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Protein

Protein FAM104A

Gene

FAM104A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM104A
Gene namesi
Name:FAM104A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000133193.12
HGNCiHGNC:25918 FAM104A
neXtProtiNX_Q969W3

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000133193
PharmGKBiPA142671787

Polymorphism and mutation databases

BioMutaiFAM104A
DMDMi308153443

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002361821 – 186Protein FAM104AAdd BLAST186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

EPDiQ969W3
MaxQBiQ969W3
PeptideAtlasiQ969W3
PRIDEiQ969W3
ProteomicsDBi75860
75861 [Q969W3-2]

PTM databases

iPTMnetiQ969W3
PhosphoSitePlusiQ969W3

Expressioni

Gene expression databases

BgeeiENSG00000133193 Expressed in 205 organ(s), highest expression level in sperm
CleanExiHS_FAM104A
ExpressionAtlasiQ969W3 baseline and differential
GenevisibleiQ969W3 HS

Organism-specific databases

HPAiHPA021459

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HEL-S-70V9HW803EBI-10281506,EBI-10175326

Protein-protein interaction databases

BioGridi124358, 6 interactors
IntActiQ969W3, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliQ969W3
SMRiQ969W3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi94 – 145Ser-richAdd BLAST52

Sequence similaritiesi

Belongs to the FAM104 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000001055
HOGENOMiHOG000231053
HOVERGENiHBG059882
InParanoidiQ969W3
OMAiNPVFHDS
OrthoDBiEOG091G11TE
PhylomeDBiQ969W3
TreeFamiTF335777

Family and domain databases

InterProiView protein in InterPro
IPR029222 FAM104
PANTHERiPTHR34763 PTHR34763, 1 hit
PfamiView protein in Pfam
PF15434 FAM104, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q969W3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGGRGADAGS SGGTGPTEGY SPPAASTRAA ARAKARGGGR GGRRNTTPSV
60 70 80 90 100
PSLRGAAPRS FHPPAAMSER LRPRKRRRNG NEEDNHLPPQ TKRSSRNPVF
110 120 130 140 150
QDSWDTESSG SDSGGSSSSS SSSINSPDRA SGPEGSLSQT MAGSSPNTPQ
160 170 180
PVPEQSALCQ GLYFHINQTL REAHFHSLQH RGRPLT
Length:186
Mass (Da):19,484
Last modified:October 5, 2010 - v2
Checksum:iBE96E7F6BC18DEB4
GO
Isoform 2 (identifier: Q969W3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-107: E → ETVPVMRNSKENRLRGNKAFCA

Show »
Length:207
Mass (Da):21,858
Checksum:i76275AFA9982B1B6
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KT76J3KT76_HUMAN
Protein FAM104A
FAM104A
103Annotation score:
J3KSI9J3KSI9_HUMAN
Protein FAM104A
FAM104A
109Annotation score:
J3KT52J3KT52_HUMAN
Protein FAM104A
FAM104A
125Annotation score:
J3KT35J3KT35_HUMAN
Protein FAM104A
FAM104A
96Annotation score:

Sequence cautioni

The sequence AAH11054 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH25238 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB55292 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC11183 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039868107E → ETVPVMRNSKENRLRGNKAF CA in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027681 mRNA Translation: BAB55292.1 Different initiation.
AK074755 mRNA Translation: BAC11183.1 Different initiation.
AK304556 mRNA Translation: BAG65351.1
AC097641 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW89116.1
BC011054 mRNA Translation: AAH11054.1 Different initiation.
BC025238 mRNA Translation: AAH25238.1 Different initiation.
U92989 mRNA No translation available.
CCDSiCCDS11693.2 [Q969W3-1]
CCDS45766.1 [Q969W3-2]
RefSeqiNP_001092302.1, NM_001098832.1 [Q969W3-2]
NP_001276339.1, NM_001289410.1
NP_001276340.1, NM_001289411.1
NP_001276341.1, NM_001289412.1
NP_116226.2, NM_032837.2 [Q969W3-1]
UniGeneiHs.741276

Genome annotation databases

EnsembliENST00000403627; ENSP00000384648; ENSG00000133193 [Q969W3-1]
ENST00000405159; ENSP00000384832; ENSG00000133193 [Q969W3-2]
GeneIDi84923
KEGGihsa:84923
UCSCiuc002jji.5 human [Q969W3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027681 mRNA Translation: BAB55292.1 Different initiation.
AK074755 mRNA Translation: BAC11183.1 Different initiation.
AK304556 mRNA Translation: BAG65351.1
AC097641 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW89116.1
BC011054 mRNA Translation: AAH11054.1 Different initiation.
BC025238 mRNA Translation: AAH25238.1 Different initiation.
U92989 mRNA No translation available.
CCDSiCCDS11693.2 [Q969W3-1]
CCDS45766.1 [Q969W3-2]
RefSeqiNP_001092302.1, NM_001098832.1 [Q969W3-2]
NP_001276339.1, NM_001289410.1
NP_001276340.1, NM_001289411.1
NP_001276341.1, NM_001289412.1
NP_116226.2, NM_032837.2 [Q969W3-1]
UniGeneiHs.741276

3D structure databases

ProteinModelPortaliQ969W3
SMRiQ969W3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124358, 6 interactors
IntActiQ969W3, 3 interactors

PTM databases

iPTMnetiQ969W3
PhosphoSitePlusiQ969W3

Polymorphism and mutation databases

BioMutaiFAM104A
DMDMi308153443

Proteomic databases

EPDiQ969W3
MaxQBiQ969W3
PeptideAtlasiQ969W3
PRIDEiQ969W3
ProteomicsDBi75860
75861 [Q969W3-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000403627; ENSP00000384648; ENSG00000133193 [Q969W3-1]
ENST00000405159; ENSP00000384832; ENSG00000133193 [Q969W3-2]
GeneIDi84923
KEGGihsa:84923
UCSCiuc002jji.5 human [Q969W3-1]

Organism-specific databases

CTDi84923
EuPathDBiHostDB:ENSG00000133193.12
GeneCardsiFAM104A
H-InvDBiHIX0014136
HIX0019625
HGNCiHGNC:25918 FAM104A
HPAiHPA021459
neXtProtiNX_Q969W3
OpenTargetsiENSG00000133193
PharmGKBiPA142671787
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000001055
HOGENOMiHOG000231053
HOVERGENiHBG059882
InParanoidiQ969W3
OMAiNPVFHDS
OrthoDBiEOG091G11TE
PhylomeDBiQ969W3
TreeFamiTF335777

Miscellaneous databases

ChiTaRSiFAM104A human
GenomeRNAii84923
PROiPR:Q969W3

Gene expression databases

BgeeiENSG00000133193 Expressed in 205 organ(s), highest expression level in sperm
CleanExiHS_FAM104A
ExpressionAtlasiQ969W3 baseline and differential
GenevisibleiQ969W3 HS

Family and domain databases

InterProiView protein in InterPro
IPR029222 FAM104
PANTHERiPTHR34763 PTHR34763, 1 hit
PfamiView protein in Pfam
PF15434 FAM104, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF104A_HUMAN
AccessioniPrimary (citable) accession number: Q969W3
Secondary accession number(s): B4E339
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 5, 2010
Last modified: September 12, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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