UniProtKB - Q96A58 (RERG_HUMAN)
Protein
Ras-related and estrogen-regulated growth inhibitor
Gene
RERG
Organism
Homo sapiens (Human)
Status
Functioni
Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential.1 Publication
Catalytic activityi
- EC:3.6.5.21 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 13 – 20 | GTP | 8 | |
Nucleotide bindingi | 60 – 64 | GTP | 5 | |
Nucleotide bindingi | 118 – 121 | GTP | 4 |
GO - Molecular functioni
- estrogen receptor binding Source: UniProtKB
- GDP binding Source: GO_Central
- GTPase activity Source: UniProtKB
- GTP binding Source: GO_Central
GO - Biological processi
- negative regulation of cell growth Source: UniProtKB
- negative regulation of cell population proliferation Source: UniProtKB
- Ras protein signal transduction Source: GO_Central
- response to hormone Source: UniProtKB
- small GTPase mediated signal transduction Source: UniProtKB
Keywordsi
Molecular function | Hydrolase |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q96A58 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:RERG |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000134533.6 |
HGNCi | HGNC:15980, RERG |
MIMi | 612664, gene |
neXtProti | NX_Q96A58 |
Subcellular locationi
Other locations
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: GO_Central
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 85004 |
OpenTargetsi | ENSG00000134533 |
PharmGKBi | PA34333 |
Miscellaneous databases
Pharosi | Q96A58, Tbio |
Polymorphism and mutation databases
BioMutai | RERG |
DMDMi | 74731090 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000082723 | 1 – 199 | Ras-related and estrogen-regulated growth inhibitorAdd BLAST | 199 |
Proteomic databases
EPDi | Q96A58 |
jPOSTi | Q96A58 |
MassIVEi | Q96A58 |
PaxDbi | Q96A58 |
PeptideAtlasi | Q96A58 |
PRIDEi | Q96A58 |
ProteomicsDBi | 75918 [Q96A58-1] 75919 [Q96A58-2] |
PTM databases
iPTMneti | Q96A58 |
PhosphoSitePlusi | Q96A58 |
Expressioni
Tissue specificityi
Detected in heart, brain, placenta, lung, liver, skin, kidney and pancreas. Detected in estrogen receptor-positive breast-derived cell lines, but not in estrogen receptor-negative cell lines. Expression is decreased or lost in a significant proportion of primary breast tumors with poor clinical prognosis.1 Publication
Inductioni
Up-regulated by estradiol. Down-regulated by tamoxifen.1 Publication
Gene expression databases
Bgeei | ENSG00000134533, Expressed in epithelium of mammary gland and 207 other tissues |
ExpressionAtlasi | Q96A58, baseline and differential |
Genevisiblei | Q96A58, HS |
Organism-specific databases
HPAi | ENSG00000134533, Tissue enhanced (endometrium) |
Interactioni
GO - Molecular functioni
- estrogen receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 124423, 2 interactors |
IntActi | Q96A58, 2 interactors |
STRINGi | 9606.ENSP00000256953 |
Miscellaneous databases
RNActi | Q96A58, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q96A58 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q96A58 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 168 – 171 | Poly-Arg | 4 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000159750 |
HOGENOMi | CLU_041217_9_7_1 |
InParanoidi | Q96A58 |
OMAi | AADMACA |
PhylomeDBi | Q96A58 |
TreeFami | TF318030 |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96A58-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAKSAEVKLA IFGRAGVGKS ALVVRFLTKR FIWEYDPTLE STYRHQATID
60 70 80 90 100
DEVVSMEILD TAGQEDTIQR EGHMRWGEGF VLVYDITDRG SFEEVLPLKN
110 120 130 140 150
ILDEIKKPKN VTLILVGNKA DLDHSRQVST EEGEKLATEL ACAFYECSAC
160 170 180 190
TGEGNITEIF YELCREVRRR RMVQGKTRRR SSTTHVKQAI NKMLTKISS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5GWE9 | F5GWE9_HUMAN | Ras-related and estrogen-regulated ... | RERG | 70 | Annotation score: | ||
F5H252 | F5H252_HUMAN | Ras-related and estrogen-regulated ... | RERG | 113 | Annotation score: | ||
