MAGOHB

Functionⁱ

Involved in mRNA splicing and in the nonsense-mediated decay (NMD) pathway.By similarity

GO - Molecular functionⁱ

RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA 3'-end processing Source: Reactome
mRNA export from nucleus Source: Reactome
mRNA splicing, via spliceosome Source: Reactome
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Source: HGNC
Inferred from genetic interactionⁱ
- 23917022
RNA export from nucleus Source: Reactome
RNA splicing
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding
Biological process	mRNA processing, mRNA splicing, mRNA transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72187 mRNA 3'-end processing R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Reactomeⁱ

R-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein mago nashi homolog 2
Gene namesⁱ	Name:MAGOHB Synonyms:MAGOH2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000111196.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25504 MAGOHB
neXtProtⁱ	NX_Q96A72

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	55110
Open Targets More...OpenTargetsⁱ	ENSG00000111196
PharmGKBⁱ	PA162394899

Polymorphism and mutation databases

BioMutaⁱ	MAGOHB
DMDMⁱ	74731095

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000174146	2 – 148	Protein mago nashi homolog 2Add BLAST		147

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineCombined sources1 Publication		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q96A72
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96A72
PaxDbⁱ	Q96A72
PeptideAtlas More...PeptideAtlasⁱ	Q96A72
PRIDEⁱ	Q96A72
ProteomicsDBⁱ	75929
TopDownProteomicsⁱ	Q96A72

PTM databases

iPTMnetⁱ	Q96A72
PhosphoSitePlusⁱ	Q96A72

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.

Gene expression databases

Bgeeⁱ	ENSG00000111196 Expressed in 171 organ(s), highest expression level in kidney
CleanExⁱ	HS_MAGOHB
ExpressionAtlasⁱ	Q96A72 baseline and differential
Genevisibleⁱ	Q96A72 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043036 HPA047754

HPAⁱ

HPA043036
HPA047754

Interactionⁱ

Subunit structureⁱ

Interacts with RBM8A and is part of the exon junction complex (EJC).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
AES	Q08117	3	EBI-746778,EBI-717810
AMOTL2	Q9Y2J4	3	EBI-746778,EBI-746752
CALCOCO2	Q13137	5	EBI-746778,EBI-739580
CCDC102B	Q68D86	5	EBI-746778,EBI-10171570
GOLGA2	Q08379	5	EBI-746778,EBI-618309
HMG20A	Q9NP66	3	EBI-746778,EBI-740641
IKZF3	Q9UKT9	6	EBI-746778,EBI-747204
KRT40	Q6A162	3	EBI-746778,EBI-10171697
MID2	Q9UJV3-2	3	EBI-746778,EBI-10172526
RBM8A	Q9Y5S9	9	EBI-746778,EBI-447231
RBMX	P38159	3	EBI-746778,EBI-743526
REL	Q04864	3	EBI-746778,EBI-307352
RUNDC3A	Q59EK9	3	EBI-746778,EBI-747225
TCF4	P15884	3	EBI-746778,EBI-533224
TERF2IP	Q9NYB0	2	EBI-746778,EBI-750109
TRIM42	Q8IWZ5	3	EBI-746778,EBI-5235829
ZNF250	P15622-3	3	EBI-746778,EBI-10177272
ZNF398	Q8TD17	5	EBI-746778,EBI-8643207

Protein-protein interaction databases

BioGridⁱ	120420, 35 interactors
ComplexPortalⁱ	CPX-680 Exon junction subcomplex MAGOHB-Y14 CPX-682 Exon junction core complex, MAGOHB variant
IntActⁱ	Q96A72, 80 interactors
Molecular INTeraction database More...MINTⁱ	Q96A72
STRINGⁱ	9606.ENSP00000319240

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96A72
SMRⁱ	Q96A72
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the mago nashi family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3392 Eukaryota ENOG4111FJ7 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003156
HOGENOMⁱ	HOG000207428
HOVERGENⁱ	HBG004353
InParanoidⁱ	Q96A72
KEGG Orthology (KO) More...KOⁱ	K12877
OMAⁱ	DRVGRQX
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0UKA
PhylomeDBⁱ	Q96A72
TreeFamⁱ	TF300128

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd11295 Mago_nashi, 1 hit
Gene3Dⁱ	3.30.1560.10, 1 hit
InterProⁱ	View protein in InterPro IPR004023 Mago_nashi IPR036605 Mago_nashi_sf
PANTHERⁱ	PTHR12638 PTHR12638, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02792 Mago_nashi, 1 hit
SUPFAMⁱ	SSF89817 SSF89817, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

Q96A72-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAVASDFYLR YYVGHKGKFG HEFLEFEFRP DGKLRYANNS NYKNDVMIRK 
        60         70         80         90        100
EAYVHKSVME ELKRIIDDSE ITKEDDALWP PPDRVGRQEL EIVIGDEHIS 
       110        120        130        140 
FTTSKIGSLI DVNQSKDPEG LRVFYYLVQD LKCLVFSLIG LHFKIKPI

