UniProtKB - Q96A49 (SYAP1_HUMAN)

BLAST

>sp|Q96A49|SYAP1_HUMAN Synapse-associated protein 1 OS=Homo sapiens OX=9606 GN=SYAP1 PE=1 SV=1
MFRGLSSWLGLQQPVAGGGQPNGDAPPEQPSETVAESAEEELQQAGDQELLHQAKDFGNY
LFNFASAATKKITESVAETAQTIKKSVEEGKIDGIIDKTIIGDFQKEQKKFVEEQHTKKS
EAAVPPWVDTNDEETIQQQILALSADKRNFLRDPPAGVQFNFDFDQMYPVALVMLQEDEL
LSKMRFALVPKLVKEEVFWRNYFYRVSLIKQSAQLTALAAQQQAAGKEEKSNGREQDLPL
AEAVRPKTPPVVIKSQLKTQEDEEEISTSPGVSEFVSDAFDACNLNQEDLRKEMEQLVLD
KKQEETAVLEEDSADWEKELQQELQEYEVVTESEKRDENWDKEIEKMLQEEN

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History
Entry version 144 (12 Sep 2018)
Sequence version 1 (01 Dec 2001)
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Protein

Synapse-associated protein 1

Gene

SYAP1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation (PubMed:23300339).1 Publication

GO - Biological processⁱ

cell differentiation Source: UniProtKB-KW
cellular response to epidermal growth factor stimulus
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23300339
cellular response to insulin-like growth factor stimulus
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23300339
cellular response to insulin stimulus
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23300339
cellular response to platelet-derived growth factor stimulus
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23300339
positive regulation of fat cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23300339
positive regulation of protein homodimerization activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23300339
positive regulation of protein serine/threonine kinase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23300339
TORC2 signaling
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23300339

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Differentiation

Biological process

Differentiation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Synapse-associated protein 1Curated Alternative name(s): BSD domain-containing signal transducer and Akt interactor protein1 Publication Short name: BSTA1 Publication
Gene namesⁱ	Name:SYAP1Imported ORF Names:PRO3113
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000169895.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16273 SYAP1
neXtProtⁱ	NX_Q96A49

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cell projection, Cytoplasm, Golgi apparatus, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	198 – 199	FW → AA: Inhibits interaction with AKT1, mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' and adipocyte differentiation. 1 Publication		2

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000169895
PharmGKBⁱ	PA38107

Polymorphism and mutation databases

BioMutaⁱ	SYAP1
DMDMⁱ	30580522

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000072355	1 – 352	Synapse-associated protein 1Add BLAST		352

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	248	PhosphothreonineCombined sources	1
Modified residueⁱ	269	PhosphoserineCombined sources	1
Modified residueⁱ	313	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated. Phosphorylation increases in a mTORC2-mediated manner in response to epidermal growth factor (EGF) stimulation.By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q96A49
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96A49
PaxDbⁱ	Q96A49
PeptideAtlas More...PeptideAtlasⁱ	Q96A49
PRIDEⁱ	Q96A49
ProteomicsDBⁱ	75912

PTM databases

iPTMnetⁱ	Q96A49
PhosphoSitePlusⁱ	Q96A49

Expressionⁱ

Tissue specificityⁱ

Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas (PubMed:23300339).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000169895 Expressed in 201 organ(s), highest expression level in adrenal tissue
CleanExⁱ	HS_SYAP1
Genevisibleⁱ	Q96A49 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA000175 HPA000882 HPA048047

HPAⁱ

HPA000175
HPA000882
HPA048047

Interactionⁱ

Subunit structureⁱ

Interacts (via phosphorylated form and BSD domain) with AKT1; this interaction is enhanced in a mTORC2-mediated manner in response to epidermal growth factor (EGF) stimulation and activates AKT1 (PubMed:23300339).1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
POT1	Q9NUX5	2	EBI-10770179,EBI-752420
THRA	P10827	4	EBI-10770179,EBI-286285

Protein-protein interaction databases

BioGridⁱ	125103, 25 interactors
IntActⁱ	Q96A49, 22 interactors
STRINGⁱ	9606.ENSP00000369500

