997]3EBI-746778,EBI-739789
EFHC2 [Q5JST6]3EBI-746778,EBI-2349927
FHL5 [Q5TD97]3EBI-746778,EBI-750641
FXR1 - isoform 2 [P51114-2]3EBI-746778,EBI-11022345
GNPDA2 - isoform 2 [Q8TDQ7-2]3EBI-746778,EBI-12197555
GOLGA2 [Q08379]6EBI-746778,EBI-618309
GPANK1 [O95872]3EBI-746778,EBI-751540
HMG20A [Q9NP66]4EBI-746778,EBI-740641
HSF2BP [O75031]3EBI-746778,EBI-7116203
IHO1 [Q8IYA8]3EBI-746778,EBI-8638439
IKZF1 - isoform Ik7 [Q13422-7]3EBI-746778,EBI-11522367
IKZF3 [Q9UKT9]7EBI-746778,EBI-747204
INCA1 [Q0VD86]3EBI-746778,EBI-6509505
KRT40 [Q6A162]3EBI-746778,EBI-10171697
KRT75 [O95678]3EBI-746778,EBI-2949715
KRTAP1-1 [Q07627]3EBI-746778,EBI-11959885
KRTAP13-2 [Q52LG2]3EBI-746778,EBI-11953846
LAS2 [Q8IYD9]3EBI-746778,EBI-749878
MID2 - isoform 2 [Q9UJV3-2]3EBI-746778,EBI-10172526
NDUFB7 [P17568]3EBI-746778,EBI-1246238
PARD6B [Q9BYG5]3EBI-746778,EBI-295391
PAX7 - isoform 2 [P23759-2]3EBI-746778,EBI-12859446
PBX4 [Q9BYU1]3EBI-746778,EBI-10302990
PKP2 - isoform 1 [Q99959-2]3EBI-746778,EBI-10987518
PRPH [P41219]3EBI-746778,EBI-752074
PRPSAP1 [Q14558]3EBI-746778,EBI-724449
PTPN21 [Q16825]3EBI-746778,EBI-2860264
RBAK [Q9NYW8]3EBI-746778,EBI-1210429
RBM8A [Q9Y5S9]12EBI-746778,EBI-447231
RBMX [P38159]3EBI-746778,EBI-743526
REL [Q04864]3EBI-746778,EBI-307352
REL - isoform 2 [Q04864-2]3EBI-746778,EBI-10829018
RUNDC3A [Q59EK9]3EBI-746778,EBI-747225
SNW1 [Q13573]3EBI-746778,EBI-632715
SPATA6 - isoform 2 [Q9NWH7-2]3EBI-746778,EBI-17860101
SPDYE4 [A6NLX3]5EBI-746778,EBI-12047907
STX11 [O75558]3EBI-746778,EBI-714135
TADA2A [O75478]3EBI-746778,EBI-742268
TCF4 [P15884]3EBI-746778,EBI-533224
TERF2IP [Q9NYB0]2EBI-746778,EBI-750109
THAP7 [Q9BT49]3EBI-746778,EBI-741350
TLE5 [Q08117]3EBI-746778,EBI-717810
TLE5 - isoform 2 [Q08117-2]3EBI-746778,EBI-11741437
TRA2A [Q13595]3EBI-746778,EBI-2685506
TRA2B [P62995]3EBI-746778,EBI-725485
TRIM27 [P14373]3EBI-746778,EBI-719493
TRIM42 [Q8IWZ5]3EBI-746778,EBI-5235829
ZBTB10 - isoform 3 [Q96DT7-3]3EBI-746778,EBI-12017160
ZBTB42 [B2RXF5]3EBI-746778,EBI-12287587
ZFP14 [Q9HCL3]3EBI-746778,EBI-6381556
ZFYVE1 [Q9HBF4]3EBI-746778,EBI-4401611
ZNF19 [P17023]3EBI-746778,EBI-12884200
ZNF250 - isoform 3 [P15622-3]3EBI-746778,EBI-10177272
ZNF398 [Q8TD17]6EBI-746778,EBI-8643207
ZNF426 [Q9BUY5]4EBI-746778,EBI-743265
ZNF438 [Q7Z4V0]3EBI-746778,EBI-11962468
ZNF446 - isoform 2 [Q9NWS9-2]3EBI-746778,EBI-740232
ZNF449 [Q6P9G9]3EBI-746778,EBI-10215956
ZNF547 [Q8IVP9]3EBI-746778,EBI-12895421
ZNF566 [Q969W8]3EBI-746778,EBI-2555762
ZNF57 [Q68EA5]3EBI-746778,EBI-8490788
ZNF620 [Q6ZNG0]3EBI-746778,EBI-4395669
ZNF774 [Q6NX45]3EBI-746778,EBI-10251462
ZNF835 [Q9Y2P0]3EBI-746778,EBI-5667516

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120420, 99 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-680, Exon junction subcomplex MAGOHB-Y14
CPX-682, Exon junction core complex, MAGOHB variant

Protein interaction database and analysis system

More...IntActi		Q96A72, 83 interactors

Molecular INTeraction database

More...MINTi		Q96A72

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000319240

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96A72, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1148
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96A72

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the mago nashi family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3392, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003156

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_109497_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96A72

KEGG Orthology (KO)

More...KOi		K12877

Identification of Orthologs from Complete Genome Data

More...OMAi		EDDTNWP

Database of Orthologous Groups

More...OrthoDBi		1373136at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96A72

