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Entry version 152 (02 Jun 2021)
Sequence version 1 (01 Dec 2001)
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Protein

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

Gene

ST6GALNAC6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycoproteins and glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3-linkage on Gal. ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:12668675, PubMed:17123352).

Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (PubMed:12668675).

Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) (By similarity).

By similarity2 Publications

Miscellaneous

The carbohydrate antigen disialyl Lewis a, which is at least partly synthesized by ST6GALNAC6, is a normal counterpart of sialyl Lewis a, better known as CA19-9, an antigen widely used as a serum marker for diagnosis of cancers in the digestive track. Disialyl Lewis a is predominantly expressed in non-malignant epithelial cells of the digestive organs, while sialyl Lewis a is preferentially expressed in cancers. Disialyl Lewis a in normal epithelial cells serves as a ligand for immunosuppressive receptors, such as SIGLEC7 and SIGLEC9, expressed on resident monocytes/macrophages and maintains immunological homeostasis of mucosal membranes in digestive organs. Sialyl Lewis a, as well as its positional isomer sialyl Lewis x, serves as a ligand for vascular cell adhesion molecule E-selectin and facilitates hematogenous metastasis through mediating adhesion of circulating cancer cells to vascular endothelium (PubMed:17760270).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.33 mM for GM1b1 Publication
  2. KM=0.46 mM for sialyl Lc4Cer1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionGlycosyltransferase, Transferase
    LigandSialic acid

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.4.99.7, 2681

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    Q969X2

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-4085001, Sialic acid metabolism
    R-HSA-9037629, Lewis blood group biosynthesis

    Protein family/group databases

    Carbohydrate-Active enZymes

    More...
    CAZyi
    GT29, Glycosyltransferase Family 29

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000001366

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (EC:2.4.99.-2 Publications)
    Alternative name(s):
    GalNAc alpha-2,6-sialyltransferase VI
    ST6GalNAc VI2 Publications
    Short name:
    ST6GalNAcVI
    Short name:
    hST6GalNAc VI
    Sialyltransferase 7F
    Short name:
    SIAT7-F
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ST6GALNAC6
    Synonyms:SIAT7F
    ORF Names:UNQ708/PRO1359
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:23364, ST6GALNAC6

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    610135, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q969X2

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...
    VEuPathDBi
    HostDB:ENSG00000160408.14

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 43CytoplasmicSequence analysisAdd BLAST43
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei44 – 64Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
    Topological domaini65 – 333LumenalSequence analysisAdd BLAST269

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    30815

    Open Targets

    More...
    OpenTargetsi
    ENSG00000160408
    ENSG00000257524

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA134891331

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q969X2, Tdark

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    ST6GALNAC6

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    74751728

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003147951 – 333Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6Add BLAST333

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi108 ↔ 256By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q969X2

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q969X2

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q969X2

    PeptideAtlas

    More...
    PeptideAtlasi
    Q969X2

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q969X2

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    75868 [Q969X2-1]
    75869 [Q969X2-2]

    PTM databases

    GlyGen: Computational and Informatics Resources for Glycoscience

    More...
    GlyGeni
    Q969X2, 1 site

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q969X2

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q969X2

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in kidney, in proximal tubule epithelial cells. Expressed in colon cell lines.2 Publications

    <p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Down-regulated in renal cancers.

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000160408, Expressed in prefrontal cortex and 184 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q969X2, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q969X2, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000160408, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Hide details

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    119039, 6 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q969X2, 5 interactors

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q969X2, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 26DisorderedSequence analysisAdd BLAST26

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the glycosyltransferase 29 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000160114

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_061099_3_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q969X2

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    HCHNCAL

    Database of Orthologous Groups

    More...
    OrthoDBi
    817470at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q969X2

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF323961

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.90.1480.20, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001675, Glyco_trans_29
    IPR038578, GT29-like_sf

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00777, Glyco_transf_29, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q969X2-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MACSRPPSQC EPTSLPPGPP AGRRHLPLSR RRREMSSNKE QRSAVFVILF
    60 70 80 90 100
    ALITILILYS SNSANEVFHY GSLRGRSRRP VNLKKWSITD GYVPILGNKT
    110 120 130 140 150
    LPSRCHQCVI VSSSSHLLGT KLGPEIERAE CTIRMNDAPT TGYSADVGNK
    160 170 180 190 200
    TTYRVVAHSS VFRVLRRPQE FVNRTPETVF IFWGPPSKMQ KPQGSLVRVI
    210 220 230 240 250
    QRAGLVFPNM EAYAVSPGRM RQFDDLFRGE TGKDREKSHS WLSTGWFTMV
    260 270 280 290 300
    IAVELCDHVH VYGMVPPNYC SQRPRLQRMP YHYYEPKGPD ECVTYIQNEH
    310 320 330
    SRKGNHHRFI TEKRVFSSWA QLYGITFSHP SWT
    Length:333
    Mass (Da):38,068
    Last modified:December 1, 2001 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5DB6FFA7D7A707C0
    GO
    Isoform 2 (identifier: Q969X2-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-34: Missing.

    Show »
    Length:299
    Mass (Da):34,291
    Checksum:iF9DAFF04008A0C5F
    GO
    Isoform 3 (identifier: Q969X2-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         272-333: QRPRLQRMPY...GITFSHPSWT → GPASSACPTT...AGVSPSQSGP

    Show »
    Length:374
    Mass (Da):40,781
    Checksum:i04DCE408DBED314E
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A0S2Z653A0A0S2Z653_HUMAN
    Alpha-N-acetylgalactosaminide alpha...
    ST6GALNAC6
    235Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A2R8YFX0A0A2R8YFX0_HUMAN
    Uncharacterized protein
    339Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F6SGE3F6SGE3_HUMAN
    Alpha-N-acetylgalactosaminide alpha...
    ST6GALNAC6
    86Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence EAW87712 differs from that shown. Reason: Erroneous gene model prediction.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti73L → M in BC036102 (PubMed:15489334).Curated1
    Sequence conflicti174R → Q in BC036102 (PubMed:15489334).Curated1
    Sequence conflicti228R → Q in BC036102 (PubMed:15489334).Curated1
    Sequence conflicti249M → T in BAB14715 (PubMed:12975309).Curated1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0303591 – 34Missing in isoform 2. 5 PublicationsAdd BLAST34
    Alternative sequenceiVSP_055722272 – 333QRPRL…HPSWT → GPASSACPTTTTSPRGRTNV SPTSRMSTVARATTTASSPR KGSSHRGPSCMASPSPTPPG PRPPSLWDLRRVRGEAASAQ PLGQGPSSGQSRLAGVSPSQ SGP in isoform 3. 1 PublicationAdd BLAST62

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AJ507293 mRNA Translation: CAD45373.1
    AB035173 mRNA Translation: BAA87035.1
    AY358672 mRNA Translation: AAQ89035.1
    AK023900 mRNA Translation: BAB14715.1
    AK057100 mRNA Translation: BAG51863.1
    CR457318 mRNA Translation: CAG33599.1
    AL157935 Genomic DNA No translation available.
    CH471090 Genomic DNA Translation: EAW87711.1
    CH471090 Genomic DNA Translation: EAW87712.1 Sequence problems.
    CH471090 Genomic DNA Translation: EAW87714.1
    BC006564 mRNA Translation: AAH06564.1
    BC007802 mRNA Translation: AAH07802.1
    BC016299 mRNA Translation: AAH16299.1
    BC036102 mRNA No translation available.

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS6882.1 [Q969X2-1]
    CCDS69668.1 [Q969X2-2]
    CCDS69669.1 [Q969X2-3]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001273928.1, NM_001286999.1 [Q969X2-3]
    NP_001273929.1, NM_001287000.1 [Q969X2-2]
    NP_001273930.1, NM_001287001.1 [Q969X2-2]
    NP_001273931.1, NM_001287002.1 [Q969X2-2]
    NP_001273932.1, NM_001287003.1
    NP_038471.2, NM_013443.4 [Q969X2-1]
    XP_011516912.1, XM_011518610.2 [Q969X2-1]
    XP_011516913.1, XM_011518611.2 [Q969X2-2]
    XP_016870148.1, XM_017014659.1 [Q969X2-3]
    XP_016870154.1, XM_017014665.1 [Q969X2-2]
    XP_016870155.1, XM_017014666.1 [Q969X2-2]
    XP_016870156.1, XM_017014667.1 [Q969X2-2]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000373141; ENSP00000362234; ENSG00000160408 [Q969X2-2]
    ENST00000373142; ENSP00000362235; ENSG00000160408 [Q969X2-3]
    ENST00000373144; ENSP00000362237; ENSG00000160408 [Q969X2-2]
    ENST00000373146; ENSP00000362239; ENSG00000160408 [Q969X2-1]
    ENST00000622357; ENSP00000477575; ENSG00000160408 [Q969X2-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    30815

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:30815

    UCSC genome browser

    More...
    UCSCi
    uc004bsn.3, human [Q969X2-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    Functional Glycomics Gateway - GTase

    ST6GalNAc VI

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AJ507293 mRNA Translation: CAD45373.1
    AB035173 mRNA Translation: BAA87035.1
    AY358672 mRNA Translation: AAQ89035.1
    AK023900 mRNA Translation: BAB14715.1
    AK057100 mRNA Translation: BAG51863.1
    CR457318 mRNA Translation: CAG33599.1
    AL157935 Genomic DNA No translation available.
    CH471090 Genomic DNA Translation: EAW87711.1
    CH471090 Genomic DNA Translation: EAW87712.1 Sequence problems.
    CH471090 Genomic DNA Translation: EAW87714.1
    BC006564 mRNA Translation: AAH06564.1
    BC007802 mRNA Translation: AAH07802.1
    BC016299 mRNA Translation: AAH16299.1
    BC036102 mRNA No translation available.
    CCDSiCCDS6882.1 [Q969X2-1]
    CCDS69668.1 [Q969X2-2]
    CCDS69669.1 [Q969X2-3]
    RefSeqiNP_001273928.1, NM_001286999.1 [Q969X2-3]
    NP_001273929.1, NM_001287000.1 [Q969X2-2]
    NP_001273930.1, NM_001287001.1 [Q969X2-2]
    NP_001273931.1, NM_001287002.1 [Q969X2-2]
    NP_001273932.1, NM_001287003.1
    NP_038471.2, NM_013443.4 [Q969X2-1]
    XP_011516912.1, XM_011518610.2 [Q969X2-1]
    XP_011516913.1, XM_011518611.2 [Q969X2-2]
    XP_016870148.1, XM_017014659.1 [Q969X2-3]
    XP_016870154.1, XM_017014665.1 [Q969X2-2]
    XP_016870155.1, XM_017014666.1 [Q969X2-2]
    XP_016870156.1, XM_017014667.1 [Q969X2-2]

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGRIDi119039, 6 interactors
    IntActiQ969X2, 5 interactors

    Chemistry databases

    SwissLipidsiSLP:000001366

    Protein family/group databases

    CAZyiGT29, Glycosyltransferase Family 29

    PTM databases

    GlyGeniQ969X2, 1 site
    iPTMnetiQ969X2
    PhosphoSitePlusiQ969X2

    Genetic variation databases

    BioMutaiST6GALNAC6
    DMDMi74751728

    Proteomic databases

    jPOSTiQ969X2
    MassIVEiQ969X2
    PaxDbiQ969X2
    PeptideAtlasiQ969X2
    PRIDEiQ969X2
    ProteomicsDBi75868 [Q969X2-1]
    75869 [Q969X2-2]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    17244, 84 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    30815

    Genome annotation databases

    EnsembliENST00000373141; ENSP00000362234; ENSG00000160408 [Q969X2-2]
    ENST00000373142; ENSP00000362235; ENSG00000160408 [Q969X2-3]
    ENST00000373144; ENSP00000362237; ENSG00000160408 [Q969X2-2]
    ENST00000373146; ENSP00000362239; ENSG00000160408 [Q969X2-1]
    ENST00000622357; ENSP00000477575; ENSG00000160408 [Q969X2-2]
    GeneIDi30815
    KEGGihsa:30815
    UCSCiuc004bsn.3, human [Q969X2-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    30815
    DisGeNETi30815

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    ST6GALNAC6
    HGNCiHGNC:23364, ST6GALNAC6
    HPAiENSG00000160408, Low tissue specificity
    MIMi610135, gene
    neXtProtiNX_Q969X2
    OpenTargetsiENSG00000160408
    ENSG00000257524
    PharmGKBiPA134891331
    VEuPathDBiHostDB:ENSG00000160408.14

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    GeneTreeiENSGT00940000160114
    HOGENOMiCLU_061099_3_0_1
    InParanoidiQ969X2
    OMAiHCHNCAL
    OrthoDBi817470at2759
    PhylomeDBiQ969X2
    TreeFamiTF323961

    Enzyme and pathway databases

    BRENDAi2.4.99.7, 2681
    PathwayCommonsiQ969X2
    ReactomeiR-HSA-4085001, Sialic acid metabolism
    R-HSA-9037629, Lewis blood group biosynthesis

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    30815, 8 hits in 995 CRISPR screens

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    ST6GALNAC6

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    30815
    PharosiQ969X2, Tdark

    Protein Ontology

    More...
    PROi
    PR:Q969X2
    RNActiQ969X2, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000160408, Expressed in prefrontal cortex and 184 other tissues
    ExpressionAtlasiQ969X2, baseline and differential
    GenevisibleiQ969X2, HS

    Family and domain databases

    Gene3Di3.90.1480.20, 1 hit
    InterProiView protein in InterPro
    IPR001675, Glyco_trans_29
    IPR038578, GT29-like_sf
    PfamiView protein in Pfam
    PF00777, Glyco_transf_29, 1 hit

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIA7F_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q969X2
    Secondary accession number(s): B3KQ01
    , Q5T9C4, Q5T9C5, Q9H8A2, Q9ULB8
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: December 1, 2001
    Last modified: June 2, 2021
    This is version 152 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families
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