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Entry version 143 (16 Oct 2019)
Sequence version 2 (07 Mar 2006)
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Protein

Protein lifeguard 3

Gene

TMBIM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695 Neutrophil degranulation

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.14.3.10 the calcium transporter a (cata) (formerly the testis-enhanced gene transfer (tegt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein lifeguard 3
Alternative name(s):
Protein RECS1 homolog
Transmembrane BAX inhibitor motif-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMBIM1
Synonyms:LFG3, RECS1
ORF Names:PP1201, PSEC0158
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23410 TMBIM1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610364 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q969X1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endosome, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64114

Open Targets

More...
OpenTargetsi
ENSG00000135926

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670804

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q969X1

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMBIM1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
93117549

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001790901 – 311Protein lifeguard 3Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei81PhosphoserineBy similarity1
Modified residuei83PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q969X1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q969X1

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q969X1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q969X1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q969X1

PeptideAtlas

More...
PeptideAtlasi
Q969X1

PRoteomics IDEntifications database

More...
PRIDEi
Q969X1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75867

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q969X1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q969X1

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q969X1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135926 Expressed in 229 organ(s), highest expression level in lower esophagus mucosa

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q969X1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q969X1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA012093
HPA070824

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122070, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q969X1, 14 interactors

Molecular INTeraction database

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MINTi
Q969X1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000409738

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BI1 family. LFG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2322 Eukaryota
COG0670 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000182650

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060393

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q969X1

KEGG Orthology (KO)

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KOi
K06890

Identification of Orthologs from Complete Genome Data

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OMAi
IYWLHML

Database of Orthologous Groups

More...
OrthoDBi
1290306at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q969X1

TreeFam database of animal gene trees

More...
TreeFami
TF319996

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006214 Bax_inhibitor_1-related

The PANTHER Classification System

More...
PANTHERi
PTHR23291 PTHR23291, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01027 Bax1-I, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 15 potential isoforms that are computationally mapped.Show allAlign All

Q969X1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNPSAPPPY EDRNPLYPGP PPPGGYGQPS VLPGGYPAYP GYPQPGYGHP
60 70 80 90 100
AGYPQPMPPT HPMPMNYGPG HGYDGEERAV SDSFGPGEWD DRKVRHTFIR
110 120 130 140 150
KVYSIISVQL LITVAIIAIF TFVEPVSAFV RRNVAVYYVS YAVFVVTYLI
160 170 180 190 200
LACCQGPRRR FPWNIILLTL FTFAMGFMTG TISSMYQTKA VIIAMIITAV
210 220 230 240 250
VSISVTIFCF QTKVDFTSCT GLFCVLGIVL LVTGIVTSIV LYFQYVYWLH
260 270 280 290 300
MLYAALGAIC FTLFLAYDTQ LVLGNRKHTI SPEDYITGAL QIYTDIIYIF
310
TFVLQLMGDR N
Length:311
Mass (Da):34,607
Last modified:March 7, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i12B5741A60C1487F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JW19C9JW19_HUMAN
Protein lifeguard 3
TMBIM1
167Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JWV9C9JWV9_HUMAN
Protein lifeguard 3
TMBIM1
171Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IZ27C9IZ27_HUMAN
Protein lifeguard 3
TMBIM1
150Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDY4F8WDY4_HUMAN
Protein lifeguard 3
TMBIM1
140Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IYT2C9IYT2_HUMAN
Protein lifeguard 3
TMBIM1
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JEN3C9JEN3_HUMAN
Protein lifeguard 3
TMBIM1
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JAP5C9JAP5_HUMAN
Protein lifeguard 3
TMBIM1
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B3KSM0B3KSM0_HUMAN
Protein lifeguard 3
TMBIM1
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DUD2B4DUD2_HUMAN
Protein lifeguard 3
TMBIM1
215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JDV0C9JDV0_HUMAN
Protein lifeguard 3
TMBIM1
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH26693 differs from that shown. Reason: Frameshift.Curated
The sequence BAB55346 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC11636 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti119I → T in BAC04516 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01738221P → L3 PublicationsCorresponds to variant dbSNP:rs2292553Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK027755 mRNA Translation: BAB55346.1 Different initiation.
AK090618 mRNA Translation: BAG52198.1
AK095270 mRNA Translation: BAC04516.1 Sequence problems.
AF193045 mRNA Translation: AAG22473.1
AK075465 mRNA Translation: BAC11636.1 Different initiation.
CH471063 Genomic DNA Translation: EAW70607.1
BC007980 mRNA Translation: AAH07980.1
BC013428 mRNA Translation: AAH13428.1
BC026348 mRNA Translation: AAH26348.1
BC026693 mRNA Translation: AAH26693.1 Frameshift.