Length:148

Mass (Da):17,276

Last modified:December 1, 2001 - v1

Checksum:ⁱ0C7D8F79ACC09E39

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5H6P7	F5H6P7_HUMAN	Protein mago nashi homolog 2 Protein mago nashi homolog 2	MAGOHB	102	Annotation score:
F5H6N1	F5H6N1_HUMAN	Protein mago nashi homolog 2 Protein mago nashi homolog 2	MAGOHB	90	Annotation score:
F5H3U9	F5H3U9_HUMAN	Protein mago nashi homolog 2 Protein mago nashi homolog 2	MAGOHB	44	Annotation score:
F5H124	F5H124_HUMAN	Protein mago nashi homolog 2 Protein mago nashi homolog 2	MAGOHB	81	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_036431	119	E → K in a breast cancer sample; somatic mutation. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF165518 mRNA Translation: AAF86648.1 AK001154 mRNA Translation: BAA91522.1 AK022720 mRNA Translation: BAB14202.1 BC010905 mRNA Translation: AAH10905.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8628.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001306914.1, NM_001319985.1 NP_060518.1, NM_018048.4
UniGeneⁱ	Hs.104650

Genome annotation databases

Ensemblⁱ	ENST00000320756; ENSP00000319240; ENSG00000111196
GeneIDⁱ	55110
KEGGⁱ	hsa:55110
UCSC genome browser More...UCSCⁱ	uc001qyq.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96A72	Mago nashi protein		HUMAN		148	UniRef100_Q96A72

Protein	Similar proteins		Species	Score	Length	Source
Q96A72	Protein mago nashi homolog		DANRE		147	UniRef90_Q96A72
Protein mago nashi homolog		SALSA		147
Protein mago nashi homolog		XENLA		146
Protein mago nashi homolog 2		MOUSE		146
Mago nashi protein		HUMAN		148
+116

Protein	Similar proteins		Species	Score	Length	Source
Q96A72	Protein mago nashi homolog		DANRE		147	UniRef50_Q96A72
Protein mago nashi homolog		SALSA		147
Protein mago nashi homolog 2		MOUSE		146
Protein mago nashi homolog		XENLA		146
Mago nashi protein		HUMAN		148
+124

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF165518 mRNA Translation: AAF86648.1 AK001154 mRNA Translation: BAA91522.1 AK022720 mRNA Translation: BAB14202.1 BC010905 mRNA Translation: AAH10905.1
CCDSⁱ	CCDS8628.1
RefSeqⁱ	NP_001306914.1, NM_001319985.1 NP_060518.1, NM_018048.4
UniGeneⁱ	Hs.104650

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5XJC	electron microscopy	3.60	v	1-148	[»]
	5YZG	electron microscopy	4.10	v	1-148	[»]
ProteinModelPortalⁱ	Q96A72
SMRⁱ	Q96A72
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120420, 35 interactors
ComplexPortalⁱ	CPX-680 Exon junction subcomplex MAGOHB-Y14 CPX-682 Exon junction core complex, MAGOHB variant
IntActⁱ	Q96A72, 80 interactors
MINTⁱ	Q96A72
STRINGⁱ	9606.ENSP00000319240

PTM databases

iPTMnetⁱ	Q96A72
PhosphoSitePlusⁱ	Q96A72

Polymorphism and mutation databases

BioMutaⁱ	MAGOHB
DMDMⁱ	74731095

Proteomic databases

EPDⁱ	Q96A72
MaxQBⁱ	Q96A72
PaxDbⁱ	Q96A72
PeptideAtlasⁱ	Q96A72
PRIDEⁱ	Q96A72
ProteomicsDBⁱ	75929
TopDownProteomicsⁱ	Q96A72

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000320756; ENSP00000319240; ENSG00000111196
GeneIDⁱ	55110
KEGGⁱ	hsa:55110
UCSCⁱ	uc001qyq.3 human

Organism-specific databases

CTDⁱ	55110
DisGeNETⁱ	55110
EuPathDBⁱ	HostDB:ENSG00000111196.9
GeneCardsⁱ	MAGOHB
HGNCⁱ	HGNC:25504 MAGOHB
HPAⁱ	HPA043036 HPA047754
neXtProtⁱ	NX_Q96A72
OpenTargetsⁱ	ENSG00000111196
PharmGKBⁱ	PA162394899
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3392 Eukaryota ENOG4111FJ7 LUCA
GeneTreeⁱ	ENSGT00390000003156
HOGENOMⁱ	HOG000207428
HOVERGENⁱ	HBG004353
InParanoidⁱ	Q96A72
KOⁱ	K12877
OMAⁱ	DRVGRQX
OrthoDBⁱ	EOG091G0UKA
PhylomeDBⁱ	Q96A72
TreeFamⁱ	TF300128

Enzyme and pathway databases

Reactomeⁱ	R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72187 mRNA 3'-end processing R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Reactomeⁱ

R-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRSⁱ	MAGOHB human
GenomeRNAiⁱ	55110
Protein Ontology More...PROⁱ	PR:Q96A72

Gene expression databases

Bgeeⁱ	ENSG00000111196 Expressed in 171 organ(s), highest expression level in kidney
CleanExⁱ	HS_MAGOHB
ExpressionAtlasⁱ	Q96A72 baseline and differential
Genevisibleⁱ	Q96A72 HS

Family and domain databases

CDDⁱ	cd11295 Mago_nashi, 1 hit
Gene3Dⁱ	3.30.1560.10, 1 hit
InterProⁱ	View protein in InterPro IPR004023 Mago_nashi IPR036605 Mago_nashi_sf
PANTHERⁱ	PTHR12638 PTHR12638, 1 hit
Pfamⁱ	View protein in Pfam PF02792 Mago_nashi, 1 hit
SUPFAMⁱ	SSF89817 SSF89817, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MGN2_HUMAN
Accessionⁱ	Q96A72Primary (citable) accession number: Q96A72
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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UniProtKB - Q96A72 (MGN2_HUMAN)

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Protein mago nashi homolog 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