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UniProtKB - Q969S8 (HDA10_HUMAN)

Entry version 170 (29 Sep 2021)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
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Protein

Polyamine deacetylase HDAC10

Gene

HDAC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Polyamine deacetylase (PDAC), which acts preferentially on N8-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954).

Exhibits attenuated catalytic activity toward N1,N8-diacetylspermidine and very low activity, if any, toward N1-acetylspermidine (PubMed:28516954).

Histone deacetylase activity has been observed in vitro (PubMed:11861901, PubMed:11726666, PubMed:11677242, PubMed:11739383).

Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039).

The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954).

May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769).

May play a role in homologous recombination (PubMed:21247901).

May promote DNA mismatch repair (PubMed:26221039).

9 Publications

Miscellaneous

Like some other members of the HD type 2 subfamily, such as HDAC4, inhibited by the antitumor drug trichostatin A (TSA).1 Publication

Caution

Protein/histone deacetylase activity in vivo is uncertain. The 3D structure analysis of the zebrafish ortholog shows that a glutamate gatekeeper and a sterically constricted active site confer specificity for N8-acetylspermidine hydrolysis and disfavour acetyllysine hydrolysis. Supporting this observation, has been shown to exhibit only very low activity, if any, towards acetyl-lysine peptide substrates (PubMed:28516954). However, histone deacetylase activity has been observed in vitro (PubMed:28516954, PubMed:11861901, PubMed:11726666, PubMed:11677242, PubMed:11739383). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039).6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=110 µM for acetylcadaverine1 Publication
  2. KM=170 µM for acetylputrescine1 Publication
  3. KM=100 µM for N8-acetylspermidine1 Publication
  4. KM=180 µM for N1-acetylspermine1 Publication
  5. KM=150 µM for N1,N8-diacetylspermidine1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei20SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei135Proton donor/acceptorBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi172ZincBy similarity1
Metal bindingi174Zinc; via pros nitrogenBy similarity1
Metal bindingi265ZincBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei272Substrate specificityBy similarity1
Binding sitei305SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processAutophagy, DNA damage, DNA recombination, DNA repair
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.5.1.48, 2681
3.5.1.98, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q969S8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2122947, NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-3214815, HDACs deacetylate histones
R-HSA-350054, Notch-HLH transcription pathway

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q969S8

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q969S8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polyamine deacetylase HDAC10 (EC:3.5.1.481 Publication, EC:3.5.1.621 Publication)
Alternative name(s):
Histone deacetylase 10
Short name:
HD10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HDAC10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18128, HDAC10

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608544, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q969S8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000100429

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

In neuroblastoma cells, may promote autophagy in response to chemotherapy-induced DNA damage and efflux of chemotherapeutics via lysosomal exocytosis, hence protecting cells from cytotoxic agents (PubMed:23801752, PubMed:29968769). Expression levels may correlate with survival in neuroblastoma patients, with low levels in the tumor correlating with long-term patient survival and high expression with poor prognosis (PubMed:23801752). Therefore has been proposed as a biomarker to predict neuroblastoma chemoresistance and treatment outcome (PubMed:23801752).1 Publication2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi135H → A: Abolishes deacetylase activity. Does not affect interaction with HDAC3. Loss of autophagy regulation. 3 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		83933

Open Targets

More...OpenTargetsi		ENSG00000100429

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38297

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q969S8, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5103

Drug and drug target database

More...DrugBanki		DB05015, Belinostat
DB13346, Bufexamac
DB06603, Panobinostat

DrugCentral

More...DrugCentrali		Q969S8

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2614

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HDAC10

Domain mapping of disease mutations (DMDM)

More...DMDMi		27734403

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001147121 – 669Polyamine deacetylase HDAC10Add BLAST669

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei393PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q969S8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q969S8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q969S8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q969S8

PeptideAtlas

More...PeptideAtlasi		Q969S8

PRoteomics IDEntifications database

More...PRIDEi		Q969S8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75833 [Q969S8-1]
75834 [Q969S8-2]
75835 [Q969S8-4]
75836 [Q969S8-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q969S8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q969S8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with high levels in liver and kidney.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100429, Expressed in granulocyte and 174 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q969S8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q969S8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000100429, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HDAC3 (PubMed:11861901).

Interacts with HDAC2 and NCOR2/SMRT (PubMed:11739383).

Interacts with HSPA8/HSC70 (PubMed:23801752).

