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UniProtKB - Q969S8 (HDA10_HUMAN)

Entry version 165 (12 Aug 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Polyamine deacetylase HDAC10

Gene

HDAC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Polyamine deacetylase (PDAC), which acts preferentially on N8-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N1,N8-diacetylspermidine and very low activity, if any, toward N1-acetylspermidine (PubMed:28516954). Histone deacetylase activity has been observed in vitro (PubMed:11861901, PubMed:11726666, PubMed:11677242, PubMed:11739383). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769). May play a role in homologous recombination (PubMed:21247901). May promote DNA mismatch repair (PubMed:26221039).9 Publications

Miscellaneous

Like some other members of the HD type 2 subfamily, such as HDAC4, inhibited by the antitumor drug trichostatin A (TSA).1 Publication

Caution

Protein/histone deacetylase activity in vivo is uncertain. The 3D structure analysis of the zebrafish ortholog shows that a glutamate gatekeeper and a sterically constricted active site confer specificity for N8-acetylspermidine hydrolysis and disfavour acetyllysine hydrolysis. Supporting this observation, has been shown to exhibit only very low activity, if any, towards acetyl-lysine peptide substrates (PubMed:28516954). However, histone deacetylase activity has been observed in vitro (PubMed:28516954, PubMed:11861901, PubMed:11726666, PubMed:11677242, PubMed:11739383). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039).6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=110 µM for acetylcadaverine1 Publication
  2. KM=170 µM for acetylputrescine1 Publication
  3. KM=100 µM for N8-acetylspermidine1 Publication
  4. KM=180 µM for N1-acetylspermine1 Publication
  5. KM=150 µM for N1,N8-diacetylspermidine1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei20SubstrateBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei135Proton donor/acceptorBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi172ZincBy similarity1
    Metal bindingi174Zinc; via pros nitrogenBy similarity1
    Metal bindingi265ZincBy similarity1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei272Substrate specificityBy similarity1
    Binding sitei305SubstrateBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase
    Biological processAutophagy, DNA damage, DNA recombination, DNA repair
    LigandMetal-binding, Zinc

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...    BRENDAi    		3.5.1.98, 2681

    Pathway Commons web resource for biological pathway data

    More...    PathwayCommonsi    		Q969S8

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-2122947, NOTCH1 Intracellular Domain Regulates Transcription
    R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants
    R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    R-HSA-3214815, HDACs deacetylate histones
    R-HSA-350054, Notch-HLH transcription pathway

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		Q969S8

    SIGNOR Signaling Network Open Resource

    More...    SIGNORi    		Q969S8

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Polyamine deacetylase HDAC10 (EC:3.5.1.481 Publication, EC:3.5.1.621 Publication)
    Alternative name(s):
    Histone deacetylase 10
    Short name:
    HD10
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:HDAC10
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...    EuPathDBi    		HostDB:ENSG00000100429.17

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:18128, HDAC10

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		608544, gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_Q969S8

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    In neuroblastoma cells, may promote autophagy in response to chemotherapy-induced DNA damage and efflux of chemotherapeutics via lysosomal exocytosis, hence protecting cells from cytotoxic agents (PubMed:23801752, PubMed:29968769). Expression levels may correlate with survival in neuroblastoma patients, with low levels in the tumor correlating with long-term patient survival and high expression with poor prognosis (PubMed:23801752). Therefore has been proposed as a biomarker to predict neuroblastoma chemoresistance and treatment outcome (PubMed:23801752).1 Publication2 Publications

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi135H → A: Abolishes deacetylase activity. Does not affect interaction with HDAC3. Loss of autophagy regulation. 3 Publications1

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		83933

    Open Targets

    More...    OpenTargetsi    		ENSG00000100429

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA38297

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		Q969S8, Tclin

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL5103

    Drug and drug target database

    More...    DrugBanki    		DB05015, Belinostat
    DB13346, Bufexamac
    DB06603, Panobinostat

    DrugCentral

    More...    DrugCentrali    		Q969S8

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...    GuidetoPHARMACOLOGYi    		2614

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		HDAC10

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		27734403

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001147121 – 669Polyamine deacetylase HDAC10Add BLAST669

