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Entry version 138 (13 Feb 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Endoplasmic reticulum-Golgi intermediate compartment protein 1

Gene

ERGIC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possible role in transport between endoplasmic reticulum and Golgi.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • endoplasmic reticulum to Golgi vesicle-mediated transport Source: HGNC
  • retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endoplasmic reticulum-Golgi intermediate compartment protein 1
Alternative name(s):
ER-Golgi intermediate compartment 32 kDa protein
Short name:
ERGIC-32
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ERGIC1
Synonyms:ERGIC32, KIAA1181Imported
ORF Names:HT034
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000113719.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29205 ERGIC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617946 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q969X5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 26CytoplasmicSequence analysisAdd BLAST26
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei27 – 47HelicalSequence analysisAdd BLAST21
Topological domaini48 – 254LumenalSequence analysisAdd BLAST207
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Topological domaini276 – 290CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Arthrogryposis multiplex congenita, neurogenic type (AMCN)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of arthrogryposis multiplex congenita, a heterogeneous group of disorders characterized by multiple joint contractures resulting, in some cases, from reduced or absent fetal movements. AMCN is due to a neurogenic defect and is characterized by congenital immobility of the limbs with fixation of multiple joints, and muscle wasting. AMCN transmission pattern is consistent with autosomal recessive inheritance in several families. Penetrance may be incomplete in females.
See also OMIM:208100
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08048098V → E in AMCN; unknown pathological significance. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
57222

MalaCards human disease database

More...
MalaCardsi
ERGIC1
MIMi208100 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000113719

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1143 Neurogenic arthrogryposis multiplex congenita

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485456

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ERGIC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
51701446

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000870231 – 290Endoplasmic reticulum-Golgi intermediate compartment protein 1Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi74N-linked (GlcNAc...) asparagine2 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q969X5

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q969X5

MaxQB - The MaxQuant DataBase

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MaxQBi
Q969X5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q969X5

PeptideAtlas

More...
PeptideAtlasi
Q969X5

PRoteomics IDEntifications database

More...
PRIDEi
Q969X5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75870
75871 [Q969X5-2]
75872 [Q969X5-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q969X5-1 [Q969X5-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q969X5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q969X5

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q969X5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000113719 Expressed in 203 organ(s), highest expression level in left adrenal gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q969X5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q969X5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA018666
HPA018900

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ERGIC3/ERV46.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121458, 39 interactors

Protein interaction database and analysis system

More...
IntActi
Q969X5, 22 interactors

Molecular INTeraction database

More...
MINTi
Q969X5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377374

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q969X5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q969X5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ERGIC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2667 Eukaryota
ENOG410XP7X LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063113

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000210954

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG081479

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q969X5

KEGG Orthology (KO)

More...
KOi
K20365

Identification of Orthologs from Complete Genome Data

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OMAi
CRFEGHF

Database of Orthologous Groups

More...
OrthoDBi
1318747at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q969X5

TreeFam database of animal gene trees

More...
TreeFami
TF354253

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012936 Erv_C
IPR039542 Erv_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07970 COPIIcoated_ERV, 1 hit
PF13850 ERGIC_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q969X5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPFDFRRFDI YRKVPKDLTQ PTYTGAIISI CCCLFILFLF LSELTGFITT
60 70 80 90 100
EVVNELYVDD PDKDSGGKID VSLNISLPNL HCELVGLDIQ DEMGRHEVGH
110 120 130 140 150
IDNSMKIPLN NGAGCRFEGQ FSINKVPGNF HVSTHSATAQ PQNPDMTHVI
160 170 180 190 200
HKLSFGDTLQ VQNIHGAFNA LGGADRLTSN PLASHDYILK IVPTVYEDKS
210 220 230 240 250
GKQRYSYQYT VANKEYVAYS HTGRIIPAIW FRYDLSPITV KYTERRQPLY
260 270 280 290
RFITTICAII GGTFTVAGIL DSCIFTASEA WKKIQLGKMH
Length:290
Mass (Da):32,592
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B13C7B8B9F8E51D
GO
Isoform 2 (identifier: Q969X5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.

Note: No experimental confirmation available.
Show »
Length:198
Mass (Da):22,160
Checksum:i931E3EBE28377777
GO
Isoform 3 (identifier: Q969X5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: Missing.
     46-52: GFITTEV → MERWAMR
     127-204: PGNFHVSTHS...VYEDKSGKQR → WKPCLSPFYL...GSGRSYSSLQ
     205-290: Missing.

