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Protein

Tumor protein p53-inducible nuclear protein 1

Gene

TP53INP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Antioxidant
Biological processApoptosis, Autophagy, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
SIGNORiQ96A56

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor protein p53-inducible nuclear protein 1
Alternative name(s):
Stress-induced protein
p53-dependent damage-inducible nuclear protein 1
Short name:
p53DINP1
Gene namesi
Name:TP53INP1
Synonyms:P53DINP1, SIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000164938.13
HGNCiHGNC:18022 TP53INP1
MIMi606185 gene
neXtProtiNX_Q96A56

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi94241
OpenTargetsiENSG00000164938
PharmGKBiPA38278

Polymorphism and mutation databases

BioMutaiTP53INP1
DMDMi61216823

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724061 – 240Tumor protein p53-inducible nuclear protein 1Add BLAST240

Proteomic databases

PaxDbiQ96A56
PeptideAtlasiQ96A56
PRIDEiQ96A56
ProteomicsDBi75914
75915 [Q96A56-2]

PTM databases

iPTMnetiQ96A56
PhosphoSitePlusiQ96A56

Expressioni

Tissue specificityi

Ubiquitously expressed.2 Publications

Inductioni

By adriamycin, gamma irradiation and H2O2, in a p53/TP53-dependent way. At lower levels by UV irradiation. By TP73.2 Publications

Gene expression databases

BgeeiENSG00000164938 Expressed in 202 organ(s), highest expression level in female gonad
CleanExiHS_TP53INP1
ExpressionAtlasiQ96A56 baseline and differential
GenevisibleiQ96A56 HS

Organism-specific databases

HPAiHPA005856

Interactioni

Subunit structurei

Interacts with p53/TP53 and HIPK2. Interacts with PRKCG, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B AND MAP1LC3C.4 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi125152, 13 interactors
IntActiQ96A56, 7 interactors
STRINGi9606.ENSP00000344215

Structurei

3D structure databases

ProteinModelPortaliQ96A56
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi25 – 37LIRAdd BLAST13

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 17Poly-Ser4
Compositional biasi20 – 61Glu-richAdd BLAST42

Domaini

The LC3 interacting region (LIR) motif mediates interaction with GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B and MAP1LC3C.

Phylogenomic databases

eggNOGiENOG410IJ9V Eukaryota
ENOG4111S9D LUCA
GeneTreeiENSGT00530000063829
HOGENOMiHOG000010288
HOVERGENiHBG055647
InParanoidiQ96A56
KOiK15310
OMAiMFVGEVN
OrthoDBiEOG091G0FZC
PhylomeDBiQ96A56
TreeFamiTF333017

Family and domain databases

InterProiView protein in InterPro
IPR029431 TP53INP
IPR029556 TP53INP1
PANTHERiPTHR31671 PTHR31671, 1 hit
PTHR31671:SF0 PTHR31671:SF0, 1 hit
PfamiView protein in Pfam
PF14839 DOR, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96A56-1) [UniParc]FASTAAdd to basket
Also known as: p53DINP1a, alpha, SIP27, TEAP

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFQRLNKMFV GEVSSSSNQE PEFNEKEDDE WILVDFIDTC TGFSAEEEEE
60 70 80 90 100
EEDISEESPT EHPSVFSCLP ASLECLADTS DSCFLQFESC PMEESWFITP
110 120 130 140 150
PPCFTAGGLT TIKVETSPME NLLIEHPSMS VYAVHNSCPG LSEATRGTDE
160 170 180 190 200
LHSPSSPRVE AQNEMGQHIH CYVAALAAHT TFLEQPKSFR PSQWIKEHSE
210 220 230 240
RQPLNRNSLR RQNLTRDCHP RQVKHNGWVV HQPCPRQYNY
Length:240
Mass (Da):27,366
Last modified:December 1, 2001 - v1
Checksum:i1950D66EDDB4A186
GO
Isoform 2 (identifier: Q96A56-2) [UniParc]FASTAAdd to basket
Also known as: p53DINP1b, beta, SIP18

The sequence of this isoform differs from the canonical sequence as follows:
     159-240: VEAQNEMGQH...HQPCPRQYNY → ARKSCL

Show »
Length:164
Mass (Da):18,244
Checksum:i8C5B27F2CFB47B8E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05140475C → R. Corresponds to variant dbSNP:rs11991800Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013176159 – 240VEAQN…RQYNY → ARKSCL in isoform 2. 2 PublicationsAdd BLAST82