Interacts with MSH2 (PubMed:26221039).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123818, 40 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q969S8

Protein interaction database and analysis system

More...IntActi		Q969S8, 30 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000216271

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q969S8

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q969S8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q969S8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 323Histone deacetylaseAdd BLAST323
Regioni361 – 387DisorderedSequence analysisAdd BLAST27

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi21 – 24Substrate specificityBy similarity4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the histone deacetylase family. HD type 2 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1343, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160061

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007727_6_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q969S8

Identification of Orthologs from Complete Genome Data

More...OMAi		CEKEQSG

Database of Orthologous Groups

More...OrthoDBi		1484694at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q969S8

TreeFam database of animal gene trees

More...TreeFami		TF106173

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.800.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000286, His_deacetylse
IPR023801, His_deacetylse_dom
IPR037138, His_deacetylse_dom_sf
IPR023696, Ureohydrolase_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00850, Hist_deacetyl, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01270, HDASUPER

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52768, SSF52768, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q969S8-1) [UniParc]FASTAAdd to basket
Also known as: Alpha1 Publication, HDAC10b1 Publication, HDAC10v11 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTALVYHED MTATRLLWDD PECEIERPER LTAALDRLRQ RGLEQRCLRL 
        60         70         80         90        100
SAREASEEEL GLVHSPEYVS LVRETQVLGK EELQALSGQF DAIYFHPSTF 
       110        120        130        140        150
HCARLAAGAG LQLVDAVLTG AVQNGLALVR PPGHHGQRAA ANGFCVFNNV 
       160        170        180        190        200
AIAAAHAKQK HGLHRILVVD WDVHHGQGIQ YLFEDDPSVL YFSWHRYEHG 
       210        220        230        240        250
RFWPFLRESD ADAVGRGQGL GFTVNLPWNQ VGMGNADYVA AFLHLLLPLA 
       260        270        280        290        300
FEFDPELVLV SAGFDSAIGD PEGQMQATPE CFAHLTQLLQ VLAGGRVCAV 
       310        320        330        340        350
LEGGYHLESL AESVCMTVQT LLGDPAPPLS GPMAPCQSAL ESIQSARAAQ 
       360        370        380        390        400
APHWKSLQQQ DVTAVPMSPS SHSPEGRPPP LLPGGPVCKA AASAPSSLLD 
       410        420        430        440        450
QPCLCPAPSV RTAVALTTPD ITLVLPPDVI QQEASALREE TEAWARPHES 
       460        470        480        490        500
LAREEALTAL GKLLYLLDGM LDGQVNSGIA ATPASAAAAT LDVAVRRGLS 
       510        520        530        540        550
HGAQRLLCVA LGQLDRPPDL AHDGRSLWLN IRGKEAAALS MFHVSTPLPV 
       560        570        580        590        600
MTGGFLSCIL GLVLPLAYGF QPDLVLVALG PGHGLQGPHA ALLAAMLRGL 
       610        620        630        640        650
AGGRVLALLE ENSTPQLAGI LARVLNGEAP PSLGPSSVAS PEDVQALMYL 
       660 
RGQLEPQWKM LQCHPHLVA
Length:669
Mass (Da):71,445
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i872D9427E6893A18
GO
Isoform 2 (identifier: Q969S8-2) [UniParc]FASTAAdd to basket
Also known as: Beta1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     252-271: Missing.

Show »
Length:649
Mass (Da):69,385
Checksum:i7756351E6BC838FB
GO
Isoform 4 (identifier: Q969S8-4) [UniParc]FASTAAdd to basket
Also known as: A, HDAC10v21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     612-669: NSTPQLAGIL...MLQCHPHLVA → VSWAGWRCCG...GPGAEWRGTS

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:658
Mass (Da):70,033
Checksum:i0EABDDA886585928
GO
Isoform 5 (identifier: Q969S8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     252-301: Missing.
     447-669: Missing.

Show »
Length:396
Mass (Da):43,016
Checksum:i22DE1D205E5856A0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J8B8C9J8B8_HUMAN
Polyamine deacetylase HDAC10
HDAC10
619Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q08AP5Q08AP5_HUMAN
HDAC10 protein
HDAC10
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti92A → T in AAS48345 (Ref. 6) Curated1
Sequence conflicti177Q → R in AAS48345 (Ref. 6) Curated1
Sequence conflicti337Q → QRC in CAC21653 (PubMed:17974005).Curated1
Sequence conflicti337Q → QRCEG no nucleotide entry (PubMed:11739383).Curated1
Sequence conflicti594A → T in AAK92205 (PubMed:11677242).Curated1
Sequence conflicti594A → T in AAK92206 (PubMed:11677242).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049356429V → I. Corresponds to variant dbSNP:rs34402301Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014698252 – 301Missing in isoform 5. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_002089252 – 271Missing in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_014699447 – 669Missing in isoform 5. 1 PublicationAdd BLAST223
Alternative sequenceiVSP_002090612 – 669NSTPQ…PHLVA → VSWAGWRCCGVGRGKGPVTA SVFAPGPELHTPASRDPGPG AEWRGTS in isoform 4. 2 PublicationsAdd BLAST58

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF426160 mRNA Translation: AAL30513.1
AF393962 mRNA Translation: AAK84023.1
AF407272 mRNA Translation: AAK92205.1
AF407273 mRNA Translation: AAK92206.1
CR456465 mRNA Translation: CAG30351.1
AY450395 mRNA Translation: AAS48345.1
AL022328 Genomic DNA No translation available.
BC125083 mRNA Translation: AAI25084.1
AL512711 mRNA Translation: CAC21653.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14088.1 [Q969S8-1]
CCDS54545.1 [Q969S8-2]

