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Protein

Synapse-associated protein 1

Gene

SYAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation (PubMed:23300339).1 Publication

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • cellular response to epidermal growth factor stimulus Source: UniProtKB
  • cellular response to insulin-like growth factor stimulus Source: UniProtKB
  • cellular response to insulin stimulus Source: UniProtKB
  • cellular response to platelet-derived growth factor stimulus Source: UniProtKB
  • positive regulation of fat cell differentiation Source: UniProtKB
  • positive regulation of protein homodimerization activity Source: UniProtKB
  • positive regulation of protein serine/threonine kinase activity Source: UniProtKB
  • TORC2 signaling Source: UniProtKB

Keywordsi

Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Synapse-associated protein 1Curated
Alternative name(s):
BSD domain-containing signal transducer and Akt interactor protein1 Publication
Short name:
BSTA1 Publication
Gene namesi
Name:SYAP1Imported
ORF Names:PRO3113
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000169895.5
HGNCiHGNC:16273 SYAP1
neXtProtiNX_Q96A49

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Golgi apparatus, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi198 – 199FW → AA: Inhibits interaction with AKT1, mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' and adipocyte differentiation. 1 Publication2

Organism-specific databases

OpenTargetsiENSG00000169895
PharmGKBiPA38107

Polymorphism and mutation databases

BioMutaiSYAP1
DMDMi30580522

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000723551 – 352Synapse-associated protein 1Add BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei248PhosphothreonineCombined sources1
Modified residuei269PhosphoserineCombined sources1
Modified residuei313PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated. Phosphorylation increases in a mTORC2-mediated manner in response to epidermal growth factor (EGF) stimulation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96A49
MaxQBiQ96A49
PaxDbiQ96A49
PeptideAtlasiQ96A49
PRIDEiQ96A49
ProteomicsDBi75912

PTM databases

iPTMnetiQ96A49
PhosphoSitePlusiQ96A49

Expressioni

Tissue specificityi

Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas (PubMed:23300339).1 Publication

Gene expression databases

BgeeiENSG00000169895
CleanExiHS_SYAP1
GenevisibleiQ96A49 HS

Organism-specific databases

HPAiHPA000175
HPA000882
HPA048047

Interactioni

Subunit structurei

Interacts (via phosphorylated form and BSD domain) with AKT1; this interaction is enhanced in a mTORC2-mediated manner in response to epidermal growth factor (EGF) stimulation and activates AKT1 (PubMed:23300339).1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi125103, 25 interactors
IntActiQ96A49, 22 interactors
STRINGi9606.ENSP00000369500

Structurei

Secondary structure

1352
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi134 – 144Combined sources11
Helixi148 – 151Combined sources4
Beta strandi156 – 158Combined sources3
Helixi164 – 177Combined sources14
Helixi179 – 187Combined sources9
Turni188 – 192Combined sources5
Helixi195 – 215Combined sources21

3D structure databases

ProteinModelPortaliQ96A49
SMRiQ96A49
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96A49

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini158 – 210BSDPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiKOG4310 Eukaryota
ENOG410ZPSV LUCA
GeneTreeiENSGT00390000007662
HOGENOMiHOG000231677
HOVERGENiHBG057553
InParanoidiQ96A49
OMAiETADWEK
OrthoDBiEOG091G0HAT
PhylomeDBiQ96A49
TreeFamiTF319666

Family and domain databases

Gene3Di1.10.3970.10, 1 hit
InterProiView protein in InterPro
IPR005607 BSD_dom
IPR035925 BSD_dom_sf
PfamiView protein in Pfam
PF03909 BSD, 1 hit
SMARTiView protein in SMART
SM00751 BSD, 1 hit
PROSITEiView protein in PROSITE
PS50858 BSD, 1 hit

Sequencei

Sequence statusi: Complete.

Q96A49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRGLSSWLG LQQPVAGGGQ PNGDAPPEQP SETVAESAEE ELQQAGDQEL
60 70 80 90 100
LHQAKDFGNY LFNFASAATK KITESVAETA QTIKKSVEEG KIDGIIDKTI
110 120 130 140 150
IGDFQKEQKK FVEEQHTKKS EAAVPPWVDT NDEETIQQQI LALSADKRNF
160 170 180 190 200
LRDPPAGVQF NFDFDQMYPV ALVMLQEDEL LSKMRFALVP KLVKEEVFWR
210 220 230 240 250
NYFYRVSLIK QSAQLTALAA QQQAAGKEEK SNGREQDLPL AEAVRPKTPP
260 270 280 290 300
VVIKSQLKTQ EDEEEISTSP GVSEFVSDAF DACNLNQEDL RKEMEQLVLD
310 320 330 340 350
KKQEETAVLE EDSADWEKEL QQELQEYEVV TESEKRDENW DKEIEKMLQE

EN
Length:352
Mass (Da):39,933
Last modified:December 1, 2001 - v1
Checksum:i2083636CF7CF75AE
GO

Sequence cautioni

The sequence AAK55531 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26P → L in AAH14657 (PubMed:15489334).Curated1
Sequence conflicti96I → T in BAB55087 (PubMed:14702039).Curated1
Sequence conflicti176Q → H in AAK55531 (PubMed:11483580).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF168955 mRNA Translation: AAK81893.1
AF338728 mRNA Translation: AAK69273.1
AK027401 mRNA Translation: BAB55087.1
CR749849 mRNA Translation: CAH18697.1
AL445467 Genomic DNA No translation available.
CH471074 Genomic DNA Translation: EAW98917.1
BC014657 mRNA Translation: AAH14657.1
AF305828 mRNA Translation: AAK55531.1 Different initiation.
CCDSiCCDS14177.1
RefSeqiNP_116185.2, NM_032796.3
UniGeneiHs.744256

Genome annotation databases

EnsembliENST00000380155; ENSP00000369500; ENSG00000169895
GeneIDi94056
KEGGihsa:94056
UCSCiuc004cxp.4 human

Similar proteinsi

Entry informationi

Entry nameiSYAP1_HUMAN
AccessioniPrimary (citable) accession number: Q96A49
Secondary accession number(s): Q68CP1
, Q96C60, Q96JQ6, Q96T20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: December 1, 2001
Last modified: July 18, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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