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei393PhosphoserineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		Q969S8

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		Q969S8

    MaxQB - The MaxQuant DataBase

    More...    MaxQBi    		Q969S8

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		Q969S8

    PeptideAtlas

    More...    PeptideAtlasi    		Q969S8

    PRoteomics IDEntifications database

    More...    PRIDEi    		Q969S8

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		75833 [Q969S8-1]
    75834 [Q969S8-2]
    75835 [Q969S8-4]
    75836 [Q969S8-5]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		Q969S8

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		Q969S8

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Widely expressed with high levels in liver and kidney.3 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000100429, Expressed in granulocyte and 173 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		Q969S8, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		Q969S8, HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000100429, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with HDAC3 (PubMed:11861901).

    Interacts with HDAC2 and NCOR2/SMRT (PubMed:11739383).

    Interacts with HSPA8/HSC70 (PubMed:23801752).

    Interacts with MSH2 (PubMed:26221039).

    4 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		123818, 39 interactors

    CORUM comprehensive resource of mammalian protein complexes

    More...    CORUMi    		Q969S8

    Protein interaction database and analysis system

    More...    IntActi    		Q969S8, 23 interactors

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000216271

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		Q969S8

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		Q969S8, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		Q969S8

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 323Histone deacetylaseAdd BLAST323

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi21 – 24Substrate specificityBy similarity4

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the histone deacetylase family. HD type 2 subfamily.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG1343, Eukaryota

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000160061

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_007727_6_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		Q969S8

    KEGG Orthology (KO)

    More...    KOi    		K18671

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		DDGRNLW

    Database of Orthologous Groups

    More...    OrthoDBi    		1484694at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		Q969S8

    TreeFam database of animal gene trees

    More...    TreeFami    		TF106173

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		3.40.800.20, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR000286, His_deacetylse
    IPR023801, His_deacetylse_dom
    IPR037138, His_deacetylse_dom_sf
    IPR023696, Ureohydrolase_dom_sf

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF00850, Hist_deacetyl, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...    PRINTSi    		PR01270, HDASUPER

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF52768, SSF52768, 2 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q969S8-1) [UniParc]FASTAAdd to basket
    Also known as: Alpha1 Publication, HDAC10b1 Publication, HDAC10v11 Publication

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MGTALVYHED MTATRLLWDD PECEIERPER LTAALDRLRQ RGLEQRCLRL 
            60         70         80         90        100
    SAREASEEEL GLVHSPEYVS LVRETQVLGK EELQALSGQF DAIYFHPSTF 
           110        120        130        140        150
    HCARLAAGAG LQLVDAVLTG AVQNGLALVR PPGHHGQRAA ANGFCVFNNV 
           160        170        180        190        200
    AIAAAHAKQK HGLHRILVVD WDVHHGQGIQ YLFEDDPSVL YFSWHRYEHG 
           210        220        230        240        250
    RFWPFLRESD ADAVGRGQGL GFTVNLPWNQ VGMGNADYVA AFLHLLLPLA 
           260        270        280        290        300
    FEFDPELVLV SAGFDSAIGD PEGQMQATPE CFAHLTQLLQ VLAGGRVCAV 
           310        320        330        340        350
    LEGGYHLESL AESVCMTVQT LLGDPAPPLS GPMAPCQSAL ESIQSARAAQ 
           360        370        380        390        400
    APHWKSLQQQ DVTAVPMSPS SHSPEGRPPP LLPGGPVCKA AASAPSSLLD 
           410        420        430        440        450
    QPCLCPAPSV RTAVALTTPD ITLVLPPDVI QQEASALREE TEAWARPHES 
           460        470        480        490        500
    LAREEALTAL GKLLYLLDGM LDGQVNSGIA ATPASAAAAT LDVAVRRGLS 
           510        520        530        540        550
    HGAQRLLCVA LGQLDRPPDL AHDGRSLWLN IRGKEAAALS MFHVSTPLPV 
           560        570        580        590        600
    MTGGFLSCIL GLVLPLAYGF QPDLVLVALG PGHGLQGPHA ALLAAMLRGL 
           610        620        630        640        650
    AGGRVLALLE ENSTPQLAGI LARVLNGEAP PSLGPSSVAS PEDVQALMYL 
           660 
    RGQLEPQWKM LQCHPHLVA
    Length:669
    Mass (Da):71,445
    Last modified:December 1, 2001 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i872D9427E6893A18
    GO
    Isoform 2 (identifier: Q969S8-2) [UniParc]FASTAAdd to basket
    Also known as: Beta1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         252-271: Missing.

    Show »
    Length:649
    Mass (Da):69,385
    Checksum:i7756351E6BC838FB
    GO
    Isoform 4 (identifier: Q969S8-4) [UniParc]FASTAAdd to basket
    Also known as: A, HDAC10v21 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         612-669: NSTPQLAGIL...MLQCHPHLVA → VSWAGWRCCG...GPGAEWRGTS

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
    Show »
    Length:658
    Mass (Da):70,033
    Checksum:i0EABDDA886585928
    GO
    Isoform 5 (identifier: Q969S8-5) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         252-301: Missing.
         447-669: Missing.

    Show »
    Length:396
    Mass (Da):43,016
    Checksum:i22DE1D205E5856A0
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    C9J8B8C9J8B8_HUMAN
    Polyamine deacetylase HDAC10
    HDAC10
    		619Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    Q08AP5Q08AP5_HUMAN
    HDAC10 protein
    HDAC10
    		96Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti92A → T in AAS48345 (Ref. 6) Curated1
    Sequence conflicti177Q → R in AAS48345 (Ref. 6) Curated1
    Sequence conflicti337Q → QRC in CAC21653 (PubMed:17974005).Curated1
    Sequence conflicti337Q → QRCEG no nucleotide entry (PubMed:11739383).Curated1
    Sequence conflicti594A → T in AAK92205 (PubMed:11677242).Curated1
    Sequence conflicti594A → T in AAK92206 (PubMed:11677242).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049356429V → I. Corresponds to variant dbSNP:rs34402301Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014698252 – 301Missing in isoform 5. 1 PublicationAdd BLAST50
    Alternative sequenceiVSP_002089252 – 271Missing in isoform 2. 1 PublicationAdd BLAST20
    Alternative sequenceiVSP_014699447 – 669Missing in isoform 5. 1 PublicationAdd BLAST223
    Alternative sequenceiVSP_002090612 – 669NSTPQ…PHLVA → VSWAGWRCCGVGRGKGPVTA SVFAPGPELHTPASRDPGPG AEWRGTS in isoform 4. 2 PublicationsAdd BLAST58

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		AF426160 mRNA Translation: AAL30513.1
    AF393962 mRNA Translation: AAK84023.1
    AF407272 mRNA Translation: AAK92205.1
    AF407273 mRNA Translation: AAK92206.1
    CR456465 mRNA Translation: CAG30351.1
    AY450395 mRNA Translation: AAS48345.1
    AL022328 Genomic DNA No translation available.
    BC125083 mRNA Translation: AAI25084.1
    AL512711 mRNA Translation: CAC21653.2

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS14088.1 [Q969S8-1]
    CCDS54545.1 [Q969S8-2]

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001152758.1, NM_001159286.1 [Q969S8-2]
    NP_114408.3, NM_032019.5 [Q969S8-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000216271; ENSP00000216271; ENSG00000100429 [Q969S8-1]
    ENST00000349505; ENSP00000343540; ENSG00000100429 [Q969S8-2]
    ENST00000454936; ENSP00000406150; ENSG00000100429 [Q969S8-5]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		83933

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:83933

    UCSC genome browser

    More...    UCSCi    		uc003bkg.4, human [Q969S8-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AF426160 mRNA Translation: AAL30513.1
    AF393962 mRNA Translation: AAK84023.1
    AF407272 mRNA Translation: AAK92205.1
    AF407273 mRNA Translation: AAK92206.1
    CR456465 mRNA Translation: CAG30351.1
    AY450395 mRNA Translation: AAS48345.1
    AL022328 Genomic DNA No translation available.
    BC125083 mRNA Translation: AAI25084.1
    AL512711 mRNA Translation: CAC21653.2
    CCDSiCCDS14088.1 [Q969S8-1]
    CCDS54545.1 [Q969S8-2]
    RefSeqiNP_001152758.1, NM_001159286.1 [Q969S8-2]
    NP_114408.3, NM_032019.5 [Q969S8-1]