TreeFam database of animal gene trees

More...TreeFami		TF300128

Family and domain databases

Conserved Domains Database

More...CDDi		cd11295, Mago_nashi, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.1560.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004023, Mago_nashi
IPR036605, Mago_nashi_sf

The PANTHER Classification System

More...PANTHERi		PTHR12638, PTHR12638, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02792, Mago_nashi, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF89817, SSF89817, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q96A72-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVASDFYLR YYVGHKGKFG HEFLEFEFRP DGKLRYANNS NYKNDVMIRK 
        60         70         80         90        100
EAYVHKSVME ELKRIIDDSE ITKEDDALWP PPDRVGRQEL EIVIGDEHIS 
       110        120        130        140 
FTTSKIGSLI DVNQSKDPEG LRVFYYLVQD LKCLVFSLIG LHFKIKPI
Length:148
Mass (Da):17,276
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0C7D8F79ACC09E39
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H3U9F5H3U9_HUMAN
Protein mago nashi homolog 2
MAGOHB
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H6P7F5H6P7_HUMAN
Protein mago nashi homolog 2
MAGOHB
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H6N1F5H6N1_HUMAN
Protein mago nashi homolog 2
MAGOHB
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H124F5H124_HUMAN
Protein mago nashi homolog 2
MAGOHB
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036431119E → K in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF165518 mRNA Translation: AAF86648.1
AK001154 mRNA Translation: BAA91522.1
AK022720 mRNA Translation: BAB14202.1
BC010905 mRNA Translation: AAH10905.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8628.1

NCBI Reference Sequences

More...RefSeqi		NP_001306914.1, NM_001319985.1
NP_060518.1, NM_018048.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000320756; ENSP00000319240; ENSG00000111196

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55110

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55110

UCSC genome browser

More...UCSCi		uc001qyq.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF165518 mRNA Translation: AAF86648.1
AK001154 mRNA Translation: BAA91522.1
AK022720 mRNA Translation: BAB14202.1
BC010905 mRNA Translation: AAH10905.1
CCDSiCCDS8628.1
RefSeqiNP_001306914.1, NM_001319985.1
NP_060518.1, NM_018048.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XJCelectron microscopy3.60v1-148[»]
5YZGelectron microscopy4.10v1-148[»]
6ICZelectron microscopy3.00v1-148[»]
6QDVelectron microscopy3.3095-145[»]
SMRiQ96A72
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120420, 99 interactors
ComplexPortaliCPX-680, Exon junction subcomplex MAGOHB-Y14
CPX-682, Exon junction core complex, MAGOHB variant
IntActiQ96A72, 83 interactors
MINTiQ96A72
STRINGi9606.ENSP00000319240

PTM databases

iPTMnetiQ96A72
PhosphoSitePlusiQ96A72
SwissPalmiQ96A72

Polymorphism and mutation databases

BioMutaiMAGOHB
DMDMi74731095

Proteomic databases

EPDiQ96A72
jPOSTiQ96A72
MassIVEiQ96A72
MaxQBiQ96A72
PaxDbiQ96A72
PeptideAtlasiQ96A72
PRIDEiQ96A72
ProteomicsDBi75929
TopDownProteomicsiQ96A72

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23361, 60 antibodies

Genome annotation databases

EnsembliENST00000320756; ENSP00000319240; ENSG00000111196
GeneIDi55110
KEGGihsa:55110
UCSCiuc001qyq.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55110
DisGeNETi55110
EuPathDBiHostDB:ENSG00000111196.9

GeneCards: human genes, protein and diseases

More...GeneCardsi		MAGOHB
HGNCiHGNC:25504, MAGOHB
HPAiENSG00000111196, Low tissue specificity
neXtProtiNX_Q96A72
OpenTargetsiENSG00000111196
PharmGKBiPA162394899

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3392, Eukaryota
GeneTreeiENSGT00390000003156
HOGENOMiCLU_109497_1_1_1
InParanoidiQ96A72
KOiK12877
OMAiEDDTNWP
OrthoDBi1373136at2759
PhylomeDBiQ96A72
TreeFamiTF300128

Enzyme and pathway databases

PathwayCommonsiQ96A72
ReactomeiR-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72163, mRNA Splicing - Major Pathway
R-HSA-72187, mRNA 3'-end processing
R-HSA-73856, RNA Polymerase II Transcription Termination
R-HSA-9010553, Regulation of expression of SLITs and ROBOs
R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55110, 36 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MAGOHB, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55110
PharosiQ96A72, Tdark

Protein Ontology

More...PROi		PR:Q96A72
RNActiQ96A72, protein

Gene expression databases

BgeeiENSG00000111196, Expressed in calcaneal tendon and 185 other tissues
ExpressionAtlasiQ96A72, baseline and differential
GenevisibleiQ96A72, HS

Family and domain databases

CDDicd11295, Mago_nashi, 1 hit
Gene3Di3.30.1560.10, 1 hit
InterProiView protein in InterPro
IPR004023, Mago_nashi
IPR036605, Mago_nashi_sf
PANTHERiPTHR12638, PTHR12638, 1 hit
PfamiView protein in Pfam
PF02792, Mago_nashi, 1 hit
SUPFAMiSSF89817, SSF89817, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMGN2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96A72
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: December 1, 2001
Last modified: October 7, 2020
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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