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Protein

Palmitoyltransferase ZDHHC16

Gene

ZDHHC16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6 (PubMed:28826475). Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (By similarity). Also required for eye development (By similarity). Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (PubMed:28826475). May play a role in DNA damage response (By similarity). May be involved in apoptosis regulation (By similarity). Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity).By similarity1 Publication

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei185S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processApoptosis, DNA damage

Enzyme and pathway databases

BRENDAi2.3.1.225 2681

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC16Curated (EC:2.3.1.2251 Publication)
Alternative name(s):
Abl-philin 21 Publication
Zinc finger DHHC domain-containing protein 16
Short name:
DHHC-16
Gene namesi
Name:ZDHHC16Imported
Synonyms:APH21 Publication
ORF Names:UNQ2570/PRO6258
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000171307.18
HGNCiHGNC:20714 ZDHHC16
MIMi616750 gene
neXtProtiNX_Q969W1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 77CytoplasmicSequence analysisAdd BLAST77
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Topological domaini99 – 116LumenalSequence analysisAdd BLAST18
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 198CytoplasmicSequence analysisAdd BLAST61
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 266LumenalSequence analysisAdd BLAST47
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Topological domaini288 – 377CytoplasmicSequence analysisAdd BLAST90

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84287
OpenTargetsiENSG00000171307
PharmGKBiPA134985701

Polymorphism and mutation databases

DMDMi37999852

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128971 – 377Palmitoyltransferase ZDHHC16Add BLAST377

Proteomic databases

MaxQBiQ969W1
PaxDbiQ969W1
PeptideAtlasiQ969W1
PRIDEiQ969W1
ProteomicsDBi75856
75857 [Q969W1-2]
75858 [Q969W1-3]
75859 [Q969W1-4]

PTM databases

iPTMnetiQ969W1
PhosphoSitePlusiQ969W1
SwissPalmiQ969W1

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000171307
CleanExiHS_ZDHHC16
ExpressionAtlasiQ969W1 baseline and differential
GenevisibleiQ969W1 HS

Organism-specific databases

HPAiHPA039893
HPA040214

Interactioni

Subunit structurei

Interacts with ABL1 (By similarity). Interacts with COPS5/JAB1 (PubMed:17123647).By similarity1 Publication

Protein-protein interaction databases

BioGridi124014, 3 interactors
IntActiQ969W1, 3 interactors
STRINGi9606.ENSP00000359891

Structurei

3D structure databases

ProteinModelPortaliQ969W1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini155 – 205DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1313 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00900000140969
HOVERGENiHBG054667
InParanoidiQ969W1
KOiK18932
OMAiKNWKLFL
OrthoDBiEOG091G0FLT
PhylomeDBiQ969W1
TreeFamiTF320809

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q969W1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGQRSLLLG PARLCLRLLL LLGYRRRCPP LLRGLVQRWR YGKVCLRSLL
60 70 80 90 100
YNSFGGSDTA VDAAFEPVYW LVDNVIRWFG VVFVVLVIVL TGSIVAIAYL
110 120 130 140 150
CVLPLILRTY SVPRLCWHFF YSHWNLILIV FHYYQAITTP PGYPPQGRND
160 170 180 190 200
IATVSICKKC IYPKPARTHH CSICNRCVLK MDHHCPWLNN CVGHYNHRYF
210 220 230 240 250
FSFCFFMTLG CVYCSYGSWD LFREAYAAIE KMKQLDKNKL QAVANQTYHQ
260 270 280 290 300
TPPPTFSFRE RMTHKSLVYL WFLCSSVALA LGALTVWHAV LISRGETSIE
310 320 330 340 350
RHINKKERRR LQAKGRVFRN PYNYGCLDNW KVFLGVDTGR HWLTRVLLPS
360 370
SHLPHGNGMS WEPPPWVTAH SASVMAV
Length:377
Mass (Da):43,633
Last modified:December 1, 2001 - v1
Checksum:i68AC733DE498A81E
GO
Isoform 2 (identifier: Q969W1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-246: Missing.

Show »
Length:361
Mass (Da):41,794
Checksum:i37D184AD737B652E
GO
Isoform 3 (identifier: Q969W1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-214: Missing.

Show »
Length:338
Mass (Da):38,858
Checksum:i19FF4C8C0360CBF3
GO
Isoform 4 (identifier: Q969W1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-146: Missing.
     231-246: Missing.

Show »
Length:296
Mass (Da):34,275
Checksum:i5761AA22DE90EB10
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01627482 – 146Missing in isoform 4. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_016275176 – 214Missing in isoform 3. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_008716231 – 246Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF258563 mRNA Translation: AAG23766.1
AJ294945 mRNA Translation: CAC82556.1
AY359080 mRNA Translation: AAQ89439.1
AL355490 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49929.1
CH471066 Genomic DNA Translation: EAW49930.1
CH471066 Genomic DNA Translation: EAW49931.1
CH471066 Genomic DNA Translation: EAW49932.1
CH471066 Genomic DNA Translation: EAW49933.1
CH471066 Genomic DNA Translation: EAW49934.1
BC004535 mRNA Translation: AAH04535.1
BC008074 mRNA Translation: AAH08074.1
BC011749 mRNA Translation: AAH11749.1
BC012830 mRNA Translation: AAH12830.1
BC033157 mRNA Translation: AAH33157.1
CCDSiCCDS7460.1 [Q969W1-1]
CCDS7461.1 [Q969W1-2]
CCDS7462.1 [Q969W1-3]
CCDS7463.1 [Q969W1-4]
RefSeqiNP_001274732.1, NM_001287803.1
NP_001274733.1, NM_001287804.1
NP_115703.2, NM_032327.3 [Q969W1-1]
NP_932160.1, NM_198043.2 [Q969W1-2]
NP_932161.1, NM_198044.2 [Q969W1-3]
NP_932162.1, NM_198045.2 [Q969W1-4]
NP_932163.1, NM_198046.2 [Q969W1-1]
XP_016872255.1, XM_017016766.1 [Q969W1-2]
XP_016872257.1, XM_017016768.1 [Q969W1-3]
UniGeneiHs.76662

Genome annotation databases

EnsembliENST00000345745; ENSP00000304487; ENSG00000171307 [Q969W1-4]
ENST00000352634; ENSP00000345383; ENSG00000171307 [Q969W1-2]
ENST00000353979; ENSP00000323360; ENSG00000171307 [Q969W1-3]
ENST00000370842; ENSP00000359879; ENSG00000171307 [Q969W1-2]
ENST00000370854; ENSP00000359891; ENSG00000171307 [Q969W1-1]
ENST00000393760; ENSP00000377357; ENSG00000171307 [Q969W1-1]
GeneIDi84287
KEGGihsa:84287
UCSCiuc001knj.5 human [Q969W1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZDH16_HUMAN
AccessioniPrimary (citable) accession number: Q969W1
Secondary accession number(s): D3DR52
, D3DR53, D3DR54, Q5JTG7, Q5JTH0, Q8N4Z6, Q8WY84, Q9BSV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: December 1, 2001
Last modified: July 18, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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