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Entry version 171 (13 Nov 2019)
Sequence version 1 (01 Dec 2001)
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Protein

U3 small nucleolar RNA-associated protein 4 homolog

Gene

UTP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase (PubMed:17699751, PubMed:19732766). May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5'-GGGACTTTCC-3' found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV (PubMed:19732766).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRibosome biogenesis, rRNA processing, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q969X6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 4 homolog
Alternative name(s):
Cirhin
UTP4 small subunit processome component
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UTP4Imported
Synonyms:CIRH1A, cPERP-E1 Publication, KIAA1988
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1983 UTP4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607456 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q969X6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
84916

MalaCards human disease database

More...
MalaCardsi
UTP4

Open Targets

More...
OpenTargetsi
ENSG00000141076

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
168583 Hereditary North American Indian childhood cirrhosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26520

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q969X6

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
UTP4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
41016916

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000509081 – 686U3 small nucleolar RNA-associated protein 4 homologAdd BLAST686

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki321Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

May be phosphorylated during mitosis; may control the association of this protein with WRD43 and UTP15.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q969X6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q969X6

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q969X6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q969X6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q969X6

PeptideAtlas

More...
PeptideAtlasi
Q969X6

PRoteomics IDEntifications database

More...
PRIDEi
Q969X6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75873 [Q969X6-1]
75874 [Q969X6-2]
75875 [Q969X6-3]

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
Q969X6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q969X6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q969X6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q969X6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000141076 Expressed in 198 organ(s), highest expression level in kidney epithelium

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q969X6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q969X6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041139
HPA043542

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HIVEP1 (PubMed:19732766)

Interacts with NOL11 (PubMed:22916032).

Interacts directly with UTP15 and WDR43 (PubMed:24219289). May be a component of the proposed t-UTP subcomplex of the ribosomal small subunit (SSU) processome containing at least UTP4, WDR43, HEATR1, UTP15, WDR75 (PubMed:17699751, PubMed:22916032).

1 Publication3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124353, 57 interactors

Protein interaction database and analysis system

More...
IntActi
Q969X6, 33 interactors

Molecular INTeraction database

More...
MINTi
Q969X6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000327179

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q969X6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati7 – 50WD 1Add BLAST44
Repeati51 – 92WD 2Add BLAST42
Repeati93 – 135WD 3Add BLAST43
Repeati136 – 181WD 4Add BLAST46
Repeati182 – 226WD 5Add BLAST45
Repeati227 – 275WD 6Add BLAST49
Repeati276 – 317WD 7Add BLAST42
Repeati318 – 377WD 8Add BLAST60
Repeati378 – 427WD 9Add BLAST50
Repeati428 – 475WD 10Add BLAST48
Repeati476 – 516WD 11Add BLAST41
Repeati517 – 566WD 12Add BLAST50
Repeati567 – 627WD 13Add BLAST61
Repeati628 – 666WD 14Add BLAST39

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2048 Eukaryota
ENOG410XQNR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153533

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q969X6

KEGG Orthology (KO)

More...
KOi
K14548

Database of Orthologous Groups

More...
OrthoDBi
376282at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q969X6

