UniProtKB - Q96A26 (F162A_HUMAN)
Protein
Protein FAM162A
Gene
FAM162A
Organism
Homo sapiens (Human)
Status
Functioni
Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly.1 Publication
GO - Biological processi
- activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
- cellular response to hypoxia Source: UniProtKB
- neuron apoptotic process Source: GO_Central
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of release of cytochrome c from mitochondria Source: UniProtKB
Keywordsi
Biological process | Apoptosis |
Enzyme and pathway databases
PathwayCommonsi | Q96A26 |
SIGNORi | Q96A26 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein FAM162AAlternative name(s): E2-induced gene 5 protein Growth and transformation-dependent protein Short name: HGTD-P |
Gene namesi | Name:FAM162A Synonyms:C3orf28, E2IG5 ORF Names:DC16, FWP001 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17865, FAM162A |
MIMi | 608017, gene |
neXtProti | NX_Q96A26 |
VEuPathDBi | HostDB:ENSG00000114023.15 |
Subcellular locationi
Mitochondrion
- Mitochondrion 2 Publications
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Cytosol
- cytosol Source: HPA
Mitochondrion
- mitochondrion Source: HPA
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 103 – 120 | HelicalSequence analysisAdd BLAST | 18 |
Keywords - Cellular componenti
Membrane, MitochondrionPathology & Biotechi
Organism-specific databases
DisGeNETi | 26355 |
OpenTargetsi | ENSG00000114023 |
PharmGKBi | PA162386916 |
Miscellaneous databases
Pharosi | Q96A26, Tbio |
Genetic variation databases
BioMutai | FAM162A |
DMDMi | 117949400 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000254635 | 1 – 154 | Protein FAM162AAdd BLAST | 154 |
Proteomic databases
EPDi | Q96A26 |
jPOSTi | Q96A26 |
MassIVEi | Q96A26 |
MaxQBi | Q96A26 |
PaxDbi | Q96A26 |
PeptideAtlasi | Q96A26 |
PRIDEi | Q96A26 |
ProteomicsDBi | 75897 |
TopDownProteomicsi | Q96A26 |
PTM databases
iPTMneti | Q96A26 |
MetOSitei | Q96A26 |
PhosphoSitePlusi | Q96A26 |
SwissPalmi | Q96A26 |
Expressioni
Inductioni
By 17-beta-estradiol. By hypoxia.1 Publication
Gene expression databases
Bgeei | ENSG00000114023, Expressed in colonic mucosa and 243 other tissues |
ExpressionAtlasi | Q96A26, baseline and differential |
Genevisiblei | Q96A26, HS |
Organism-specific databases
HPAi | ENSG00000114023, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with HSP90AB1; HSP90AB1 is essential for FAM162A mitochondrial localization and pro-apoptotic activity.
Interacts with VDAC2; the interaction is probably involved in inducing mitochondrial permability transition.
2 PublicationsBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 117691, 36 interactors |
IntActi | Q96A26, 15 interactors |
MINTi | Q96A26 |
STRINGi | 9606.ENSP00000419088 |
Miscellaneous databases
RNActi | Q96A26, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 76 – 102 | Required for proapoptotic activityAdd BLAST | 27 |
Sequence similaritiesi
Belongs to the UPF0389 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S1PN, Eukaryota |
GeneTreei | ENSGT00640000091497 |
InParanoidi | Q96A26 |
OMAi | TSTYSHR |
OrthoDBi | 1470947at2759 |
PhylomeDBi | Q96A26 |
TreeFami | TF323771 |
Family and domain databases
InterProi | View protein in InterPro IPR009432, DUF1075 |
PANTHERi | PTHR13674, PTHR13674, 1 hit |
Pfami | View protein in Pfam PF06388, DUF1075, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q96A26-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSLSGLRLA AGSCFRLCER DVSSSLRLTR SSDLKRINGF CTKPQESPGA
60 70 80 90 100
PSRTYNRVPL HKPTDWQKKI LIWSGRFKKE DEIPETVSLE MLDAAKNKMR
