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Entry version 157 (07 Oct 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Sorting nexin-21

Gene

SNX21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate. May be involved in several stages of intracellular trafficking.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei171Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei173Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei198Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei212Phosphatidylinositol 3-phosphateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport
LigandLipid-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q969T3

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q969T3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sorting nexin-21
Alternative name(s):
Sorting nexin L
Short name:
SNX-L1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SNX21
Synonyms:C20orf161, SNXL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000124104.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16154, SNX21

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q969T3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000124104

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25703

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q969T3, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SNX21

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20140138

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002138701 – 373Sorting nexin-21Add BLAST373

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q969T3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q969T3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q969T3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q969T3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q969T3

PeptideAtlas

More...
PeptideAtlasi
Q969T3

PRoteomics IDEntifications database

More...
PRIDEi
Q969T3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
63536
63537
75842 [Q969T3-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q969T3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q969T3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in fetus liver, but only weakly expressed in brain, skeleton muscle, smooth muscle, and cardiac muscle, kidney, and adrenal gland.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000124104, Expressed in right ovary and 213 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q969T3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q969T3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000124104, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124677, 40 interactors

Protein interaction database and analysis system

More...
IntActi
Q969T3, 33 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000418593

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q969T3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q969T3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini129 – 246PXPROSITE-ProRule annotationAdd BLAST118

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2101, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063759

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q969T3

KEGG Orthology (KO)

More...
KOi
K17932

Identification of Orthologs from Complete Genome Data

More...
OMAi
AWQLQTQ

Database of Orthologous Groups

More...
OrthoDBi
1322681at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q969T3

TreeFam database of animal gene trees

More...
TreeFami
TF326807

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit
3.30.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001683, Phox
IPR036871, PX_dom_sf
IPR039937, SNX20/SNX21
IPR011990, TPR-like_helical_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR20939, PTHR20939, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00787, PX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00312, PX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 1 hit
SSF64268, SSF64268, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50195, PX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q969T3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHRGTQEGAM ASRLLHRLRH ALAGDGPGEA AASPEAEQFP ESSELEDDDA
60 70 80 90 100
EGLSSRLSGT LSFTSAEDDE DDEDEDDEEA GPDQLPLGDG TSGEDAERSP
110 120 130 140 150
PPDGQWGSQL LARQLQDFWK KSRNTLAPQR LLFEVTSANV VKDPPSKYVL
160 170 180 190 200
YTLAVIGPGP PDCQPAQISR RYSDFERLHR NLQRQFRGPM AAISFPRKRL
210 220 230 240 250
RRNFTAETIA RRSRAFEQFL GHLQAVPELR HAPDLQDFFV LPELRRAQSL
260 270 280 290 300
TCTGLYREAL ALWANAWQLQ AQLGTPSGPD RPLLTLAGLA VCHQELEDPG
310 320 330 340 350
EARACCEKAL QLLGDKSLHP LLAPFLEAHV RLSWRLGLDK RQSEARLQAL
360 370
QEAGLTPTPP PSLKELLIKE VLD
Length:373
Mass (Da):41,365
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i83E4A752BAAEA7B5
GO
Isoform 2 (identifier: Q969T3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-199: RKR → QSH
     200-373: Missing.

Show »
Length:199
Mass (Da):21,842
Checksum:iCEDD7CD4B0C771C0
GO
Isoform 3 (identifier: Q969T3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-373: LYTLAVIGPG...KELLIKEVLD → TNLSSTPSP

Show »
Length:158
Mass (Da):17,020
Checksum:i248CFCF7EA1F6D38
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JZH3Q5JZH3_HUMAN
Sorting nexin-21
SNX21
364Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q05DJ0Q05DJ0_HUMAN
SNX21 protein
SNX21
165Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JZH4Q5JZH4_HUMAN
Sorting nexin-21
SNX21
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052482154A → T1 PublicationCorresponds to variant dbSNP:rs4638862Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_047115150 – 373LYTLA…KEVLD → TNLSSTPSP in isoform 3. CuratedAdd BLAST224
Alternative sequenceiVSP_045048197 – 199RKR → QSH in isoform 2. 1 Publication3
Alternative sequenceiVSP_045049200 – 373Missing in isoform 2. 1 PublicationAdd BLAST174

