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UniProtKB - Q969Z3 (MARC2_HUMAN)

Entry version 156 (25 May 2022)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
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Protein

Mitochondrial amidoxime reducing component 2

Gene

MTARC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed:21029045, PubMed:24423752).

As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability (PubMed:21029045, PubMed:24423752).

May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis (PubMed:21029045).

Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction (PubMed:21029045).

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mo-molybdopterin1 PublicationNote: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=830 µM for benzamidoxime2 Publications
  2. KM=400 µM for benzamidoxime (at pH 6.0 and 37 degrees Celsius)1 Publication
  3. KM=3 mM for NOHA2 Publications
  4. KM=3.7 mM for NHAM2 Publications
  1. Vmax=307 nmol/min/mg enzyme toward benzamidoxime2 Publications
  2. Vmax=119 nmol/min/mg enzyme toward benzamidoxime (at pH 6.0 and 37 degrees Celsius)1 Publication
  3. Vmax=373 nmol/min/mg enzyme toward NOHA2 Publications
  4. Vmax=36.5 nmol/min/mg enzyme toward NHAM2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandMolybdenum

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.7.2.1, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q969Z3

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-211945, Phase I - Functionalization of compounds

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q969Z3

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q969Z3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitochondrial amidoxime reducing component 21 Publication (EC:1.7.-.-)
Short name:
mARC21 Publication
Alternative name(s):
Molybdenum cofactor sulfurase C-terminal domain-containing protein 2
Short name:
MOSC domain-containing protein 2
Short name:
Moco sulfurase C-terminal domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MTARC2Imported
Synonyms:MARC2, MOSC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26064, MTARC2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		614127, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q969Z3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000117791

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane, Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		54996

Open Targets

More...OpenTargetsi		ENSG00000117791

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671345

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q969Z3, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4523423

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MARC2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74760692

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 35MitochondrionSequence analysisAdd BLAST35
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000027334036 – 335Mitochondrial amidoxime reducing component 2Add BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki59Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki138Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki144Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei156N6-acetyllysine; alternateBy similarity1
Cross-linki156Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Cross-linki166Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki173Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki187Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki287Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki294Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q969Z3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q969Z3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q969Z3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q969Z3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q969Z3

PeptideAtlas

More...PeptideAtlasi		Q969Z3

PRoteomics IDEntifications database

More...PRIDEi		Q969Z3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75882 [Q969Z3-1]
75883 [Q969Z3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q969Z3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q969Z3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000117791, Expressed in left lobe of thyroid gland and 224 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q969Z3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q969Z3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000117791, Tissue enhanced (kidney, liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a complex composed of cytochrome b5, NADH-cytochrome b5 reductase (CYB5R3) and MTARC2.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120329, 36 interactors

Protein interaction database and analysis system

More...IntActi		Q969Z3, 10 interactors

Molecular INTeraction database

More...MINTi		Q969Z3

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000355880

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q969Z3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q969Z3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q969Z3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini188 – 334MOSCPROSITE-ProRule annotationAdd BLAST147

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2362, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159665

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_028286_6_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q969Z3

Identification of Orthologs from Complete Genome Data

More...OMAi		GYPFLLI

Database of Orthologous Groups

More...OrthoDBi		919343at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q969Z3

TreeFam database of animal gene trees

More...TreeFami		TF316807

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005302, MoCF_Sase_C
IPR005303, MOSC_N
IPR011037, Pyrv_Knase-like_insert_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03473, MOSC, 1 hit
PF03476, MOSC_N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50800, SSF50800, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51340, MOSC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q969Z3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGASSSSALA RLGLPARPWP RWLGVAALGL AAVALGTVAW RRAWPRRRRR 
        60         70         80         90        100
LQQVGTVAKL WIYPVKSCKG VPVSEAECTA MGLRSGNLRD RFWLVIKEDG 
       110        120        130        140        150
HMVTARQEPR LVLISIIYEN NCLIFRAPDM DQLVLPSKQP SSNKLHNCRI 
       160        170        180        190        200
FGLDIKGRDC GNEAAKWFTN FLKTEAYRLV QFETNMKGRT SRKLLPTLDQ 
       210        220        230        240        250
NFQVAYPDYC PLLIMTDASL VDLNTRMEKK MKMENFRPNI VVTGCDAFEE 
       260        270        280        290        300
DTWDELLIGS VEVKKVMACP RCILTTVDPD TGVIDRKQPL DTLKSYRLCD 
       310        320        330 
PSERELYKLS PLFGIYYSVE KIGSLRVGDP VYRMV
Length:335
Mass (Da):38,023
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4C6A9B8B9AC0F74D
GO
Isoform 2 (identifier: Q969Z3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     251-257: DTWDELL → ASATRRD
     258-335: Missing.

Show »
Length:257
Mass (Da):29,103
Checksum:i8938E1231A0ACB9B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X1WI34X1WI34_HUMAN
Mitochondrial amidoxime reducing co...
MTARC2
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6V6Z1F6V6Z1_HUMAN
Mitochondrial amidoxime reducing co...
MTARC2
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91287 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti169T → A in CAL38507 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0622753A → S1 PublicationCorresponds to variant dbSNP:rs72472370Ensembl.1
Natural variantiVAR_030133244G → S Decreased catalytic efficiency toward benzamidoxime; no effect on affinity for benzamidoxime; no effect on binding of the molybdenum cofactor. 2 PublicationsCorresponds to variant dbSNP:rs3795535Ensembl.1
Natural variantiVAR_070777245C → W Decreased catalytic activity toward benzamidoxime; no effect on affinity for benzamidoxime; no effect on binding of the molybdenum cofactor. 1 PublicationCorresponds to variant dbSNP:rs76664695Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_022513251 – 257DTWDELL → ASATRRD in isoform 2. 1 Publication7
Alternative sequenceiVSP_022514258 – 335Missing in isoform 2. 1 PublicationAdd BLAST78

