Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Copine-4

Gene

CPNE4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.By similarity

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Copine-4Curated
Alternative name(s):
Copine IVBy similarityImported
Copine-81 Publication
Gene namesi
Name:CPNE4Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000196353.11
HGNCiHGNC:2317 CPNE4
MIMi604208 gene
neXtProtiNX_Q96A23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi131034
OpenTargetsiENSG00000196353
PharmGKBiPA26834

Polymorphism and mutation databases

BioMutaiCPNE4
DMDMi26006702

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001448411 – 557Copine-4Add BLAST557

Proteomic databases

EPDiQ96A23
MaxQBiQ96A23
PaxDbiQ96A23
PeptideAtlasiQ96A23
PRIDEiQ96A23
ProteomicsDBi75894
75895 [Q96A23-2]
TopDownProteomicsiQ96A23-1 [Q96A23-1]

PTM databases

iPTMnetiQ96A23
PhosphoSitePlusiQ96A23

Expressioni

Tissue specificityi

Widely expressed (PubMed:12670487, PubMed:12949241). Expressed strongly in the brain, heart and prostate (PubMed:12670487, PubMed:12949241). Expressed strongly in peripheral blood leukocytes (PubMed:12949241).2 Publications

Gene expression databases

BgeeiENSG00000196353 Expressed in 124 organ(s), highest expression level in lateral nuclear group of thalamus
CleanExiHS_CPNE4
ExpressionAtlasiQ96A23 baseline and differential
GenevisibleiQ96A23 HS

Organism-specific databases

HPAiHPA032036
HPA078300

Interactioni

Subunit structurei

Interacts (via VWFA domain) with ACTB, BCOR, BICD2, CCDC22, CDC42BPB, CEP162, MYCBP2, NONO, PDCD6, PITPNM2, RDX, SKIL, SKT, SPTBN1, UBE2O and WTAP (PubMed:12522145).1 Publication

Protein-protein interaction databases

BioGridi126267, 48 interactors
IntActiQ96A23, 1 interactor
STRINGi9606.ENSP00000411904

Structurei

3D structure databases

ProteinModelPortaliQ96A23
SMRiQ96A23
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 130C2 1PROSITE-ProRule annotationAdd BLAST107
Domaini141 – 246C2 2PROSITE-ProRule annotationAdd BLAST106
Domaini305 – 507VWFAPROSITE-ProRule annotationAdd BLAST203

Sequence similaritiesi

Belongs to the copine family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1327 Eukaryota
ENOG410XPC8 LUCA
GeneTreeiENSGT00760000119085
HOGENOMiHOG000220898
HOVERGENiHBG066841
InParanoidiQ96A23
OMAiFLGAMEC
OrthoDBiEOG091G05IT
PhylomeDBiQ96A23
TreeFamiTF316419

Family and domain databases

CDDicd04047 C2B_Copine, 1 hit
cd01459 vWA_copine_like, 1 hit
Gene3Di2.60.40.150, 2 hits
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037768 C2B_Copine
IPR010734 Copine
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF07002 Copine, 1 hit
SMARTiView protein in SMART
SM00239 C2, 2 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96A23-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKKMSNIYES AANTLGIFNS PCLTKVELRV ACKGISDRDA LSKPDPCVIL
60 70 80 90 100
KMQSHGQWFE VDRTEVIRTC INPVYSKLFT VDFYFEEVQR LRFEVHDISS
110 120 130 140 150
NHNGLKEADF LGGMECTLGQ IVSQRKLSKS LLKHGNTAGK SSITVIAEEL
160 170 180 190 200
SGNDDYVELA FNARKLDDKD FFSKSDPFLE IFRMNDDATQ QLVHRTEVVM
210 220 230 240 250
NNLSPAWKSF KVSVNSLCSG DPDRRLKCIV WDWDSNGKHD FIGEFTSTFK
260 270 280 290 300
EMRGAMEGKQ VQWECINPKY KAKKKNYKNS GTVILNLCKI HKMHSFLDYI
310 320 330 340 350
MGGCQIQFTV AIDFTASNGD PRNSCSLHYI HPYQPNEYLK ALVAVGEICQ
360 370 380 390 400
DYDSDKMFPA FGFGARIPPE YTVSHDFAIN FNEDNPECAG IQGVVEAYQS
410 420 430 440 450
CLPKLQLYGP TNIAPIIQKV AKSASEETNT KEASQYFILL ILTDGVITDM
460 470 480 490 500
ADTREAIVHA SHLPMSVIIV GVGNADFSDM QMLDGDDGIL RSPKGEPVLR
510 520 530 540 550
DIVQFVPFRN FKHASPAALA KSVLAEVPNQ VVDYYNGKGI KPKCSSEMYE

SSRTLAP
Length:557
Mass (Da):62,395
Last modified:December 1, 2001 - v1
Checksum:i34AA5F103FE3C7BD
GO
Isoform 2 (identifier: Q96A23-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAVEPSSSESIKRRAGRRM

Show »
Length:575
Mass (Da):64,394
Checksum:iFC2685D643DD0AAA
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RCT2D6RCT2_HUMAN
Copine-4
CPNE4
169Annotation score:
D6RI99D6RI99_HUMAN
Copine-4
CPNE4
82Annotation score:
D6RFY4D6RFY4_HUMAN
Copine-4
CPNE4
73Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0012141M → MAVEPSSSESIKRRAGRRM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF465770 mRNA Translation: AAL74190.1
AF465771 mRNA Translation: AAL74191.1
AK056175 mRNA Translation: BAB71111.1
CH471052 Genomic DNA Translation: EAW79206.1
CH471052 Genomic DNA Translation: EAW79207.1
BC014396 mRNA Translation: AAH14396.1
BC075046 mRNA Translation: AAH75046.1
CCDSiCCDS3072.1 [Q96A23-1]
CCDS75010.1 [Q96A23-2]
RefSeqiNP_001276041.1, NM_001289112.1 [Q96A23-2]
NP_570720.1, NM_130808.2 [Q96A23-1]
NP_702907.1, NM_153429.1 [Q96A23-2]
XP_016861182.1, XM_017005693.1
UniGeneiHs.199877

Genome annotation databases

EnsembliENST00000429747; ENSP00000411904; ENSG00000196353 [Q96A23-1]
ENST00000502818; ENSP00000421646; ENSG00000196353 [Q96A23-2]
ENST00000511604; ENSP00000423811; ENSG00000196353 [Q96A23-1]
ENST00000512055; ENSP00000421705; ENSG00000196353 [Q96A23-1]
ENST00000512332; ENSP00000424853; ENSG00000196353 [Q96A23-2]
ENST00000617767; ENSP00000478878; ENSG00000196353 [Q96A23-2]
GeneIDi131034
KEGGihsa:131034
UCSCiuc003eok.5 human [Q96A23-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF465770 mRNA Translation: AAL74190.1
AF465771 mRNA Translation: AAL74191.1
AK056175 mRNA Translation: BAB71111.1
CH471052 Genomic DNA Translation: EAW79206.1
CH471052 Genomic DNA Translation: EAW79207.1
BC014396 mRNA Translation: AAH14396.1
BC075046 mRNA Translation: AAH75046.1
CCDSiCCDS3072.1 [Q96A23-1]
CCDS75010.1 [Q96A23-2]
RefSeqiNP_001276041.1, NM_001289112.1 [Q96A23-2]
NP_570720.1, NM_130808.2 [Q96A23-1]
NP_702907.1, NM_153429.1 [Q96A23-2]
XP_016861182.1, XM_017005693.1
UniGeneiHs.199877

3D structure databases

ProteinModelPortaliQ96A23
SMRiQ96A23
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126267, 48 interactors
IntActiQ96A23, 1 interactor
STRINGi9606.ENSP00000411904

PTM databases

iPTMnetiQ96A23
PhosphoSitePlusiQ96A23

Polymorphism and mutation databases

BioMutaiCPNE4
DMDMi26006702

Proteomic databases

EPDiQ96A23
MaxQBiQ96A23
PaxDbiQ96A23
PeptideAtlasiQ96A23
PRIDEiQ96A23
ProteomicsDBi75894
75895 [Q96A23-2]
TopDownProteomicsiQ96A23-1 [Q96A23-1]

Protocols and materials databases

DNASUi131034
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000429747; ENSP00000411904; ENSG00000196353 [Q96A23-1]
ENST00000502818; ENSP00000421646; ENSG00000196353 [Q96A23-2]
ENST00000511604; ENSP00000423811; ENSG00000196353 [Q96A23-1]
ENST00000512055; ENSP00000421705; ENSG00000196353 [Q96A23-1]
ENST00000512332; ENSP00000424853; ENSG00000196353 [Q96A23-2]
ENST00000617767; ENSP00000478878; ENSG00000196353 [Q96A23-2]
GeneIDi131034
KEGGihsa:131034
UCSCiuc003eok.5 human [Q96A23-1]

Organism-specific databases

CTDi131034
DisGeNETi131034
EuPathDBiHostDB:ENSG00000196353.11
GeneCardsiCPNE4
HGNCiHGNC:2317 CPNE4
HPAiHPA032036
HPA078300
MIMi604208 gene
neXtProtiNX_Q96A23
OpenTargetsiENSG00000196353
PharmGKBiPA26834
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1327 Eukaryota
ENOG410XPC8 LUCA
GeneTreeiENSGT00760000119085
HOGENOMiHOG000220898
HOVERGENiHBG066841
InParanoidiQ96A23
OMAiFLGAMEC
OrthoDBiEOG091G05IT
PhylomeDBiQ96A23
TreeFamiTF316419

Miscellaneous databases

ChiTaRSiCPNE4 human
GeneWikiiCPNE4
GenomeRNAii131034
PROiPR:Q96A23
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196353 Expressed in 124 organ(s), highest expression level in lateral nuclear group of thalamus
CleanExiHS_CPNE4
ExpressionAtlasiQ96A23 baseline and differential
GenevisibleiQ96A23 HS

Family and domain databases

CDDicd04047 C2B_Copine, 1 hit
cd01459 vWA_copine_like, 1 hit
Gene3Di2.60.40.150, 2 hits
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037768 C2B_Copine
IPR010734 Copine
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF07002 Copine, 1 hit
SMARTiView protein in SMART
SM00239 C2, 2 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCPNE4_HUMAN
AccessioniPrimary (citable) accession number: Q96A23
Secondary accession number(s): D3DNC5, Q8TEX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again