110 120 130 140 150
VKISYLMIAL TVVGCIFMVI EGKKAAQRHE TLTSLNLEKK ARLKEEAAMK
AKTE
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8W7Q4 | F8W7Q4_HUMAN | Protein FAM162A | FAM162A | 144 | Annotation score: | ||
E9PH05 | E9PH05_HUMAN | Protein FAM162A | FAM162A | 141 | Annotation score: |
Sequence cautioni
The sequence AAF09484 differs from that shown. Reason: Frameshift.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028849 | 50 | A → V1 PublicationCorresponds to variant dbSNP:rs17850692Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF191020 mRNA Translation: AAF09484.1 Frameshift. AF201944 mRNA Translation: AAF86880.1 AF107495 mRNA Translation: AAG39275.1 BC010896 mRNA Translation: AAH10896.1 BC015060 mRNA Translation: AAH15060.1 |
CCDSi | CCDS43139.1 |
RefSeqi | NP_055182.3, NM_014367.3 |
Genome annotation databases
Ensembli | ENST00000477892; ENSP00000419088; ENSG00000114023 |
GeneIDi | 26355 |
KEGGi | hsa:26355 |
UCSCi | uc003eez.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF191020 mRNA Translation: AAF09484.1 Frameshift. AF201944 mRNA Translation: AAF86880.1 AF107495 mRNA Translation: AAG39275.1 BC010896 mRNA Translation: AAH10896.1 BC015060 mRNA Translation: AAH15060.1 |
CCDSi | CCDS43139.1 |
RefSeqi | NP_055182.3, NM_014367.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 117691, 36 interactors |
IntActi | Q96A26, 15 interactors |
MINTi | Q96A26 |
STRINGi | 9606.ENSP00000419088 |
PTM databases
iPTMneti | Q96A26 |
MetOSitei | Q96A26 |
PhosphoSitePlusi | Q96A26 |
SwissPalmi | Q96A26 |
Genetic variation databases
BioMutai | FAM162A |
DMDMi | 117949400 |
Proteomic databases
EPDi | Q96A26 |
jPOSTi | Q96A26 |
MassIVEi | Q96A26 |
MaxQBi | Q96A26 |
PaxDbi | Q96A26 |
PeptideAtlasi | Q96A26 |
PRIDEi | Q96A26 |
ProteomicsDBi | 75897 |
TopDownProteomicsi | Q96A26 |
Protocols and materials databases
Antibodypediai | 32893, 77 antibodies |
Genome annotation databases
Ensembli | ENST00000477892; ENSP00000419088; ENSG00000114023 |
GeneIDi | 26355 |
KEGGi | hsa:26355 |
UCSCi | uc003eez.4, human |
Organism-specific databases
CTDi | 26355 |
DisGeNETi | 26355 |
GeneCardsi | FAM162A |
HGNCi | HGNC:17865, FAM162A |
HPAi | ENSG00000114023, Low tissue specificity |
MIMi | 608017, gene |
neXtProti | NX_Q96A26 |
OpenTargetsi | ENSG00000114023 |
PharmGKBi | PA162386916 |
VEuPathDBi | HostDB:ENSG00000114023.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S1PN, Eukaryota |
GeneTreei | ENSGT00640000091497 |
InParanoidi | Q96A26 |
OMAi | TSTYSHR |
OrthoDBi | 1470947at2759 |
PhylomeDBi | Q96A26 |
TreeFami | TF323771 |
Enzyme and pathway databases
PathwayCommonsi | Q96A26 |
SIGNORi | Q96A26 |
Miscellaneous databases
BioGRID-ORCSi | 26355, 8 hits in 880 CRISPR screens |
ChiTaRSi | FAM162A, human |
GenomeRNAii | 26355 |
Pharosi | Q96A26, Tbio |
PROi | PR:Q96A26 |
RNActi | Q96A26, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000114023, Expressed in colonic mucosa and 243 other tissues |
ExpressionAtlasi | Q96A26, baseline and differential |
Genevisiblei | Q96A26, HS |
Family and domain databases
InterProi | View protein in InterPro IPR009432, DUF1075 |
PANTHERi | PTHR13674, PTHR13674, 1 hit |
Pfami | View protein in Pfam PF06388, DUF1075, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F162A_HUMAN | |
Accessioni | Q96A26Primary (citable) accession number: Q96A26 Secondary accession number(s): Q9NRN6, Q9UJX8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | October 31, 2006 | |
Last modified: | February 10, 2021 | |
This is version 131 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families