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Protein

Protein lifeguard 3

Gene

TMBIM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling.

GO - Molecular functioni

  • death receptor binding Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Protein family/group databases

TCDBi1.A.14.3.10 the calcium transporter a (cata) (formerly the testis-enhanced gene transfer (tegt) family

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lifeguard 3
Alternative name(s):
Protein RECS1 homolog
Transmembrane BAX inhibitor motif-containing protein 1
Gene namesi
Name:TMBIM1
Synonyms:LFG3, RECS1
ORF Names:PP1201, PSEC0158
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000135926.12
HGNCiHGNC:23410 TMBIM1
MIMi610364 gene
neXtProtiNX_Q969X1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64114
OpenTargetsiENSG00000135926
PharmGKBiPA142670804

Polymorphism and mutation databases

BioMutaiTMBIM1
DMDMi93117549

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001790901 – 311Protein lifeguard 3Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei81PhosphoserineBy similarity1
Modified residuei83PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ969X1
MaxQBiQ969X1
PaxDbiQ969X1
PeptideAtlasiQ969X1
PRIDEiQ969X1
ProteomicsDBi75867

PTM databases

iPTMnetiQ969X1
PhosphoSitePlusiQ969X1
SwissPalmiQ969X1

Expressioni

Gene expression databases

BgeeiENSG00000135926 Expressed in 229 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_TMBIM1
ExpressionAtlasiQ969X1 baseline and differential
GenevisibleiQ969X1 HS

Organism-specific databases

HPAiHPA012093
HPA070824

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122070, 6 interactors
IntActiQ969X1, 13 interactors
STRINGi9606.ENSP00000258412

Structurei

3D structure databases

ProteinModelPortaliQ969X1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BI1 family. LFG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2322 Eukaryota
COG0670 LUCA
GeneTreeiENSGT00500000044791
HOGENOMiHOG000060393
HOVERGENiHBG012084
InParanoidiQ969X1
KOiK06890
OMAiTLACCQG
OrthoDBiEOG091G0JRK
PhylomeDBiQ969X1
TreeFamiTF319996

Family and domain databases

InterProiView protein in InterPro
IPR006214 Bax_inhibitor_1-related
PANTHERiPTHR23291 PTHR23291, 1 hit
PfamiView protein in Pfam
PF01027 Bax1-I, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 15 potential isoforms that are computationally mapped.Show allAlign All

Q969X1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNPSAPPPY EDRNPLYPGP PPPGGYGQPS VLPGGYPAYP GYPQPGYGHP
60 70 80 90 100
AGYPQPMPPT HPMPMNYGPG HGYDGEERAV SDSFGPGEWD DRKVRHTFIR
110 120 130 140 150
KVYSIISVQL LITVAIIAIF TFVEPVSAFV RRNVAVYYVS YAVFVVTYLI
160 170 180 190 200
LACCQGPRRR FPWNIILLTL FTFAMGFMTG TISSMYQTKA VIIAMIITAV
210 220 230 240 250
VSISVTIFCF QTKVDFTSCT GLFCVLGIVL LVTGIVTSIV LYFQYVYWLH
260 270 280 290 300
MLYAALGAIC FTLFLAYDTQ LVLGNRKHTI SPEDYITGAL QIYTDIIYIF
310
TFVLQLMGDR N
Length:311
Mass (Da):34,607
Last modified:March 7, 2006 - v2
Checksum:i12B5741A60C1487F
GO

Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JW19C9JW19_HUMAN
Protein lifeguard 3
TMBIM1
167Annotation score:
C9JWV9C9JWV9_HUMAN
Protein lifeguard 3
TMBIM1
171Annotation score:
C9IZ27C9IZ27_HUMAN
Protein lifeguard 3
TMBIM1
150Annotation score:
B3KSM0B3KSM0_HUMAN
Protein lifeguard 3
TMBIM1
137Annotation score:
F8WDY4F8WDY4_HUMAN
Protein lifeguard 3
TMBIM1
140Annotation score:
C9JEN3C9JEN3_HUMAN
Protein lifeguard 3
TMBIM1
106Annotation score:
C9IYT2C9IYT2_HUMAN
Protein lifeguard 3
TMBIM1
107Annotation score:
C9JAP5C9JAP5_HUMAN
Protein lifeguard 3
TMBIM1
91Annotation score:
B4DUD2B4DUD2_HUMAN
Protein lifeguard 3
TMBIM1
215Annotation score:
C9JN47C9JN47_HUMAN
Protein lifeguard 3
TMBIM1
73Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence AAH26693 differs from that shown. Reason: Frameshift at position 6.Curated
The sequence BAB55346 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC11636 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti119I → T in BAC04516 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01738221P → L3 PublicationsCorresponds to variant dbSNP:rs2292553Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027755 mRNA Translation: BAB55346.1 Different initiation.
AK090618 mRNA Translation: BAG52198.1
AK095270 mRNA Translation: BAC04516.1 Sequence problems.
AF193045 mRNA Translation: AAG22473.1
AK075465 mRNA Translation: BAC11636.1 Different initiation.
CH471063 Genomic DNA Translation: EAW70607.1
BC007980 mRNA Translation: AAH07980.1
BC013428 mRNA Translation: AAH13428.1
BC026348 mRNA Translation: AAH26348.1
BC026693 mRNA Translation: AAH26693.1 Frameshift.
CCDSiCCDS2412.1
RefSeqiNP_001308356.1, NM_001321427.1
NP_001308357.1, NM_001321428.1
NP_001308358.1, NM_001321429.1
NP_001308359.1, NM_001321430.1
NP_001308361.1, NM_001321432.1
NP_001308362.1, NM_001321433.1
NP_001308364.1, NM_001321435.1
NP_001308365.1, NM_001321436.1
NP_071435.2, NM_022152.5
XP_011509929.1, XM_011511627.1
UniGeneiHs.591605

Genome annotation databases

EnsembliENST00000258412; ENSP00000258412; ENSG00000135926
ENST00000396809; ENSP00000380025; ENSG00000135926
ENST00000444881; ENSP00000409738; ENSG00000135926
GeneIDi64114
KEGGihsa:64114
UCSCiuc002vho.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027755 mRNA Translation: BAB55346.1 Different initiation.
AK090618 mRNA Translation: BAG52198.1
AK095270 mRNA Translation: BAC04516.1 Sequence problems.
AF193045 mRNA Translation: AAG22473.1
AK075465 mRNA Translation: BAC11636.1 Different initiation.
CH471063 Genomic DNA Translation: EAW70607.1
BC007980 mRNA Translation: AAH07980.1
BC013428 mRNA Translation: AAH13428.1
BC026348 mRNA Translation: AAH26348.1
BC026693 mRNA Translation: AAH26693.1 Frameshift.
CCDSiCCDS2412.1
RefSeqiNP_001308356.1, NM_001321427.1
NP_001308357.1, NM_001321428.1
NP_001308358.1, NM_001321429.1
NP_001308359.1, NM_001321430.1
NP_001308361.1, NM_001321432.1
NP_001308362.1, NM_001321433.1
NP_001308364.1, NM_001321435.1
NP_001308365.1, NM_001321436.1
NP_071435.2, NM_022152.5
XP_011509929.1, XM_011511627.1
UniGeneiHs.591605

3D structure databases

ProteinModelPortaliQ969X1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122070, 6 interactors
IntActiQ969X1, 13 interactors
STRINGi9606.ENSP00000258412

Protein family/group databases

TCDBi1.A.14.3.10 the calcium transporter a (cata) (formerly the testis-enhanced gene transfer (tegt) family

PTM databases

iPTMnetiQ969X1
PhosphoSitePlusiQ969X1
SwissPalmiQ969X1

Polymorphism and mutation databases

BioMutaiTMBIM1
DMDMi93117549

Proteomic databases

EPDiQ969X1
MaxQBiQ969X1
PaxDbiQ969X1
PeptideAtlasiQ969X1
PRIDEiQ969X1
ProteomicsDBi75867

Protocols and materials databases

DNASUi64114
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258412; ENSP00000258412; ENSG00000135926
ENST00000396809; ENSP00000380025; ENSG00000135926
ENST00000444881; ENSP00000409738; ENSG00000135926
GeneIDi64114
KEGGihsa:64114
UCSCiuc002vho.2 human

Organism-specific databases

CTDi64114
DisGeNETi64114
EuPathDBiHostDB:ENSG00000135926.12
GeneCardsiTMBIM1
HGNCiHGNC:23410 TMBIM1
HPAiHPA012093
HPA070824
MIMi610364 gene
neXtProtiNX_Q969X1
OpenTargetsiENSG00000135926
PharmGKBiPA142670804
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2322 Eukaryota
COG0670 LUCA
GeneTreeiENSGT00500000044791
HOGENOMiHOG000060393
HOVERGENiHBG012084
InParanoidiQ969X1
KOiK06890
OMAiTLACCQG
OrthoDBiEOG091G0JRK
PhylomeDBiQ969X1
TreeFamiTF319996

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

GenomeRNAii64114
PROiPR:Q969X1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135926 Expressed in 229 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_TMBIM1
ExpressionAtlasiQ969X1 baseline and differential
GenevisibleiQ969X1 HS

Family and domain databases

InterProiView protein in InterPro
IPR006214 Bax_inhibitor_1-related
PANTHERiPTHR23291 PTHR23291, 1 hit
PfamiView protein in Pfam
PF01027 Bax1-I, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLFG3_HUMAN
AccessioniPrimary (citable) accession number: Q969X1
Secondary accession number(s): B3KQY6
, Q8N1R3, Q8TAM3, Q96K13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: March 7, 2006
Last modified: November 7, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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