    3D structure databases

    SMRiQ969S8
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGRIDi123818, 39 interactors
    CORUMiQ969S8
    IntActiQ969S8, 23 interactors
    STRINGi9606.ENSP00000216271

    Chemistry databases

    BindingDBiQ969S8
    ChEMBLiCHEMBL5103
    DrugBankiDB05015, Belinostat
    DB13346, Bufexamac
    DB06603, Panobinostat
    DrugCentraliQ969S8
    GuidetoPHARMACOLOGYi2614

    PTM databases

    iPTMnetiQ969S8
    PhosphoSitePlusiQ969S8

    Polymorphism and mutation databases

    BioMutaiHDAC10
    DMDMi27734403

    Proteomic databases

    jPOSTiQ969S8
    MassIVEiQ969S8
    MaxQBiQ969S8
    PaxDbiQ969S8
    PeptideAtlasiQ969S8
    PRIDEiQ969S8
    ProteomicsDBi75833 [Q969S8-1]
    75834 [Q969S8-2]
    75835 [Q969S8-4]
    75836 [Q969S8-5]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		14233, 469 antibodies

    The DNASU plasmid repository

    More...    DNASUi    		83933

    Genome annotation databases

    EnsembliENST00000216271; ENSP00000216271; ENSG00000100429 [Q969S8-1]
    ENST00000349505; ENSP00000343540; ENSG00000100429 [Q969S8-2]
    ENST00000454936; ENSP00000406150; ENSG00000100429 [Q969S8-5]
    GeneIDi83933
    KEGGihsa:83933
    UCSCiuc003bkg.4, human [Q969S8-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		83933
    DisGeNETi83933
    EuPathDBiHostDB:ENSG00000100429.17

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		HDAC10
    HGNCiHGNC:18128, HDAC10
    HPAiENSG00000100429, Low tissue specificity
    MIMi608544, gene
    neXtProtiNX_Q969S8
    OpenTargetsiENSG00000100429
    PharmGKBiPA38297

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG1343, Eukaryota
    GeneTreeiENSGT00940000160061
    HOGENOMiCLU_007727_6_0_1
    InParanoidiQ969S8
    KOiK18671
    OMAiDDGRNLW
    OrthoDBi1484694at2759
    PhylomeDBiQ969S8
    TreeFamiTF106173

    Enzyme and pathway databases

    BRENDAi3.5.1.98, 2681
    PathwayCommonsiQ969S8
    ReactomeiR-HSA-2122947, NOTCH1 Intracellular Domain Regulates Transcription
    R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants
    R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    R-HSA-3214815, HDACs deacetylate histones
    R-HSA-350054, Notch-HLH transcription pathway
    SABIO-RKiQ969S8
    SIGNORiQ969S8

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		83933, 0 hits in 875 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		HDAC10, human

    The Gene Wiki collection of pages on human genes and proteins

    More...    GeneWikii    		HDAC10

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		83933
    PharosiQ969S8, Tclin

    Protein Ontology

    More...    PROi    		PR:Q969S8
    RNActiQ969S8, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000100429, Expressed in granulocyte and 173 other tissues
    ExpressionAtlasiQ969S8, baseline and differential
    GenevisibleiQ969S8, HS

    Family and domain databases

    Gene3Di3.40.800.20, 2 hits
    InterProiView protein in InterPro
    IPR000286, His_deacetylse
    IPR023801, His_deacetylse_dom
    IPR037138, His_deacetylse_dom_sf
    IPR023696, Ureohydrolase_dom_sf
    PfamiView protein in Pfam
    PF00850, Hist_deacetyl, 1 hit
    PRINTSiPR01270, HDASUPER
    SUPFAMiSSF52768, SSF52768, 2 hits

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHDA10_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q969S8
    Secondary accession number(s): Q08AP4
    , Q6STF9, Q96P77, Q96P78, Q9H028, Q9UGX1, Q9UGX2
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
    Last sequence update: December 1, 2001
    Last modified: August 12, 2020
    This is version 165 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families
    5. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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