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	134 – 144	Combined sources	11
Helixⁱ	148 – 151	Combined sources	4
Beta strandⁱ	156 – 158	Combined sources	3
Helixⁱ	164 – 177	Combined sources	14
Helixⁱ	179 – 187	Combined sources	9
Turnⁱ	188 – 192	Combined sources	5
Helixⁱ	195 – 215	Combined sources	21

Show more details

3D structure databases

ProteinModelPortalⁱ	Q96A49
SMRⁱ	Q96A49
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q96A49

EvolutionaryTraceⁱ

Q96A49

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	158 – 210	BSDPROSITE-ProRule annotationAdd BLAST		53

Phylogenomic databases

eggNOGⁱ	KOG4310 Eukaryota ENOG410ZPSV LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007662
HOGENOMⁱ	HOG000231677
HOVERGENⁱ	HBG057553
InParanoidⁱ	Q96A49
OMAⁱ	ETADWEK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HAT
PhylomeDBⁱ	Q96A49
TreeFamⁱ	TF319666

Family and domain databases

Gene3Dⁱ	1.10.3970.10, 1 hit
InterProⁱ	View protein in InterPro IPR005607 BSD_dom IPR035925 BSD_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03909 BSD, 1 hit
SMARTⁱ	View protein in SMART SM00751 BSD, 1 hit
PROSITEⁱ	View protein in PROSITE PS50858 BSD, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q96A49-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFRGLSSWLG LQQPVAGGGQ PNGDAPPEQP SETVAESAEE ELQQAGDQEL 
        60         70         80         90        100
LHQAKDFGNY LFNFASAATK KITESVAETA QTIKKSVEEG KIDGIIDKTI 
       110        120        130        140        150
IGDFQKEQKK FVEEQHTKKS EAAVPPWVDT NDEETIQQQI LALSADKRNF 
       160        170        180        190        200
LRDPPAGVQF NFDFDQMYPV ALVMLQEDEL LSKMRFALVP KLVKEEVFWR 
       210        220        230        240        250
NYFYRVSLIK QSAQLTALAA QQQAAGKEEK SNGREQDLPL AEAVRPKTPP 
       260        270        280        290        300
VVIKSQLKTQ EDEEEISTSP GVSEFVSDAF DACNLNQEDL RKEMEQLVLD 
       310        320        330        340        350
KKQEETAVLE EDSADWEKEL QQELQEYEVV TESEKRDENW DKEIEKMLQE 

EN

Length:352

Mass (Da):39,933

Last modified:December 1, 2001 - v1

Checksum:ⁱ2083636CF7CF75AE

Sequence cautionⁱ

The sequence AAK55531 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	26	P → L in AAH14657 (PubMed:15489334).Curated	1
Sequence conflictⁱ	96	I → T in BAB55087 (PubMed:14702039).Curated	1
Sequence conflictⁱ	176	Q → H in AAK55531 (PubMed:11483580).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF168955 mRNA Translation: AAK81893.1 AF338728 mRNA Translation: AAK69273.1 AK027401 mRNA Translation: BAB55087.1 CR749849 mRNA Translation: CAH18697.1 AL445467 Genomic DNA No translation available. CH471074 Genomic DNA Translation: EAW98917.1 BC014657 mRNA Translation: AAH14657.1 AF305828 mRNA Translation: AAK55531.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14177.1
NCBI Reference Sequences More...RefSeqⁱ	NP_116185.2, NM_032796.3
UniGeneⁱ	Hs.744256

Genome annotation databases

Ensemblⁱ	ENST00000380155; ENSP00000369500; ENSG00000169895
GeneIDⁱ	94056
KEGGⁱ	hsa:94056
UCSC genome browser More...UCSCⁱ	uc004cxp.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96A49	cDNA FLJ60548, highly similar to Synapse-associated protein 1		HUMAN		186	UniRef100_Q96A49

Protein	Similar proteins		Species	Score	Length	Source
Q96A49	cDNA FLJ60548, highly similar to Synapse-associated protein 1		HUMAN		186	UniRef90_Q96A49
Uncharacterized protein		PAPAN		407
Uncharacterized protein		MACFA		407
Synapse-associated protein 1		MACMU		352
Uncharacterized protein		CERAT		352
+43

