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Protein

39S ribosomal protein L24, mitochondrial

Gene

MRPL24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L24, mitochondrial
Short name:
L24mt
Short name:
MRP-L24
Alternative name(s):
Mitochondrial large ribosomal subunit protein uL24m1 Publication
Gene namesi
Name:MRPL24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143314.12
HGNCiHGNC:14037 MRPL24
MIMi611836 gene
neXtProtiNX_Q96A35

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143314
PharmGKBiPA30954

Polymorphism and mutation databases

BioMutaiMRPL24
DMDMi74751733

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 9MitochondrionBy similarity9
ChainiPRO_000027048810 – 21639S ribosomal protein L24, mitochondrialAdd BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96A35
MaxQBiQ96A35
PaxDbiQ96A35
PeptideAtlasiQ96A35
PRIDEiQ96A35
ProteomicsDBi75904
TopDownProteomicsiQ96A35

PTM databases

iPTMnetiQ96A35
PhosphoSitePlusiQ96A35
SwissPalmiQ96A35

Expressioni

Gene expression databases

BgeeiENSG00000143314 Expressed in 224 organ(s), highest expression level in prostate gland
CleanExiHS_MRPL24
ExpressionAtlasiQ96A35 baseline and differential
GenevisibleiQ96A35 HS

Organism-specific databases

HPAiHPA030295
HPA054323

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.3 Publications

Protein-protein interaction databases

BioGridi122732, 76 interactors
CORUMiQ96A35
IntActiQ96A35, 22 interactors
MINTiQ96A35
STRINGi9606.ENSP00000354525

Structurei

Secondary structure

1216
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ96A35
SMRiQ96A35
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 89KOWAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi40 – 43Poly-Arg4

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1708 Eukaryota
COG0198 LUCA
GeneTreeiENSGT00390000014542
HOVERGENiHBG093899
InParanoidiQ96A35
KOiK02895
OMAiQTHDYKT
OrthoDBiEOG091G0EA2
PhylomeDBiQ96A35
TreeFamiTF105984

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR005824 KOW
IPR014722 Rib_L2_dom2
IPR003256 Ribosomal_L24
IPR005825 Ribosomal_L24/26_CS
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR12903 PTHR12903, 1 hit
PfamiView protein in Pfam
PF00467 KOW, 1 hit
PF17136 ribosomal_L24, 1 hit
SMARTiView protein in SMART
SM00739 KOW, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
TIGRFAMsiTIGR01079 rplX_bact, 1 hit
PROSITEiView protein in PROSITE
PS01108 RIBOSOMAL_L24, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q96A35-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLSALLALA SKVTLPPHYR YGMSPPGSVA DKRKNPPWIR RRPVVVEPIS
60 70 80 90 100
DEDWYLFCGD TVEILEGKDA GKQGKVVQVI RQRNWVVVGG LNTHYRYIGK
110 120 130 140 150
TMDYRGTMIP SEAPLLHRQV KLVDPMDRKP TEIEWRFTEA GERVRVSTRS
160 170 180 190 200
GRIIPKPEFP RADGIVPETW IDGPKDTSVE DALERTYVPC LKTLQEEVME
210
AMGIKETRKY KKVYWY
Length:216
Mass (Da):24,915
Last modified:December 1, 2001 - v1
Checksum:i2A1F5C88001557D0
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6RJ73X6RJ73_HUMAN
39S ribosomal protein L24, mitochon...
MRPL24
173Annotation score:
X6RHI2X6RHI2_HUMAN
39S ribosomal protein L24, mitochon...
MRPL24
98Annotation score:
X6RIR5X6RIR5_HUMAN
39S ribosomal protein L24, mitochon...
MRPL24
68Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109I → V in BAB14929 (PubMed:14702039).Curated1
Sequence conflicti109I → V in BAD96220 (Ref. 3) Curated1
Sequence conflicti119Q → H in BAB14929 (PubMed:14702039).Curated1
Sequence conflicti134E → D in BAB14929 (PubMed:14702039).Curated1
Sequence conflicti142E → Q in BAB14929 (PubMed:14702039).Curated1
Sequence conflicti208R → Q in BAD96786 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024570 mRNA Translation: BAB14929.1
CR457329 mRNA Translation: CAG33610.1
AK222500 mRNA Translation: BAD96220.1
AK223066 mRNA Translation: BAD96786.1
AL590666 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52913.1
CH471121 Genomic DNA Translation: EAW52914.1
BC012440 mRNA Translation: AAH12440.1
BC016700 mRNA Translation: AAH16700.1
AB051341 Genomic DNA Translation: BAB54931.2
CCDSiCCDS1155.1
RefSeqiNP_078816.2, NM_024540.3
NP_663781.1, NM_145729.2
XP_011508283.1, XM_011509981.2
XP_011508284.1, XM_011509982.2
UniGeneiHs.418233