Show »
Length:159
Mass (Da):17,778
Checksum:iFB02DEBA58B1D20D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z2U2F2Z2U2_HUMAN
Endoplasmic reticulum-Golgi interme...
ERGIC1
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z3Q5F2Z3Q5_HUMAN
Endoplasmic reticulum-Golgi interme...
ERGIC1
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2P5F2Z2P5_HUMAN
Endoplasmic reticulum-Golgi interme...
ERGIC1
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GTQ3A0A1B0GTQ3_HUMAN
Endoplasmic reticulum-Golgi interme...
ERGIC1
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAV2H0YAV2_HUMAN
Endoplasmic reticulum-Golgi interme...
ERGIC1
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG44724 differs from that shown. Reason: Frameshift at positions 100 and 150.Curated
The sequence BAA86495 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08048098V → E in AMCN; unknown pathological significance. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0115601 – 92Missing in isoform 2. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_0115611 – 45Missing in isoform 3. 2 PublicationsAdd BLAST45
Alternative sequenceiVSP_01156246 – 52GFITTEV → MERWAMR in isoform 3. 2 Publications7
Alternative sequenceiVSP_011563127 – 204PGNFH…SGKQR → WKPCLSPFYLLPFPAVSPLP GNWLWRHSLDLTLTQPPASE GSCPAAWPFLLRIWMGVQAP WGFKPLMAGSGRSYSSLQ in isoform 3. 2 PublicationsAdd BLAST78
Alternative sequenceiVSP_011564205 – 290Missing in isoform 3. 2 PublicationsAdd BLAST86

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB033007 mRNA Translation: BAA86495.1 Different initiation.
AF267855 mRNA Translation: AAG44724.1 Frameshift.
AL136753 mRNA Translation: CAB66687.1
CR533474 mRNA Translation: CAG38505.1
BC012766 mRNA Translation: AAH12766.1
BC014490 mRNA Translation: AAH14490.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34292.1 [Q969X5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001026881.1, NM_001031711.2 [Q969X5-1]
XP_006714955.1, XM_006714892.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.509163

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000326654; ENSP00000325127; ENSG00000113719 [Q969X5-3]
ENST00000393784; ENSP00000377374; ENSG00000113719 [Q969X5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
57222

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57222

UCSC genome browser

More...
UCSCi
uc003mbw.5 human [Q969X5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033007 mRNA Translation: BAA86495.1 Different initiation.
AF267855 mRNA Translation: AAG44724.1 Frameshift.
AL136753 mRNA Translation: CAB66687.1
CR533474 mRNA Translation: CAG38505.1
BC012766 mRNA Translation: AAH12766.1
BC014490 mRNA Translation: AAH14490.1
CCDSiCCDS34292.1 [Q969X5-1]
RefSeqiNP_001026881.1, NM_001031711.2 [Q969X5-1]
XP_006714955.1, XM_006714892.1
UniGeneiHs.509163

3D structure databases

ProteinModelPortaliQ969X5
SMRiQ969X5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121458, 39 interactors
IntActiQ969X5, 22 interactors
MINTiQ969X5
STRINGi9606.ENSP00000377374

PTM databases

iPTMnetiQ969X5
PhosphoSitePlusiQ969X5
SwissPalmiQ969X5

Polymorphism and mutation databases

BioMutaiERGIC1
DMDMi51701446

Proteomic databases

EPDiQ969X5
jPOSTiQ969X5
MaxQBiQ969X5
PaxDbiQ969X5
PeptideAtlasiQ969X5
PRIDEiQ969X5
ProteomicsDBi75870
75871 [Q969X5-2]
75872 [Q969X5-3]
TopDownProteomicsiQ969X5-1 [Q969X5-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326654; ENSP00000325127; ENSG00000113719 [Q969X5-3]
ENST00000393784; ENSP00000377374; ENSG00000113719 [Q969X5-1]
GeneIDi57222
KEGGihsa:57222
UCSCiuc003mbw.5 human [Q969X5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57222
DisGeNETi57222
EuPathDBiHostDB:ENSG00000113719.15

GeneCards: human genes, protein and diseases

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GeneCardsi
ERGIC1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0005421
HGNCiHGNC:29205 ERGIC1
HPAiHPA018666
HPA018900
MalaCardsiERGIC1
MIMi208100 phenotype
617946 gene
neXtProtiNX_Q969X5
OpenTargetsiENSG00000113719
Orphaneti1143 Neurogenic arthrogryposis multiplex congenita
PharmGKBiPA143485456

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2667 Eukaryota
ENOG410XP7X LUCA
GeneTreeiENSGT00530000063113
HOGENOMiHOG000210954
HOVERGENiHBG081479
InParanoidiQ969X5
KOiK20365
OMAiCRFEGHF
OrthoDBi1318747at2759
PhylomeDBiQ969X5
TreeFamiTF354253

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ERGIC1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57222

Protein Ontology

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PROi
PR:Q969X5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000113719 Expressed in 203 organ(s), highest expression level in left adrenal gland
ExpressionAtlasiQ969X5 baseline and differential
GenevisibleiQ969X5 HS

Family and domain databases

InterProiView protein in InterPro
IPR012936 Erv_C
IPR039542 Erv_N
PfamiView protein in Pfam
PF07970 COPIIcoated_ERV, 1 hit
PF13850 ERGIC_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiERGI1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q969X5
Secondary accession number(s): Q9H0L0, Q9H2J2, Q9ULN9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: December 1, 2001
Last modified: February 13, 2019
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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