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Protein

Protein phosphatase 1 regulatory subunit 14A

Gene

PPP1R14A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtein phosphatase inhibitor

Enzyme and pathway databases

ReactomeiR-HSA-5625740 RHO GTPases activate PKNs
SIGNORiQ96A00

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 14A
Alternative name(s):
17 kDa PKC-potentiated inhibitory protein of PP1
Protein kinase C-potentiated inhibitor protein of 17 kDa
Short name:
CPI-17
Gene namesi
Name:PPP1R14A
Synonyms:CPI17, PPP1INL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000167641.10
HGNCiHGNC:14871 PPP1R14A
MIMi608153 gene
neXtProtiNX_Q96A00

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi94274
OpenTargetsiENSG00000167641
PharmGKBiPA33623

Polymorphism and mutation databases

BioMutaiPPP1R14A
DMDMi55583974

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000714861 – 147Protein phosphatase 1 regulatory subunit 14AAdd BLAST147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26PhosphoserineCombined sources1
Modified residuei38Phosphothreonine; by PKC1 Publication1
Modified residuei128PhosphoserineCombined sources1
Modified residuei134PhosphoserineCombined sources1
Modified residuei136PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96A00
MaxQBiQ96A00
PaxDbiQ96A00
PeptideAtlasiQ96A00
PRIDEiQ96A00
ProteomicsDBi75885
75886 [Q96A00-2]

PTM databases

iPTMnetiQ96A00
PhosphoSitePlusiQ96A00

Expressioni

Tissue specificityi

Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta.1 Publication

Gene expression databases

BgeeiENSG00000167641
CleanExiHS_PPP1R14A
ExpressionAtlasiQ96A00 baseline and differential
GenevisibleiQ96A00 HS

Organism-specific databases

HPAiCAB005044
CAB009803
HPA042097
HPA054534

Interactioni

Protein-protein interaction databases

BioGridi125153, 18 interactors
IntActiQ96A00, 1 interactor
MINTiQ96A00
STRINGi9606.ENSP00000301242

Structurei

3D structure databases

ProteinModelPortaliQ96A00
SMRiQ96A00
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni35 – 120InhibitoryAdd BLAST86

Sequence similaritiesi

Belongs to the PP1 inhibitor family.Curated

Phylogenomic databases

eggNOGiENOG410IZE6 Eukaryota
ENOG4111Q1J LUCA
GeneTreeiENSGT00390000003608
HOGENOMiHOG000231993
HOVERGENiHBG054419
InParanoidiQ96A00
KOiK12328
OMAiLHKQPGF
OrthoDBiEOG091G122D
PhylomeDBiQ96A00
TreeFamiTF105546

Family and domain databases

Gene3Di1.10.150.220, 1 hit
InterProiView protein in InterPro
IPR008025 CPI-17
IPR036658 CPI-17_sf
PANTHERiPTHR16188 PTHR16188, 1 hit
PfamiView protein in Pfam
PF05361 PP1_inhibitor, 1 hit
SUPFAMiSSF81790 SSF81790, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96A00-1) [UniParc]FASTAAdd to basket
Also known as: CPI-17alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAQRLGKRV LSKLQSPSRA RGPGGSPGGL QKRHARVTVK YDRRELQRRL
60 70 80 90 100
DVEKWIDGRL EELYRGMEAD MPDEINIDEL LELESEEERS RKIQGLLKSC
110 120 130 140
GKPVEDFIQE LLAKLQGLHR QPGLRQPSPS HDGSLSPLQD RARTAHP
Length:147
Mass (Da):16,693
Last modified:December 1, 2001 - v1
Checksum:i470EE2C082FF7319
GO
Isoform 2 (identifier: Q96A00-2) [UniParc]FASTAAdd to basket
Also known as: CPI-17beta

The sequence of this isoform differs from the canonical sequence as follows:
     68-94: Missing.

Show »
Length:120
Mass (Da):13,480
Checksum:iB729738ABCE93AC5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti123G → R in AAP97242 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01184168 – 94Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB056508 mRNA Translation: BAB62502.1
AB056509 mRNA Translation: BAB62503.1
AF123763 mRNA Translation: AAP97242.1
AY050668 Genomic DNA Translation: AAL24445.1
AY050670 mRNA Translation: AAL25828.1
BC021089 mRNA Translation: AAH21089.1
CCDSiCCDS12509.1 [Q96A00-1]
CCDS58660.1 [Q96A00-2]
PIRiJC7719
RefSeqiNP_001230876.1, NM_001243947.1 [Q96A00-2]
NP_150281.1, NM_033256.2 [Q96A00-1]
UniGeneiHs.631569

Genome annotation databases

EnsembliENST00000301242; ENSP00000301242; ENSG00000167641 [Q96A00-1]
ENST00000347262; ENSP00000301243; ENSG00000167641 [Q96A00-2]
GeneIDi94274
KEGGihsa:94274
UCSCiuc002ohq.3 human [Q96A00-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPP14A_HUMAN
AccessioniPrimary (citable) accession number: Q96A00
Secondary accession number(s): Q7Z4X7, Q96S54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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