TreeFam database of animal gene trees

More...
TreeFami
TF313159

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400 WD40, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q969X6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGEFKVHRVR FFNYVPSGIR CVAYNNQSNR LAVSRTDGTV EIYNLSANYF
60 70 80 90 100
QEKFFPGHES RATEALCWAE GQRLFSAGLN GEIMEYDLQA LNIKYAMDAF
110 120 130 140 150
GGPIWSMAAS PSGSQLLVGC EDGSVKLFQI TPDKIQFERN FDRQKSRILS
160 170 180 190 200
LSWHPSGTHI AAGSIDYISV FDVKSGSAVH KMIVDRQYMG VSKRKCIVWG
210 220 230 240 250
VAFLSDGTII SVDSAGKVQF WDSATGTLVK SHLIANADVQ SIAVADQEDS
260 270 280 290 300
FVVGTAEGTV FHFQLVPVTS NSSEKQWVRT KPFQHHTHDV RTVAHSPTAL
310 320 330 340 350
ISGGTDTHLV FRPLMEKVEV KNYDAALRKI TFPHRCLISC SKKRQLLLFQ
360 370 380 390 400
FAHHLELWRL GSTVATGKNG DTLPLSKNAD HLLHLKTKGP ENIICSCISP
410 420 430 440 450
CGSWIAYSTV SRFFLYRLNY EHDNISLKRV SKMPAFLRSA LQILFSEDST
460 470 480 490 500
KLFVASNQGA LHIVQLSGGS FKHLHAFQPQ SGTVEAMCLL AVSPDGNWLA
510 520 530 540 550
ASGTSAGVHV YNVKQLKLHC TVPAYNFPVT AMAIAPNTNN LVIAHSDQQV
560 570 580 590 600
FEYSIPDKQY TDWSRTVQKQ GFHHLWLQRD TPITHISFHP KRPMHILLHD
610 620 630 640 650
AYMFCIIDKS LPLPNDKTLL YNPFPPTNES DVIRRRTAHA FKISKIYKPL
660 670 680
LFMDLLDERT LVAVERPLDD IIAQLPPPIK KKKFGT
Length:686
Mass (Da):76,890
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i595D8B2F47C03299
GO
Isoform 2 (identifier: Q969X6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-482: Missing.

Show »
Length:571
Mass (Da):64,119
Checksum:i933667DDFFA4F345
GO
Isoform 3 (identifier: Q969X6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     612-625: PLPNDKTLLYNPFP → VSSSLLPPKSSSES
     626-686: Missing.

Note: May be due to intron retention.
Show »
Length:625
Mass (Da):69,639
Checksum:iC1E06A47C8E5078D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BSH7H3BSH7_HUMAN
U3 small nucleolar RNA-associated p...
UTP4
700Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4T9I3L4T9_HUMAN
U3 small nucleolar RNA-associated p...
UTP4
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPD7H3BPD7_HUMAN
U3 small nucleolar RNA-associated p...
UTP4
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSI1J3KSI1_HUMAN
U3 small nucleolar RNA-associated p...
UTP4
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRM8H3BRM8_HUMAN
U3 small nucleolar RNA-associated p...
UTP4
211Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSE6J3KSE6_HUMAN
U3 small nucleolar RNA-associated p...
UTP4
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KTR0J3KTR0_HUMAN
U3 small nucleolar RNA-associated p...
UTP4
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YWK2A0A0J9YWK2_HUMAN
U3 small nucleolar RNA-associated p...
UTP4
450Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YWM9A0A0J9YWM9_HUMAN
U3 small nucleolar RNA-associated p...
UTP4
511Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YXV4A0A0J9YXV4_HUMAN
U3 small nucleolar RNA-associated p...
UTP4
396Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB55100 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB55116 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB55212 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB85574 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti101G → V in BAB55116 (PubMed:14702039).Curated1
Sequence conflicti290V → M in BAB55251 (PubMed:14702039).Curated1
Sequence conflicti378N → S in BAB55100 (PubMed:14702039).Curated1
Sequence conflicti419N → S in BAC11214 (PubMed:14702039).Curated1
Sequence conflicti594M → V in BAB55100 (PubMed:14702039).Curated1
Sequence conflicti624F → L in BAC11214 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053388438R → H. Corresponds to variant dbSNP:rs8056684Ensembl.1
Natural variantiVAR_017445565R → W Found in patients with North American Indian childhood cirrhosis; unknown pathological significance; does not affect nucleolar protein location; decreased interaction with HIVEP1 measured in yeast two-hybrid screening. 3 PublicationsCorresponds to variant dbSNP:rs119465999EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009201368 – 482Missing in isoform 2. 1 PublicationAdd BLAST115
Alternative sequenceiVSP_009202612 – 625PLPND…YNPFP → VSSSLLPPKSSSES in isoform 3. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_009203626 – 686Missing in isoform 3. 2 PublicationsAdd BLAST61

