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Protein

Antizyme inhibitor 2

Gene

AZIN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240). Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (PubMed:20188728).2 Publications

Caution

Was initially reported to have ornithine decarboxylase (PubMed:11587527) or arginine decarboxylase (PubMed:14738999) activities, but it was later found that the mouse ortholog does not possess either of them.2 Publications

GO - Molecular functioni

GO - Biological processi

  • agmatine biosynthetic process Source: Reactome
  • negative regulation of protein catabolic process Source: UniProtKB
  • positive regulation of catalytic activity Source: UniProtKB
  • positive regulation of polyamine transmembrane transport Source: UniProtKB
  • putrescine biosynthetic process from ornithine Source: GO_Central
  • putrescine transport Source: UniProtKB
  • spermatogenesis Source: UniProtKB
  • trans-Golgi network membrane organization Source: UniProtKB

Keywordsi

Biological processPolyamine biosynthesis, Transport
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:HS06971-MONOMER
BRENDAi4.1.1.17 2681
4.1.1.19 2681
ReactomeiR-HSA-351143 Agmatine biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Antizyme inhibitor 2
Short name:
AzI2
Alternative name(s):
Arginine decarboxylase
Short name:
ADC
Short name:
ARGDC
Ornithine decarboxylase-like protein
Short name:
ODC-like protein
ornithine decarboxylase paralog
Short name:
ODC-p
Gene namesi
Name:AZIN2
Synonyms:ADC, KIAA1945, ODCP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000142920.16
HGNCiHGNC:29957 AZIN2
MIMi608353 gene
neXtProtiNX_Q96A70

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi113451
OpenTargetsiENSG00000142920
PharmGKBiPA142672642

Chemistry databases

DrugBankiDB00125 L-Arginine
DB00114 Pyridoxal Phosphate

Polymorphism and mutation databases

BioMutaiADC
DMDMi24636807

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001499441 – 460Antizyme inhibitor 2Add BLAST460

Post-translational modificationi

Ubiquitinated, leading to its proteosomal degradation; a process that is reduced in presence of antizymes. May also be degraded through the lysosomal degradative pathway in a proteosomal-independent manner.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei70Not modifiedBy similarity1

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ96A70
PaxDbiQ96A70
PeptideAtlasiQ96A70
PRIDEiQ96A70
ProteomicsDBi75924
75925 [Q96A70-2]
75926 [Q96A70-3]
75927 [Q96A70-4]
75928 [Q96A70-5]

PTM databases

iPTMnetiQ96A70
PhosphoSitePlusiQ96A70

Expressioni

Tissue specificityi

Expressed in the neocortex, thalamus, hippocampus, cerebellum, medulla oblongata, gray and white matter. Expressed in neurons, oligodendrocytes, basket, Purkinje and pyramidal cells. Expressed in spermatocytes and Leydig cells of the testis. Expressed in luteal theca cells lining corpus luteum cysts and in hilus cells of the ovary. Expressed in primary and neoplastic mast cells (MC) (at protein level). Highly expressed in brain. Also expressed in testis.5 Publications

Gene expression databases

BgeeiENSG00000142920 Expressed in 161 organ(s), highest expression level in testis
GenevisibleiQ96A70 HS

Interactioni

Subunit structurei

Monomer. Interacts with OAZ1, OAZ2 and OAZ3; this interaction disrupts the interaction between the antizyme and ODC1. Does not form a heterodimer with ODC1.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi125246, 10 interactors
IntActiQ96A70, 1 interactor
STRINGi9606.ENSP00000294517

Structurei

3D structure databases

ProteinModelPortaliQ96A70
SMRiQ96A70
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni117 – 140Necessary for polyamine uptake stimulationBy similarityAdd BLAST24

Domaini

The N-terminus domain is necessary for its localization to the ER-Golgi intermediate compartment (ERGIC).By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0622 Eukaryota
COG0019 LUCA
GeneTreeiENSGT00390000011560
HOVERGENiHBG005456
InParanoidiQ96A70
KOiK01583
OMAiMCKPLSC
OrthoDBiEOG091G0AJV
PhylomeDBiQ96A70
TreeFamiTF300760