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017926 mRNA Translation: BAB62149.1
AB017927 mRNA Translation: BAB62150.1
AB062056 Genomic DNA Translation: BAB62151.1
AB062056 Genomic DNA Translation: BAB62152.1
AF409114 mRNA Translation: AAL04513.1
AF409115 mRNA Translation: AAL04514.1
AK315071 mRNA Translation: BAG37542.1
CH471060 Genomic DNA Translation: EAW91740.1
BC074813 mRNA Translation: AAH74813.1
BC074868 mRNA Translation: AAH74868.1
CCDSiCCDS47899.1 [Q96A56-2]
CCDS6265.1 [Q96A56-1]
RefSeqiNP_001129205.1, NM_001135733.1 [Q96A56-2]
NP_150601.1, NM_033285.3 [Q96A56-1]
XP_011515688.1, XM_011517386.2 [Q96A56-1]
UniGeneiHs.492261

Genome annotation databases

EnsembliENST00000342697; ENSP00000344215; ENSG00000164938 [Q96A56-1]
ENST00000448464; ENSP00000390063; ENSG00000164938 [Q96A56-2]
GeneIDi94241
KEGGihsa:94241
UCSCiuc003yhg.4 human [Q96A56-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017926 mRNA Translation: BAB62149.1
AB017927 mRNA Translation: BAB62150.1
AB062056 Genomic DNA Translation: BAB62151.1
AB062056 Genomic DNA Translation: BAB62152.1
AF409114 mRNA Translation: AAL04513.1
AF409115 mRNA Translation: AAL04514.1
AK315071 mRNA Translation: BAG37542.1
CH471060 Genomic DNA Translation: EAW91740.1
BC074813 mRNA Translation: AAH74813.1
BC074868 mRNA Translation: AAH74868.1
CCDSiCCDS47899.1 [Q96A56-2]
CCDS6265.1 [Q96A56-1]
RefSeqiNP_001129205.1, NM_001135733.1 [Q96A56-2]
NP_150601.1, NM_033285.3 [Q96A56-1]
XP_011515688.1, XM_011517386.2 [Q96A56-1]
UniGeneiHs.492261

3D structure databases

ProteinModelPortaliQ96A56
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125152, 13 interactors
IntActiQ96A56, 7 interactors
STRINGi9606.ENSP00000344215

PTM databases

iPTMnetiQ96A56
PhosphoSitePlusiQ96A56

Polymorphism and mutation databases

BioMutaiTP53INP1
DMDMi61216823

Proteomic databases

PaxDbiQ96A56
PeptideAtlasiQ96A56
PRIDEiQ96A56
ProteomicsDBi75914
75915 [Q96A56-2]

Protocols and materials databases

DNASUi94241
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342697; ENSP00000344215; ENSG00000164938 [Q96A56-1]
ENST00000448464; ENSP00000390063; ENSG00000164938 [Q96A56-2]
GeneIDi94241
KEGGihsa:94241
UCSCiuc003yhg.4 human [Q96A56-1]

Organism-specific databases

CTDi94241
DisGeNETi94241
EuPathDBiHostDB:ENSG00000164938.13
GeneCardsiTP53INP1
HGNCiHGNC:18022 TP53INP1
HPAiHPA005856
MIMi606185 gene
neXtProtiNX_Q96A56
OpenTargetsiENSG00000164938
PharmGKBiPA38278
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ9V Eukaryota
ENOG4111S9D LUCA
GeneTreeiENSGT00530000063829
HOGENOMiHOG000010288
HOVERGENiHBG055647
InParanoidiQ96A56
KOiK15310
OMAiMFVGEVN
OrthoDBiEOG091G0FZC
PhylomeDBiQ96A56
TreeFamiTF333017

Enzyme and pathway databases

ReactomeiR-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
SIGNORiQ96A56

Miscellaneous databases

ChiTaRSiTP53INP1 human
GeneWikiiTP53INP1
GenomeRNAii94241
PROiPR:Q96A56
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164938 Expressed in 202 organ(s), highest expression level in female gonad
CleanExiHS_TP53INP1
ExpressionAtlasiQ96A56 baseline and differential
GenevisibleiQ96A56 HS

Family and domain databases

InterProiView protein in InterPro
IPR029431 TP53INP
IPR029556 TP53INP1
PANTHERiPTHR31671 PTHR31671, 1 hit
PTHR31671:SF0 PTHR31671:SF0, 1 hit
PfamiView protein in Pfam
PF14839 DOR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT53I1_HUMAN
AccessioniPrimary (citable) accession number: Q96A56
Secondary accession number(s): B2RCE5, Q969R9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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