F5GYR1 | F5GYR1_HUMAN | Ras-related and estrogen-regulated ... | RERG | 38 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043393 | 21 – 39 | Missing in isoform 2. 1 PublicationAdd BLAST | 19 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF339750 mRNA Translation: AAK98530.1 AK295343 mRNA Translation: BAG58314.1 AK313881 mRNA Translation: BAG36607.1 AC007543 Genomic DNA No translation available. AC022334 Genomic DNA No translation available. AC092183 Genomic DNA No translation available. CH471094 Genomic DNA Translation: EAW96345.1 BC007997 mRNA Translation: AAH07997.1 |
CCDSi | CCDS53753.1 [Q96A58-2] CCDS8673.1 [Q96A58-1] |
RefSeqi | NP_001177655.1, NM_001190726.1 [Q96A58-2] NP_116307.1, NM_032918.2 [Q96A58-1] |
Genome annotation databases
Ensembli | ENST00000256953; ENSP00000256953; ENSG00000134533 [Q96A58-1] ENST00000536465; ENSP00000438280; ENSG00000134533 [Q96A58-1] ENST00000538313; ENSP00000441505; ENSG00000134533 [Q96A58-1] ENST00000546331; ENSP00000444485; ENSG00000134533 [Q96A58-2] |
GeneIDi | 85004 |
KEGGi | hsa:85004 |
UCSCi | uc001rcs.4, human [Q96A58-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF339750 mRNA Translation: AAK98530.1 AK295343 mRNA Translation: BAG58314.1 AK313881 mRNA Translation: BAG36607.1 AC007543 Genomic DNA No translation available. AC022334 Genomic DNA No translation available. AC092183 Genomic DNA No translation available. CH471094 Genomic DNA Translation: EAW96345.1 BC007997 mRNA Translation: AAH07997.1 |
CCDSi | CCDS53753.1 [Q96A58-2] CCDS8673.1 [Q96A58-1] |
RefSeqi | NP_001177655.1, NM_001190726.1 [Q96A58-2] NP_116307.1, NM_032918.2 [Q96A58-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2ATV | X-ray | 1.90 | A | 1-174 | [»] | |
SMRi | Q96A58 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 124423, 2 interactors |
IntActi | Q96A58, 2 interactors |
STRINGi | 9606.ENSP00000256953 |
PTM databases
iPTMneti | Q96A58 |
PhosphoSitePlusi | Q96A58 |
Polymorphism and mutation databases
BioMutai | RERG |
DMDMi | 74731090 |
Proteomic databases
EPDi | Q96A58 |
jPOSTi | Q96A58 |
MassIVEi | Q96A58 |
PaxDbi | Q96A58 |
PeptideAtlasi | Q96A58 |
PRIDEi | Q96A58 |
ProteomicsDBi | 75918 [Q96A58-1] 75919 [Q96A58-2] |
Protocols and materials databases
Antibodypediai | 23714, 132 antibodies |
DNASUi | 85004 |
Genome annotation databases
Ensembli | ENST00000256953; ENSP00000256953; ENSG00000134533 [Q96A58-1] ENST00000536465; ENSP00000438280; ENSG00000134533 [Q96A58-1] ENST00000538313; ENSP00000441505; ENSG00000134533 [Q96A58-1] ENST00000546331; ENSP00000444485; ENSG00000134533 [Q96A58-2] |
GeneIDi | 85004 |
KEGGi | hsa:85004 |
UCSCi | uc001rcs.4, human [Q96A58-1] |
Organism-specific databases
CTDi | 85004 |
DisGeNETi | 85004 |
EuPathDBi | HostDB:ENSG00000134533.6 |
GeneCardsi | RERG |
HGNCi | HGNC:15980, RERG |
HPAi | ENSG00000134533, Tissue enhanced (endometrium) |
MIMi | 612664, gene |
neXtProti | NX_Q96A58 |
OpenTargetsi | ENSG00000134533 |
PharmGKBi | PA34333 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000159750 |
HOGENOMi | CLU_041217_9_7_1 |
InParanoidi | Q96A58 |
OMAi | AADMACA |
PhylomeDBi | Q96A58 |
TreeFami | TF318030 |
Enzyme and pathway databases
PathwayCommonsi | Q96A58 |
Miscellaneous databases
BioGRID-ORCSi | 85004, 4 hits in 846 CRISPR screens |
ChiTaRSi | RERG, human |
EvolutionaryTracei | Q96A58 |
GenomeRNAii | 85004 |
Pharosi | Q96A58, Tbio |
PROi | PR:Q96A58 |
RNActi | Q96A58, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000134533, Expressed in epithelium of mammary gland and 207 other tissues |
ExpressionAtlasi | Q96A58, baseline and differential |
Genevisiblei | Q96A58, HS |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RERG_HUMAN | |
Accessioni | Q96A58Primary (citable) accession number: Q96A58 Secondary accession number(s): B2R9R0, B4DI02 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 162 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM