RERG

Functionⁱ

Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	13 – 20	GTP	8
Nucleotide bindingⁱ	60 – 64	GTP	5
Nucleotide bindingⁱ	118 – 121	GTP	4

GO - Molecular functionⁱ

estrogen receptor binding
Source: UniProtKB
Non-traceable author statementⁱ
- 11533059
GDP binding
Source: UniProtKB
Traceable author statementⁱ
- 11533059
GTPase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11533059
GTP binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of cell growth
Source: UniProtKB
Inferred from direct assayⁱ
- 11533059
negative regulation of cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 11533059
response to hormone
Source: UniProtKB
Inferred from direct assayⁱ
- 11533059
small GTPase mediated signal transduction
Source: UniProtKB
Non-traceable author statementⁱ
- 11533059

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	GTP-binding, Nucleotide-binding

Ligand

GTP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-related and estrogen-regulated growth inhibitor
Gene namesⁱ	Name:RERG
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000134533.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15980 RERG
MIMⁱ	612664 gene
neXtProtⁱ	NX_Q96A58

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	85004
Open Targets More...OpenTargetsⁱ	ENSG00000134533
PharmGKBⁱ	PA34333

Polymorphism and mutation databases

BioMutaⁱ	RERG
DMDMⁱ	74731090

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000082723	1 – 199	Ras-related and estrogen-regulated growth inhibitorAdd BLAST		199

Proteomic databases

EPDⁱ	Q96A58
PaxDbⁱ	Q96A58
PeptideAtlas More...PeptideAtlasⁱ	Q96A58
PRIDEⁱ	Q96A58
ProteomicsDBⁱ	75918 75919 [Q96A58-2]

PTM databases

iPTMnetⁱ	Q96A58
PhosphoSitePlusⁱ	Q96A58

Expressionⁱ

Tissue specificityⁱ

Detected in heart, brain, placenta, lung, liver, skin, kidney and pancreas. Detected in estrogen receptor-positive breast-derived cell lines, but not in estrogen receptor-negative cell lines. Expression is decreased or lost in a significant proportion of primary breast tumors with poor clinical prognosis.1 Publication

Inductionⁱ

Up-regulated by estradiol. Down-regulated by tamoxifen.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000134533 Expressed in 195 organ(s), highest expression level in epithelium of mammary gland
CleanExⁱ	HS_RERG
ExpressionAtlasⁱ	Q96A58 baseline and differential
Genevisibleⁱ	Q96A58 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA041387

HPAⁱ

HPA041387

Interactionⁱ

GO - Molecular functionⁱ

estrogen receptor binding
Source: UniProtKB
Non-traceable author statementⁱ
- 11533059

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	124423, 2 interactors
IntActⁱ	Q96A58, 1 interactor
STRINGⁱ	9606.ENSP00000256953

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	7 – 12	Combined sources	6
Helixⁱ	19 – 28	Combined sources	10
Beta strandⁱ	41 – 49	Combined sources	9
Beta strandⁱ	52 – 60	Combined sources	9
Helixⁱ	68 – 76	Combined sources	9
Beta strandⁱ	78 – 85	Combined sources	8
Helixⁱ	89 – 93	Combined sources	5
Helixⁱ	95 – 106	Combined sources	12
Beta strandⁱ	113 – 118	Combined sources	6
Helixⁱ	120 – 125	Combined sources	6
Helixⁱ	130 – 140	Combined sources	11
Beta strandⁱ	142 – 146	Combined sources	5
Turnⁱ	149 – 151	Combined sources	3
Helixⁱ	156 – 171	Combined sources	16

Show more details

3D structure databases

ProteinModelPortalⁱ	Q96A58
SMRⁱ	Q96A58
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q96A58

EvolutionaryTraceⁱ

Q96A58

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	168 – 171	Poly-Arg		4

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0395 Eukaryota COG1100 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00860000133678
HOGENOMⁱ	HOG000233973
HOVERGENⁱ	HBG009351
InParanoidⁱ	Q96A58
KEGG Orthology (KO) More...KOⁱ	K07855
OMAⁱ	MRWGDGF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0M6D
PhylomeDBⁱ	Q96A58
TreeFamⁱ	TF318030

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase IPR020849 Small_GTPase_Ras-type
PANTHERⁱ	PTHR24070 PTHR24070, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51421 RAS, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q96A58-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKSAEVKLA IFGRAGVGKS ALVVRFLTKR FIWEYDPTLE STYRHQATID 
        60         70         80         90        100
DEVVSMEILD TAGQEDTIQR EGHMRWGEGF VLVYDITDRG SFEEVLPLKN 
       110        120        130        140        150
ILDEIKKPKN VTLILVGNKA DLDHSRQVST EEGEKLATEL ACAFYECSAC 
       160        170        180        190 
TGEGNITEIF YELCREVRRR RMVQGKTRRR SSTTHVKQAI NKMLTKISS

Length:199

Mass (Da):22,608

Last modified:December 1, 2001 - v1

Checksum:ⁱ18A0F8BDD40CEAF0

GO

Isoform 2 (identifier: Q96A58-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
21-39: Missing.

« Hide

        10         20         30         40         50
MAKSAEVKLA IFGRAGVGKS ESTYRHQATI DDEVVSMEIL DTAGQEDTIQ 
        60         70         80         90        100
REGHMRWGEG FVLVYDITDR GSFEEVLPLK NILDEIKKPK NVTLILVGNK 
       110        120        130        140        150
ADLDHSRQVS TEEGEKLATE LACAFYECSA CTGEGNITEI FYELCREVRR 
       160        170        180
RRMVQGKTRR RSSTTHVKQA INKMLTKISS

Note: No experimental confirmation available.

Show »

Length:180

Mass (Da):20,258

Checksum:ⁱ7ED342E305E84D22

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5GWE9	F5GWE9_HUMAN	Ras-related and estrogen-regulated ... Ras-related and estrogen-regulated growth inhibitor	RERG	70	Annotation score:
F5H252	F5H252_HUMAN	Ras-related and estrogen-regulated ... Ras-related and estrogen-regulated growth inhibitor	RERG	113	Annotation score:
F5GYR1	F5GYR1_HUMAN	Ras-related and estrogen-regulated ... Ras-related and estrogen-regulated growth inhibitor	RERG	38	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_043393	21 – 39	Missing in isoform 2. 1 PublicationAdd BLAST		19

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF339750 mRNA Translation: AAK98530.1 AK295343 mRNA Translation: BAG58314.1 AK313881 mRNA Translation: BAG36607.1 AC007543 Genomic DNA No translation available. AC022334 Genomic DNA No translation available. AC092183 Genomic DNA No translation available. CH471094 Genomic DNA Translation: EAW96345.1 BC007997 mRNA Translation: AAH07997.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS53753.1 [Q96A58-2] CCDS8673.1 [Q96A58-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001177655.1, NM_001190726.1 [Q96A58-2] NP_116307.1, NM_032918.2 [Q96A58-1]
UniGeneⁱ	Hs.199487

Genome annotation databases

Ensemblⁱ	ENST00000256953; ENSP00000256953; ENSG00000134533 [Q96A58-1] ENST00000536465; ENSP00000438280; ENSG00000134533 [Q96A58-1] ENST00000538313; ENSP00000441505; ENSG00000134533 [Q96A58-1] ENST00000546331; ENSP00000444485; ENSG00000134533 [Q96A58-2]
GeneIDⁱ	85004
KEGGⁱ	hsa:85004
UCSC genome browser More...UCSCⁱ	uc001rcs.4 human [Q96A58-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q96A58	RAS-like, estrogen-regulated, growth inhibitor, isoform CRA_a		HUMAN		199	UniRef100_Q96A58
RAS like estrogen regulated growth inhibitor		MACMU		199
RAS like estrogen regulated growth inhibitor		RHIBE		199
RAS like estrogen regulated growth inhibitor		MACFA		199
RAS like estrogen regulated growth inhibitor		PONAB		199
+10
Q96A58-2	RERG isoform 3		PONAB		180	UniRef100_A0A2J8SQP6
Uncharacterized protein		COLAP		180
Uncharacterized protein		CERAT		180
Uncharacterized protein		RHIRO		180
Uncharacterized protein		PAPAN		180
+4

Protein	Similar proteins		Species	Score	Length	Source
Q96A58	Ras-related and estrogen-regulated growth inhibitor		BOVIN		199	UniRef90_Q96A58
RAS-like, estrogen-regulated, growth inhibitor, isoform CRA_a		HUMAN		199
RAS like estrogen regulated growth inhibitor		MACMU		199
RAS like estrogen regulated growth inhibitor		RHIBE		199
RAS like estrogen regulated growth inhibitor		MACFA		199
+71
Q96A58-2	Ras-related and estrogen-regulated growth inhibitor		MOUSE		180	UniRef90_E9PUF8
RAS like estrogen regulated growth inhibitor		PANTR		180
Uncharacterized protein		PANPA		180
Ras-related and estrogen-regulated growth inhibitor isoform 2		CALJA		180
Uncharacterized protein		PROCO		180
+32

Protein	Similar proteins		Species	Score	Length	Source
Q96A58	Ras-related and estrogen-regulated growth inhibitor		BOVIN		199	UniRef50_Q96A58
RAS-like, estrogen-regulated, growth inhibitor, isoform CRA_a		HUMAN		199
RAS like estrogen regulated growth inhibitor		MACMU		199
RAS like estrogen regulated growth inhibitor		RHIBE		199
RAS like estrogen regulated growth inhibitor		MACFA		199
+143
Q96A58-2	RAS like estrogen regulated growth inhibitor		ANOCA		180	UniRef50_G1KY71
Uncharacterized protein		TAKRU		189
Uncharacterized protein		XIPMA		186
Uncharacterized protein		BAMTH		184
Uncharacterized protein		BIOGL		188
+40

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF339750 mRNA Translation: AAK98530.1 AK295343 mRNA Translation: BAG58314.1 AK313881 mRNA Translation: BAG36607.1 AC007543 Genomic DNA No translation available. AC022334 Genomic DNA No translation available. AC092183 Genomic DNA No translation available. CH471094 Genomic DNA Translation: EAW96345.1 BC007997 mRNA Translation: AAH07997.1
CCDSⁱ	CCDS53753.1 [Q96A58-2] CCDS8673.1 [Q96A58-1]
RefSeqⁱ	NP_001177655.1, NM_001190726.1 [Q96A58-2] NP_116307.1, NM_032918.2 [Q96A58-1]
UniGeneⁱ	Hs.199487

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2ATV	X-ray	1.90	A	1-174	[»]
ProteinModelPortalⁱ	Q96A58
SMRⁱ	Q96A58
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	124423, 2 interactors
IntActⁱ	Q96A58, 1 interactor
STRINGⁱ	9606.ENSP00000256953

PTM databases

iPTMnetⁱ	Q96A58
PhosphoSitePlusⁱ	Q96A58

Polymorphism and mutation databases

BioMutaⁱ	RERG
DMDMⁱ	74731090

Proteomic databases

EPDⁱ	Q96A58
PaxDbⁱ	Q96A58
PeptideAtlasⁱ	Q96A58
PRIDEⁱ	Q96A58
ProteomicsDBⁱ	75918 75919 [Q96A58-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	85004
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000256953; ENSP00000256953; ENSG00000134533 [Q96A58-1] ENST00000536465; ENSP00000438280; ENSG00000134533 [Q96A58-1] ENST00000538313; ENSP00000441505; ENSG00000134533 [Q96A58-1] ENST00000546331; ENSP00000444485; ENSG00000134533 [Q96A58-2]
GeneIDⁱ	85004
KEGGⁱ	hsa:85004
UCSCⁱ	uc001rcs.4 human [Q96A58-1]

Organism-specific databases

CTDⁱ	85004
DisGeNETⁱ	85004
EuPathDBⁱ	HostDB:ENSG00000134533.6
GeneCardsⁱ	RERG
HGNCⁱ	HGNC:15980 RERG
HPAⁱ	HPA041387
MIMⁱ	612664 gene
neXtProtⁱ	NX_Q96A58
OpenTargetsⁱ	ENSG00000134533
PharmGKBⁱ	PA34333
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0395 Eukaryota COG1100 LUCA
GeneTreeⁱ	ENSGT00860000133678
HOGENOMⁱ	HOG000233973
HOVERGENⁱ	HBG009351
InParanoidⁱ	Q96A58
KOⁱ	K07855
OMAⁱ	MRWGDGF
OrthoDBⁱ	EOG091G0M6D
PhylomeDBⁱ	Q96A58
TreeFamⁱ	TF318030

Miscellaneous databases

ChiTaRSⁱ	RERG human
EvolutionaryTraceⁱ	Q96A58
GenomeRNAiⁱ	85004
Protein Ontology More...PROⁱ	PR:Q96A58
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000134533 Expressed in 195 organ(s), highest expression level in epithelium of mammary gland
CleanExⁱ	HS_RERG
ExpressionAtlasⁱ	Q96A58 baseline and differential
Genevisibleⁱ	Q96A58 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase IPR020849 Small_GTPase_Ras-type
PANTHERⁱ	PTHR24070 PTHR24070, 1 hit
Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51421 RAS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RERG_HUMAN
Accessionⁱ	Q96A58Primary (citable) accession number: Q96A58 Secondary accession number(s): B2R9R0, B4DI02
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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UniRef

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Supporting data

UniProtKB - Q96A58 (RERG_HUMAN)

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Ras-related and estrogen-regulated growth inhibitor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