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Protein

Transmembrane protein 203

Gene

TMEM203

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the regulation of cellular calcium homeotasis (PubMed:25996873). Required for spermatogenesis (PubMed:25996873).1 Publication

GO - Biological processi

  • cellular calcium ion homeostasis Source: UniProtKB
  • spermatogenesis Source: UniProtKB

Protein family/group databases

TCDBi8.A.76.1.1 the tmem203 or pf14967 (tmem203) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 203
Gene namesi
Name:TMEM203
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000187713.6
HGNCiHGNC:28217 TMEM203
MIMi616499 gene
neXtProtiNX_Q969S6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Transmembranei50 – 72HelicalSequence analysisAdd BLAST23
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187713
PharmGKBiPA162406377

Polymorphism and mutation databases

BioMutaiTMEM203
DMDMi74731059

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003172031 – 136Transmembrane protein 203Add BLAST136

Proteomic databases

PaxDbiQ969S6
PRIDEiQ969S6
ProteomicsDBi75832

Expressioni

Gene expression databases

BgeeiENSG00000187713
CleanExiHS_TMEM203
GenevisibleiQ969S6 HS

Interactioni

Subunit structurei

Interacts with ATP2A2, ITPR3 and STIM1.1 Publication

Protein-protein interaction databases

BioGridi125117, 3 interactors
IntActiQ969S6, 29 interactors
STRINGi9606.ENSP00000375053

Structurei

3D structure databases

ProteinModelPortaliQ969S6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY4R Eukaryota
ENOG4111SGD LUCA
GeneTreeiENSGT00510000049510
HOGENOMiHOG000007895
HOVERGENiHBG059488
InParanoidiQ969S6
OMAiFEIWINL
OrthoDBiEOG091G0UU5
PhylomeDBiQ969S6
TreeFamiTF323514

Family and domain databases

InterProiView protein in InterPro
IPR019396 TM_Fragile-X-F-assoc
PfamiView protein in Pfam
PF10269 Tmemb_185A, 1 hit

Sequencei

Sequence statusi: Complete.

Q969S6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFSLRELVQ WLGFATFEIF VHLLALLVFS VLLALRVDGL VPGLSWWNVF
60 70 80 90 100
VPFFAADGLS TYFTTIVSVR LFQDGEKRLA VLRLFWVLTV LSLKFVFEML
110 120 130
LCQKLAEQTR ELWFGLITSP LFILLQLLMI RACRVN
Length:136
Mass (Da):15,760
Last modified:December 1, 2001 - v1
Checksum:i87CA7D87F00B16FC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96V → F in AAH67786 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471090 Genomic DNA Translation: EAW88365.1
BC009283 mRNA Translation: AAH09283.1
BC009461 mRNA Translation: AAH09461.1
BC067786 mRNA Translation: AAH67786.1
CCDSiCCDS35185.1
RefSeqiNP_444273.1, NM_053045.1
UniGeneiHs.231029

Genome annotation databases

EnsembliENST00000343666; ENSP00000375053; ENSG00000187713
GeneIDi94107
KEGGihsa:94107
UCSCiuc004clv.4 human

Similar proteinsi

Entry informationi

Entry nameiTM203_HUMAN
AccessioniPrimary (citable) accession number: Q969S6
Secondary accession number(s): Q6NW08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: July 18, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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