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Protein

Tektin-1

Gene

TEKT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.

GO - Biological processi

  • cilium assembly Source: GO_Central
  • cilium movement involved in cell motility Source: GO_Central
  • flagellated sperm motility Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Tektin-1
Gene namesi
Name:TEKT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000167858.12
HGNCiHGNC:15534 TEKT1
MIMi609002 gene
neXtProtiNX_Q969V4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi83659
OpenTargetsiENSG00000167858
PharmGKBiPA37976

Polymorphism and mutation databases

BioMutaiTEKT1
DMDMi25009461

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001845621 – 418Tektin-1Add BLAST418

Proteomic databases

EPDiQ969V4
PaxDbiQ969V4
PeptideAtlasiQ969V4
PRIDEiQ969V4
ProteomicsDBi75852

PTM databases

iPTMnetiQ969V4
PhosphoSitePlusiQ969V4
SwissPalmiQ969V4

Expressioni

Tissue specificityi

Predominantly expressed in testis.1 Publication

Gene expression databases

BgeeiENSG00000167858 Expressed in 88 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_TEKT1
ExpressionAtlasiQ969V4 baseline and differential
GenevisibleiQ969V4 HS

Organism-specific databases

HPAiHPA044444
HPA062285

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi123716, 10 interactors
IntActiQ969V4, 26 interactors
STRINGi9606.ENSP00000341346

Structurei

3D structure databases

ProteinModelPortaliQ969V4
SMRiQ969V4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili21 – 107Sequence analysisAdd BLAST87
Coiled coili134 – 177Sequence analysisAdd BLAST44
Coiled coili266 – 308Sequence analysisAdd BLAST43
Coiled coili333 – 384Sequence analysisAdd BLAST52

Sequence similaritiesi

Belongs to the tektin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2685 Eukaryota
ENOG410XSCN LUCA
GeneTreeiENSGT00390000016344
HOGENOMiHOG000246943
HOVERGENiHBG056503
InParanoidiQ969V4
KOiK18628
OMAiANKSQYH
OrthoDBiEOG091G0AJL
PhylomeDBiQ969V4
TreeFamiTF320754

Family and domain databases

InterProiView protein in InterPro
IPR000435 Tektin
PANTHERiPTHR19960 PTHR19960, 1 hit
PRINTSiPR00511 TEKTIN

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q969V4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKLLQPPPK FLPSEWHIAN KNQYHRADAQ RSRSERLVAE SQRLVDEIEK
60 70 80 90 100
TTRKSQSDVN KKLEQRLEEV QFWKKELDDK LEQLVNVTDD LLIYKIRLEK
110 120 130 140 150
ALETLKEPLH ITETCLAYRE KRIGIDLVHD TVEHELIKEA EIIQGIMALL
160 170 180 190 200
TRTLEEASEQ IRMNRSAKYN LEKDLKDKFV ALTIDDICFS LNNNSPNIRY
210 220 230 240 250
SENAVRIEPN SVSLEDWLDF SSTNVEKADK QRNNSLMLKA LVDRILSQTA
260 270 280 290 300
NDLRKQCDVV DTAFKNGLKD TKDARDKLAD HLAKVMEEIA SQEKNITALE
310 320 330 340 350
KAILDQEGPA KVAHTRLETR THRPNVELCR DVAQYRLMKE VQEITHNVAR
360 370 380 390 400
LKETLAQAQA ELKGLHRRQL ALQEEIQVKE NTIYIDEVLC MQMRKSIPLR
410
DGEDHGVWAG GLRPDAVC
Length:418
Mass (Da):48,283
Last modified:December 1, 2001 - v1
Checksum:i724A9172C627BA52
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L3D4I3L3D4_HUMAN
Tektin-1
TEKT1
80Annotation score:
I3L357I3L357_HUMAN
Tektin-1
TEKT1
64Annotation score:
I3L122I3L122_HUMAN
Tektin-1
TEKT1
144Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034548146I → V. Corresponds to variant dbSNP:rs34431552Ensembl.1
Natural variantiVAR_022150254R → C. Corresponds to variant dbSNP:rs3744395Ensembl.1
Natural variantiVAR_022151332V → I. Corresponds to variant dbSNP:rs2271233Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF357879 mRNA Translation: AAL27695.1
CH471108 Genomic DNA Translation: EAW90284.1
CH471108 Genomic DNA Translation: EAW90285.1
BC014599 mRNA Translation: AAH14599.1
CCDSiCCDS11083.1
RefSeqiNP_444515.1, NM_053285.1
UniGeneiHs.462108

Genome annotation databases

EnsembliENST00000338694; ENSP00000341346; ENSG00000167858
GeneIDi83659
KEGGihsa:83659
UCSCiuc002gdt.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF357879 mRNA Translation: AAL27695.1
CH471108 Genomic DNA Translation: EAW90284.1
CH471108 Genomic DNA Translation: EAW90285.1
BC014599 mRNA Translation: AAH14599.1
CCDSiCCDS11083.1
RefSeqiNP_444515.1, NM_053285.1
UniGeneiHs.462108

3D structure databases

ProteinModelPortaliQ969V4
SMRiQ969V4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123716, 10 interactors
IntActiQ969V4, 26 interactors
STRINGi9606.ENSP00000341346

PTM databases

iPTMnetiQ969V4
PhosphoSitePlusiQ969V4
SwissPalmiQ969V4

Polymorphism and mutation databases

BioMutaiTEKT1
DMDMi25009461

Proteomic databases

EPDiQ969V4
PaxDbiQ969V4
PeptideAtlasiQ969V4
PRIDEiQ969V4
ProteomicsDBi75852

Protocols and materials databases

DNASUi83659
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338694; ENSP00000341346; ENSG00000167858
GeneIDi83659
KEGGihsa:83659
UCSCiuc002gdt.4 human

Organism-specific databases

CTDi83659
DisGeNETi83659
EuPathDBiHostDB:ENSG00000167858.12
GeneCardsiTEKT1
HGNCiHGNC:15534 TEKT1
HPAiHPA044444
HPA062285
MIMi609002 gene
neXtProtiNX_Q969V4
OpenTargetsiENSG00000167858
PharmGKBiPA37976
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2685 Eukaryota
ENOG410XSCN LUCA
GeneTreeiENSGT00390000016344
HOGENOMiHOG000246943
HOVERGENiHBG056503
InParanoidiQ969V4
KOiK18628
OMAiANKSQYH
OrthoDBiEOG091G0AJL
PhylomeDBiQ969V4
TreeFamiTF320754

Miscellaneous databases

GeneWikiiTEKT1
GenomeRNAii83659
PROiPR:Q969V4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167858 Expressed in 88 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_TEKT1
ExpressionAtlasiQ969V4 baseline and differential
GenevisibleiQ969V4 HS

Family and domain databases

InterProiView protein in InterPro
IPR000435 Tektin
PANTHERiPTHR19960 PTHR19960, 1 hit
PRINTSiPR00511 TEKTIN
ProtoNetiSearch...

Entry informationi

Entry nameiTEKT1_HUMAN
AccessioniPrimary (citable) accession number: Q969V4
Secondary accession number(s): D3DTM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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