UniProtKB - Q96A49 (SYAP1_HUMAN)
Protein
Synapse-associated protein 1
Gene
SYAP1
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation (PubMed:23300339).1 Publication
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- cellular response to epidermal growth factor stimulus Source: UniProtKB
- cellular response to insulin-like growth factor stimulus Source: UniProtKB
- cellular response to insulin stimulus Source: UniProtKB
- cellular response to platelet-derived growth factor stimulus Source: UniProtKB
- positive regulation of fat cell differentiation Source: UniProtKB
- positive regulation of protein serine/threonine kinase activity Source: UniProtKB
- TORC2 signaling Source: UniProtKB
Keywordsi
Biological process | Differentiation |
Enzyme and pathway databases
PathwayCommonsi | Q96A49 |
Names & Taxonomyi
Protein namesi | Recommended name: Synapse-associated protein 1CuratedAlternative name(s): BSD domain-containing signal transducer and Akt interactor protein1 Publication Short name: BSTA1 Publication |
Gene namesi | Name:SYAP1Imported ORF Names:PRO3113 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000169895.5 |
HGNCi | HGNC:16273, SYAP1 |
neXtProti | NX_Q96A49 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus By similarity
Plasma membrane
- presynaptic cell membrane By similarity
- postsynaptic cell membrane By similarity
Other locations
- perinuclear region By similarity
- Perikaryon By similarity
- axon By similarity
- dendrite By similarity
- growth cone By similarity
- Membrane 1 Publication
Note: Localizes to cholinergic neuromuscular junctions and in actin-rich growth cone regions (By similarity). Membrane-associated in a epidermal growth factor (EGF)-dependent manner (PubMed:23300339).By similarity1 Publication
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: UniProtKB
- postsynaptic membrane Source: UniProtKB
- presynaptic membrane Source: UniProtKB
Other locations
- axon Source: UniProtKB
- dendrite Source: UniProtKB
- growth cone Source: UniProtKB
- perikaryon Source: UniProtKB
- perinuclear region of cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasm, Golgi apparatus, Membrane, Postsynaptic cell membrane, SynapsePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 198 – 199 | FW → AA: Inhibits interaction with AKT1, mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' and adipocyte differentiation. 1 Publication | 2 |
Organism-specific databases
OpenTargetsi | ENSG00000169895 |
PharmGKBi | PA38107 |
Miscellaneous databases
Pharosi | Q96A49, Tdark |
Polymorphism and mutation databases
BioMutai | SYAP1 |
DMDMi | 30580522 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000072355 | 1 – 352 | Synapse-associated protein 1Add BLAST | 352 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 248 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 269 | PhosphoserineCombined sources | 1 | |
Modified residuei | 313 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated. Phosphorylation increases in a mTORC2-mediated manner in response to epidermal growth factor (EGF) stimulation.By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q96A49 |
jPOSTi | Q96A49 |
MassIVEi | Q96A49 |
MaxQBi | Q96A49 |
PaxDbi | Q96A49 |
PeptideAtlasi | Q96A49 |
PRIDEi | Q96A49 |
ProteomicsDBi | 75912 |
PTM databases
iPTMneti | Q96A49 |
MetOSitei | Q96A49 |
PhosphoSitePlusi | Q96A49 |
Expressioni
Tissue specificityi
Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas (PubMed:23300339).1 Publication
Gene expression databases
Bgeei | ENSG00000169895, Expressed in adrenal tissue and 216 other tissues |
Genevisiblei | Q96A49, HS |
Organism-specific databases
HPAi | ENSG00000169895, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (via phosphorylated form and BSD domain) with AKT1; this interaction is enhanced in a mTORC2-mediated manner in response to epidermal growth factor (EGF) stimulation and activates AKT1 (PubMed:23300339).
1 PublicationBinary interactionsi
Hide detailsQ96A49
Protein-protein interaction databases
BioGRIDi | 125103, 47 interactors |
IntActi | Q96A49, 30 interactors |
STRINGi | 9606.ENSP00000369500 |
Miscellaneous databases
RNActi | Q96A49, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | Q96A49 |
SMRi | Q96A49 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q96A49 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 158 – 210 | BSDPROSITE-ProRule annotationAdd BLAST | 53 |
Phylogenomic databases
eggNOGi | KOG4310, Eukaryota |
GeneTreei | ENSGT00390000007662 |
HOGENOMi | CLU_046184_1_1_1 |
InParanoidi | Q96A49 |
OMAi | FGSYLFN |
OrthoDBi | 782515at2759 |
PhylomeDBi | Q96A49 |
TreeFami | TF319666 |
Family and domain databases
Gene3Di | 1.10.3970.10, 1 hit |
InterProi | View protein in InterPro IPR005607, BSD_dom IPR035925, BSD_dom_sf |
Pfami | View protein in Pfam PF03909, BSD, 1 hit |
SMARTi | View protein in SMART SM00751, BSD, 1 hit |
PROSITEi | View protein in PROSITE PS50858, BSD, 1 hit |
i Sequence
Sequence statusi: Complete.
Q96A49-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFRGLSSWLG LQQPVAGGGQ PNGDAPPEQP SETVAESAEE ELQQAGDQEL
60 70 80 90 100
LHQAKDFGNY LFNFASAATK KITESVAETA QTIKKSVEEG KIDGIIDKTI
110 120 130 140 150
IGDFQKEQKK FVEEQHTKKS EAAVPPWVDT NDEETIQQQI LALSADKRNF
160 170 180 190 200
LRDPPAGVQF NFDFDQMYPV ALVMLQEDEL LSKMRFALVP KLVKEEVFWR
210 220 230 240 250
NYFYRVSLIK QSAQLTALAA QQQAAGKEEK SNGREQDLPL AEAVRPKTPP
260 270 280 290 300
VVIKSQLKTQ EDEEEISTSP GVSEFVSDAF DACNLNQEDL RKEMEQLVLD
310 320 330 340 350
KKQEETAVLE EDSADWEKEL QQELQEYEVV TESEKRDENW DKEIEKMLQE
EN
Sequence cautioni
The sequence AAK55531 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 26 | P → L in AAH14657 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 96 | I → T in BAB55087 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 176 | Q → H in AAK55531 (PubMed:11483580).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF168955 mRNA Translation: AAK81893.1 AF338728 mRNA Translation: AAK69273.1 AK027401 mRNA Translation: BAB55087.1 CR749849 mRNA Translation: CAH18697.1 AL445467 Genomic DNA No translation available. CH471074 Genomic DNA Translation: EAW98917.1 BC014657 mRNA Translation: AAH14657.1 AF305828 mRNA Translation: AAK55531.1 Different initiation. |
CCDSi | CCDS14177.1 |
RefSeqi | NP_116185.2, NM_032796.3 |
Genome annotation databases
Ensembli | ENST00000380155; ENSP00000369500; ENSG00000169895 |
GeneIDi | 94056 |
KEGGi | hsa:94056 |
UCSCi | uc004cxp.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF168955 mRNA Translation: AAK81893.1 AF338728 mRNA Translation: AAK69273.1 AK027401 mRNA Translation: BAB55087.1 CR749849 mRNA Translation: CAH18697.1 AL445467 Genomic DNA No translation available. CH471074 Genomic DNA Translation: EAW98917.1 BC014657 mRNA Translation: AAH14657.1 AF305828 mRNA Translation: AAK55531.1 Different initiation. |
CCDSi | CCDS14177.1 |
RefSeqi | NP_116185.2, NM_032796.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1X3A | NMR | - | A | 130-216 | [»] | |
BMRBi | Q96A49 | |||||
SMRi | Q96A49 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 125103, 47 interactors |
IntActi | Q96A49, 30 interactors |
STRINGi | 9606.ENSP00000369500 |
PTM databases
iPTMneti | Q96A49 |
MetOSitei | Q96A49 |
PhosphoSitePlusi | Q96A49 |
Polymorphism and mutation databases
BioMutai | SYAP1 |
DMDMi | 30580522 |
Proteomic databases
EPDi | Q96A49 |
jPOSTi | Q96A49 |
MassIVEi | Q96A49 |
MaxQBi | Q96A49 |
PaxDbi | Q96A49 |
PeptideAtlasi | Q96A49 |
PRIDEi | Q96A49 |
ProteomicsDBi | 75912 |
Protocols and materials databases
Antibodypediai | 395, 124 antibodies |
DNASUi | 94056 |
Genome annotation databases
Ensembli | ENST00000380155; ENSP00000369500; ENSG00000169895 |
GeneIDi | 94056 |
KEGGi | hsa:94056 |
UCSCi | uc004cxp.4, human |
Organism-specific databases
CTDi | 94056 |
EuPathDBi | HostDB:ENSG00000169895.5 |
GeneCardsi | SYAP1 |
HGNCi | HGNC:16273, SYAP1 |
HPAi | ENSG00000169895, Low tissue specificity |
neXtProti | NX_Q96A49 |
OpenTargetsi | ENSG00000169895 |
PharmGKBi | PA38107 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4310, Eukaryota |
GeneTreei | ENSGT00390000007662 |
HOGENOMi | CLU_046184_1_1_1 |
InParanoidi | Q96A49 |
OMAi | FGSYLFN |
OrthoDBi | 782515at2759 |
PhylomeDBi | Q96A49 |
TreeFami | TF319666 |
Enzyme and pathway databases
PathwayCommonsi | Q96A49 |
Miscellaneous databases
BioGRID-ORCSi | 94056, 8 hits in 475 CRISPR screens |
ChiTaRSi | SYAP1, human |
EvolutionaryTracei | Q96A49 |
GeneWikii | SYAP1 |
GenomeRNAii | 94056 |
Pharosi | Q96A49, Tdark |
PROi | PR:Q96A49 |
RNActi | Q96A49, protein |
Gene expression databases
Bgeei | ENSG00000169895, Expressed in adrenal tissue and 216 other tissues |
Genevisiblei | Q96A49, HS |
Family and domain databases
Gene3Di | 1.10.3970.10, 1 hit |
InterProi | View protein in InterPro IPR005607, BSD_dom IPR035925, BSD_dom_sf |
Pfami | View protein in Pfam PF03909, BSD, 1 hit |
SMARTi | View protein in SMART SM00751, BSD, 1 hit |
PROSITEi | View protein in PROSITE PS50858, BSD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SYAP1_HUMAN | |
Accessioni | Q96A49Primary (citable) accession number: Q96A49 Secondary accession number(s): Q68CP1 Q96T20 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 9, 2003 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM