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UniProtKB - Q969S8 (HDA10_HUMAN)

Protein

Histone deacetylase 10

Gene

HDAC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. EC:3.5.1.98

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei135By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Hydrolase, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.5.1.98 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-3214815 HDACs deacetylate histones

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q969S8

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q969S8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone deacetylase 10 (EC:3.5.1.98)
Short name:
HD10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HDAC10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000100429.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:18128 HDAC10

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608544 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q969S8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi135H → A: Abolishes deacetylase activity. Does not affect interaction with HDAC3. 2 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		83933

Open Targets

More...OpenTargetsi		ENSG00000100429

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38297

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5103

Drug and drug target database

More...DrugBanki		DB05015 Belinostat
DB06603 Panobinostat

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2614

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HDAC10

Domain mapping of disease mutations (DMDM)

More...DMDMi		27734403

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001147121 – 669Histone deacetylase 10Add BLAST669

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei393PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q969S8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q969S8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q969S8

PeptideAtlas

More...PeptideAtlasi		Q969S8

PRoteomics IDEntifications database

More...PRIDEi		Q969S8

ProteomicsDB human proteome resource

More...ProteomicsDBi		75833
75834 [Q969S8-2]
75835 [Q969S8-4]
75836 [Q969S8-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q969S8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q969S8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. High expression in liver, spleen, pancreas and kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100429 Expressed in 157 organ(s), highest expression level in pituitary gland

CleanEx database of gene expression profiles

More...CleanExi		HS_HDAC10

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q969S8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q969S8 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB045977
HPA056514

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HDAC2, HDAC3 and NCOR2.2 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		123818, 36 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q969S8

Protein interaction database and analysis system

More...IntActi		Q969S8, 11 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000216271

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q969S8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q969S8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q969S8

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 323Histone deacetylaseAdd BLAST323

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the histone deacetylase family. HD type 2 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1343 Eukaryota
COG0123 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160061

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG051892

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q969S8

KEGG Orthology (KO)

More...KOi		K18671

Identification of Orthologs from Complete Genome Data

More...OMAi		LSQSVCM

Database of Orthologous Groups

More...OrthoDBi		EOG091G0210

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q969S8

TreeFam database of animal gene trees

More...TreeFami		TF106173

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.800.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000286 His_deacetylse
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR10625 PTHR10625, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00850 Hist_deacetyl, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01270 HDASUPER

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52768 SSF52768, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q969S8-1) [UniParc]FASTAAdd to basket
Also known as: B, Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTALVYHED MTATRLLWDD PECEIERPER LTAALDRLRQ RGLEQRCLRL 
        60         70         80         90        100
SAREASEEEL GLVHSPEYVS LVRETQVLGK EELQALSGQF DAIYFHPSTF 
       110        120        130        140        150
HCARLAAGAG LQLVDAVLTG AVQNGLALVR PPGHHGQRAA ANGFCVFNNV 
       160        170        180        190        200
AIAAAHAKQK HGLHRILVVD WDVHHGQGIQ YLFEDDPSVL YFSWHRYEHG 
       210        220        230        240        250
RFWPFLRESD ADAVGRGQGL GFTVNLPWNQ VGMGNADYVA AFLHLLLPLA 
       260        270        280        290        300
FEFDPELVLV SAGFDSAIGD PEGQMQATPE CFAHLTQLLQ VLAGGRVCAV 
       310        320        330        340        350
LEGGYHLESL AESVCMTVQT LLGDPAPPLS GPMAPCQSAL ESIQSARAAQ 
       360        370        380        390        400
APHWKSLQQQ DVTAVPMSPS SHSPEGRPPP LLPGGPVCKA AASAPSSLLD 
       410        420        430        440        450
QPCLCPAPSV RTAVALTTPD ITLVLPPDVI QQEASALREE TEAWARPHES 
       460        470        480        490        500
LAREEALTAL GKLLYLLDGM LDGQVNSGIA ATPASAAAAT LDVAVRRGLS 
       510        520        530        540        550
HGAQRLLCVA LGQLDRPPDL AHDGRSLWLN IRGKEAAALS MFHVSTPLPV 
       560        570        580        590        600
MTGGFLSCIL GLVLPLAYGF QPDLVLVALG PGHGLQGPHA ALLAAMLRGL 
       610        620        630        640        650
AGGRVLALLE ENSTPQLAGI LARVLNGEAP PSLGPSSVAS PEDVQALMYL 
       660 
RGQLEPQWKM LQCHPHLVA
Length:669
Mass (Da):71,445
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i872D9427E6893A18
GO
Isoform 2 (identifier: Q969S8-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     252-271: Missing.

Show »
Length:649
Mass (Da):69,385
Checksum:i7756351E6BC838FB
GO
Isoform 4 (identifier: Q969S8-4) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     612-669: NSTPQLAGIL...MLQCHPHLVA → VSWAGWRCCG...GPGAEWRGTS

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:658
Mass (Da):70,033
Checksum:i0EABDDA886585928
GO
Isoform 5 (identifier: Q969S8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     252-301: Missing.
     447-669: Missing.

Show »
Length:396
Mass (Da):43,016
Checksum:i22DE1D205E5856A0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J8B8C9J8B8_HUMAN
Histone deacetylase
HDAC10
619Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q08AP5Q08AP5_HUMAN
HDAC10 protein
HDAC10
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti92A → T in AAS48345 (Ref. 6) Curated1
Sequence conflicti177Q → R in AAS48345 (Ref. 6) Curated1
Sequence conflicti337Q → QRC in CAC21653 (PubMed:17974005).Curated1
Sequence conflicti594A → T in AAK92205 (PubMed:11677242).Curated1
Sequence conflicti594A → T in AAK92206 (PubMed:11677242).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049356429V → I. Corresponds to variant dbSNP:rs34402301Ensembl.1
Natural variantiVAR_015067584G → C1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014698252 – 301Missing in isoform 5. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_002089252 – 271Missing in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_014699447 – 669Missing in isoform 5. 1 PublicationAdd BLAST223
Alternative sequenceiVSP_002090612 – 669NSTPQ…PHLVA → VSWAGWRCCGVGRGKGPVTA SVFAPGPELHTPASRDPGPG AEWRGTS in isoform 4. 2 PublicationsAdd BLAST58

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF426160 mRNA Translation: AAL30513.1
AF393962 mRNA Translation: AAK84023.1
AF407272 mRNA Translation: AAK92205.1
AF407273 mRNA Translation: AAK92206.1
CR456465 mRNA Translation: CAG30351.1
AY450395 mRNA Translation: AAS48345.1
AL022328 Genomic DNA No translation available.
BC125083 mRNA Translation: AAI25084.1
AL512711 mRNA Translation: CAC21653.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14088.1 [Q969S8-1]
CCDS54545.1 [Q969S8-2]

NCBI Reference Sequences

More...RefSeqi		NP_001152758.1, NM_001159286.1 [Q969S8-2]
NP_114408.3, NM_032019.5 [Q969S8-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.26593

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000216271; ENSP00000216271; ENSG00000100429 [Q969S8-1]
ENST00000349505; ENSP00000343540; ENSG00000100429 [Q969S8-2]
ENST00000454936; ENSP00000406150; ENSG00000100429 [Q969S8-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		83933

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:83933

UCSC genome browser

More...UCSCi		uc003bkg.4 human [Q969S8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF426160 mRNA Translation: AAL30513.1
AF393962 mRNA Translation: AAK84023.1
AF407272 mRNA Translation: AAK92205.1
AF407273 mRNA Translation: AAK92206.1
CR456465 mRNA Translation: CAG30351.1
AY450395 mRNA Translation: AAS48345.1
AL022328 Genomic DNA No translation available.
BC125083 mRNA Translation: AAI25084.1
AL512711 mRNA Translation: CAC21653.2
CCDSiCCDS14088.1 [Q969S8-1]
CCDS54545.1 [Q969S8-2]
RefSeqiNP_001152758.1, NM_001159286.1 [Q969S8-2]
NP_114408.3, NM_032019.5 [Q969S8-1]
UniGeneiHs.26593

3D structure databases

ProteinModelPortaliQ969S8
SMRiQ969S8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123818, 36 interactors
CORUMiQ969S8
IntActiQ969S8, 11 interactors
STRINGi9606.ENSP00000216271

Chemistry databases

BindingDBiQ969S8
ChEMBLiCHEMBL5103
DrugBankiDB05015 Belinostat
DB06603 Panobinostat
GuidetoPHARMACOLOGYi2614

PTM databases

iPTMnetiQ969S8
PhosphoSitePlusiQ969S8

Polymorphism and mutation databases

BioMutaiHDAC10
DMDMi27734403

Proteomic databases

EPDiQ969S8
MaxQBiQ969S8
PaxDbiQ969S8
PeptideAtlasiQ969S8
PRIDEiQ969S8
ProteomicsDBi75833
75834 [Q969S8-2]
75835 [Q969S8-4]
75836 [Q969S8-5]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		83933
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216271; ENSP00000216271; ENSG00000100429 [Q969S8-1]
ENST00000349505; ENSP00000343540; ENSG00000100429 [Q969S8-2]
ENST00000454936; ENSP00000406150; ENSG00000100429 [Q969S8-5]
GeneIDi83933
KEGGihsa:83933
UCSCiuc003bkg.4 human [Q969S8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		83933
DisGeNETi83933
EuPathDBiHostDB:ENSG00000100429.17

GeneCards: human genes, protein and diseases

More...GeneCardsi		HDAC10

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0080289
HGNCiHGNC:18128 HDAC10
HPAiCAB045977
HPA056514
MIMi608544 gene
neXtProtiNX_Q969S8
OpenTargetsiENSG00000100429
PharmGKBiPA38297

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1343 Eukaryota
COG0123 LUCA
GeneTreeiENSGT00940000160061
HOVERGENiHBG051892
InParanoidiQ969S8
KOiK18671
OMAiLSQSVCM
OrthoDBiEOG091G0210
PhylomeDBiQ969S8
TreeFamiTF106173

Enzyme and pathway databases

BRENDAi3.5.1.98 2681
ReactomeiR-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-3214815 HDACs deacetylate histones
SABIO-RKiQ969S8
SIGNORiQ969S8

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HDAC10 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		HDAC10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		83933

Protein Ontology

More...PROi		PR:Q969S8

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000100429 Expressed in 157 organ(s), highest expression level in pituitary gland
CleanExiHS_HDAC10
ExpressionAtlasiQ969S8 baseline and differential
GenevisibleiQ969S8 HS

Family and domain databases

Gene3Di3.40.800.20, 2 hits
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 1 hit
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PRINTSiPR01270 HDASUPER
SUPFAMiSSF52768 SSF52768, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHDA10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q969S8
Secondary accession number(s): Q08AP4
, Q6STF9, Q96P77, Q96P78, Q9H028, Q9UGX1, Q9UGX2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: December 1, 2001
Last modified: December 5, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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