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Protein

Myosin regulatory light chain 2, skeletal muscle isoform

Gene

MYLPF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

This chain binds calcium.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi38 – 49Sequence analysisAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor protein, Muscle protein, Myosin
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-445355 Smooth Muscle Contraction
SIGNORiQ96A32

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin regulatory light chain 2, skeletal muscle isoform
Alternative name(s):
Fast skeletal myosin light chain 2
MLC2B
Gene namesi
Name:MYLPFBy similarity
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000180209.11
HGNCiHGNC:29824 MYLPF
MIMi617378 gene
neXtProtiNX_Q96A32

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi29895
OpenTargetsiENSG00000180209
PharmGKBiPA164723287

Polymorphism and mutation databases

BioMutaiMYLPF
DMDMi74760696

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002837462 – 169Myosin regulatory light chain 2, skeletal muscle isoformBy similarityAdd BLAST168

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N,N,N-trimethylalanineBy similarity1
Modified residuei15PhosphoserineBy similarity1
Modified residuei16PhosphoserineBy similarity1
Modified residuei25PhosphothreonineBy similarity1
Modified residuei35PhosphothreonineBy similarity1
Modified residuei75PhosphoserineBy similarity1
Modified residuei101PhosphothreonineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ96A32
PeptideAtlasiQ96A32
PRIDEiQ96A32
ProteomicsDBi75901

PTM databases

iPTMnetiQ96A32
PhosphoSitePlusiQ96A32

Expressioni

Tissue specificityi

Expressed in fetal and adult skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000180209 Expressed in 121 organ(s), highest expression level in quadriceps femoris
ExpressionAtlasiQ96A32 baseline and differential
GenevisibleiQ96A32 HS

Organism-specific databases

HPAiHPA039262
HPA055059

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Protein-protein interaction databases

BioGridi118947, 8 interactors
IntActiQ96A32, 3 interactors
STRINGi9606.ENSP00000325239

Structurei

3D structure databases

ProteinModelPortaliQ96A32
SMRiQ96A32
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 60EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini95 – 130EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini131 – 166EF-hand 3PROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0031 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000119196
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiQ96A32
KOiK12758
PhylomeDBiQ96A32
TreeFamiTF314218

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13405 EF-hand_6, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q96A32-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPKRAKRRT VEGGSSSVFS MFDQTQIQEF KEAFTVIDQN RDGIIDKEDL
60 70 80 90 100
RDTFAAMGRL NVKNEELDAM MKEASGPINF TVFLTMFGEK LKGADPEDVI
110 120 130 140 150
TGAFKVLDPE GKGTIKKKFL EELLTTQCDR FSQEEIKNMW AAFPPDVGGN
160
VDYKNICYVI THGDAKDQE
Length:169
Mass (Da):19,015
Last modified:December 1, 2001 - v1
Checksum:i2CE585D6B1F8769D
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BPK4H3BPK4_HUMAN
Myosin regulatory light chain 2, sk...
MYLPF
199Annotation score:
H3BN54H3BN54_HUMAN
Myosin regulatory light chain 2, sk...
MYLPF
135Annotation score:
H3BML9H3BML9_HUMAN
Myosin regulatory light chain 2, sk...
MYLPF
118Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11V → VA in CAA40762 (PubMed:14756420).Curated1
Sequence conflicti11V → VA in AAA91848 (Ref. 2) Curated1
Sequence conflicti169E → D in CAG33244 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57543 mRNA Translation: CAA40762.1
M21812 mRNA Translation: AAA91848.1
AF363061 mRNA Translation: AAK52797.1
CR456963 mRNA Translation: CAG33244.1
AK314082 mRNA Translation: BAG36780.1
CH471192 Genomic DNA Translation: EAW52254.1
BC012571 mRNA Translation: AAH12571.1
CCDSiCCDS10677.1
RefSeqiNP_001311387.1, NM_001324458.1
NP_001311388.1, NM_001324459.1
NP_037424.2, NM_013292.4
UniGeneiHs.50889

Genome annotation databases

EnsembliENST00000322861; ENSP00000325239; ENSG00000180209
GeneIDi29895
KEGGihsa:29895
UCSCiuc002dxv.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57543 mRNA Translation: CAA40762.1
M21812 mRNA Translation: AAA91848.1
AF363061 mRNA Translation: AAK52797.1
CR456963 mRNA Translation: CAG33244.1
AK314082 mRNA Translation: BAG36780.1
CH471192 Genomic DNA Translation: EAW52254.1
BC012571 mRNA Translation: AAH12571.1
CCDSiCCDS10677.1
RefSeqiNP_001311387.1, NM_001324458.1
NP_001311388.1, NM_001324459.1
NP_037424.2, NM_013292.4
UniGeneiHs.50889

3D structure databases

ProteinModelPortaliQ96A32
SMRiQ96A32
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118947, 8 interactors
IntActiQ96A32, 3 interactors
STRINGi9606.ENSP00000325239

PTM databases

iPTMnetiQ96A32
PhosphoSitePlusiQ96A32

Polymorphism and mutation databases

BioMutaiMYLPF
DMDMi74760696

Proteomic databases

PaxDbiQ96A32
PeptideAtlasiQ96A32
PRIDEiQ96A32
ProteomicsDBi75901

Protocols and materials databases

DNASUi29895
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322861; ENSP00000325239; ENSG00000180209
GeneIDi29895
KEGGihsa:29895
UCSCiuc002dxv.2 human

Organism-specific databases

CTDi29895
DisGeNETi29895
EuPathDBiHostDB:ENSG00000180209.11
GeneCardsiMYLPF
HGNCiHGNC:29824 MYLPF
HPAiHPA039262
HPA055059
MIMi617378 gene
neXtProtiNX_Q96A32
OpenTargetsiENSG00000180209
PharmGKBiPA164723287
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0031 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000119196
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiQ96A32
KOiK12758
PhylomeDBiQ96A32
TreeFamiTF314218

Enzyme and pathway databases

ReactomeiR-HSA-445355 Smooth Muscle Contraction
SIGNORiQ96A32

Miscellaneous databases

ChiTaRSiMYLPF human
GenomeRNAii29895
PROiPR:Q96A32
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180209 Expressed in 121 organ(s), highest expression level in quadriceps femoris
ExpressionAtlasiQ96A32 baseline and differential
GenevisibleiQ96A32 HS

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13405 EF-hand_6, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMLRS_HUMAN
AccessioniPrimary (citable) accession number: Q96A32
Secondary accession number(s): B2RA83, Q14843, Q6IB41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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