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB075868 mRNA Translation: BAB85574.2 Different initiation.
AK027419 mRNA Translation: BAB55100.1 Different initiation.
AK027445 mRNA Translation: BAB55116.1 Different initiation.
AK027584 mRNA Translation: BAB55212.1 Different initiation.
AK027634 mRNA Translation: BAB55251.1
AK027675 mRNA Translation: BAB55287.1
AK074795 mRNA Translation: BAC11214.1
BC000167 mRNA Translation: AAH00167.1
BC009348 mRNA Translation: AAH09348.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10872.1 [Q969X6-1]

NCBI Reference Sequences

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RefSeqi
NP_116219.2, NM_032830.2 [Q969X6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000314423; ENSP00000327179; ENSG00000141076 [Q969X6-1]
ENST00000352319; ENSP00000339164; ENSG00000141076 [Q969X6-2]
ENST00000563094; ENSP00000456622; ENSG00000141076 [Q969X6-3]
ENST00000575702; ENSP00000458843; ENSG00000262788

Database of genes from NCBI RefSeq genomes

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GeneIDi
84916

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84916

UCSC genome browser

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UCSCi
uc002ewr.3 human [Q969X6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075868 mRNA Translation: BAB85574.2 Different initiation.
AK027419 mRNA Translation: BAB55100.1 Different initiation.
AK027445 mRNA Translation: BAB55116.1 Different initiation.
AK027584 mRNA Translation: BAB55212.1 Different initiation.
AK027634 mRNA Translation: BAB55251.1
AK027675 mRNA Translation: BAB55287.1
AK074795 mRNA Translation: BAC11214.1
BC000167 mRNA Translation: AAH00167.1
BC009348 mRNA Translation: AAH09348.1
CCDSiCCDS10872.1 [Q969X6-1]
RefSeqiNP_116219.2, NM_032830.2 [Q969X6-1]

3D structure databases

SMRiQ969X6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi124353, 57 interactors
IntActiQ969X6, 33 interactors
MINTiQ969X6
STRINGi9606.ENSP00000327179

PTM databases

iPTMnetiQ969X6
PhosphoSitePlusiQ969X6
SwissPalmiQ969X6

Polymorphism and mutation databases

BioMutaiUTP4
DMDMi41016916

2D gel databases

SWISS-2DPAGEiQ969X6

Proteomic databases

EPDiQ969X6
jPOSTiQ969X6
MassIVEiQ969X6
MaxQBiQ969X6
PaxDbiQ969X6
PeptideAtlasiQ969X6
PRIDEiQ969X6
ProteomicsDBi75873 [Q969X6-1]
75874 [Q969X6-2]
75875 [Q969X6-3]

Genome annotation databases

EnsembliENST00000314423; ENSP00000327179; ENSG00000141076 [Q969X6-1]
ENST00000352319; ENSP00000339164; ENSG00000141076 [Q969X6-2]
ENST00000563094; ENSP00000456622; ENSG00000141076 [Q969X6-3]
ENST00000575702; ENSP00000458843; ENSG00000262788
GeneIDi84916
KEGGihsa:84916
UCSCiuc002ewr.3 human [Q969X6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84916
DisGeNETi84916

GeneCards: human genes, protein and diseases

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GeneCardsi
UTP4
HGNCiHGNC:1983 UTP4
HPAiHPA041139
HPA043542
MalaCardsiUTP4
MIMi607456 gene
neXtProtiNX_Q969X6
OpenTargetsiENSG00000141076
Orphaneti168583 Hereditary North American Indian childhood cirrhosis
PharmGKBiPA26520

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2048 Eukaryota
ENOG410XQNR LUCA
GeneTreeiENSGT00940000153533
InParanoidiQ969X6
KOiK14548
OrthoDBi376282at2759
PhylomeDBiQ969X6
TreeFamiTF313159

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
SignaLinkiQ969X6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
UTP4 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CIRH1A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84916
PharosiQ969X6

Protein Ontology

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PROi
PR:Q969X6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000141076 Expressed in 198 organ(s), highest expression level in kidney epithelium
ExpressionAtlasiQ969X6 baseline and differential
GenevisibleiQ969X6 HS

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 10 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUTP4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q969X6
Secondary accession number(s): Q8NCD9
, Q8TF14, Q96SP0, Q96SR9, Q96SZ9, Q96T13, Q9BWK6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: December 1, 2001
Last modified: November 13, 2019
This is version 171 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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