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Protein

Exocyst complex component 4

Gene

EXOC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • PDZ domain binding Source: Ensembl
  • protein N-terminus binding Source: UniProtKB
  • Ral GTPase binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-264876 Insulin processing
R-HSA-5620916 VxPx cargo-targeting to cilium

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.F.2.1.2 the octameric exocyst (exocyst) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exocyst complex component 4
Alternative name(s):
Exocyst complex component Sec8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EXOC4
Synonyms:KIAA1699, SEC8, SEC8L1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000131558.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30389 EXOC4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608185 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96A65

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
60412

Open Targets

More...
OpenTargetsi
ENSG00000131558

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134944654

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EXOC4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
24418674

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001189342 – 974Exocyst complex component 4Add BLAST973

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei9N6-acetyllysineCombined sources1
Modified residuei32PhosphoserineCombined sources1
Modified residuei226PhosphoserineCombined sources1
Modified residuei233PhosphothreonineCombined sources1
Modified residuei237PhosphothreonineCombined sources1
Modified residuei468PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96A65

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96A65

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96A65

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96A65

PeptideAtlas

More...
PeptideAtlasi
Q96A65

PRoteomics IDEntifications database

More...
PRIDEi
Q96A65

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75923

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96A65

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96A65

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000131558 Expressed in 202 organ(s), highest expression level in corpus callosum

CleanEx database of gene expression profiles

More...
CleanExi
HS_EXOC4

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96A65 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031443
HPA031444

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with BIRC6/bruce. Interacts with MYRIP (By similarity). Interacts with SH3BP1; required for the localization of both SH3BP1 and the exocyst to the leading edge of migrating cells (PubMed:21658605).By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121906, 62 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q96A65

Database of interacting proteins

More...
DIPi
DIP-32976N

Protein interaction database and analysis system

More...
IntActi
Q96A65, 52 interactors

Molecular INTeraction database

More...
MINTi
Q96A65

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000253861

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q96A65

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96A65

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili32 – 114Sequence analysisAdd BLAST83

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEC8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3691 Eukaryota
ENOG410Z8N0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001439

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000044203

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG036151

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96A65

KEGG Orthology (KO)

More...
KOi
K06111

Identification of Orthologs from Complete Genome Data

More...
OMAi
KEHRRNA

Database of Orthologous Groups

More...
OrthoDBi
96167at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96A65

TreeFam database of animal gene trees

More...
TreeFami
TF313954

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039682 Sec8/EXOC4
IPR007191 Sec8_exocyst

The PANTHER Classification System

More...
PANTHERi
PTHR14146 PTHR14146, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04048 Sec8_exocyst, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96A65-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAEAAGGKY RSTVSKSKDP SGLLISVIRT LSTSDDVEDR ENEKGRLEEA
60 70 80 90 100
YEKCDRDLDE LIVQHYTELT TAIRTYQSIT ERITNSRNKI KQVKENLLSC
110 120 130 140 150
KMLLHCKRDE LRKLWIEGIE HKHVLNLLDE IENIKQVPQK LEQCMASKHY
160 170 180 190 200
LSATDMLVSA VESLEGPLLQ VEGLSDLRLE LHSKKMNLHL VLIDELHRHL
210 220 230 240 250
YIKSTSRVVQ RNKEKGKISS LVKDASVPLI DVTNLPTPRK FLDTSHYSTA
260 270 280 290 300
GSSSVREINL QDIKEDLELD PEENSTLFMG ILIKGLAKLK KIPETVKAII
310 320 330 340 350
ERLEQELKQI VKRSTTQVAD SGYQRGENVT VENQPRLLLE LLELLFDKFN
360 370 380 390 400
AVAAAHSVVL GYLQDTVVTP LTQQEDIKLY DMADVWVKIQ DVLQMLLTEY
410 420 430 440 450
LDMKNTRTAS EPSAQLSYAS TGREFAAFFA KKKPQRPKNS LFKFESSSHA
460 470 480 490 500
ISMSAYLREQ RRELYSRSGE LQGGPDDNLI EGGGTKFVCK PGARNITVIF
510 520 530 540 550
HPLLRFIQEI EHALGLGPAK QCPLREFLTV YIKNIFLNQV LAEINKEIEG
560 570 580 590 600
VTKTSDPLKI LANADTMKVL GVQRPLLQST IIVEKTVQDL LNLMHDLSAY
610 620 630 640 650
SDQFLNMVCV KLQEYKDTCT AAYRGIVQSE EKLVISASWA KDDDISRLLK
660 670 680 690 700
SLPNWMNMAQ PKQLRPKREE EEDFIRAAFG KESEVLIGNL GDKLIPPQDI
710 720 730 740 750
LRDVSDLKAL ANMHESLEWL ASRTKSAFSN LSTSQMLSPA QDSHTNTDLP
760 770 780 790 800
PVSEQIMQTL SELAKSFQDM ADRCLLVLHL EVRVHCFHYL IPLAKEGNYA
810 820 830 840 850
IVANVESMDY DPLVVKLNKD ISAIEEAMSA SLQQHKFQYI FEGLGHLISC
860 870 880 890 900
ILINGAQYFR RISESGIKKM CRNIFVLQQN LTNITMSREA DLDFARQYYE
910 920 930 940 950
MLYNTADELL NLVVDQGVKY TELEYIHALT LLHRSQTGVG ELTTQNTRLQ
960 970
RLKEIICEQA AIKQATKDKK ITTV
Length:974
Mass (Da):110,498
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i122CD929C2635786
GO
Isoform 2 (identifier: Q96A65-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     474-974: Missing.

Note: Gene prediction based on EST data.
Show »
Length:473
Mass (Da):53,857
Checksum:i22D54FC6F3334D88
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti293P → S in CAD39134 (PubMed:17974005).Curated1
Sequence conflicti338L → T in AAF66445 (Ref. 9) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036292220S → F in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036293599A → T in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs768209201Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_047159474 – 974Missing in isoform 2. CuratedAdd BLAST501

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF380839 mRNA Translation: AAK57456.1
AK022751 mRNA Translation: BAB14225.1
AK027688 mRNA Translation: BAB55298.1
AL831989 mRNA Translation: CAD89977.1
AL834475 mRNA Translation: CAD39134.1
AC007790 Genomic DNA No translation available.
AC009178 Genomic DNA No translation available.
AC009180 Genomic DNA No translation available.
AC009358 Genomic DNA No translation available.
AC024086 Genomic DNA No translation available.
AC083872 Genomic DNA No translation available.
AC083875 Genomic DNA No translation available.
AC093147 Genomic DNA No translation available.
CH236950 Genomic DNA Translation: EAL24073.1
CH471070 Genomic DNA Translation: EAW83804.1
AB051486 mRNA Translation: BAB21790.1
AF132734 mRNA Translation: AAF66445.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43648.1 [Q96A65-2]
CCDS5829.1 [Q96A65-1]

NCBI Reference Sequences

More...
RefSeqi
NP_068579.3, NM_021807.3 [Q96A65-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.321273

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000253861; ENSP00000253861; ENSG00000131558 [Q96A65-1]
ENST00000393161; ENSP00000376868; ENSG00000131558 [Q96A65-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
60412

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:60412

UCSC genome browser

More...
UCSCi
uc003vrj.4 human [Q96A65-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380839 mRNA Translation: AAK57456.1
AK022751 mRNA Translation: BAB14225.1
AK027688 mRNA Translation: BAB55298.1
AL831989 mRNA Translation: CAD89977.1
AL834475 mRNA Translation: CAD39134.1
AC007790 Genomic DNA No translation available.
AC009178 Genomic DNA No translation available.
AC009180 Genomic DNA No translation available.
AC009358 Genomic DNA No translation available.
AC024086 Genomic DNA No translation available.
AC083872 Genomic DNA No translation available.
AC083875 Genomic DNA No translation available.
AC093147 Genomic DNA No translation available.
CH236950 Genomic DNA Translation: EAL24073.1
CH471070 Genomic DNA Translation: EAW83804.1
AB051486 mRNA Translation: BAB21790.1
AF132734 mRNA Translation: AAF66445.1
CCDSiCCDS43648.1 [Q96A65-2]
CCDS5829.1 [Q96A65-1]
RefSeqiNP_068579.3, NM_021807.3 [Q96A65-1]
UniGeneiHs.321273

3D structure databases

ProteinModelPortaliQ96A65
SMRiQ96A65
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121906, 62 interactors
CORUMiQ96A65
DIPiDIP-32976N
IntActiQ96A65, 52 interactors
MINTiQ96A65
STRINGi9606.ENSP00000253861

Protein family/group databases

TCDBi1.F.2.1.2 the octameric exocyst (exocyst) family

PTM databases

iPTMnetiQ96A65
PhosphoSitePlusiQ96A65

Polymorphism and mutation databases

BioMutaiEXOC4
DMDMi24418674

Proteomic databases

EPDiQ96A65
jPOSTiQ96A65
MaxQBiQ96A65
PaxDbiQ96A65
PeptideAtlasiQ96A65
PRIDEiQ96A65
ProteomicsDBi75923

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
60412
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253861; ENSP00000253861; ENSG00000131558 [Q96A65-1]
ENST00000393161; ENSP00000376868; ENSG00000131558 [Q96A65-2]
GeneIDi60412
KEGGihsa:60412
UCSCiuc003vrj.4 human [Q96A65-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
60412
DisGeNETi60412
EuPathDBiHostDB:ENSG00000131558.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EXOC4
HGNCiHGNC:30389 EXOC4
HPAiHPA031443
HPA031444
MIMi608185 gene
neXtProtiNX_Q96A65
OpenTargetsiENSG00000131558
PharmGKBiPA134944654

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3691 Eukaryota
ENOG410Z8N0 LUCA
GeneTreeiENSGT00390000001439
HOGENOMiHOG000044203
HOVERGENiHBG036151
InParanoidiQ96A65
KOiK06111
OMAiKEHRRNA
OrthoDBi96167at2759
PhylomeDBiQ96A65
TreeFamiTF313954

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-264876 Insulin processing
R-HSA-5620916 VxPx cargo-targeting to cilium

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
EXOC4 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
EXOC4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
60412

Protein Ontology

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PROi
PR:Q96A65

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000131558 Expressed in 202 organ(s), highest expression level in corpus callosum
CleanExiHS_EXOC4
GenevisibleiQ96A65 HS

Family and domain databases

InterProiView protein in InterPro
IPR039682 Sec8/EXOC4
IPR007191 Sec8_exocyst
PANTHERiPTHR14146 PTHR14146, 1 hit
PfamiView protein in Pfam
PF04048 Sec8_exocyst, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEXOC4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96A65
Secondary accession number(s): E9PED2
, Q541U8, Q9C0G4, Q9H9K0, Q9P102
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: December 1, 2001
Last modified: January 16, 2019
This is version 165 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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