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Protein

Exocyst complex component 4

Gene

EXOC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.By similarity

GO - Molecular functioni

  • PDZ domain binding Source: Ensembl
  • protein N-terminus binding Source: UniProtKB
  • Ral GTPase binding Source: UniProtKB

GO - Biological processi

  • chemical synaptic transmission Source: GO_Central
  • exocytosis Source: GO_Central
  • Golgi to plasma membrane transport Source: GO_Central
  • paraxial mesoderm formation Source: Ensembl
  • protein targeting to membrane Source: GO_Central
  • regulation of macroautophagy Source: ParkinsonsUK-UCL
  • vesicle docking involved in exocytosis Source: InterPro

Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-264876 Insulin processing
R-HSA-5620916 VxPx cargo-targeting to cilium

Protein family/group databases

TCDBi1.F.2.1.2 the octameric exocyst (exocyst) family

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 4
Alternative name(s):
Exocyst complex component Sec8
Gene namesi
Name:EXOC4
Synonyms:KIAA1699, SEC8, SEC8L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000131558.14
HGNCiHGNC:30389 EXOC4
MIMi608185 gene
neXtProtiNX_Q96A65

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection

Pathology & Biotechi

Organism-specific databases

DisGeNETi60412
OpenTargetsiENSG00000131558
PharmGKBiPA134944654

Polymorphism and mutation databases

BioMutaiEXOC4
DMDMi24418674

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001189342 – 974Exocyst complex component 4Add BLAST973

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei9N6-acetyllysineCombined sources1
Modified residuei32PhosphoserineCombined sources1
Modified residuei226PhosphoserineCombined sources1
Modified residuei233PhosphothreonineCombined sources1
Modified residuei237PhosphothreonineCombined sources1
Modified residuei468PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96A65
MaxQBiQ96A65
PaxDbiQ96A65
PeptideAtlasiQ96A65
PRIDEiQ96A65
ProteomicsDBi75923

PTM databases

iPTMnetiQ96A65
PhosphoSitePlusiQ96A65

Expressioni

Gene expression databases

BgeeiENSG00000131558 Expressed in 202 organ(s), highest expression level in corpus callosum
CleanExiHS_EXOC4
GenevisibleiQ96A65 HS

Organism-specific databases

HPAiHPA031443
HPA031444

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with BIRC6/bruce. Interacts with MYRIP (By similarity). Interacts with SH3BP1; required for the localization of both SH3BP1 and the exocyst to the leading edge of migrating cells (PubMed:21658605).By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121906, 61 interactors
CORUMiQ96A65
DIPiDIP-32976N
IntActiQ96A65, 52 interactors
MINTiQ96A65
STRINGi9606.ENSP00000253861

Structurei

3D structure databases

ProteinModelPortaliQ96A65
SMRiQ96A65
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili32 – 114Sequence analysisAdd BLAST83

Sequence similaritiesi

Belongs to the SEC8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3691 Eukaryota
ENOG410Z8N0 LUCA
GeneTreeiENSGT00390000001439
HOGENOMiHOG000044203
HOVERGENiHBG036151
InParanoidiQ96A65
KOiK06111
OMAiKEHRRNA
OrthoDBiEOG091G0QUY
PhylomeDBiQ96A65
TreeFamiTF313954

Family and domain databases

InterProiView protein in InterPro
IPR039682 Sec8/EXOC4
IPR007191 Sec8_exocyst
PANTHERiPTHR14146 PTHR14146, 1 hit
PfamiView protein in Pfam
PF04048 Sec8_exocyst, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96A65-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAEAAGGKY RSTVSKSKDP SGLLISVIRT LSTSDDVEDR ENEKGRLEEA
60 70 80 90 100
YEKCDRDLDE LIVQHYTELT TAIRTYQSIT ERITNSRNKI KQVKENLLSC
110 120 130 140 150
KMLLHCKRDE LRKLWIEGIE HKHVLNLLDE IENIKQVPQK LEQCMASKHY
160 170 180 190 200
LSATDMLVSA VESLEGPLLQ VEGLSDLRLE LHSKKMNLHL VLIDELHRHL
210 220 230 240 250
YIKSTSRVVQ RNKEKGKISS LVKDASVPLI DVTNLPTPRK FLDTSHYSTA
260 270 280 290 300
GSSSVREINL QDIKEDLELD PEENSTLFMG ILIKGLAKLK KIPETVKAII
310 320 330 340 350
ERLEQELKQI VKRSTTQVAD SGYQRGENVT VENQPRLLLE LLELLFDKFN
360 370 380 390 400
AVAAAHSVVL GYLQDTVVTP LTQQEDIKLY DMADVWVKIQ DVLQMLLTEY
410 420 430 440 450
LDMKNTRTAS EPSAQLSYAS TGREFAAFFA KKKPQRPKNS LFKFESSSHA
460 470 480 490 500
ISMSAYLREQ RRELYSRSGE LQGGPDDNLI EGGGTKFVCK PGARNITVIF
510 520 530 540 550
HPLLRFIQEI EHALGLGPAK QCPLREFLTV YIKNIFLNQV LAEINKEIEG
560 570 580 590 600
VTKTSDPLKI LANADTMKVL GVQRPLLQST IIVEKTVQDL LNLMHDLSAY
610 620 630 640 650
SDQFLNMVCV KLQEYKDTCT AAYRGIVQSE EKLVISASWA KDDDISRLLK
660 670 680 690 700
SLPNWMNMAQ PKQLRPKREE EEDFIRAAFG KESEVLIGNL GDKLIPPQDI
710 720 730 740 750
LRDVSDLKAL ANMHESLEWL ASRTKSAFSN LSTSQMLSPA QDSHTNTDLP
760 770 780 790 800
PVSEQIMQTL SELAKSFQDM ADRCLLVLHL EVRVHCFHYL IPLAKEGNYA
810 820 830 840 850
IVANVESMDY DPLVVKLNKD ISAIEEAMSA SLQQHKFQYI FEGLGHLISC
860 870 880 890 900
ILINGAQYFR RISESGIKKM CRNIFVLQQN LTNITMSREA DLDFARQYYE
910 920 930 940 950
MLYNTADELL NLVVDQGVKY TELEYIHALT LLHRSQTGVG ELTTQNTRLQ
960 970
RLKEIICEQA AIKQATKDKK ITTV
Length:974
Mass (Da):110,498
Last modified:December 1, 2001 - v1
Checksum:i122CD929C2635786
GO
Isoform 2 (identifier: Q96A65-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     474-974: Missing.

Note: Gene prediction based on EST data.
Show »
Length:473
Mass (Da):53,857
Checksum:i22D54FC6F3334D88
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti293P → S in CAD39134 (PubMed:17974005).Curated1
Sequence conflicti338L → T in AAF66445 (Ref. 9) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036292220S → F in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036293599A → T in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs768209201Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047159474 – 974Missing in isoform 2. CuratedAdd BLAST501

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380839 mRNA Translation: AAK57456.1
AK022751 mRNA Translation: BAB14225.1
AK027688 mRNA Translation: BAB55298.1
AL831989 mRNA Translation: CAD89977.1
AL834475 mRNA Translation: CAD39134.1
AC007790 Genomic DNA No translation available.
AC009178 Genomic DNA No translation available.
AC009180 Genomic DNA No translation available.
AC009358 Genomic DNA No translation available.
AC024086 Genomic DNA No translation available.
AC083872 Genomic DNA No translation available.
AC083875 Genomic DNA No translation available.
AC093147 Genomic DNA No translation available.
CH236950 Genomic DNA Translation: EAL24073.1
CH471070 Genomic DNA Translation: EAW83804.1
AB051486 mRNA Translation: BAB21790.1
AF132734 mRNA Translation: AAF66445.1
CCDSiCCDS43648.1 [Q96A65-2]
CCDS5829.1 [Q96A65-1]
RefSeqiNP_068579.3, NM_021807.3 [Q96A65-1]
UniGeneiHs.321273

Genome annotation databases

EnsembliENST00000253861; ENSP00000253861; ENSG00000131558 [Q96A65-1]
ENST00000393161; ENSP00000376868; ENSG00000131558 [Q96A65-2]
GeneIDi60412
KEGGihsa:60412
UCSCiuc003vrj.4 human [Q96A65-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380839 mRNA Translation: AAK57456.1
AK022751 mRNA Translation: BAB14225.1
AK027688 mRNA Translation: BAB55298.1
AL831989 mRNA Translation: CAD89977.1
AL834475 mRNA Translation: CAD39134.1
AC007790 Genomic DNA No translation available.
AC009178 Genomic DNA No translation available.
AC009180 Genomic DNA No translation available.
AC009358 Genomic DNA No translation available.
AC024086 Genomic DNA No translation available.
AC083872 Genomic DNA No translation available.
AC083875 Genomic DNA No translation available.
AC093147 Genomic DNA No translation available.
CH236950 Genomic DNA Translation: EAL24073.1
CH471070 Genomic DNA Translation: EAW83804.1
AB051486 mRNA Translation: BAB21790.1
AF132734 mRNA Translation: AAF66445.1
CCDSiCCDS43648.1 [Q96A65-2]
CCDS5829.1 [Q96A65-1]
RefSeqiNP_068579.3, NM_021807.3 [Q96A65-1]
UniGeneiHs.321273

3D structure databases

ProteinModelPortaliQ96A65
SMRiQ96A65
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121906, 61 interactors
CORUMiQ96A65
DIPiDIP-32976N
IntActiQ96A65, 52 interactors
MINTiQ96A65
STRINGi9606.ENSP00000253861

Protein family/group databases

TCDBi1.F.2.1.2 the octameric exocyst (exocyst) family

PTM databases

iPTMnetiQ96A65
PhosphoSitePlusiQ96A65

Polymorphism and mutation databases

BioMutaiEXOC4
DMDMi24418674

Proteomic databases

EPDiQ96A65
MaxQBiQ96A65
PaxDbiQ96A65
PeptideAtlasiQ96A65
PRIDEiQ96A65
ProteomicsDBi75923

Protocols and materials databases

DNASUi60412
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253861; ENSP00000253861; ENSG00000131558 [Q96A65-1]
ENST00000393161; ENSP00000376868; ENSG00000131558 [Q96A65-2]
GeneIDi60412
KEGGihsa:60412
UCSCiuc003vrj.4 human [Q96A65-1]

Organism-specific databases

CTDi60412
DisGeNETi60412
EuPathDBiHostDB:ENSG00000131558.14
GeneCardsiEXOC4
HGNCiHGNC:30389 EXOC4
HPAiHPA031443
HPA031444
MIMi608185 gene
neXtProtiNX_Q96A65
OpenTargetsiENSG00000131558
PharmGKBiPA134944654
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3691 Eukaryota
ENOG410Z8N0 LUCA
GeneTreeiENSGT00390000001439
HOGENOMiHOG000044203
HOVERGENiHBG036151
InParanoidiQ96A65
KOiK06111
OMAiKEHRRNA
OrthoDBiEOG091G0QUY
PhylomeDBiQ96A65
TreeFamiTF313954

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-264876 Insulin processing
R-HSA-5620916 VxPx cargo-targeting to cilium

Miscellaneous databases

ChiTaRSiEXOC4 human
GeneWikiiEXOC4
GenomeRNAii60412
PROiPR:Q96A65
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131558 Expressed in 202 organ(s), highest expression level in corpus callosum
CleanExiHS_EXOC4
GenevisibleiQ96A65 HS

Family and domain databases

InterProiView protein in InterPro
IPR039682 Sec8/EXOC4
IPR007191 Sec8_exocyst
PANTHERiPTHR14146 PTHR14146, 1 hit
PfamiView protein in Pfam
PF04048 Sec8_exocyst, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEXOC4_HUMAN
AccessioniPrimary (citable) accession number: Q96A65
Secondary accession number(s): E9PED2
, Q541U8, Q9C0G4, Q9H9K0, Q9P102
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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