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Entry version 161 (22 Apr 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Antizyme inhibitor 2

Gene

AZIN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240). Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (PubMed:20188728).2 Publications

Caution

Was initially reported to have ornithine decarboxylase (PubMed:11587527) or arginine decarboxylase (PubMed:14738999) activities, but it was later found that the mouse ortholog does not possess either of them.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPolyamine biosynthesis, Transport
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS06971-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
4.1.1.17 2681
4.1.1.19 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-351143 Agmatine biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Antizyme inhibitor 2
Short name:
AzI2
Alternative name(s):
Arginine decarboxylase
Short name:
ADC
Short name:
ARGDC
Ornithine decarboxylase-like protein
Short name:
ODC-like protein
ornithine decarboxylase paralog
Short name:
ODC-p
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AZIN2
Synonyms:ADC, KIAA1945, ODCP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29957 AZIN2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608353 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96A70

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
113451

Open Targets

More...
OpenTargetsi
ENSG00000142920

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672642

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96A70 Tbio

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00125 Arginine
DB00114 Pyridoxal phosphate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AZIN2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
24636807

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001499441 – 460Antizyme inhibitor 2Add BLAST460

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated, leading to its proteasomal degradation; a process that is reduced in presence of antizymes. May also be degraded through the lysosomal degradative pathway in a proteasomal-independent manner.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei70Not modifiedBy similarity1

Keywords - PTMi

Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96A70

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96A70

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96A70

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96A70

PeptideAtlas

More...
PeptideAtlasi
Q96A70

PRoteomics IDEntifications database

More...
PRIDEi
Q96A70

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75924 [Q96A70-1]
75925 [Q96A70-2]
75926 [Q96A70-3]
75927 [Q96A70-4]
75928 [Q96A70-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96A70

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96A70

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the neocortex, thalamus, hippocampus, cerebellum, medulla oblongata, gray and white matter. Expressed in neurons, oligodendrocytes, basket, Purkinje and pyramidal cells. Expressed in spermatocytes and Leydig cells of the testis. Expressed in luteal theca cells lining corpus luteum cysts and in hilus cells of the ovary. Expressed in primary and neoplastic mast cells (MC) (at protein level). Highly expressed in brain. Also expressed in testis.5 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000142920 Expressed in testis and 160 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96A70 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96A70 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000142920 Tissue enhanced (brain, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

Interacts with OAZ1, OAZ2 and OAZ3; this interaction disrupts the interaction between the antizyme and ODC1. Does not form a heterodimer with ODC1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
125246, 14 interactors

Protein interaction database and analysis system

More...
IntActi
Q96A70, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000294517

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96A70 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96A70

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni117 – 140Necessary for polyamine uptake stimulationBy similarityAdd BLAST24

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus domain is necessary for its localization to the ER-Golgi intermediate compartment (ERGIC).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0622 Eukaryota
COG0019 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182995

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_026444_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96A70

KEGG Orthology (KO)

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KOi
K01583

Identification of Orthologs from Complete Genome Data

More...
OMAi
TPLSCGW

Database of Orthologous Groups

More...
OrthoDBi
725914at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96A70

TreeFam database of animal gene trees

More...
TreeFami
TF300760

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.37.10, 1 hit
3.20.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR031173 Azin2
IPR022643 De-COase2_C
IPR022657 De-COase2_CS
IPR022644 De-COase2_N
IPR022653 De-COase2_pyr-phos_BS
IPR000183 Orn/DAP/Arg_de-COase
IPR002433 Orn_de-COase
IPR029066 PLP-binding_barrel

The PANTHER Classification System

More...
PANTHERi
PTHR11482 PTHR11482, 1 hit
PTHR11482:SF4 PTHR11482:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PF00278 Orn_DAP_Arg_deC, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01179 ODADCRBXLASE
PR01182 ORNDCRBXLASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00878 ODR_DC_2_1, 1 hit
PS00879 ODR_DC_2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96A70-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGYLSESDF VMVEEGFSTR DLLKELTLGA SQATTDEVAA FFVADLGAIV
60 70 80 90 100
RKHFCFLKCL PRVRPFYAVK CNSSPGVLKV LAQLGLGFSC ANKAEMELVQ
110 120 130 140 150
HIGIPASKII CANPCKQIAQ IKYAAKHGIQ LLSFDNEMEL AKVVKSHPSA
160 170 180 190 200
KMVLCIATDD SHSLSCLSLK FGVSLKSCRH LLENAKKHHV EVVGVSFHIG
210 220 230 240 250
SGCPDPQAYA QSIADARLVF EMGTELGHKM HVLDLGGGFP GTEGAKVRFE
260 270 280 290 300
EIASVINSAL DLYFPEGCGV DIFAELGRYY VTSAFTVAVS IIAKKEVLLD
310 320 330 340 350
QPGREEENGS TSKTIVYHLD EGVYGIFNSV LFDNICPTPI LQKKPSTEQP
360 370 380 390 400
LYSSSLWGPA VDGCDCVAEG LWLPQLHVGD WLVFDNMGAY TVGMGSPFWG
410 420 430 440 450
TQACHITYAM SRVAWEALRR QLMAAEQEDD VEGVCKPLSC GWEITDTLCV
460
GPVFTPASIM
Length:460
Mass (Da):49,980
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0E00667CA4BB0B56
GO
Isoform 2 (identifier: Q96A70-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     305-305: E → EAPLPPPHIATCAASEPSPPA

Show »
Length:480
Mass (Da):51,886
Checksum:iDA50F0600F2EC947
GO
Isoform 3 (identifier: Q96A70-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     344-362: KPSTEQPLYSSSLWGPAVD → SKNHSPCYMSLESIHFIAV
     363-460: Missing.

