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Protein

Melanin-concentrating hormone receptor 2

Gene

MCHR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
SIGNORiQ969V1

Names & Taxonomyi

Protein namesi
Recommended name:
Melanin-concentrating hormone receptor 2
Short name:
MCH receptor 2
Short name:
MCH-R2
Short name:
MCHR-2
Alternative name(s):
G-protein coupled receptor 145
GPRv17
MCH-2R
Short name:
MCH2
Short name:
MCH2R
Gene namesi
Name:MCHR2
Synonyms:GPR145, SLT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000152034.10
HGNCiHGNC:20867 MCHR2
MIMi606111 gene
neXtProtiNX_Q969V1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 60Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini61 – 69CytoplasmicSequence analysis9
Transmembranei70 – 90Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini91 – 104ExtracellularSequence analysisAdd BLAST14
Transmembranei105 – 129Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini130 – 154CytoplasmicSequence analysisAdd BLAST25
Transmembranei155 – 175Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini176 – 200ExtracellularSequence analysisAdd BLAST25
Transmembranei201 – 221Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini222 – 252CytoplasmicSequence analysisAdd BLAST31
Transmembranei253 – 273Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini274 – 288ExtracellularSequence analysisAdd BLAST15
Transmembranei289 – 309Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini310 – 340CytoplasmicSequence analysisAdd BLAST31

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84539
OpenTargetsiENSG00000152034
PharmGKBiPA134950856

Chemistry databases

ChEMBLiCHEMBL5038
GuidetoPHARMACOLOGYi281

Polymorphism and mutation databases

BioMutaiMCHR2
DMDMi34098673

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697401 – 340Melanin-concentrating hormone receptor 2Add BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi17N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ969V1
PeptideAtlasiQ969V1
PRIDEiQ969V1
ProteomicsDBi75849

Expressioni

Tissue specificityi

Specifically expressed in the brain, with highest levels in cerebral cortex, hippocampus and amygdala. No expression detected in the cerebellum, thalamus or hypothalamus.

Gene expression databases

BgeeiENSG00000152034
CleanExiHS_MCHR2
GenevisibleiQ969V1 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000281806

Chemistry databases

BindingDBiQ969V1

Structurei

3D structure databases

ProteinModelPortaliQ969V1
SMRiQ969V1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118797
HOGENOMiHOG000000704
HOVERGENiHBG098164
InParanoidiQ969V1
KOiK05054
OMAiITTFFFP
OrthoDBiEOG091G0DIE
PhylomeDBiQ969V1
TreeFamiTF315737

Family and domain databases

CDDicd15339 7tmA_MCHR2, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR008362 MCH2_receptor
IPR008361 MCH_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01784 MCH2RECEPTOR
PR01783 MCHRECEPTOR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q969V1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPFHASCWN TSAELLNKSW NKEFAYQTAS VVDTVILPSM IGIICSTGLV
60 70 80 90 100
GNILIVFTII RSRKKTVPDI YICNLAVADL VHIVGMPFLI HQWARGGEWV
110 120 130 140 150
FGGPLCTIIT SLDTCNQFAC SAIMTVMSVD RYFALVQPFR LTRWRTRYKT
160 170 180 190 200
IRINLGLWAA SFILALPVWV YSKVIKFKDG VESCAFDLTS PDDVLWYTLY
210 220 230 240 250
LTITTFFFPL PLILVCYILI LCYTWEMYQQ NKDARCCNPS VPKQRVMKLT
260 270 280 290 300
KMVLVLVVVF ILSAAPYHVI QLVNLQMEQP TLAFYVGYYL SICLSYASSS
310 320 330 340
INPFLYILLS GNFQKRLPQI QRRATEKEIN NMGNTLKSHF
Length:340
Mass (Da):38,849
Last modified:December 1, 2001 - v1
Checksum:i754A302BB951FAC6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02666163R → K No changes in receptor binding or functional signaling. 1 PublicationCorresponds to variant dbSNP:rs147988902Ensembl.1
Natural variantiVAR_026662152R → Q No changes in receptor binding or functional signaling. 1 PublicationCorresponds to variant dbSNP:rs62434070Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB060151 mRNA Translation: BAB55677.1
AY029596 mRNA Translation: AAK38157.1
AF399937 mRNA Translation: AAL05528.1
AF347063 mRNA Translation: AAK32193.1
AB058849 mRNA Translation: BAB87842.1
AY562946 mRNA Translation: AAS72374.1
AK123634 mRNA Translation: BAG53926.1
AL590725 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48460.1
BC095515 mRNA Translation: AAH95515.1
CCDSiCCDS5044.1
PIRiJC7695
RefSeqiNP_001035269.1, NM_001040179.1
NP_115892.2, NM_032503.2
UniGeneiHs.591342

Genome annotation databases

EnsembliENST00000281806; ENSP00000281806; ENSG00000152034
ENST00000369212; ENSP00000358214; ENSG00000152034
GeneIDi84539
KEGGihsa:84539
UCSCiuc003pqh.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMCHR2_HUMAN
AccessioniPrimary (citable) accession number: Q969V1
Secondary accession number(s): B3KVW4
, E1P5D7, Q5VTV7, Q6Q377, Q9BXA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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