Family and domain databases

Gene3Di2.40.37.10, 1 hit
3.20.20.10, 1 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR031173 Azin2
IPR022643 De-COase2_C
IPR022657 De-COase2_CS
IPR022644 De-COase2_N
IPR022653 De-COase2_pyr-phos_BS
IPR000183 Orn/DAP/Arg_de-COase
IPR002433 Orn_de-COase
IPR029066 PLP-binding_barrel
PANTHERiPTHR11482 PTHR11482, 1 hit
PTHR11482:SF4 PTHR11482:SF4, 1 hit
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PF00278 Orn_DAP_Arg_deC, 1 hit
PRINTSiPR01179 ODADCRBXLASE
PR01182 ORNDCRBXLASE
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
PROSITEiView protein in PROSITE
PS00878 ODR_DC_2_1, 1 hit
PS00879 ODR_DC_2_2, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q96A70-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGYLSESDF VMVEEGFSTR DLLKELTLGA SQATTDEVAA FFVADLGAIV
60 70 80 90 100
RKHFCFLKCL PRVRPFYAVK CNSSPGVLKV LAQLGLGFSC ANKAEMELVQ
110 120 130 140 150
HIGIPASKII CANPCKQIAQ IKYAAKHGIQ LLSFDNEMEL AKVVKSHPSA
160 170 180 190 200
KMVLCIATDD SHSLSCLSLK FGVSLKSCRH LLENAKKHHV EVVGVSFHIG
210 220 230 240 250
SGCPDPQAYA QSIADARLVF EMGTELGHKM HVLDLGGGFP GTEGAKVRFE
260 270 280 290 300
EIASVINSAL DLYFPEGCGV DIFAELGRYY VTSAFTVAVS IIAKKEVLLD
310 320 330 340 350
QPGREEENGS TSKTIVYHLD EGVYGIFNSV LFDNICPTPI LQKKPSTEQP
360 370 380 390 400
LYSSSLWGPA VDGCDCVAEG LWLPQLHVGD WLVFDNMGAY TVGMGSPFWG
410 420 430 440 450
TQACHITYAM SRVAWEALRR QLMAAEQEDD VEGVCKPLSC GWEITDTLCV
460
GPVFTPASIM
Length:460
Mass (Da):49,980
Last modified:December 1, 2001 - v1
Checksum:i0E00667CA4BB0B56
GO
Isoform 2 (identifier: Q96A70-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     305-305: E → EAPLPPPHIATCAASEPSPPA

Show »
Length:480
Mass (Da):51,886
Checksum:iDA50F0600F2EC947
GO
Isoform 3 (identifier: Q96A70-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     344-362: KPSTEQPLYSSSLWGPAVD → SKNHSPCYMSLESIHFIAV
     363-460: Missing.

Show »
Length:362
Mass (Da):39,357
Checksum:i39D276D8C9746B1C
GO
Isoform 4 (identifier: Q96A70-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-151: K → KFVQQRGTACLIR
     344-362: KPSTEQPLYSSSLWGPAVD → SKNHSPCYMSLESIHFIAV
     363-460: Missing.

Show »
Length:374
Mass (Da):40,730
Checksum:i85EDB219B7463152
GO
Isoform 6 (identifier: Q96A70-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-251: Missing.
     344-362: KPSTEQPLYSSSLWGPAVD → SKNHSPCYMSLESIHFIAV
     363-460: Missing.

Show »
Length:204
Mass (Da):22,300
Checksum:i2FB9097EBD4C9F69
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 35MAGYL…SQATT → QQGSSVASTEPGSGTWKDHG WHAQGASWMGSHIHPLLVIQ in BAB85531 (PubMed:11853319).CuratedAdd BLAST35

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050611288A → S. Corresponds to variant dbSNP:rs16835244Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00375494 – 251Missing in isoform 6. 1 PublicationAdd BLAST158
Alternative sequenceiVSP_003755151K → KFVQQRGTACLIR in isoform 4. 1 Publication1
Alternative sequenceiVSP_003756305E → EAPLPPPHIATCAASEPSPP A in isoform 2. 1 Publication1
Alternative sequenceiVSP_003757344 – 362KPSTE…GPAVD → SKNHSPCYMSLESIHFIAV in isoform 3, isoform 4 and isoform 6. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_003758363 – 460Missing in isoform 3, isoform 4 and isoform 6. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050634 mRNA Translation: AAL08049.1
AY050635 mRNA Translation: AAL08050.1
AY050636 mRNA Translation: AAL08051.1
AY050637 mRNA Translation: AAL08052.1
AY050638 mRNA Translation: AAL08053.1
AY325129 mRNA Translation: AAQ62560.1
AB075825 mRNA Translation: BAB85531.1
AK057051 mRNA Translation: BAB71356.1
AK095127 mRNA Translation: BAC04489.1
AK315677 mRNA Translation: BAG38042.1
AL020995 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07472.1
CH471059 Genomic DNA Translation: EAX07481.1
BC010449 mRNA Translation: AAH10449.1
BC028128 mRNA Translation: AAH28128.1
CCDSiCCDS375.1 [Q96A70-1]
CCDS76138.1 [Q96A70-2]
RefSeqiNP_001280491.1, NM_001293562.1 [Q96A70-1]
NP_001288752.1, NM_001301823.1
NP_001288753.1, NM_001301824.1
NP_001288754.1, NM_001301825.1 [Q96A70-2]
NP_001288755.1, NM_001301826.1 [Q96A70-3]
NP_443724.1, NM_052998.3 [Q96A70-1]
XP_005270461.1, XM_005270404.2 [Q96A70-1]
XP_005270464.1, XM_005270407.1
XP_011538865.1, XM_011540563.1 [Q96A70-3]
XP_016855657.1, XM_017000168.1
XP_016855658.1, XM_017000169.1
XP_016855659.1, XM_017000170.1
XP_016855660.1, XM_017000171.1
XP_016855661.1, XM_017000172.1
XP_016855662.1, XM_017000173.1
XP_016855664.1, XM_017000175.1
UniGeneiHs.101807

Genome annotation databases

EnsembliENST00000294517; ENSP00000294517; ENSG00000142920 [Q96A70-1]
ENST00000373440; ENSP00000362539; ENSG00000142920 [Q96A70-5]
ENST00000373441; ENSP00000362540; ENSG00000142920 [Q96A70-2]
ENST00000373443; ENSP00000362542; ENSG00000142920 [Q96A70-1]
GeneIDi113451
KEGGihsa:113451
UCSCiuc001bwr.3 human [Q96A70-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050634 mRNA Translation: AAL08049.1
AY050635 mRNA Translation: AAL08050.1
AY050636 mRNA Translation: AAL08051.1
AY050637 mRNA Translation: AAL08052.1
AY050638 mRNA Translation: AAL08053.1
AY325129 mRNA Translation: AAQ62560.1
AB075825 mRNA Translation: BAB85531.1
AK057051 mRNA Translation: BAB71356.1
AK095127 mRNA Translation: BAC04489.1
AK315677 mRNA Translation: BAG38042.1
AL020995 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07472.1
CH471059 Genomic DNA Translation: EAX07481.1
BC010449 mRNA Translation: AAH10449.1
BC028128 mRNA Translation: AAH28128.1
CCDSiCCDS375.1 [Q96A70-1]
CCDS76138.1 [Q96A70-2]
RefSeqiNP_001280491.1, NM_001293562.1 [Q96A70-1]
NP_001288752.1, NM_001301823.1
NP_001288753.1, NM_001301824.1
NP_001288754.1, NM_001301825.1 [Q96A70-2]
NP_001288755.1, NM_001301826.1 [Q96A70-3]
NP_443724.1, NM_052998.3 [Q96A70-1]
XP_005270461.1, XM_005270404.2 [Q96A70-1]
XP_005270464.1, XM_005270407.1
XP_011538865.1, XM_011540563.1 [Q96A70-3]
XP_016855657.1, XM_017000168.1
XP_016855658.1, XM_017000169.1
XP_016855659.1, XM_017000170.1
XP_016855660.1, XM_017000171.1
XP_016855661.1, XM_017000172.1
XP_016855662.1, XM_017000173.1
XP_016855664.1, XM_017000175.1
UniGeneiHs.101807

3D structure databases

ProteinModelPortaliQ96A70
SMRiQ96A70
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125246, 10 interactors
IntActiQ96A70, 1 interactor
STRINGi9606.ENSP00000294517

Chemistry databases

DrugBankiDB00125 L-Arginine
DB00114 Pyridoxal Phosphate

PTM databases

iPTMnetiQ96A70
PhosphoSitePlusiQ96A70

Polymorphism and mutation databases

BioMutaiADC
DMDMi24636807

Proteomic databases

MaxQBiQ96A70
PaxDbiQ96A70
PeptideAtlasiQ96A70
PRIDEiQ96A70
ProteomicsDBi75924
75925 [Q96A70-2]
75926 [Q96A70-3]
75927 [Q96A70-4]
75928 [Q96A70-5]

Protocols and materials databases

DNASUi113451
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294517; ENSP00000294517; ENSG00000142920 [Q96A70-1]
ENST00000373440; ENSP00000362539; ENSG00000142920 [Q96A70-5]
ENST00000373441; ENSP00000362540; ENSG00000142920 [Q96A70-2]
ENST00000373443; ENSP00000362542; ENSG00000142920 [Q96A70-1]
GeneIDi113451
KEGGihsa:113451
UCSCiuc001bwr.3 human [Q96A70-1]

Organism-specific databases

CTDi113451
DisGeNETi113451
EuPathDBiHostDB:ENSG00000142920.16
GeneCardsiAZIN2
HGNCiHGNC:29957 AZIN2
MIMi608353 gene
neXtProtiNX_Q96A70
OpenTargetsiENSG00000142920
PharmGKBiPA142672642
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0622 Eukaryota
COG0019 LUCA
GeneTreeiENSGT00390000011560
HOVERGENiHBG005456
InParanoidiQ96A70
KOiK01583
OMAiMCKPLSC
OrthoDBiEOG091G0AJV
PhylomeDBiQ96A70
TreeFamiTF300760

Enzyme and pathway databases

BioCyciMetaCyc:HS06971-MONOMER
BRENDAi4.1.1.17 2681
4.1.1.19 2681
ReactomeiR-HSA-351143 Agmatine biosynthesis

Miscellaneous databases

GeneWikiiADC_(gene)
GenomeRNAii113451
PROiPR:Q96A70
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000142920 Expressed in 161 organ(s), highest expression level in testis
GenevisibleiQ96A70 HS

Family and domain databases

Gene3Di2.40.37.10, 1 hit
3.20.20.10, 1 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR031173 Azin2
IPR022643 De-COase2_C
IPR022657 De-COase2_CS
IPR022644 De-COase2_N
IPR022653 De-COase2_pyr-phos_BS
IPR000183 Orn/DAP/Arg_de-COase
IPR002433 Orn_de-COase
IPR029066 PLP-binding_barrel
PANTHERiPTHR11482 PTHR11482, 1 hit
PTHR11482:SF4 PTHR11482:SF4, 1 hit
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PF00278 Orn_DAP_Arg_deC, 1 hit
PRINTSiPR01179 ODADCRBXLASE
PR01182 ORNDCRBXLASE
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
PROSITEiView protein in PROSITE
PS00878 ODR_DC_2_1, 1 hit
PS00879 ODR_DC_2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAZIN2_HUMAN
AccessioniPrimary (citable) accession number: Q96A70
Secondary accession number(s): B2RDU5
, D3DPQ9, Q5TIF4, Q5TIF5, Q5TIF6, Q8TF56, Q96L54, Q96L55, Q96L56, Q96L57, Q96MD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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