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Protein

Tumor necrosis factor receptor superfamily member 19L

Gene

RELT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in apoptosis (PubMed:28688764, PubMed:19969290). Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed (PubMed:16530727).3 Publications

GO - Biological processi

  • apoptotic process Source: UniProtKB

Keywordsi

Molecular functionReceptor
Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 19L
Alternative name(s):
Receptor expressed in lymphoid tissues
Gene namesi
Name:RELT
Synonyms:TNFRSF19L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000054967.12
HGNCiHGNC:13764 RELT
MIMi611211 gene
neXtProtiNX_Q969Z4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 162ExtracellularSequence analysisAdd BLAST137
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 430CytoplasmicSequence analysisAdd BLAST247

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi350F → A: Loss of interaction with STK39. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000054967
PharmGKBiPA162401092

Polymorphism and mutation databases

BioMutaiRELT
DMDMi21264092

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 252 PublicationsAdd BLAST25
ChainiPRO_000003459926 – 430Tumor necrosis factor receptor superfamily member 19LAdd BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 65By similarity
Disulfide bondi71 ↔ 90By similarity
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei223PhosphothreonineCombined sources1

Post-translational modificationi

Phosphorylated in vitro by OXSR1 (PubMed:16389068). Phosphorylated by STK39 (PubMed:16530727).2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ969Z4
MaxQBiQ969Z4
PaxDbiQ969Z4
PeptideAtlasiQ969Z4
PRIDEiQ969Z4
ProteomicsDBi75884

PTM databases

iPTMnetiQ969Z4
PhosphoSitePlusiQ969Z4

Expressioni

Tissue specificityi

Spleen, lymph node, brain, breast and peripheral blood leukocytes (at protein level) (PubMed:28688764). Expressed highly in bone marrow and fetal liver. Very low levels in skeletal muscle, testis and colon. Not detected in kidney and pancreas.2 Publications

Gene expression databases

BgeeiENSG00000054967 Expressed in 155 organ(s), highest expression level in blood
CleanExiHS_RELT
ExpressionAtlasiQ969Z4 baseline and differential
GenevisibleiQ969Z4 HS

Organism-specific databases

HPAiHPA062824
HPA071518

Interactioni

Subunit structurei

Interacts with TRAF1 (PubMed:11313261). Interacts with RELL1, RELL2 and OXSR1 (PubMed:16389068). Interacts with PLSCR1 (PubMed:22052202). Interacts with STK39 (PubMed:16530727).4 Publications

Protein-protein interaction databases

BioGridi124388, 20 interactors
STRINGi9606.ENSP00000064780

Structurei

3D structure databases

ProteinModelPortaliQ969Z4
SMRiQ969Z4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati50 – 90TNFR-CysAdd BLAST41

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi349 – 352RFRV motif; mediates interaction with STK391 Publication4

Sequence similaritiesi

Belongs to the RELT family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKJV Eukaryota
ENOG410YDMP LUCA
GeneTreeiENSGT00530000063385
HOGENOMiHOG000134238
HOVERGENiHBG062274
InParanoidiQ969Z4
KOiK05156
OMAiCGDCQPG
OrthoDBiEOG091G0ADI
PhylomeDBiQ969Z4
TreeFamiTF332339

Family and domain databases

CDDicd13419 TNFRSF19L, 1 hit
InterProiView protein in InterPro
IPR022248 TNF_rcpt_RELT
IPR022333 TNFR_19-like
IPR034048 TNFRSF19L_N
PANTHERiPTHR23097:SF37 PTHR23097:SF37, 1 hit
PfamiView protein in Pfam
PF12606 RELT, 1 hit
PRINTSiPR01970 TNFACTORR19L

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q969Z4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPSLLCRPL SCFLMLLPWP LATLTSTTLW QCPPGEEPDL DPGQGTLCRP
60 70 80 90 100
CPPGTFSAAW GSSPCQPHAR CSLWRRLEAQ VGMATRDTLC GDCWPGWFGP
110 120 130 140 150
WGVPRVPCQP CSWAPLGTHG CDEWGRRARR GVEVAAGASS GGETRQPGNG
160 170 180 190 200
TRAGGPEETA AQYAVIAIVP VFCLMGLLGI LVCNLLKRKG YHCTAHKEVG
210 220 230 240 250
PGPGGGGSGI NPAYRTEDAN EDTIGVLVRL ITEKKENAAA LEELLKEYHS
260 270 280 290 300
KQLVQTSHRP VSKLPPAPPN VPHICPHRHH LHTVQGLASL SGPCCSRCSQ
310 320 330 340 350
KKWPEVLLSP EAVAATTPVP SLLPNPTRVP KAGAKAGRQG EITILSVGRF
360 370 380 390 400
RVARIPEQRT SSMVSEVKTI TEAGPSWGDL PDSPQPGLPP EQQALLGSGG
410 420 430
SRTKWLKPPA ENKAEENRYV VRLSESNLVI
Length:430
Mass (Da):46,092
Last modified:December 1, 2001 - v1
Checksum:i4A5AB9AE32D36101
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H2T5F5H2T5_HUMAN
Tumor necrosis factor receptor supe...
RELT
101Annotation score:
F5GYS9F5GYS9_HUMAN
Tumor necrosis factor receptor supe...
RELT
103Annotation score:

Sequence cautioni

The sequence BAB84954 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti122D → S in BAB84954 (Ref. 4) Curated1
Sequence conflicti187K → E in BAB55441 (PubMed:14702039).Curated1
Sequence conflicti273H → R in BAB55441 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022614332A → V1 PublicationCorresponds to variant dbSNP:rs12362779Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF319553 mRNA Translation: AAK77356.1
AK027899 mRNA Translation: BAB55441.1
BC001812 mRNA No translation available.
BC017279 mRNA Translation: AAH17279.1
BC051810 mRNA Translation: AAH51810.2
AK074128 mRNA Translation: BAB84954.1 Frameshift.
CCDSiCCDS8222.1
RefSeqiNP_116260.2, NM_032871.3
NP_689408.1, NM_152222.1
UniGeneiHs.533720

Genome annotation databases

EnsembliENST00000064780; ENSP00000064780; ENSG00000054967
ENST00000393580; ENSP00000377207; ENSG00000054967
GeneIDi84957
KEGGihsa:84957
UCSCiuc001otv.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF319553 mRNA Translation: AAK77356.1
AK027899 mRNA Translation: BAB55441.1
BC001812 mRNA No translation available.
BC017279 mRNA Translation: AAH17279.1
BC051810 mRNA Translation: AAH51810.2
AK074128 mRNA Translation: BAB84954.1 Frameshift.
CCDSiCCDS8222.1
RefSeqiNP_116260.2, NM_032871.3
NP_689408.1, NM_152222.1
UniGeneiHs.533720

3D structure databases

ProteinModelPortaliQ969Z4
SMRiQ969Z4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124388, 20 interactors
STRINGi9606.ENSP00000064780

PTM databases

iPTMnetiQ969Z4
PhosphoSitePlusiQ969Z4

Polymorphism and mutation databases

BioMutaiRELT
DMDMi21264092

Proteomic databases

EPDiQ969Z4
MaxQBiQ969Z4
PaxDbiQ969Z4
PeptideAtlasiQ969Z4
PRIDEiQ969Z4
ProteomicsDBi75884

Protocols and materials databases

DNASUi84957
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000064780; ENSP00000064780; ENSG00000054967
ENST00000393580; ENSP00000377207; ENSG00000054967
GeneIDi84957
KEGGihsa:84957
UCSCiuc001otv.4 human

Organism-specific databases

CTDi84957
EuPathDBiHostDB:ENSG00000054967.12
GeneCardsiRELT
HGNCiHGNC:13764 RELT
HPAiHPA062824
HPA071518
MIMi611211 gene
neXtProtiNX_Q969Z4
OpenTargetsiENSG00000054967
PharmGKBiPA162401092
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKJV Eukaryota
ENOG410YDMP LUCA
GeneTreeiENSGT00530000063385
HOGENOMiHOG000134238
HOVERGENiHBG062274
InParanoidiQ969Z4
KOiK05156
OMAiCGDCQPG
OrthoDBiEOG091G0ADI
PhylomeDBiQ969Z4
TreeFamiTF332339

Miscellaneous databases

ChiTaRSiRELT human
GeneWikiiRELT
GenomeRNAii84957
PROiPR:Q969Z4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000054967 Expressed in 155 organ(s), highest expression level in blood
CleanExiHS_RELT
ExpressionAtlasiQ969Z4 baseline and differential
GenevisibleiQ969Z4 HS

Family and domain databases

CDDicd13419 TNFRSF19L, 1 hit
InterProiView protein in InterPro
IPR022248 TNF_rcpt_RELT
IPR022333 TNFR_19-like
IPR034048 TNFRSF19L_N
PANTHERiPTHR23097:SF37 PTHR23097:SF37, 1 hit
PfamiView protein in Pfam
PF12606 RELT, 1 hit
PRINTSiPR01970 TNFACTORR19L
ProtoNetiSearch...

Entry informationi

Entry nameiTR19L_HUMAN
AccessioniPrimary (citable) accession number: Q969Z4
Secondary accession number(s): Q86V34, Q96JU1, Q9BUX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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