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Entry version 145 (10 Apr 2019)
Sequence version 1 (01 Dec 2001)
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Protein

FAST kinase domain-containing protein 4

Gene

TBRG4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6. May play a role in cell cycle progression (PubMed:9383053).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FAST kinase domain-containing protein 41 Publication
Alternative name(s):
Cell cycle progression restoration protein 2
Short name:
Cell cycle progression protein 2
Protein TBRG4
Transforming growth factor beta regulator 4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TBRG4Imported
Synonyms:CPR21 Publication, FASTKD41 Publication, KIAA0948
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000136270.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17443 TBRG4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611325 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q969Z0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi531D → A: Does not affect location in mitochondria; fails to rescue the increased accumulation of the level of mature MT-ND3, MT-CO3, MT-CYB or MT-ND5 mRNA in TBRG4-deficient cells; does not abolish the accumulation of the MT-ND5-CYB precursor RNA in a TBRG4-deficient cell line. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9238

Open Targets

More...
OpenTargetsi
ENSG00000136270

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134882196

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TBRG4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74731072

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 107MitochondrionSequence analysisAdd BLAST107
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000273026108 – 631FAST kinase domain-containing protein 4Add BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei553PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q969Z0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q969Z0

MaxQB - The MaxQuant DataBase

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MaxQBi
Q969Z0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q969Z0

PeptideAtlas

More...
PeptideAtlasi
Q969Z0

PRoteomics IDEntifications database

More...
PRIDEi
Q969Z0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75880
75881 [Q969Z0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q969Z0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q969Z0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed (PubMed:12759187). Expression detected in spleen, thymus, testis, ovary, colon, heart, smooth muscle, kidney, brain, lung, liver and white adipose tissue with highest expression in smooth muscle (PubMed:20869947).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000136270 Expressed in 153 organ(s), highest expression level in heart left ventricle

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q969Z0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q969Z0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020582
HPA050430

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114666, 43 interactors

Protein interaction database and analysis system

More...
IntActi
Q969Z0, 35 interactors

Molecular INTeraction database

More...
MINTi
Q969Z0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000258770

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q969Z0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini561 – 619RAPPROSITE-ProRule annotationAdd BLAST59

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

RAP domain is required for TBRG4 function in mRNA stability and translation.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAST kinase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IEJA Eukaryota
ENOG4111EYX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182779

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG094028

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q969Z0

Identification of Orthologs from Complete Genome Data

More...
OMAi
ELRWTEI

Database of Orthologous Groups

More...
OrthoDBi
1209476at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q969Z0

TreeFam database of animal gene trees

More...
TreeFami
TF324885

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013579 FAST_2
IPR010622 FAST_Leu-rich
IPR013584 RAP

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06743 FAST_1, 1 hit
PF08368 FAST_2, 1 hit
PF08373 RAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00952 RAP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51286 RAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q969Z0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAHLVKRCT CLLREAARQA PAMAPVGRLR LAWVAHKTLT SSATSPISHL
60 70 80 90 100
PGSLMEPVEK ERASTPYIEK QVDHLIKKAT RPEELLELLG GSHDLDSNQA
110 120 130 140 150
AMVLIRLSHL LSEKPEDKGL LIQDAHFHQL LCLLNSQIAS VWHGTLSKLL
160 170 180 190 200
GSLYALGIPK ASKELQSVEQ EVRWRMRKLK YKHLAFLAES CATLSQEQHS
210 220 230 240 250
QELLAELLTH LERRWTEIED SHTLVTVMMK VGHLSEPLMN RLEDKCLELV
260 270 280 290 300
EHFGPNELRK VLVMLAAQSR RSVPLLRAIS YHLVQKPFSL TKDVLLDVAY
310 320 330 340 350
AYGKLSFHQT QVSQRLATDL LSLMPSLTSG EVAHCAKSFA LLKWLSLPLF
360 370 380 390 400
EAFAQHVLNR AQDITLPHLC SVLLAFARLN FHPDQEDQFF SLVHEKLGSE
410 420 430 440 450
LPGLEPALQV DLVWALCVLQ QAREAELQAV LHPEFHIQFL GGKSQKDQNT
460 470 480 490 500
FQKLLHINAT ALLEYPEYSG PLLPASAVAP GPSALDRKVT PLQKELQETL
510 520 530 540 550
KGLLGSADKG SLEVATQYGW VLDAEVLLDS DGEFLPVRDF VAPHLAQPTG
560 570 580 590 600
SQSPPPGSKR LAFLRWEFPN FNSRSKDLLG RFVLARRHIV AAGFLIVDVP
610 620 630
FYEWLELKSE WQKGAYLKDK MRKAVAEELA K
Length:631
Mass (Da):70,738
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4EFC3AF5D5BBABD3
GO
Isoform 2 (identifier: Q969Z0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     246-355: Missing.

Show »
Length:521
Mass (Da):58,443
Checksum:iCE2A279B0BFEE5B6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J7P5C9J7P5_HUMAN
FAST kinase domain-containing prote...
TBRG4
248Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IZN7C9IZN7_HUMAN
FAST kinase domain-containing prote...
TBRG4
283Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J347C9J347_HUMAN
FAST kinase domain-containing prote...
TBRG4
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J618C9J618_HUMAN
FAST kinase domain-containing prote...
TBRG4
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J5A2C9J5A2_HUMAN
FAST kinase domain-containing prote...
TBRG4
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4R5H7C4R5_HUMAN
FAST kinase domain-containing prote...
TBRG4
274Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB69312 differs from that shown. Reason: Frameshift at positions 211, 479, 498 and 576.Curated
The sequence BAA76792 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti365T → A in BAD96663 (Ref. 3) Curated1
Sequence conflicti489V → E in AAB69312 (PubMed:9383053).Curated1
Sequence conflicti524A → S in AAB69312 (PubMed:9383053).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03007122A → S1 PublicationCorresponds to variant dbSNP:rs2304694Ensembl.1
Natural variantiVAR_03007257P → L1 PublicationCorresponds to variant dbSNP:rs2304693Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_022460246 – 355Missing in isoform 2. 2 PublicationsAdd BLAST110

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB023165 mRNA Translation: BAA76792.2 Different initiation.
AK222943 mRNA Translation: BAD96663.1
AL833840 mRNA Translation: CAD38700.1
CH236960 Genomic DNA Translation: EAL23744.1
CH236960 Genomic DNA Translation: EAL23745.1
CH471128 Genomic DNA Translation: EAW61051.1
CH471128 Genomic DNA Translation: EAW61052.1
CH471128 Genomic DNA Translation: EAW61054.1
CH471128 Genomic DNA Translation: EAW61055.1
BC002732 mRNA Translation: AAH02732.2
BC014918 mRNA Translation: AAH14918.1
BC017235 mRNA Translation: AAH17235.1
AF011792 mRNA Translation: AAB69312.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5501.1 [Q969Z0-1]
CCDS5502.1 [Q969Z0-2]

NCBI Reference Sequences

More...
RefSeqi
NP_004740.2, NM_004749.3 [Q969Z0-1]
NP_112162.1, NM_030900.3 [Q969Z0-2]
NP_954573.1, NM_199122.2 [Q969Z0-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.231411
Hs.741611

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000258770; ENSP00000258770; ENSG00000136270 [Q969Z0-1]
ENST00000361278; ENSP00000354992; ENSG00000136270 [Q969Z0-2]
ENST00000395655; ENSP00000379016; ENSG00000136270 [Q969Z0-2]
ENST00000494076; ENSP00000420597; ENSG00000136270 [Q969Z0-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9238

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9238

UCSC genome browser

More...
UCSCi
uc003tmv.5 human [Q969Z0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023165 mRNA Translation: BAA76792.2 Different initiation.
AK222943 mRNA Translation: BAD96663.1
AL833840 mRNA Translation: CAD38700.1
CH236960 Genomic DNA Translation: EAL23744.1
CH236960 Genomic DNA Translation: EAL23745.1
CH471128 Genomic DNA Translation: EAW61051.1
CH471128 Genomic DNA Translation: EAW61052.1
CH471128 Genomic DNA Translation: EAW61054.1
CH471128 Genomic DNA Translation: EAW61055.1
BC002732 mRNA Translation: AAH02732.2
BC014918 mRNA Translation: AAH14918.1
BC017235 mRNA Translation: AAH17235.1
AF011792 mRNA Translation: AAB69312.1 Frameshift.
CCDSiCCDS5501.1 [Q969Z0-1]
CCDS5502.1 [Q969Z0-2]
RefSeqiNP_004740.2, NM_004749.3 [Q969Z0-1]
NP_112162.1, NM_030900.3 [Q969Z0-2]
NP_954573.1, NM_199122.2 [Q969Z0-2]
UniGeneiHs.231411
Hs.741611

3D structure databases

ProteinModelPortaliQ969Z0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114666, 43 interactors
IntActiQ969Z0, 35 interactors
MINTiQ969Z0
STRINGi9606.ENSP00000258770

PTM databases

iPTMnetiQ969Z0
PhosphoSitePlusiQ969Z0

Polymorphism and mutation databases

BioMutaiTBRG4
DMDMi74731072

Proteomic databases

EPDiQ969Z0
jPOSTiQ969Z0
MaxQBiQ969Z0
PaxDbiQ969Z0
PeptideAtlasiQ969Z0
PRIDEiQ969Z0
ProteomicsDBi75880
75881 [Q969Z0-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
9238
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258770; ENSP00000258770; ENSG00000136270 [Q969Z0-1]
ENST00000361278; ENSP00000354992; ENSG00000136270 [Q969Z0-2]
ENST00000395655; ENSP00000379016; ENSG00000136270 [Q969Z0-2]
ENST00000494076; ENSP00000420597; ENSG00000136270 [Q969Z0-1]
GeneIDi9238
KEGGihsa:9238
UCSCiuc003tmv.5 human [Q969Z0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9238
DisGeNETi9238
EuPathDBiHostDB:ENSG00000136270.13

GeneCards: human genes, protein and diseases

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GeneCardsi
TBRG4
HGNCiHGNC:17443 TBRG4
HPAiHPA020582
HPA050430
MIMi611325 gene
neXtProtiNX_Q969Z0
OpenTargetsiENSG00000136270
PharmGKBiPA134882196

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEJA Eukaryota
ENOG4111EYX LUCA
GeneTreeiENSGT00950000182779
HOVERGENiHBG094028
InParanoidiQ969Z0
OMAiELRWTEI
OrthoDBi1209476at2759
PhylomeDBiQ969Z0
TreeFamiTF324885

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TBRG4 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TBRG4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9238

Protein Ontology

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PROi
PR:Q969Z0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000136270 Expressed in 153 organ(s), highest expression level in heart left ventricle
ExpressionAtlasiQ969Z0 baseline and differential
GenevisibleiQ969Z0 HS

Family and domain databases

InterProiView protein in InterPro
IPR013579 FAST_2
IPR010622 FAST_Leu-rich
IPR013584 RAP
PfamiView protein in Pfam
PF06743 FAST_1, 1 hit
PF08368 FAST_2, 1 hit
PF08373 RAP, 1 hit
SMARTiView protein in SMART
SM00952 RAP, 1 hit
PROSITEiView protein in PROSITE
PS51286 RAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFAKD4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q969Z0
Secondary accession number(s): A4D2L2
, A4D2L3, D3DVL5, D3DVL6, O14710, Q53GI8, Q8NDM4, Q9BUC6, Q9Y2F6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 1, 2001
Last modified: April 10, 2019
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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