The Consensus CDS (CCDS) project

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CCDSi
CCDS2412.1

NCBI Reference Sequences

More...
RefSeqi
NP_001308356.1, NM_001321427.1
NP_001308357.1, NM_001321428.1
NP_001308358.1, NM_001321429.1
NP_001308359.1, NM_001321430.1
NP_001308361.1, NM_001321432.1
NP_001308362.1, NM_001321433.1
NP_001308364.1, NM_001321435.1
NP_001308365.1, NM_001321436.1
NP_071435.2, NM_022152.5
XP_011509929.1, XM_011511627.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000258412; ENSP00000258412; ENSG00000135926
ENST00000396809; ENSP00000380025; ENSG00000135926
ENST00000444881; ENSP00000409738; ENSG00000135926

Database of genes from NCBI RefSeq genomes

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GeneIDi
64114

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:64114

UCSC genome browser

More...
UCSCi
uc002vho.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027755 mRNA Translation: BAB55346.1 Different initiation.
AK090618 mRNA Translation: BAG52198.1
AK095270 mRNA Translation: BAC04516.1 Sequence problems.
AF193045 mRNA Translation: AAG22473.1
AK075465 mRNA Translation: BAC11636.1 Different initiation.
CH471063 Genomic DNA Translation: EAW70607.1
BC007980 mRNA Translation: AAH07980.1
BC013428 mRNA Translation: AAH13428.1
BC026348 mRNA Translation: AAH26348.1
BC026693 mRNA Translation: AAH26693.1 Frameshift.
CCDSiCCDS2412.1
RefSeqiNP_001308356.1, NM_001321427.1
NP_001308357.1, NM_001321428.1
NP_001308358.1, NM_001321429.1
NP_001308359.1, NM_001321430.1
NP_001308361.1, NM_001321432.1
NP_001308362.1, NM_001321433.1
NP_001308364.1, NM_001321435.1
NP_001308365.1, NM_001321436.1
NP_071435.2, NM_022152.5
XP_011509929.1, XM_011511627.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi122070, 6 interactors
IntActiQ969X1, 14 interactors
MINTiQ969X1
STRINGi9606.ENSP00000409738

Protein family/group databases

TCDBi1.A.14.3.10 the calcium transporter a (cata) (formerly the testis-enhanced gene transfer (tegt) family

PTM databases

iPTMnetiQ969X1
PhosphoSitePlusiQ969X1
SwissPalmiQ969X1

Polymorphism and mutation databases

BioMutaiTMBIM1
DMDMi93117549

Proteomic databases

EPDiQ969X1
jPOSTiQ969X1
MassIVEiQ969X1
MaxQBiQ969X1
PaxDbiQ969X1
PeptideAtlasiQ969X1
PRIDEiQ969X1
ProteomicsDBi75867

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
64114

Genome annotation databases

EnsembliENST00000258412; ENSP00000258412; ENSG00000135926
ENST00000396809; ENSP00000380025; ENSG00000135926
ENST00000444881; ENSP00000409738; ENSG00000135926
GeneIDi64114
KEGGihsa:64114
UCSCiuc002vho.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64114
DisGeNETi64114

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMBIM1
HGNCiHGNC:23410 TMBIM1
HPAiHPA012093
HPA070824
MIMi610364 gene
neXtProtiNX_Q969X1
OpenTargetsiENSG00000135926
PharmGKBiPA142670804

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2322 Eukaryota
COG0670 LUCA
GeneTreeiENSGT00950000182650
HOGENOMiHOG000060393
InParanoidiQ969X1
KOiK06890
OMAiIYWLHML
OrthoDBi1290306at2759
PhylomeDBiQ969X1
TreeFamiTF319996

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TMBIM1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64114
PharosiQ969X1

Protein Ontology

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PROi
PR:Q969X1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000135926 Expressed in 229 organ(s), highest expression level in lower esophagus mucosa
ExpressionAtlasiQ969X1 baseline and differential
GenevisibleiQ969X1 HS

Family and domain databases

InterProiView protein in InterPro
IPR006214 Bax_inhibitor_1-related
PANTHERiPTHR23291 PTHR23291, 1 hit
PfamiView protein in Pfam
PF01027 Bax1-I, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLFG3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q969X1
Secondary accession number(s): B3KQY6
, Q8N1R3, Q8TAM3, Q96K13
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: March 7, 2006
Last modified: October 16, 2019
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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