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UniProtKB - Q96A46 (MFRN2_HUMAN)

Entry version 164 (25 May 2022)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
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Protein

Mitoferrin-2

Gene

SLC25A28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe2+, is then probably delivered to ferrochelatase to catalyze Fe2+ incorporation into protoprophyrin IX to make heme (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96A46

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1362409, Mitochondrial iron-sulfur cluster biogenesis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q96A46

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.29.5.8, the mitochondrial carrier (mc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitoferrin-2
Alternative name(s):
Mitochondrial RNA-splicing protein 3/4 homolog
Short name:
MRS3/4
Short name:
hMRS3/4
Mitochondrial iron transporter 2
Solute carrier family 25 member 28
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC25A28
Synonyms:MFRN2
ORF Names:NPD016
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:23472, SLC25A28

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609767, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96A46

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000155287

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei72 – 91Helical; Name=1Sequence analysisAdd BLAST20
Transmembranei133 – 152Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei170 – 189Helical; Name=3Sequence analysisAdd BLAST20
Transmembranei227 – 246Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei261 – 280Helical; Name=5Sequence analysisAdd BLAST20
Transmembranei327 – 346Helical; Name=6Sequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		81894

Open Targets

More...OpenTargetsi		ENSG00000155287

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134867966

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96A46, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC25A28

Domain mapping of disease mutations (DMDM)

More...DMDMi		74751734

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002352551 – 364Mitoferrin-2Add BLAST364

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96A46

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96A46

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96A46

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96A46

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96A46

PeptideAtlas

More...PeptideAtlasi		Q96A46

PRoteomics IDEntifications database

More...PRIDEi		Q96A46

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75908 [Q96A46-1]
75909 [Q96A46-2]
75910 [Q96A46-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96A46

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96A46

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Expressed in placenta, lung, kidney, pancreas, liver, brain, skeletal muscle and heart.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000155287, Expressed in urinary bladder and 227 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96A46, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96A46, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000155287, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123626, 32 interactors

Protein interaction database and analysis system

More...IntActi		Q96A46, 4 interactors

Molecular INTeraction database

More...MINTi		Q96A46

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000359526

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96A46, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q96A46

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96A46

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati70 – 158Solcar 1Add BLAST89
Repeati168 – 252Solcar 2Add BLAST85
Repeati259 – 352Solcar 3Add BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 28DisorderedSequence analysisAdd BLAST28
Regioni40 – 60DisorderedSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0760, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157049

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_015166_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96A46

Identification of Orthologs from Complete Genome Data

More...OMAi		KVMNPSQ

Database of Orthologous Groups

More...OrthoDBi		1056670at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96A46

TreeFam database of animal gene trees

More...TreeFami		TF314118

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.50.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018108, Mitochondrial_sb/sol_carrier
IPR023395, Mt_carrier_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00153, Mito_carr, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103506, SSF103506, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50920, SOLCAR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96A46-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELEGRGAGG VAGGPAAGPG RSPGESALLD GWLQRGVGRG AGGGEAGACR 
        60         70         80         90        100
PPVRQDPDSG PDYEALPAGA TVTTHMVAGA VAGILEHCVM YPIDCVKTRM 
       110        120        130        140        150
QSLQPDPAAR YRNVLEALWR IIRTEGLWRP MRGLNVTATG AGPAHALYFA 
       160        170        180        190        200
CYEKLKKTLS DVIHPGGNSH IANGAAGCVA TLLHDAAMNP AEVVKQRMQM 
       210        220        230        240        250
YNSPYHRVTD CVRAVWQNEG AGAFYRSYTT QLTMNVPFQA IHFMTYEFLQ 
       260        270        280        290        300
EHFNPQRRYN PSSHVLSGAC AGAVAAAATT PLDVCKTLLN TQESLALNSH 
       310        320        330        340        350
ITGHITGMAS AFRTVYQVGG VTAYFRGVQA RVIYQIPSTA IAWSVYEFFK 
       360 
YLITKRQEEW RAGK
Length:364
Mass (Da):39,272
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i22049C4F8DD7A577
GO
Isoform 2 (identifier: Q96A46-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-187: Missing.

