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Entry version 163 (02 Jun 2021)
Sequence version 2 (25 Oct 2004)
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Protein

Nicalin

Gene

NCLN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of a ribosome-associated translocon complex involved in multi-pass membrane protein transport into the endoplasmic reticulum (ER) membrane and biogenesis (PubMed:32820719).

May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NOMO (By similarity).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q969V3

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M28.978

Transport Classification Database

More...
TCDBi
8.A.144.1.1, the nicalin (nicalin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nicalin
Alternative name(s):
Nicastrin-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NCLN
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26923, NCLN

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609156, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q969V3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000125912.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini43 – 522LumenalSequence analysisAdd BLAST480
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei523 – 543HelicalSequence analysisAdd BLAST21
Topological domaini544 – 563CytoplasmicSequence analysisAdd BLAST20

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
56926

Open Targets

More...
OpenTargetsi
ENSG00000125912

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134898417

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q969V3, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NCLN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
68052797

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 42Sequence analysisAdd BLAST42
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001968743 – 563NicalinAdd BLAST521

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi241N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi428N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q969V3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q969V3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q969V3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q969V3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q969V3

PeptideAtlas

More...
PeptideAtlasi
Q969V3

PRoteomics IDEntifications database

More...
PRIDEi
Q969V3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
75850 [Q969V3-1]
75851 [Q969V3-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1566, 5 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
Q969V3, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q969V3

MetOSite database of methionine sulfoxide sites

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MetOSitei
Q969V3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q969V3

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q969V3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000125912, Expressed in mucosa of transverse colon and 174 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q969V3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q969V3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000125912, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a complex with NOMO and TMEM147, resulting in a stabilization of the 3 proteins, which are otherwise quickly degraded by the proteasome (PubMed:20538592). The ribosome-associated ER translocon complex includes SEC61A1, SEC61B, SEC61G, TMCO1, CCDC47, NCLN/Nicalin, NOMO and TMEM147; in the absence of ribosomes, only the complex forms with NCLN/Nicalin, NOMO and TMEM147 remains intact (PubMed:32820719). Participates in a large protein complex, which is not related to the gamma-secretase complex (PubMed:15257293).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
121253, 63 interactors

Protein interaction database and analysis system

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IntActi
Q969V3, 22 interactors

Molecular INTeraction database

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MINTi
Q969V3

STRING: functional protein association networks

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STRINGi
9606.ENSP00000246117

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q969V3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q969V3

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nicastrin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2526, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00500000044945

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_034102_2_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q969V3

Identification of Orthologs from Complete Genome Data

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OMAi
NTSRHCV

Database of Orthologous Groups

More...
OrthoDBi
424149at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q969V3

TreeFam database of animal gene trees

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TreeFami
TF105849

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016574, Nicalin
IPR007484, Peptidase_M28

The PANTHER Classification System

More...
PANTHERi
PTHR31826, PTHR31826, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04389, Peptidase_M28, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF011018, Nicalin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q969V3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLEEAGEVLE NMLKASCLPL GFIVFLPAVL LLVAPPLPAA DAAHEFTVYR
60 70 80 90 100
MQQYDLQGQP YGTRNAVLNT EARTMAAEVL SRRCVLMRLL DFSYEQYQKA
110 120 130 140 150
LRQSAGAVVI ILPRAMAAVP QDVVRQFMEI EPEMLAMETA VPVYFAVEDE
160 170 180 190 200
ALLSIYKQTQ AASASQGSAS AAEVLLRTAT ANGFQMVTSG VQSKAVSDWL
210 220 230 240 250
IASVEGRLTG LGGEDLPTIV IVAHYDAFGV APWLSLGADS NGSGVSVLLE
260 270 280 290 300
LARLFSRLYT YKRTHAAYNL LFFASGGGKF NYQGTKRWLE DNLDHTDSSL
310 320 330 340 350
LQDNVAFVLC LDTVGRGSSL HLHVSKPPRE GTLQHAFLRE LETVAAHQFP
360 370 380 390 400
EVRFSMVHKR INLAEDVLAW EHERFAIRRL PAFTLSHLES HRDGQRSSIM
410 420 430 440 450
DVRSRVDSKT LTRNTRIIAE ALTRVIYNLT EKGTPPDMPV FTEQMQIQQE
460 470 480 490 500
QLDSVMDWLT NQPRAAQLVD KDSTFLSTLE HHLSRYLKDV KQHHVKADKR
510 520 530 540 550
DPEFVFYDQL KQVMNAYRVK PAVFDLLLAV GIAAYLGMAY VAVQHFSLLY
560
KTVQRLLVKA KTQ
Length:563
Mass (Da):62,974
Last modified:October 25, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5E74EDF6ABA6F44F
GO
Isoform 2 (identifier: Q969V3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     446-446: Missing.

Show »
Length:562
Mass (Da):62,846
Checksum:iC66C473B8BF9DA6D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EMW4K7EMW4_HUMAN
Nicalin
NCLN hCG_23630
489Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENM2K7ENM2_HUMAN
Nicalin
NCLN
328Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGP7A0A0C4DGP7_HUMAN
Nicalin
NCLN
350Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EN96K7EN96_HUMAN
Nicalin
NCLN
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELZ9K7ELZ9_HUMAN
Nicalin
NCLN
282Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQ66K7EQ66_HUMAN
Nicalin
NCLN
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH03076 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH25926 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAB66502 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti19P → L in CAG38597 (Ref. 6) Curated1
Sequence conflicti124V → A in BAD18812 (PubMed:14702039).Curated1
Sequence conflicti207R → W in CAG38597 (Ref. 6) Curated1
Sequence conflicti387H → L in AAH03076 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050276214E → D. Corresponds to variant dbSNP:rs11671067Ensembl.1
Natural variantiVAR_022552551K → R2 PublicationsCorresponds to variant dbSNP:rs2288949Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013851446Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK172848 mRNA Translation: BAD18812.1
AC005331 Genomic DNA Translation: AAC27667.1
AC011547 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69330.1
CH471139 Genomic DNA Translation: EAW69333.1
BC003076 mRNA Translation: AAH03076.2 Different initiation.
BC007275 mRNA Translation: AAH07275.1
BC008920 mRNA Translation: AAH08920.2
BC010064 mRNA Translation: AAH10064.2
BC013283 mRNA Translation: AAH13283.2
BC019091 mRNA Translation: AAH19091.2
BC025926 mRNA Translation: AAH25926.1 Different initiation.
AL136567 mRNA Translation: CAB66502.1 Different initiation.
CR533566 mRNA Translation: CAG38597.1
AL365369 mRNA Translation: CAB96945.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32869.1 [Q969V3-1]

NCBI Reference Sequences

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RefSeqi
NP_001308392.1, NM_001321463.1 [Q969V3-2]
NP_064555.2, NM_020170.3 [Q969V3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000246117; ENSP00000246117; ENSG00000125912 [Q969V3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
56926

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:56926

UCSC genome browser

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UCSCi
uc002lxi.4, human [Q969V3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172848 mRNA Translation: BAD18812.1
AC005331 Genomic DNA Translation: AAC27667.1
AC011547 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69330.1
CH471139 Genomic DNA Translation: EAW69333.1
BC003076 mRNA Translation: AAH03076.2 Different initiation.
BC007275 mRNA Translation: AAH07275.1
BC008920 mRNA Translation: AAH08920.2
BC010064 mRNA Translation: AAH10064.2
BC013283 mRNA Translation: AAH13283.2
BC019091 mRNA Translation: AAH19091.2
BC025926 mRNA Translation: AAH25926.1 Different initiation.
AL136567 mRNA Translation: CAB66502.1 Different initiation.
CR533566 mRNA Translation: CAG38597.1
AL365369 mRNA Translation: CAB96945.1
CCDSiCCDS32869.1 [Q969V3-1]
RefSeqiNP_001308392.1, NM_001321463.1 [Q969V3-2]
NP_064555.2, NM_020170.3 [Q969V3-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6W6Lelectron microscopy3.8451-563[»]
SMRiQ969V3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi121253, 63 interactors
IntActiQ969V3, 22 interactors
MINTiQ969V3
STRINGi9606.ENSP00000246117

Protein family/group databases

MEROPSiM28.978
TCDBi8.A.144.1.1, the nicalin (nicalin) family

PTM databases

GlyConnecti1566, 5 N-Linked glycans (1 site)
GlyGeniQ969V3, 2 sites
iPTMnetiQ969V3
MetOSiteiQ969V3
PhosphoSitePlusiQ969V3
SwissPalmiQ969V3

Genetic variation databases

BioMutaiNCLN
DMDMi68052797

Proteomic databases

EPDiQ969V3
jPOSTiQ969V3
MassIVEiQ969V3
MaxQBiQ969V3
PaxDbiQ969V3
PeptideAtlasiQ969V3
PRIDEiQ969V3
ProteomicsDBi75850 [Q969V3-1]
75851 [Q969V3-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
1889, 134 antibodies

The DNASU plasmid repository

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DNASUi
56926

Genome annotation databases

EnsembliENST00000246117; ENSP00000246117; ENSG00000125912 [Q969V3-1]
GeneIDi56926
KEGGihsa:56926
UCSCiuc002lxi.4, human [Q969V3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
56926
DisGeNETi56926

GeneCards: human genes, protein and diseases

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GeneCardsi
NCLN
HGNCiHGNC:26923, NCLN
HPAiENSG00000125912, Low tissue specificity
MIMi609156, gene
neXtProtiNX_Q969V3
OpenTargetsiENSG00000125912
PharmGKBiPA134898417
VEuPathDBiHostDB:ENSG00000125912.10

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2526, Eukaryota
GeneTreeiENSGT00500000044945
HOGENOMiCLU_034102_2_0_1
InParanoidiQ969V3
OMAiNTSRHCV
OrthoDBi424149at2759
PhylomeDBiQ969V3
TreeFamiTF105849

Enzyme and pathway databases

PathwayCommonsiQ969V3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
56926, 25 hits in 998 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NCLN, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NCLN

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
56926
PharosiQ969V3, Tbio

Protein Ontology

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PROi
PR:Q969V3
RNActiQ969V3, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000125912, Expressed in mucosa of transverse colon and 174 other tissues
ExpressionAtlasiQ969V3, baseline and differential
GenevisibleiQ969V3, HS

Family and domain databases

InterProiView protein in InterPro
IPR016574, Nicalin
IPR007484, Peptidase_M28
PANTHERiPTHR31826, PTHR31826, 1 hit
PfamiView protein in Pfam
PF04389, Peptidase_M28, 1 hit
PIRSFiPIRSF011018, Nicalin, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCLN_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q969V3
Secondary accession number(s): D6W613
, O75252, Q6FI60, Q6ZMB7, Q8TAT7, Q96H48, Q96IS7, Q9BQH9, Q9BTX4, Q9NPP2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: October 25, 2004
Last modified: June 2, 2021
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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