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Protein

Adiponectin receptor protein 1

Gene

ADIPOR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:25855295, PubMed:12802337). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi191Zinc1 Publication1
Metal bindingi337Zinc1 Publication1
Metal bindingi341Zinc1 Publication1

GO - Molecular functioni

  • adipokinetic hormone receptor activity Source: UniProtKB
  • adiponectin binding Source: UniProtKB
  • identical protein binding Source: Ensembl
  • metal ion binding Source: UniProtKB-KW
  • protein heterodimerization activity Source: Ensembl
  • protein kinase binding Source: BHF-UCL
  • signaling receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processFatty acid metabolism, Lipid metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-163680 AMPK inhibits chREBP transcriptional activation activity
SIGNORiQ96A54

Protein family/group databases

TCDBi1.C.113.1.9 the hly iii (hly iii) family

Names & Taxonomyi

Protein namesi
Recommended name:
Adiponectin receptor protein 11 Publication
Alternative name(s):
Progestin and adipoQ receptor family member 11 Publication
Progestin and adipoQ receptor family member I
Gene namesi
Name:ADIPOR1Imported
Synonyms:PAQR11 Publication, TESBP1A
ORF Names:CGI-45
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000159346.12
HGNCiHGNC:24040 ADIPOR1
MIMi607945 gene
neXtProtiNX_Q96A54

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 136Cytoplasmic1 PublicationAdd BLAST136
Transmembranei137 – 157Helical; Name=11 PublicationAdd BLAST21
Topological domaini158 – 170Extracellular1 PublicationAdd BLAST13
Transmembranei171 – 191Helical; Name=21 PublicationAdd BLAST21
Topological domaini192 – 203Cytoplasmic1 PublicationAdd BLAST12
Transmembranei204 – 224Helical; Name=31 PublicationAdd BLAST21
Topological domaini225 – 234Extracellular1 Publication10
Transmembranei235 – 255Helical; Name=41 PublicationAdd BLAST21
Topological domaini256 – 264Cytoplasmic1 Publication9
Transmembranei265 – 285Helical; Name=51 PublicationAdd BLAST21
Topological domaini286 – 298Extracellular1 PublicationAdd BLAST13
Transmembranei299 – 319Helical; Name=61 PublicationAdd BLAST21
Topological domaini320 – 337Cytoplasmic1 PublicationAdd BLAST18
Transmembranei338 – 358Helical; Name=71 PublicationAdd BLAST21
Topological domaini359 – 375Extracellular1 PublicationAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi161 – 167MYFMAPL → SGSSGGS: Decreases activation of AMPK in response to ADIPOQ binding; when associated with 229-G--G-231 and 291-S--S-297. 1 Publication7
Mutagenesisi191H → A: Decreases activation of AMPK in response to ADIPOQ binding; when associated with A-208; A-337 and A-341. 1 Publication1
Mutagenesisi208D → A: Decreases activation of AMPK in response to ADIPOQ binding; when associated with A-191; A-337 and A-341. 1 Publication1
Mutagenesisi229 – 231YCS → GGG: Decreases activation of AMPK in response to ADIPOQ binding; when associated with 161-S--S-167 and 291-S--S-297. 1 Publication3
Mutagenesisi291 – 297FVKATTV → SSSGGGS: Decreases activation of AMPK in response to ADIPOQ binding; when associated with 161-S--S-167 and 229-G--G-231. 1 Publication7
Mutagenesisi337H → A: Decreases activation of AMPK in response to ADIPOQ binding; when associated with A-191; A-208 and A-341. 1 Publication1
Mutagenesisi341H → A: Decreases activation of AMPK in response to ADIPOQ binding; when associated with A-191; A-208 and A-337. 1 Publication1

Organism-specific databases

DisGeNETi51094
OpenTargetsiENSG00000159346
PharmGKBiPA134861801

Chemistry databases

ChEMBLiCHEMBL3392946

Polymorphism and mutation databases

BioMutaiADIPOR1
DMDMi38372248

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002188271 – 375Adiponectin receptor protein 1Add BLAST375