Show »
Length:362
Mass (Da):39,357
Checksum:i39D276D8C9746B1C
GO
Isoform 4 (identifier: Q96A70-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-151: K → KFVQQRGTACLIR
     344-362: KPSTEQPLYSSSLWGPAVD → SKNHSPCYMSLESIHFIAV
     363-460: Missing.

Show »
Length:374
Mass (Da):40,730
Checksum:i85EDB219B7463152
GO
Isoform 6 (identifier: Q96A70-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-251: Missing.
     344-362: KPSTEQPLYSSSLWGPAVD → SKNHSPCYMSLESIHFIAV
     363-460: Missing.

Show »
Length:204
Mass (Da):22,300
Checksum:i2FB9097EBD4C9F69
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A499FIG4A0A499FIG4_HUMAN
Antizyme inhibitor 2
AZIN2
202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494BZU1A0A494BZU1_HUMAN
Antizyme inhibitor 2
AZIN2
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1 – 35MAGYL…SQATT → QQGSSVASTEPGSGTWKDHG WHAQGASWMGSHIHPLLVIQ in BAB85531 (PubMed:11853319).CuratedAdd BLAST35

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050611288A → S. Corresponds to variant dbSNP:rs16835244Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00375494 – 251Missing in isoform 6. 1 PublicationAdd BLAST158
Alternative sequenceiVSP_003755151K → KFVQQRGTACLIR in isoform 4. 1 Publication1
Alternative sequenceiVSP_003756305E → EAPLPPPHIATCAASEPSPP A in isoform 2. 1 Publication1
Alternative sequenceiVSP_003757344 – 362KPSTE…GPAVD → SKNHSPCYMSLESIHFIAV in isoform 3, isoform 4 and isoform 6. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_003758363 – 460Missing in isoform 3, isoform 4 and isoform 6. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY050634 mRNA Translation: AAL08049.1
AY050635 mRNA Translation: AAL08050.1
AY050636 mRNA Translation: AAL08051.1
AY050637 mRNA Translation: AAL08052.1
AY050638 mRNA Translation: AAL08053.1
AY325129 mRNA Translation: AAQ62560.1
AB075825 mRNA Translation: BAB85531.1
AK057051 mRNA Translation: BAB71356.1
AK095127 mRNA Translation: BAC04489.1
AK315677 mRNA Translation: BAG38042.1
AL020995 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07472.1
CH471059 Genomic DNA Translation: EAX07481.1
BC010449 mRNA Translation: AAH10449.1
BC028128 mRNA Translation: AAH28128.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS375.1 [Q96A70-1]
CCDS76138.1 [Q96A70-2]

NCBI Reference Sequences

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RefSeqi
NP_001280491.1, NM_001293562.1 [Q96A70-1]
NP_001288752.1, NM_001301823.1
NP_001288753.1, NM_001301824.1
NP_001288754.1, NM_001301825.1 [Q96A70-2]
NP_001288755.1, NM_001301826.1 [Q96A70-3]
NP_443724.1, NM_052998.3 [Q96A70-1]
XP_005270461.1, XM_005270404.2 [Q96A70-1]
XP_005270464.1, XM_005270407.1
XP_011538865.1, XM_011540563.1 [Q96A70-3]
XP_016855657.1, XM_017000168.1
XP_016855658.1, XM_017000169.1
XP_016855659.1, XM_017000170.1
XP_016855660.1, XM_017000171.1
XP_016855661.1, XM_017000172.1
XP_016855662.1, XM_017000173.1
XP_016855664.1, XM_017000175.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000294517; ENSP00000294517; ENSG00000142920 [Q96A70-1]
ENST00000373441; ENSP00000362540; ENSG00000142920 [Q96A70-2]
ENST00000373443; ENSP00000362542; ENSG00000142920 [Q96A70-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
113451

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:113451

UCSC genome browser

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UCSCi
uc001bwr.3 human [Q96A70-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050634 mRNA Translation: AAL08049.1
AY050635 mRNA Translation: AAL08050.1
AY050636 mRNA Translation: AAL08051.1
AY050637 mRNA Translation: AAL08052.1
AY050638 mRNA Translation: AAL08053.1
AY325129 mRNA Translation: AAQ62560.1
AB075825 mRNA Translation: BAB85531.1
AK057051 mRNA Translation: BAB71356.1
AK095127 mRNA Translation: BAC04489.1
AK315677 mRNA Translation: BAG38042.1
AL020995 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07472.1
CH471059 Genomic DNA Translation: EAX07481.1
BC010449 mRNA Translation: AAH10449.1
BC028128 mRNA Translation: AAH28128.1
CCDSiCCDS375.1 [Q96A70-1]
CCDS76138.1 [Q96A70-2]
RefSeqiNP_001280491.1, NM_001293562.1 [Q96A70-1]
NP_001288752.1, NM_001301823.1
NP_001288753.1, NM_001301824.1
NP_001288754.1, NM_001301825.1 [Q96A70-2]
NP_001288755.1, NM_001301826.1 [Q96A70-3]
NP_443724.1, NM_052998.3 [Q96A70-1]
XP_005270461.1, XM_005270404.2 [Q96A70-1]
XP_005270464.1, XM_005270407.1
XP_011538865.1, XM_011540563.1 [Q96A70-3]
XP_016855657.1, XM_017000168.1
XP_016855658.1, XM_017000169.1
XP_016855659.1, XM_017000170.1
XP_016855660.1, XM_017000171.1
XP_016855661.1, XM_017000172.1
XP_016855662.1, XM_017000173.1
XP_016855664.1, XM_017000175.1

3D structure databases

SMRiQ96A70
ModBaseiSearch...

Protein-protein interaction databases

BioGridi125246, 14 interactors
IntActiQ96A70, 10 interactors
STRINGi9606.ENSP00000294517

Chemistry databases

DrugBankiDB00125 Arginine
DB00114 Pyridoxal phosphate

PTM databases

iPTMnetiQ96A70
PhosphoSitePlusiQ96A70

Polymorphism and mutation databases

BioMutaiAZIN2
DMDMi24636807

Proteomic databases

jPOSTiQ96A70
MassIVEiQ96A70
MaxQBiQ96A70
PaxDbiQ96A70
PeptideAtlasiQ96A70
PRIDEiQ96A70
ProteomicsDBi75924 [Q96A70-1]
75925 [Q96A70-2]
75926 [Q96A70-3]
75927 [Q96A70-4]
75928 [Q96A70-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
31397 71 antibodies

The DNASU plasmid repository

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DNASUi
113451

Genome annotation databases

EnsembliENST00000294517; ENSP00000294517; ENSG00000142920 [Q96A70-1]
ENST00000373441; ENSP00000362540; ENSG00000142920 [Q96A70-2]
ENST00000373443; ENSP00000362542; ENSG00000142920 [Q96A70-1]
GeneIDi113451
KEGGihsa:113451
UCSCiuc001bwr.3 human [Q96A70-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
113451
DisGeNETi113451

GeneCards: human genes, protein and diseases

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GeneCardsi
AZIN2
HGNCiHGNC:29957 AZIN2
HPAiENSG00000142920 Tissue enhanced (brain, testis)
MIMi608353 gene
neXtProtiNX_Q96A70
OpenTargetsiENSG00000142920
PharmGKBiPA142672642

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0622 Eukaryota
COG0019 LUCA
GeneTreeiENSGT00950000182995
HOGENOMiCLU_026444_1_1_1
InParanoidiQ96A70
KOiK01583
OMAiTPLSCGW
OrthoDBi725914at2759
PhylomeDBiQ96A70
TreeFamiTF300760

Enzyme and pathway databases

BioCyciMetaCyc:HS06971-MONOMER
BRENDAi4.1.1.17 2681
4.1.1.19 2681
ReactomeiR-HSA-351143 Agmatine biosynthesis

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ADC_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
113451
PharosiQ96A70 Tbio

Protein Ontology

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PROi
PR:Q96A70
RNActiQ96A70 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000142920 Expressed in testis and 160 other tissues
ExpressionAtlasiQ96A70 baseline and differential
GenevisibleiQ96A70 HS

Family and domain databases

Gene3Di2.40.37.10, 1 hit
3.20.20.10, 1 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR031173 Azin2
IPR022643 De-COase2_C
IPR022657 De-COase2_CS
IPR022644 De-COase2_N
IPR022653 De-COase2_pyr-phos_BS
IPR000183 Orn/DAP/Arg_de-COase
IPR002433 Orn_de-COase
IPR029066 PLP-binding_barrel
PANTHERiPTHR11482 PTHR11482, 1 hit
PTHR11482:SF4 PTHR11482:SF4, 1 hit
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PF00278 Orn_DAP_Arg_deC, 1 hit
PRINTSiPR01179 ODADCRBXLASE
PR01182 ORNDCRBXLASE
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
PROSITEiView protein in PROSITE
PS00878 ODR_DC_2_1, 1 hit
PS00879 ODR_DC_2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAZIN2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96A70
Secondary accession number(s): B2RDU5
, D3DPQ9, Q5TIF4, Q5TIF5, Q5TIF6, Q8TF56, Q96L54, Q96L55, Q96L56, Q96L57, Q96MD9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: April 22, 2020
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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