NCBI Reference Sequences

More...RefSeqi		NP_001152758.1, NM_001159286.1 [Q969S8-2]
NP_114408.3, NM_032019.5 [Q969S8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000216271; ENSP00000216271; ENSG00000100429 [Q969S8-1]
ENST00000349505; ENSP00000343540; ENSG00000100429 [Q969S8-2]
ENST00000454936; ENSP00000406150; ENSG00000100429 [Q969S8-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		83933

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:83933

UCSC genome browser

More...UCSCi		uc003bkg.4, human [Q969S8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF426160 mRNA Translation: AAL30513.1
AF393962 mRNA Translation: AAK84023.1
AF407272 mRNA Translation: AAK92205.1
AF407273 mRNA Translation: AAK92206.1
CR456465 mRNA Translation: CAG30351.1
AY450395 mRNA Translation: AAS48345.1
AL022328 Genomic DNA No translation available.
BC125083 mRNA Translation: AAI25084.1
AL512711 mRNA Translation: CAC21653.2
CCDSiCCDS14088.1 [Q969S8-1]
CCDS54545.1 [Q969S8-2]
RefSeqiNP_001152758.1, NM_001159286.1 [Q969S8-2]
NP_114408.3, NM_032019.5 [Q969S8-1]

3D structure databases

SMRiQ969S8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123818, 40 interactors
CORUMiQ969S8
IntActiQ969S8, 30 interactors
STRINGi9606.ENSP00000216271

Chemistry databases

BindingDBiQ969S8
ChEMBLiCHEMBL5103
DrugBankiDB05015, Belinostat
DB13346, Bufexamac
DB06603, Panobinostat
DrugCentraliQ969S8
GuidetoPHARMACOLOGYi2614

PTM databases

iPTMnetiQ969S8
PhosphoSitePlusiQ969S8

Genetic variation databases

BioMutaiHDAC10
DMDMi27734403

Proteomic databases

jPOSTiQ969S8
MassIVEiQ969S8
MaxQBiQ969S8
PaxDbiQ969S8
PeptideAtlasiQ969S8
PRIDEiQ969S8
ProteomicsDBi75833 [Q969S8-1]
75834 [Q969S8-2]
75835 [Q969S8-4]
75836 [Q969S8-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		14233, 486 antibodies

The DNASU plasmid repository

More...DNASUi		83933

Genome annotation databases

EnsembliENST00000216271; ENSP00000216271; ENSG00000100429 [Q969S8-1]
ENST00000349505; ENSP00000343540; ENSG00000100429 [Q969S8-2]
ENST00000454936; ENSP00000406150; ENSG00000100429 [Q969S8-5]
GeneIDi83933
KEGGihsa:83933
UCSCiuc003bkg.4, human [Q969S8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		83933
DisGeNETi83933

GeneCards: human genes, protein and diseases

More...GeneCardsi		HDAC10
HGNCiHGNC:18128, HDAC10
HPAiENSG00000100429, Low tissue specificity
MIMi608544, gene
neXtProtiNX_Q969S8
OpenTargetsiENSG00000100429
PharmGKBiPA38297
VEuPathDBiHostDB:ENSG00000100429

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1343, Eukaryota
GeneTreeiENSGT00940000160061
HOGENOMiCLU_007727_6_0_1
InParanoidiQ969S8
OMAiCEKEQSG
OrthoDBi1484694at2759
PhylomeDBiQ969S8
TreeFamiTF106173

Enzyme and pathway databases

BRENDAi3.5.1.48, 2681
3.5.1.98, 2681
PathwayCommonsiQ969S8
ReactomeiR-HSA-2122947, NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-3214815, HDACs deacetylate histones
R-HSA-350054, Notch-HLH transcription pathway
SABIO-RKiQ969S8
SIGNORiQ969S8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		83933, 1 hit in 1022 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HDAC10, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		HDAC10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		83933
PharosiQ969S8, Tclin

Protein Ontology

More...PROi		PR:Q969S8
RNActiQ969S8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000100429, Expressed in granulocyte and 174 other tissues
ExpressionAtlasiQ969S8, baseline and differential
GenevisibleiQ969S8, HS

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286, His_deacetylse
IPR023801, His_deacetylse_dom
IPR037138, His_deacetylse_dom_sf
IPR023696, Ureohydrolase_dom_sf
PfamiView protein in Pfam
PF00850, Hist_deacetyl, 1 hit
PRINTSiPR01270, HDASUPER
SUPFAMiSSF52768, SSF52768, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHDA10_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q969S8
Secondary accession number(s): Q08AP4
, Q6STF9, Q96P77, Q96P78, Q9H028, Q9UGX1, Q9UGX2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: December 1, 2001
Last modified: September 29, 2021
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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