Genome annotation databases

EnsembliENST00000361531; ENSP00000354525; ENSG00000143314
ENST00000368211; ENSP00000357194; ENSG00000143314
GeneIDi79590
KEGGihsa:79590
UCSCiuc001fpw.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024570 mRNA Translation: BAB14929.1
CR457329 mRNA Translation: CAG33610.1
AK222500 mRNA Translation: BAD96220.1
AK223066 mRNA Translation: BAD96786.1
AL590666 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52913.1
CH471121 Genomic DNA Translation: EAW52914.1
BC012440 mRNA Translation: AAH12440.1
BC016700 mRNA Translation: AAH16700.1
AB051341 Genomic DNA Translation: BAB54931.2
CCDSiCCDS1155.1
RefSeqiNP_078816.2, NM_024540.3
NP_663781.1, NM_145729.2
XP_011508283.1, XM_011509981.2
XP_011508284.1, XM_011509982.2
UniGeneiHs.418233

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40V1-216[»]
3J9Melectron microscopy3.50V1-216[»]
5OOLelectron microscopy3.06V1-216[»]
5OOMelectron microscopy3.03V1-216[»]
ProteinModelPortaliQ96A35
SMRiQ96A35
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122732, 76 interactors
CORUMiQ96A35
IntActiQ96A35, 22 interactors
MINTiQ96A35
STRINGi9606.ENSP00000354525

PTM databases

iPTMnetiQ96A35
PhosphoSitePlusiQ96A35
SwissPalmiQ96A35

Polymorphism and mutation databases

BioMutaiMRPL24
DMDMi74751733

Proteomic databases

EPDiQ96A35
MaxQBiQ96A35
PaxDbiQ96A35
PeptideAtlasiQ96A35
PRIDEiQ96A35
ProteomicsDBi75904
TopDownProteomicsiQ96A35

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361531; ENSP00000354525; ENSG00000143314
ENST00000368211; ENSP00000357194; ENSG00000143314
GeneIDi79590
KEGGihsa:79590
UCSCiuc001fpw.2 human

Organism-specific databases

CTDi79590
EuPathDBiHostDB:ENSG00000143314.12
GeneCardsiMRPL24
HGNCiHGNC:14037 MRPL24
HPAiHPA030295
HPA054323
MIMi611836 gene
neXtProtiNX_Q96A35
OpenTargetsiENSG00000143314
PharmGKBiPA30954
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1708 Eukaryota
COG0198 LUCA
GeneTreeiENSGT00390000014542
HOVERGENiHBG093899
InParanoidiQ96A35
KOiK02895
OMAiQTHDYKT
OrthoDBiEOG091G0EA2
PhylomeDBiQ96A35
TreeFamiTF105984

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

GeneWikiiMRPL24
GenomeRNAii79590
PROiPR:Q96A35
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143314 Expressed in 224 organ(s), highest expression level in prostate gland
CleanExiHS_MRPL24
ExpressionAtlasiQ96A35 baseline and differential
GenevisibleiQ96A35 HS

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR005824 KOW
IPR014722 Rib_L2_dom2
IPR003256 Ribosomal_L24
IPR005825 Ribosomal_L24/26_CS
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR12903 PTHR12903, 1 hit
PfamiView protein in Pfam
PF00467 KOW, 1 hit
PF17136 ribosomal_L24, 1 hit
SMARTiView protein in SMART
SM00739 KOW, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
TIGRFAMsiTIGR01079 rplX_bact, 1 hit
PROSITEiView protein in PROSITE
PS01108 RIBOSOMAL_L24, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM24_HUMAN
AccessioniPrimary (citable) accession number: Q96A35
Secondary accession number(s): D3DVC8
, Q53G65, Q53HT0, Q5SYZ9, Q5SZ00, Q5SZ02, Q96Q70, Q9H7G3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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