UniProtKB - Q96A04 (TSACC_HUMAN)
Protein
TSSK6-activating co-chaperone protein
Gene
TSACC
Organism
Homo sapiens (Human)
Status
Functioni
Co-chaperone that facilitates HSP-mediated activation of TSSK6.1 Publication
GO - Molecular functioni
- chaperone binding Source: UniProtKB
Keywordsi
Molecular function | Chaperone |
Enzyme and pathway databases
PathwayCommonsi | Q96A04 |
Names & Taxonomyi
Protein namesi | Recommended name: TSSK6-activating co-chaperone proteinAlternative name(s): SSTK-interacting protein Short name: SSTK-IP |
Gene namesi | Name:TSACC Synonyms:C1orf182 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000163467.11 |
HGNCi | HGNC:30636, TSACC |
neXtProti | NX_Q96A04 |
Subcellular locationi
Other locations
- cytoplasm Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 128229 |
OpenTargetsi | ENSG00000163467 |
PharmGKBi | PA142672430 |
Miscellaneous databases
Pharosi | Q96A04, Tbio |
Polymorphism and mutation databases
BioMutai | TSACC |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000271073 | 1 – 125 | TSSK6-activating co-chaperone proteinAdd BLAST | 125 |
Proteomic databases
PaxDbi | Q96A04 |
PeptideAtlasi | Q96A04 |
PRIDEi | Q96A04 |
ProteomicsDBi | 75887 |
PTM databases
iPTMneti | Q96A04 |
PhosphoSitePlusi | Q96A04 |
Expressioni
Tissue specificityi
Expressed in testis but is absent from mature sperm.1 Publication
Gene expression databases
Bgeei | ENSG00000163467, Expressed in right testis and 125 other tissues |
ExpressionAtlasi | Q96A04, baseline and differential |
Genevisiblei | Q96A04, HS |
Organism-specific databases
HPAi | ENSG00000163467, Tissue enriched (testis) |
Interactioni
Subunit structurei
Interacts with HSP70. Associates with HSP90.
Interacts with TSSK6; this interaction is direct and recruits TSACC to HSP90.
1 PublicationBinary interactionsi
Hide detailsGO - Molecular functioni
- chaperone binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 126101, 4 interactors |
IntActi | Q96A04, 4 interactors |
MINTi | Q96A04 |
STRINGi | 9606.ENSP00000357238 |
Miscellaneous databases
RNActi | Q96A04, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the TSACC family.Curated
Phylogenomic databases
eggNOGi | ENOG502SWRI, Eukaryota |
GeneTreei | ENSGT00390000012524 |
HOGENOMi | CLU_162380_0_0_1 |
InParanoidi | Q96A04 |
OMAi | GNAVPLC |
OrthoDBi | 1511256at2759 |
PhylomeDBi | Q96A04 |
TreeFami | TF337043 |
Family and domain databases
InterProi | View protein in InterPro IPR031679, SSTK-IP |
PANTHERi | PTHR37368, PTHR37368, 1 hit |
Pfami | View protein in Pfam PF15836, SSTK-IP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q96A04-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MERHTSHPNR KVPAKEEANA VPLCRAKPSP SYINLQASSP PATFLNIQTT
60 70 80 90 100
KLPSVDHKPK ECLGLLECMY ANLQLQTQLA QQQMAVLEHL QASVTQLAPG
110 120
RGSNNSSLPA LSPNPLLNHL PQFSK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketV9GYT6 | V9GYT6_HUMAN | TSSK6-activating co-chaperone prote... | TSACC | 100 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061567 | 54 | S → L. Corresponds to variant dbSNP:rs41265043Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY048672 mRNA Translation: AAL07513.1 AY048673 mRNA Translation: AAL07514.1 AL589685 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW52964.1 CH471121 Genomic DNA Translation: EAW52965.1 BC014605 mRNA Translation: AAH14605.1 |
CCDSi | CCDS1141.1 |
RefSeqi | NP_001291746.1, NM_001304817.1 NP_001291747.1, NM_001304818.1 NP_001291748.1, NM_001304819.1 NP_001291749.1, NM_001304820.1 NP_001291750.1, NM_001304821.1 NP_001291751.1, NM_001304822.1 NP_001291752.1, NM_001304823.1 NP_001291753.1, NM_001304824.1 NP_001291754.1, NM_001304825.1 NP_001291755.1, NM_001304826.1 NP_653228.1, NM_144627.4 |
Genome annotation databases
Ensembli | ENST00000368251; ENSP00000357234; ENSG00000163467 ENST00000368252; ENSP00000357235; ENSG00000163467 ENST00000368253; ENSP00000357236; ENSG00000163467 ENST00000368254; ENSP00000357237; ENSG00000163467 ENST00000368255; ENSP00000357238; ENSG00000163467 |
GeneIDi | 128229 |
KEGGi | hsa:128229 |
UCSCi | uc001foo.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY048672 mRNA Translation: AAL07513.1 AY048673 mRNA Translation: AAL07514.1 AL589685 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW52964.1 CH471121 Genomic DNA Translation: EAW52965.1 BC014605 mRNA Translation: AAH14605.1 |
CCDSi | CCDS1141.1 |
RefSeqi | NP_001291746.1, NM_001304817.1 NP_001291747.1, NM_001304818.1 NP_001291748.1, NM_001304819.1 NP_001291749.1, NM_001304820.1 NP_001291750.1, NM_001304821.1 NP_001291751.1, NM_001304822.1 NP_001291752.1, NM_001304823.1 NP_001291753.1, NM_001304824.1 NP_001291754.1, NM_001304825.1 NP_001291755.1, NM_001304826.1 NP_653228.1, NM_144627.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 126101, 4 interactors |
IntActi | Q96A04, 4 interactors |
MINTi | Q96A04 |
STRINGi | 9606.ENSP00000357238 |
PTM databases
iPTMneti | Q96A04 |
PhosphoSitePlusi | Q96A04 |
Polymorphism and mutation databases
BioMutai | TSACC |
Proteomic databases
PaxDbi | Q96A04 |
PeptideAtlasi | Q96A04 |
PRIDEi | Q96A04 |
ProteomicsDBi | 75887 |
Protocols and materials databases
Antibodypediai | 34213, 56 antibodies |
DNASUi | 128229 |
Genome annotation databases
Ensembli | ENST00000368251; ENSP00000357234; ENSG00000163467 ENST00000368252; ENSP00000357235; ENSG00000163467 ENST00000368253; ENSP00000357236; ENSG00000163467 ENST00000368254; ENSP00000357237; ENSG00000163467 ENST00000368255; ENSP00000357238; ENSG00000163467 |
GeneIDi | 128229 |
KEGGi | hsa:128229 |
UCSCi | uc001foo.4, human |
Organism-specific databases
CTDi | 128229 |
DisGeNETi | 128229 |
EuPathDBi | HostDB:ENSG00000163467.11 |
GeneCardsi | TSACC |
HGNCi | HGNC:30636, TSACC |
HPAi | ENSG00000163467, Tissue enriched (testis) |
neXtProti | NX_Q96A04 |
OpenTargetsi | ENSG00000163467 |
PharmGKBi | PA142672430 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SWRI, Eukaryota |
GeneTreei | ENSGT00390000012524 |
HOGENOMi | CLU_162380_0_0_1 |
InParanoidi | Q96A04 |
OMAi | GNAVPLC |
OrthoDBi | 1511256at2759 |
PhylomeDBi | Q96A04 |
TreeFami | TF337043 |
Enzyme and pathway databases
PathwayCommonsi | Q96A04 |
Miscellaneous databases
BioGRID-ORCSi | 128229, 18 hits in 841 CRISPR screens |
ChiTaRSi | TSACC, human |
GenomeRNAii | 128229 |
Pharosi | Q96A04, Tbio |
PROi | PR:Q96A04 |
RNActi | Q96A04, protein |
Gene expression databases
Bgeei | ENSG00000163467, Expressed in right testis and 125 other tissues |
ExpressionAtlasi | Q96A04, baseline and differential |
Genevisiblei | Q96A04, HS |
Family and domain databases
InterProi | View protein in InterPro IPR031679, SSTK-IP |
PANTHERi | PTHR37368, PTHR37368, 1 hit |
Pfami | View protein in Pfam PF15836, SSTK-IP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TSACC_HUMAN | |
Accessioni | Q96A04Primary (citable) accession number: Q96A04 Secondary accession number(s): D3DVB9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations