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Entry version 146 (11 Dec 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Palmitoyltransferase ZDHHC16

Gene

ZDHHC16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6 (PubMed:28826475). Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (By similarity). Also required for eye development (By similarity). Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (PubMed:28826475). May play a role in DNA damage response (By similarity). May be involved in apoptosis regulation (By similarity). Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei185S-palmitoyl cysteine intermediateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processApoptosis, DNA damage

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.3.1.225 2681

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC16Curated (EC:2.3.1.2251 Publication)
Alternative name(s):
Abl-philin 21 Publication
Zinc finger DHHC domain-containing protein 16
Short name:
DHHC-16
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZDHHC16Imported
Synonyms:APH21 Publication
ORF Names:UNQ2570/PRO6258
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000171307.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20714 ZDHHC16

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616750 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q969W1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 77CytoplasmicSequence analysisAdd BLAST77
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Topological domaini99 – 116LumenalSequence analysisAdd BLAST18
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 198CytoplasmicSequence analysisAdd BLAST61
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 266LumenalSequence analysisAdd BLAST47
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Topological domaini288 – 377CytoplasmicSequence analysisAdd BLAST90

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84287

Open Targets

More...
OpenTargetsi
ENSG00000171307

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134985701

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q969W1 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZDHHC16

Domain mapping of disease mutations (DMDM)

More...
DMDMi
37999852

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002128971 – 377Palmitoyltransferase ZDHHC16Add BLAST377

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q969W1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q969W1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q969W1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q969W1

PeptideAtlas

More...
PeptideAtlasi
Q969W1

PRoteomics IDEntifications database

More...
PRIDEi
Q969W1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75856 [Q969W1-1]
75857 [Q969W1-2]
75858 [Q969W1-3]
75859 [Q969W1-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q969W1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q969W1

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q969W1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171307 Expressed in 197 organ(s), highest expression level in parotid gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q969W1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q969W1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039893
HPA040214

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ABL1 (By similarity).

Interacts with COPS5/JAB1 (PubMed:17123647).

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124014, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q969W1, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377357

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q969W1 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini155 – 205DHHCPROSITE-ProRule annotationAdd BLAST51

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1313 Eukaryota
COG5273 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155032

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q969W1

KEGG Orthology (KO)

More...
KOi
K18932

Identification of Orthologs from Complete Genome Data

More...
OMAi
VEAVSMC

Database of Orthologous Groups

More...
OrthoDBi
1491968at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q969W1

TreeFam database of animal gene trees

More...
TreeFami
TF320809

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
IPR039859 ZDH16

The PANTHER Classification System

More...
PANTHERi
PTHR12246 PTHR12246, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01529 DHHC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50216 DHHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q969W1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRGQRSLLLG PARLCLRLLL LLGYRRRCPP LLRGLVQRWR YGKVCLRSLL
60 70 80 90 100
YNSFGGSDTA VDAAFEPVYW LVDNVIRWFG VVFVVLVIVL TGSIVAIAYL
110 120 130 140 150
CVLPLILRTY SVPRLCWHFF YSHWNLILIV FHYYQAITTP PGYPPQGRND
160 170 180 190 200
IATVSICKKC IYPKPARTHH CSICNRCVLK MDHHCPWLNN CVGHYNHRYF
210 220 230 240 250
FSFCFFMTLG CVYCSYGSWD LFREAYAAIE KMKQLDKNKL QAVANQTYHQ
260 270 280 290 300
TPPPTFSFRE RMTHKSLVYL WFLCSSVALA LGALTVWHAV LISRGETSIE
310 320 330 340 350
RHINKKERRR LQAKGRVFRN PYNYGCLDNW KVFLGVDTGR HWLTRVLLPS
360 370
SHLPHGNGMS WEPPPWVTAH SASVMAV
Length:377
Mass (Da):43,633
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i68AC733DE498A81E
GO
Isoform 2 (identifier: Q969W1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-246: Missing.

Show »
Length:361
Mass (Da):41,794
Checksum:i37D184AD737B652E
GO
Isoform 3 (identifier: Q969W1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-214: Missing.

Show »
Length:338
Mass (Da):38,858
Checksum:i19FF4C8C0360CBF3
GO
Isoform 4 (identifier: Q969W1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-146: Missing.
     231-246: Missing.

Show »
Length:296
Mass (Da):34,275
Checksum:i5761AA22DE90EB10
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AMU0B1AMU0_HUMAN
Palmitoyltransferase
ZDHHC16
307Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AMU5B1AMU5_HUMAN
Palmitoyltransferase
ZDHHC16
213Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y536H0Y536_HUMAN
Palmitoyltransferase
ZDHHC16
301Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6E9H0Y6E9_HUMAN
Palmitoyltransferase
ZDHHC16
319Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AMT9B1AMT9_HUMAN
Palmitoyltransferase
ZDHHC16
242Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01627482 – 146Missing in isoform 4. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_016275176 – 214Missing in isoform 3. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_008716231 – 246Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF258563 mRNA Translation: AAG23766.1
AJ294945 mRNA Translation: CAC82556.1
AY359080 mRNA Translation: AAQ89439.1
AL355490 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49929.1
CH471066 Genomic DNA Translation: EAW49930.1
CH471066 Genomic DNA Translation: EAW49931.1
CH471066 Genomic DNA Translation: EAW49932.1
CH471066 Genomic DNA Translation: EAW49933.1
CH471066 Genomic DNA Translation: EAW49934.1
BC004535 mRNA Translation: AAH04535.1
BC008074 mRNA Translation: AAH08074.1
BC011749 mRNA Translation: AAH11749.1
BC012830 mRNA Translation: AAH12830.1
BC033157 mRNA Translation: AAH33157.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7460.1 [Q969W1-1]
CCDS7461.1 [Q969W1-2]
CCDS7462.1 [Q969W1-3]
CCDS7463.1 [Q969W1-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001274732.1, NM_001287803.1
NP_001274733.1, NM_001287804.1
NP_115703.2, NM_032327.3 [Q969W1-1]
NP_932160.1, NM_198043.2 [Q969W1-2]
NP_932161.1, NM_198044.2 [Q969W1-3]
NP_932162.1, NM_198045.2 [Q969W1-4]
NP_932163.1, NM_198046.2 [Q969W1-1]
XP_016872255.1, XM_017016766.1 [Q969W1-2]
XP_016872257.1, XM_017016768.1 [Q969W1-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000345745; ENSP00000304487; ENSG00000171307 [Q969W1-4]
ENST00000352634; ENSP00000345383; ENSG00000171307 [Q969W1-2]
ENST00000353979; ENSP00000323360; ENSG00000171307 [Q969W1-3]
ENST00000370842; ENSP00000359879; ENSG00000171307 [Q969W1-2]
ENST00000370854; ENSP00000359891; ENSG00000171307 [Q969W1-1]
ENST00000393760; ENSP00000377357; ENSG00000171307 [Q969W1-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84287

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84287

UCSC genome browser

More...
UCSCi
uc001knj.5 human [Q969W1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF258563 mRNA Translation: AAG23766.1
AJ294945 mRNA Translation: CAC82556.1
AY359080 mRNA Translation: AAQ89439.1
AL355490 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49929.1
CH471066 Genomic DNA Translation: EAW49930.1
CH471066 Genomic DNA Translation: EAW49931.1
CH471066 Genomic DNA Translation: EAW49932.1
CH471066 Genomic DNA Translation: EAW49933.1
CH471066 Genomic DNA Translation: EAW49934.1
BC004535 mRNA Translation: AAH04535.1
BC008074 mRNA Translation: AAH08074.1
BC011749 mRNA Translation: AAH11749.1
BC012830 mRNA Translation: AAH12830.1
BC033157 mRNA Translation: AAH33157.1
CCDSiCCDS7460.1 [Q969W1-1]
CCDS7461.1 [Q969W1-2]
CCDS7462.1 [Q969W1-3]
CCDS7463.1 [Q969W1-4]
RefSeqiNP_001274732.1, NM_001287803.1
NP_001274733.1, NM_001287804.1
NP_115703.2, NM_032327.3 [Q969W1-1]
NP_932160.1, NM_198043.2 [Q969W1-2]
NP_932161.1, NM_198044.2 [Q969W1-3]
NP_932162.1, NM_198045.2 [Q969W1-4]
NP_932163.1, NM_198046.2 [Q969W1-1]
XP_016872255.1, XM_017016766.1 [Q969W1-2]
XP_016872257.1, XM_017016768.1 [Q969W1-3]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi124014, 3 interactors
IntActiQ969W1, 3 interactors
STRINGi9606.ENSP00000377357

PTM databases

iPTMnetiQ969W1
PhosphoSitePlusiQ969W1
SwissPalmiQ969W1

Polymorphism and mutation databases

BioMutaiZDHHC16
DMDMi37999852

Proteomic databases

jPOSTiQ969W1
MassIVEiQ969W1
MaxQBiQ969W1
PaxDbiQ969W1
PeptideAtlasiQ969W1
PRIDEiQ969W1
ProteomicsDBi75856 [Q969W1-1]
75857 [Q969W1-2]
75858 [Q969W1-3]
75859 [Q969W1-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
84287

Genome annotation databases

EnsembliENST00000345745; ENSP00000304487; ENSG00000171307 [Q969W1-4]
ENST00000352634; ENSP00000345383; ENSG00000171307 [Q969W1-2]
ENST00000353979; ENSP00000323360; ENSG00000171307 [Q969W1-3]
ENST00000370842; ENSP00000359879; ENSG00000171307 [Q969W1-2]
ENST00000370854; ENSP00000359891; ENSG00000171307 [Q969W1-1]
ENST00000393760; ENSP00000377357; ENSG00000171307 [Q969W1-1]
GeneIDi84287
KEGGihsa:84287
UCSCiuc001knj.5 human [Q969W1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84287
DisGeNETi84287
EuPathDBiHostDB:ENSG00000171307.18

GeneCards: human genes, protein and diseases

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GeneCardsi
ZDHHC16
HGNCiHGNC:20714 ZDHHC16
HPAiHPA039893
HPA040214
MIMi616750 gene
neXtProtiNX_Q969W1
OpenTargetsiENSG00000171307
PharmGKBiPA134985701

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1313 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00940000155032
InParanoidiQ969W1
KOiK18932
OMAiVEAVSMC
OrthoDBi1491968at2759
PhylomeDBiQ969W1
TreeFamiTF320809

Enzyme and pathway databases

BRENDAi2.3.1.225 2681

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZDHHC16 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84287
PharosiQ969W1 Tdark

Protein Ontology

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PROi
PR:Q969W1
RNActiQ969W1 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000171307 Expressed in 197 organ(s), highest expression level in parotid gland
ExpressionAtlasiQ969W1 baseline and differential
GenevisibleiQ969W1 HS

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
IPR039859 ZDH16
PANTHERiPTHR12246 PTHR12246, 1 hit
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZDH16_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q969W1
Secondary accession number(s): D3DR52
, D3DR53, D3DR54, Q5JTG7, Q5JTH0, Q8N4Z6, Q8WY84, Q9BSV3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: December 1, 2001
Last modified: December 11, 2019
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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