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL136931 mRNA Translation: CAB66865.1
AM393631 mRNA Translation: CAL38507.1
EU567145 Genomic DNA Translation: ACB21048.1
AL359353 Genomic DNA No translation available.
AL606726 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93293.1
CH471100 Genomic DNA Translation: EAW93294.1
BC011973 mRNA Translation: AAH11973.1
BC015829 mRNA Translation: AAH15829.2
BC016859 mRNA Translation: AAH16859.1
AK000612 mRNA Translation: BAA91287.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1525.1 [Q969Z3-1]
CCDS81425.1 [Q969Z3-2]

NCBI Reference Sequences

More...RefSeqi		NP_001304267.1, NM_001317338.1 [Q969Z3-1]
NP_001317971.1, NM_001331042.1 [Q969Z3-2]
NP_060368.2, NM_017898.4 [Q969Z3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000359316.6; ENSP00000352266.2; ENSG00000117791.16 [Q969Z3-2]
ENST00000366913.8; ENSP00000355880.3; ENSG00000117791.16

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54996

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54996

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000366913.8; ENSP00000355880.3; NM_017898.5; NP_060368.2

UCSC genome browser

More...UCSCi		uc001hmq.4, human [Q969Z3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136931 mRNA Translation: CAB66865.1
AM393631 mRNA Translation: CAL38507.1
EU567145 Genomic DNA Translation: ACB21048.1
AL359353 Genomic DNA No translation available.
AL606726 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93293.1
CH471100 Genomic DNA Translation: EAW93294.1
BC011973 mRNA Translation: AAH11973.1
BC015829 mRNA Translation: AAH15829.2
BC016859 mRNA Translation: AAH16859.1
AK000612 mRNA Translation: BAA91287.1 Different initiation.
CCDSiCCDS1525.1 [Q969Z3-1]
CCDS81425.1 [Q969Z3-2]
RefSeqiNP_001304267.1, NM_001317338.1 [Q969Z3-1]
NP_001317971.1, NM_001331042.1 [Q969Z3-2]
NP_060368.2, NM_017898.4 [Q969Z3-1]

3D structure databases

AlphaFoldDBiQ969Z3
SMRiQ969Z3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120329, 36 interactors
IntActiQ969Z3, 10 interactors
MINTiQ969Z3
STRINGi9606.ENSP00000355880

Chemistry databases

ChEMBLiCHEMBL4523423

PTM databases

iPTMnetiQ969Z3
PhosphoSitePlusiQ969Z3

Genetic variation databases

BioMutaiMARC2
DMDMi74760692

Proteomic databases

EPDiQ969Z3
jPOSTiQ969Z3
MassIVEiQ969Z3
MaxQBiQ969Z3
PaxDbiQ969Z3
PeptideAtlasiQ969Z3
PRIDEiQ969Z3
ProteomicsDBi75882 [Q969Z3-1]
75883 [Q969Z3-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2381, 138 antibodies from 21 providers

The DNASU plasmid repository

More...DNASUi		54996

Genome annotation databases

EnsembliENST00000359316.6; ENSP00000352266.2; ENSG00000117791.16 [Q969Z3-2]
ENST00000366913.8; ENSP00000355880.3; ENSG00000117791.16
GeneIDi54996
KEGGihsa:54996
MANE-SelectiENST00000366913.8; ENSP00000355880.3; NM_017898.5; NP_060368.2
UCSCiuc001hmq.4, human [Q969Z3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54996
DisGeNETi54996

GeneCards: human genes, protein and diseases

More...GeneCardsi		MTARC2
HGNCiHGNC:26064, MTARC2
HPAiENSG00000117791, Tissue enhanced (kidney, liver)
MIMi614127, gene
neXtProtiNX_Q969Z3
OpenTargetsiENSG00000117791
PharmGKBiPA142671345
VEuPathDBiHostDB:ENSG00000117791

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2362, Eukaryota
GeneTreeiENSGT00940000159665
HOGENOMiCLU_028286_6_2_1
InParanoidiQ969Z3
OMAiGYPFLLI
OrthoDBi919343at2759
PhylomeDBiQ969Z3
TreeFamiTF316807

Enzyme and pathway databases

BRENDAi1.7.2.1, 2681
PathwayCommonsiQ969Z3
ReactomeiR-HSA-211945, Phase I - Functionalization of compounds
SABIO-RKiQ969Z3
SignaLinkiQ969Z3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54996, 2 hits in 828 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MARC2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MOSC2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54996
PharosiQ969Z3, Tbio

Protein Ontology

More...PROi		PR:Q969Z3
RNActiQ969Z3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000117791, Expressed in left lobe of thyroid gland and 224 other tissues
ExpressionAtlasiQ969Z3, baseline and differential
GenevisibleiQ969Z3, HS

Family and domain databases

InterProiView protein in InterPro
IPR005302, MoCF_Sase_C
IPR005303, MOSC_N
IPR011037, Pyrv_Knase-like_insert_dom_sf
PfamiView protein in Pfam
PF03473, MOSC, 1 hit
PF03476, MOSC_N, 1 hit
SUPFAMiSSF50800, SSF50800, 1 hit
PROSITEiView protein in PROSITE
PS51340, MOSC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMARC2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q969Z3
Secondary accession number(s): B2D0R5
, D3DTB3, Q0JSK7, Q5VT67, Q5VXC7, Q7L317, Q9H066, Q9NWU0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 1, 2001
Last modified: May 25, 2022
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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