Proteomic databases

EPDiQ96A54
MaxQBiQ96A54
PaxDbiQ96A54
PeptideAtlasiQ96A54
PRIDEiQ96A54
ProteomicsDBi75913

PTM databases

iPTMnetiQ96A54
PhosphoSitePlusiQ96A54

Expressioni

Tissue specificityi

Widely expressed (PubMed:16044242). Highly expressed in heart and skeletal muscle (PubMed:12802337). Expressed at intermediate level in brain, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes (PubMed:12802337). Weakly expressed in colon, thymus and small intestine (PubMed:12802337).2 Publications

Gene expression databases

BgeeiENSG00000159346 Expressed in 226 organ(s), highest expression level in blood
CleanExiHS_ADIPOR1
ExpressionAtlasiQ96A54 baseline and differential
GenevisibleiQ96A54 HS

Interactioni

Subunit structurei

May form homooligomers and heterooligomers with ADIPOR2.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119283, 25 interactors
DIPiDIP-48622N
IntActiQ96A54, 10 interactors
MINTiQ96A54
STRINGi9606.ENSP00000341785

Chemistry databases

BindingDBiQ96A54

Structurei

Secondary structure

1375
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ96A54
SMRiQ96A54
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminus is cytoplasmic and the C-terminus is extracellular, contrary to what is observed for G-protein coupled receptors. Unlike G-protein coupled receptors, transmembrane helices are not kinked or tilted relative to the plane of the membrane.1 Publication

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0748 Eukaryota
COG1272 LUCA
GeneTreeiENSGT00530000062926
HOGENOMiHOG000197115
HOVERGENiHBG013916
InParanoidiQ96A54
KOiK07297
OMAiDYCGIAM
OrthoDBiEOG091G04EU
PhylomeDBiQ96A54
TreeFamiTF313640

Family and domain databases

InterProiView protein in InterPro
IPR004254 AdipoR/HlyIII-related
PANTHERiPTHR20855 PTHR20855, 1 hit
PfamiView protein in Pfam
PF03006 HlyIII, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q96A54-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSHKGSVVA QGNGAPASNR EADTVELAEL GPLLEEKGKR VIANPPKAEE
60 70 80 90 100
EQTCPVPQEE EEEVRVLTLP LQAHHAMEKM EEFVYKVWEG RWRVIPYDVL
110 120 130 140 150
PDWLKDNDYL LHGHRPPMPS FRACFKSIFR IHTETGNIWT HLLGFVLFLF
160 170 180 190 200
LGILTMLRPN MYFMAPLQEK VVFGMFFLGA VLCLSFSWLF HTVYCHSEKV
210 220 230 240 250
SRTFSKLDYS GIALLIMGSF VPWLYYSFYC SPQPRLIYLS IVCVLGISAI
260 270 280 290 300
IVAQWDRFAT PKHRQTRAGV FLGLGLSGVV PTMHFTIAEG FVKATTVGQM
310 320 330 340 350
GWFFLMAVMY ITGAGLYAAR IPERFFPGKF DIWFQSHQIF HVLVVAAAFV
360 370
HFYGVSNLQE FRYGLEGGCT DDTLL
Length:375
Mass (Da):42,616
Last modified:December 1, 2001 - v1
Checksum:i1CC0300A7D178EB0
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J0W7C9J0W7_HUMAN
Adiponectin receptor protein 1
ADIPOR1
205Annotation score:
C9JNM5C9JNM5_HUMAN
Adiponectin receptor protein 1
ADIPOR1
266Annotation score:
F8W782F8W782_HUMAN
Adiponectin receptor protein 1
ADIPOR1
171Annotation score:

Sequence cautioni

The sequence AAD34040 differs from that shown. Reason: Frameshift at position 369.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti183C → W in BAG50922 (PubMed:14702039).Curated1
Sequence conflicti340F → Y in BAD96223 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424279 mRNA Translation: AAR08367.1
AF125179 mRNA Translation: AAQ13552.1
AF151803 mRNA Translation: AAD34040.1 Frameshift.
AK001484 mRNA Translation: BAG50922.1
AK222503 mRNA Translation: BAD96223.1
CH471067 Genomic DNA Translation: EAW91450.1
BC001594 mRNA Translation: AAH01594.1
BC010743 mRNA Translation: AAH10743.1
CCDSiCCDS1430.1
RefSeqiNP_001277482.1, NM_001290553.1
NP_001277486.1, NM_001290557.1
NP_001277558.1, NM_001290629.1
NP_057083.2, NM_015999.5
UniGeneiHs.5298
Hs.713729