Show »
Length:177
Mass (Da):20,045
Checksum:iE5370283AAF732E3
GO
Isoform 3 (identifier: Q96A46-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-188: Missing.
     189-192: NPAE → MALL

Show »
Length:176
Mass (Da):19,931
Checksum:i4A4831AC572309D4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6RFA8X6RFA8_HUMAN
Mitoferrin-2
SLC25A28
225Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH47312 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0184131 – 188Missing in isoform 3. 2 PublicationsAdd BLAST188
Alternative sequenceiVSP_0184141 – 187Missing in isoform 2. 1 PublicationAdd BLAST187
Alternative sequenceiVSP_018415189 – 192NPAE → MALL in isoform 3. 2 Publications4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF327402 mRNA Translation: AAK49519.1
AF327403 mRNA Translation: AAK49520.1
AJ303077 mRNA Translation: CAC27996.1
AJ303078 mRNA Translation: CAC27997.1
AF267854 mRNA Translation: AAG44723.1
AL831943 mRNA Translation: CAH10774.1
AL353719 Genomic DNA No translation available.
BC047312 mRNA Translation: AAH47312.1 Different initiation.
BC058937 mRNA Translation: AAH58937.1
BC076399 mRNA Translation: AAH76399.1
BC094821 mRNA Translation: AAH94821.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41559.1 [Q96A46-1]

NCBI Reference Sequences

More...RefSeqi		NP_112489.3, NM_031212.3 [Q96A46-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000370495.6; ENSP00000359526.4; ENSG00000155287.11

Database of genes from NCBI RefSeq genomes

More...GeneIDi		81894

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:81894

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000370495.6; ENSP00000359526.4; NM_031212.4; NP_112489.3

UCSC genome browser

More...UCSCi		uc001kpx.3, human [Q96A46-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327402 mRNA Translation: AAK49519.1
AF327403 mRNA Translation: AAK49520.1
AJ303077 mRNA Translation: CAC27996.1
AJ303078 mRNA Translation: CAC27997.1
AF267854 mRNA Translation: AAG44723.1
AL831943 mRNA Translation: CAH10774.1
AL353719 Genomic DNA No translation available.
BC047312 mRNA Translation: AAH47312.1 Different initiation.
BC058937 mRNA Translation: AAH58937.1
BC076399 mRNA Translation: AAH76399.1
BC094821 mRNA Translation: AAH94821.1
CCDSiCCDS41559.1 [Q96A46-1]
RefSeqiNP_112489.3, NM_031212.3 [Q96A46-1]

3D structure databases

AlphaFoldDBiQ96A46
SMRiQ96A46
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123626, 32 interactors
IntActiQ96A46, 4 interactors
MINTiQ96A46
STRINGi9606.ENSP00000359526

Protein family/group databases

TCDBi2.A.29.5.8, the mitochondrial carrier (mc) family

PTM databases

iPTMnetiQ96A46
PhosphoSitePlusiQ96A46

Genetic variation databases

BioMutaiSLC25A28
DMDMi74751734

Proteomic databases

EPDiQ96A46
jPOSTiQ96A46
MassIVEiQ96A46
MaxQBiQ96A46
PaxDbiQ96A46
PeptideAtlasiQ96A46
PRIDEiQ96A46
ProteomicsDBi75908 [Q96A46-1]
75909 [Q96A46-2]
75910 [Q96A46-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31086, 139 antibodies from 19 providers

The DNASU plasmid repository

More...DNASUi		81894

Genome annotation databases

EnsembliENST00000370495.6; ENSP00000359526.4; ENSG00000155287.11
GeneIDi81894
KEGGihsa:81894
MANE-SelectiENST00000370495.6; ENSP00000359526.4; NM_031212.4; NP_112489.3
UCSCiuc001kpx.3, human [Q96A46-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		81894
DisGeNETi81894

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC25A28
HGNCiHGNC:23472, SLC25A28
HPAiENSG00000155287, Low tissue specificity
MIMi609767, gene
neXtProtiNX_Q96A46
OpenTargetsiENSG00000155287
PharmGKBiPA134867966
VEuPathDBiHostDB:ENSG00000155287

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0760, Eukaryota
GeneTreeiENSGT00940000157049
HOGENOMiCLU_015166_3_1_1
InParanoidiQ96A46
OMAiKVMNPSQ
OrthoDBi1056670at2759
PhylomeDBiQ96A46
TreeFamiTF314118

Enzyme and pathway databases

PathwayCommonsiQ96A46
ReactomeiR-HSA-1362409, Mitochondrial iron-sulfur cluster biogenesis
SignaLinkiQ96A46

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		81894, 157 hits in 1082 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLC25A28, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		81894
PharosiQ96A46, Tbio

Protein Ontology

More...PROi		PR:Q96A46
RNActiQ96A46, protein

The Stanford Online Universal Resource for Clones and ESTs

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Gene expression databases

BgeeiENSG00000155287, Expressed in urinary bladder and 227 other tissues
ExpressionAtlasiQ96A46, baseline and differential
GenevisibleiQ96A46, HS

Family and domain databases

Gene3Di1.50.40.10, 2 hits
InterProiView protein in InterPro
IPR018108, Mitochondrial_sb/sol_carrier
IPR023395, Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153, Mito_carr, 3 hits
SUPFAMiSSF103506, SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920, SOLCAR, 3 hits

MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMFRN2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96A46
Secondary accession number(s): Q4VBZ0
, Q5T777, Q86VX5, Q969G8, Q9H2J3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: May 25, 2022
This is version 164 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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