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF395845 mRNA Translation: AAK73126.1
AF523834 mRNA Translation: AAM77915.1
AL591562 mRNA Translation: CAC39140.1
AL008726 Genomic DNA No translation available.
BC019823 mRNA Translation: AAH19823.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13376.1 [Q969T3-2]
CCDS13377.1 [Q969T3-1]
CCDS42883.1 [Q969T3-3]

NCBI Reference Sequences

More...
RefSeqi
NP_219489.1, NM_033421.3 [Q969T3-1]
NP_690857.1, NM_152897.2 [Q969T3-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000342644; ENSP00000344586; ENSG00000124104 [Q969T3-2]
ENST00000462307; ENSP00000420169; ENSG00000124104 [Q969T3-3]
ENST00000491381; ENSP00000418593; ENSG00000124104 [Q969T3-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
90203

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:90203

UCSC genome browser

More...
UCSCi
uc002xps.2, human [Q969T3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395845 mRNA Translation: AAK73126.1
AF523834 mRNA Translation: AAM77915.1
AL591562 mRNA Translation: CAC39140.1
AL008726 Genomic DNA No translation available.
BC019823 mRNA Translation: AAH19823.1
CCDSiCCDS13376.1 [Q969T3-2]
CCDS13377.1 [Q969T3-1]
CCDS42883.1 [Q969T3-3]
RefSeqiNP_219489.1, NM_033421.3 [Q969T3-1]
NP_690857.1, NM_152897.2 [Q969T3-2]

3D structure databases

SMRiQ969T3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124677, 40 interactors
IntActiQ969T3, 33 interactors
STRINGi9606.ENSP00000418593

PTM databases

iPTMnetiQ969T3
PhosphoSitePlusiQ969T3

Polymorphism and mutation databases

BioMutaiSNX21
DMDMi20140138

Proteomic databases

EPDiQ969T3
jPOSTiQ969T3
MassIVEiQ969T3
MaxQBiQ969T3
PaxDbiQ969T3
PeptideAtlasiQ969T3
PRIDEiQ969T3
ProteomicsDBi63536
63537
75842 [Q969T3-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
27775, 79 antibodies

The DNASU plasmid repository

More...
DNASUi
90203

Genome annotation databases

EnsembliENST00000342644; ENSP00000344586; ENSG00000124104 [Q969T3-2]
ENST00000462307; ENSP00000420169; ENSG00000124104 [Q969T3-3]
ENST00000491381; ENSP00000418593; ENSG00000124104 [Q969T3-1]
GeneIDi90203
KEGGihsa:90203
UCSCiuc002xps.2, human [Q969T3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
90203
EuPathDBiHostDB:ENSG00000124104.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SNX21
HGNCiHGNC:16154, SNX21
HPAiENSG00000124104, Low tissue specificity
neXtProtiNX_Q969T3
OpenTargetsiENSG00000124104
PharmGKBiPA25703

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2101, Eukaryota
GeneTreeiENSGT00530000063759
InParanoidiQ969T3
KOiK17932
OMAiAWQLQTQ
OrthoDBi1322681at2759
PhylomeDBiQ969T3
TreeFamiTF326807

Enzyme and pathway databases

PathwayCommonsiQ969T3
SignaLinkiQ969T3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
90203, 6 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SNX21, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SNX21

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
90203
PharosiQ969T3, Tdark

Protein Ontology

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PROi
PR:Q969T3
RNActiQ969T3, protein

Gene expression databases

BgeeiENSG00000124104, Expressed in right ovary and 213 other tissues
ExpressionAtlasiQ969T3, baseline and differential
GenevisibleiQ969T3, HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683, Phox
IPR036871, PX_dom_sf
IPR039937, SNX20/SNX21
IPR011990, TPR-like_helical_dom_sf
PANTHERiPTHR20939, PTHR20939, 1 hit
PfamiView protein in Pfam
PF00787, PX, 1 hit
SMARTiView protein in SMART
SM00312, PX, 1 hit
SUPFAMiSSF48452, SSF48452, 1 hit
SSF64268, SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195, PX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSNX21_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q969T3
Secondary accession number(s): Q5JZH5
, Q5JZH6, Q5JZH7, Q8WUR6, Q9BR16
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: October 7, 2020
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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