Genome annotation databases

EnsembliENST00000340990; ENSP00000341785; ENSG00000159346
GeneIDi51094
KEGGihsa:51094
UCSCiuc001gyq.7 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424279 mRNA Translation: AAR08367.1
AF125179 mRNA Translation: AAQ13552.1
AF151803 mRNA Translation: AAD34040.1 Frameshift.
AK001484 mRNA Translation: BAG50922.1
AK222503 mRNA Translation: BAD96223.1
CH471067 Genomic DNA Translation: EAW91450.1
BC001594 mRNA Translation: AAH01594.1
BC010743 mRNA Translation: AAH10743.1
CCDSiCCDS1430.1
RefSeqiNP_001277482.1, NM_001290553.1
NP_001277486.1, NM_001290557.1
NP_001277558.1, NM_001290629.1
NP_057083.2, NM_015999.5
UniGeneiHs.5298
Hs.713729

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WXVX-ray2.90A89-375[»]
5LXGX-ray2.73A89-375[»]
ProteinModelPortaliQ96A54
SMRiQ96A54
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119283, 25 interactors
DIPiDIP-48622N
IntActiQ96A54, 10 interactors
MINTiQ96A54
STRINGi9606.ENSP00000341785

Chemistry databases

BindingDBiQ96A54
ChEMBLiCHEMBL3392946

Protein family/group databases

TCDBi1.C.113.1.9 the hly iii (hly iii) family

PTM databases

iPTMnetiQ96A54
PhosphoSitePlusiQ96A54

Polymorphism and mutation databases

BioMutaiADIPOR1
DMDMi38372248

Proteomic databases

EPDiQ96A54
MaxQBiQ96A54
PaxDbiQ96A54
PeptideAtlasiQ96A54
PRIDEiQ96A54
ProteomicsDBi75913

Protocols and materials databases

DNASUi51094
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340990; ENSP00000341785; ENSG00000159346
GeneIDi51094
KEGGihsa:51094
UCSCiuc001gyq.7 human

Organism-specific databases

CTDi51094
DisGeNETi51094
EuPathDBiHostDB:ENSG00000159346.12
GeneCardsiADIPOR1
HGNCiHGNC:24040 ADIPOR1
MIMi607945 gene
neXtProtiNX_Q96A54
OpenTargetsiENSG00000159346
PharmGKBiPA134861801
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0748 Eukaryota
COG1272 LUCA
GeneTreeiENSGT00530000062926
HOGENOMiHOG000197115
HOVERGENiHBG013916
InParanoidiQ96A54
KOiK07297
OMAiDYCGIAM
OrthoDBiEOG091G04EU
PhylomeDBiQ96A54
TreeFamiTF313640

Enzyme and pathway databases

ReactomeiR-HSA-163680 AMPK inhibits chREBP transcriptional activation activity
SIGNORiQ96A54

Miscellaneous databases

ChiTaRSiADIPOR1 human
GeneWikiiADIPOR1
GenomeRNAii51094
PROiPR:Q96A54
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159346 Expressed in 226 organ(s), highest expression level in blood
CleanExiHS_ADIPOR1
ExpressionAtlasiQ96A54 baseline and differential
GenevisibleiQ96A54 HS

Family and domain databases

InterProiView protein in InterPro
IPR004254 AdipoR/HlyIII-related
PANTHERiPTHR20855 PTHR20855, 1 hit
PfamiView protein in Pfam
PF03006 HlyIII, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAQR1_HUMAN
AccessioniPrimary (citable) accession number: Q96A54
Secondary accession number(s): B3KMB0
, Q53HS7, Q53YY6, Q9Y360
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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