Protein	Similar proteins		Species	Score	Length	Source
Q96A49	cDNA FLJ60548, highly similar to Synapse-associated protein 1		HUMAN		186	UniRef50_Q96A49
Uncharacterized protein		MACFA		407
Synapse-associated protein 1		MACMU		352
Uncharacterized protein		CERAT		352
Uncharacterized protein		MACNE		352
+181

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF168955 mRNA Translation: AAK81893.1 AF338728 mRNA Translation: AAK69273.1 AK027401 mRNA Translation: BAB55087.1 CR749849 mRNA Translation: CAH18697.1 AL445467 Genomic DNA No translation available. CH471074 Genomic DNA Translation: EAW98917.1 BC014657 mRNA Translation: AAH14657.1 AF305828 mRNA Translation: AAK55531.1 Different initiation.
CCDSⁱ	CCDS14177.1
RefSeqⁱ	NP_116185.2, NM_032796.3
UniGeneⁱ	Hs.744256

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1X3A	NMR	-	A	130-216	[»]
ProteinModelPortalⁱ	Q96A49
SMRⁱ	Q96A49
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	125103, 25 interactors
IntActⁱ	Q96A49, 22 interactors
STRINGⁱ	9606.ENSP00000369500

PTM databases

iPTMnetⁱ	Q96A49
PhosphoSitePlusⁱ	Q96A49

Polymorphism and mutation databases

BioMutaⁱ	SYAP1
DMDMⁱ	30580522

Proteomic databases

EPDⁱ	Q96A49
MaxQBⁱ	Q96A49
PaxDbⁱ	Q96A49
PeptideAtlasⁱ	Q96A49
PRIDEⁱ	Q96A49
ProteomicsDBⁱ	75912

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	94056
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000380155; ENSP00000369500; ENSG00000169895
GeneIDⁱ	94056
KEGGⁱ	hsa:94056
UCSCⁱ	uc004cxp.4 human

Organism-specific databases

CTDⁱ	94056
EuPathDBⁱ	HostDB:ENSG00000169895.5
GeneCardsⁱ	SYAP1
HGNCⁱ	HGNC:16273 SYAP1
HPAⁱ	HPA000175 HPA000882 HPA048047
neXtProtⁱ	NX_Q96A49
OpenTargetsⁱ	ENSG00000169895
PharmGKBⁱ	PA38107
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4310 Eukaryota ENOG410ZPSV LUCA
GeneTreeⁱ	ENSGT00390000007662
HOGENOMⁱ	HOG000231677
HOVERGENⁱ	HBG057553
InParanoidⁱ	Q96A49
OMAⁱ	ETADWEK
OrthoDBⁱ	EOG091G0HAT
PhylomeDBⁱ	Q96A49
TreeFamⁱ	TF319666

Miscellaneous databases

ChiTaRSⁱ	SYAP1 human
EvolutionaryTraceⁱ	Q96A49
GeneWikiⁱ	SYAP1
GenomeRNAiⁱ	94056
Protein Ontology More...PROⁱ	PR:Q96A49

Gene expression databases

Bgeeⁱ	ENSG00000169895 Expressed in 201 organ(s), highest expression level in adrenal tissue
CleanExⁱ	HS_SYAP1
Genevisibleⁱ	Q96A49 HS

Family and domain databases

Gene3Dⁱ	1.10.3970.10, 1 hit
InterProⁱ	View protein in InterPro IPR005607 BSD_dom IPR035925 BSD_dom_sf
Pfamⁱ	View protein in Pfam PF03909 BSD, 1 hit
SMARTⁱ	View protein in SMART SM00751 BSD, 1 hit
PROSITEⁱ	View protein in PROSITE PS50858 BSD, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SYAP1_HUMAN
Accessionⁱ	Q96A49Primary (citable) accession number: Q96A49 Secondary accession number(s): Q68CP1 , Q96C60, Q96JQ6, Q96T20
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 9, 2003
	Last sequence update:	December 1, 2001
	Last modified:	September 12, 2018
	This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96A49 (SYAP1_HUMAN)

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Synapse-associated protein 1

SYAP1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Plasma membrane

Other locations

Cytosol

Extracellular region or secreted

Golgi apparatus

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